JP2018520993A5 - - Google Patents
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- JP2018520993A5 JP2018520993A5 JP2017557938A JP2017557938A JP2018520993A5 JP 2018520993 A5 JP2018520993 A5 JP 2018520993A5 JP 2017557938 A JP2017557938 A JP 2017557938A JP 2017557938 A JP2017557938 A JP 2017557938A JP 2018520993 A5 JP2018520993 A5 JP 2018520993A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 140
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 120
- 102000050320 human TNFRSF4 Human genes 0.000 claims description 120
- 239000000427 antigen Substances 0.000 claims description 88
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- 108091007433 antigens Proteins 0.000 claims description 88
- 230000035772 mutation Effects 0.000 claims description 50
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- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 18
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
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- 102220626433 Methyl-CpG-binding domain protein 2_P93A_mutation Human genes 0.000 claims description 14
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- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 2
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- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
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- 241000589516 Pseudomonas Species 0.000 claims description 2
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- 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 claims description 2
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- YPBKTZBXSBLTDK-PKNBQFBNSA-N (3e)-3-[(3-bromo-4-fluoroanilino)-nitrosomethylidene]-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole Chemical group NS(=O)(=O)NCCNC1=NON\C1=C(N=O)/NC1=CC=C(F)C(Br)=C1 YPBKTZBXSBLTDK-PKNBQFBNSA-N 0.000 claims 1
- RFMMMVDNIPUKGG-YFKPBYRVSA-N N-acetyl-L-glutamic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCC(O)=O RFMMMVDNIPUKGG-YFKPBYRVSA-N 0.000 claims 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021066377A JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2023122389A JP2023156367A (ja) | 2015-05-07 | 2023-07-27 | 抗ｏｘ４０抗体及びその使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158515P | 2015-05-07 | 2015-05-07 | |
| US62/158,515 | 2015-05-07 | ||
| US201562161198P | 2015-05-13 | 2015-05-13 | |
| US62/161,198 | 2015-05-13 | ||
| US201562262373P | 2015-12-02 | 2015-12-02 | |
| US62/262,373 | 2015-12-02 | ||
| US201662323458P | 2016-04-15 | 2016-04-15 | |
| US62/323,458 | 2016-04-15 | ||
| PCT/US2016/031257 WO2016179517A1 (en) | 2015-05-07 | 2016-05-06 | Anti-ox40 antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021066377A Division JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520993A JP2018520993A (ja) | 2018-08-02 |
| JP2018520993A5 true JP2018520993A5 (OSRAM) | 2019-06-13 |
| JP6867955B2 JP6867955B2 (ja) | 2021-05-12 |
Family
ID=56015132
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557938A Active JP6867955B2 (ja) | 2015-05-07 | 2016-05-06 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2021066377A Active JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2023122389A Pending JP2023156367A (ja) | 2015-05-07 | 2023-07-27 | 抗ｏｘ４０抗体及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021066377A Active JP7404303B2 (ja) | 2015-05-07 | 2021-04-09 | 抗ｏｘ４０抗体及びその使用方法 |
| JP2023122389A Pending JP2023156367A (ja) | 2015-05-07 | 2023-07-27 | 抗ｏｘ４０抗体及びその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US10259882B2 (OSRAM) |
| EP (1) | EP3292152A1 (OSRAM) |
| JP (3) | JP6867955B2 (OSRAM) |
| KR (1) | KR20180015650A (OSRAM) |
| CN (2) | CN115109158A (OSRAM) |
| AU (2) | AU2016256911B2 (OSRAM) |
| BR (1) | BR112017023849A2 (OSRAM) |
| CA (1) | CA2984794A1 (OSRAM) |
| EA (1) | EA201792451A1 (OSRAM) |
| HK (1) | HK1250513A1 (OSRAM) |
| IL (1) | IL255278A0 (OSRAM) |
| MA (1) | MA42043A (OSRAM) |
| MX (1) | MX2017014188A (OSRAM) |
| MY (1) | MY189692A (OSRAM) |
| PH (1) | PH12017502013B1 (OSRAM) |
| SG (1) | SG11201708804WA (OSRAM) |
| TW (2) | TWI716405B (OSRAM) |
| WO (1) | WO2016179517A1 (OSRAM) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME02678B (me) * | 2010-08-23 | 2017-06-20 | Univ Texas | Antitijela na ox-40 i postupci njihove primjene |
| UA119319C2 (uk) | 2013-03-18 | 2019-06-10 | Біосерокс Продактс Б.В. | Гуманізоване антитіло до cd134 (ox40) і його застосування |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| BR112017016681A2 (pt) * | 2015-02-06 | 2018-04-10 | Heat Biologics Inc | vetor de coexpressão de vacina e moléculas coestimulatórias |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| PH12017502013B1 (en) | 2015-05-07 | 2022-07-22 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| EP3363816A4 (en) | 2015-10-15 | 2019-10-09 | Dingfu Biotarget Co., Ltd. | ANTI-OX40 ANTIBODIES AND USES THEREOF |
| SG11201804265XA (en) | 2015-12-02 | 2018-06-28 | Agenus Inc | Antibodies and methods of use thereof |
| WO2017096182A1 (en) * | 2015-12-03 | 2017-06-08 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
| MX2018007204A (es) | 2015-12-16 | 2018-12-11 | Gritstone Oncology Inc | Identificacion, fabricacion y uso de neoantigeno. |
| TWI765885B (zh) * | 2016-04-21 | 2022-06-01 | 美商菲歐普提斯公司 | 利用黑色素校正之測定組織氧飽和度的方法和裝置 |
| CA3026474A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| CA3041340A1 (en) * | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| KR102603681B1 (ko) | 2016-12-07 | 2023-11-17 | 아게누스 인코포레이티드 | 항체 및 이의 사용방법 |
| CR20190330A (es) * | 2016-12-15 | 2019-12-19 | Abbvie Biotherapeutics Inc | Anticuerpos anti-ox40 y sus usos |
| EA201991207A1 (ru) | 2016-12-19 | 2019-12-30 | Гленмарк Фармасьютикалс С.А. | Новые агонисты tnfr и их применение |
| CN108623686A (zh) | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | 抗ox40抗体及其用途 |
| EP3612234B1 (en) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Combination therapy with an anti-axl antibody-drug conjugate |
| EP3612236A1 (en) | 2017-04-20 | 2020-02-26 | ADC Therapeutics SA | Combination therapy with an anti-cd25 antibody-drug conjugate |
| WO2018217064A2 (ko) | 2017-05-26 | 2018-11-29 | 주식회사 녹십자랩셀 | 형질전환된 t세포를 이용한 자연살해세포의 배양방법 |
| JP7145891B2 (ja) | 2017-06-14 | 2022-10-03 | アーデーセー セラピューティクス ソシエテ アノニム | 抗ｃｄ１９ ａｄｃを投与するための投与レジメ |
| KR20200064085A (ko) * | 2017-09-07 | 2020-06-05 | 큐 바이오파마, 인크. | 접합 부위를 갖는 t-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법 |
| AU2018348165B2 (en) | 2017-10-10 | 2025-09-04 | Seattle Project Corp. | Neoantigen identification using hotspots |
| US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
| CN109970864A (zh) * | 2017-12-28 | 2019-07-05 | 上海细胞治疗研究院 | 一种双向激活共刺激分子受体及其用途 |
| CN108218990B (zh) | 2017-12-29 | 2021-03-02 | 南京优迈生物科技有限公司 | 分离的抗体或其抗原结合片段及其在肿瘤治疗中的应用 |
| EP4074732A1 (en) | 2018-05-11 | 2022-10-19 | Wuxi Biologics (Shanghai) Co. Ltd. | Fully human antibodies against ox40, method for preparing the same, and use thereof |
| SG11202010469QA (en) | 2018-05-23 | 2020-11-27 | Adc Therapeutics Sa | Molecular adjuvant |
| DK4257600T3 (da) | 2018-07-03 | 2025-05-26 | Gilead Sciences Inc | Antistoffer rettet mod hiv gp120 og fremgangsmåder til at bruge dem |
| US20210277135A1 (en) | 2018-07-13 | 2021-09-09 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a method of treating a cancer or a solid tumor |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| EP3858857A1 (en) | 2018-09-26 | 2021-08-04 | Jiangsu Hengrui Medicine Co., Ltd. | An anti-ox40 antibody, antigen-binding fragment thereof, and the pharmaceutical use |
| CN113166263A (zh) | 2018-10-11 | 2021-07-23 | 印希比股份有限公司 | Dll3单域抗体及其治疗性组合物 |
| CN120623346A (zh) | 2018-10-11 | 2025-09-12 | 因荷布瑞克斯生物科学公司 | Pd-1单结构域抗体及其治疗组合物 |
| SG11202104662UA (en) * | 2018-11-14 | 2021-06-29 | Green Cross Lab Cell Corp | Method for culturing cord blood-derived natural killer cells using transformed t-cells |
| JP7346576B2 (ja) | 2018-12-25 | 2023-09-19 | ハンクス バイオファーマシューティクス，インコーポレイテッド | 抗ｏｘ４０モノクローナル抗体とその応用 |
| US10442866B1 (en) * | 2019-01-23 | 2019-10-15 | Beijing Mabworks Biotech Co. Ltd | Antibodies binding OX40 and uses thereof |
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| TWI762925B (zh) | 2019-05-21 | 2022-05-01 | 美商基利科學股份有限公司 | 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法 |
| NZ783169A (en) | 2019-06-25 | 2024-12-20 | Gilead Sciences Inc | Flt3l-fc fusion proteins and methods of use |
| CN114040776B (zh) * | 2019-06-28 | 2024-05-14 | 江苏恒瑞医药股份有限公司 | Tlr激动剂与抗ox40抗体或其抗原结合片段联合在制备治疗肿瘤的药物中的用途 |
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| CN118178645A (zh) | 2019-10-18 | 2024-06-14 | 四十七公司 | 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法 |
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| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
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| US20160347848A1 (en) | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| JP6797137B2 (ja) | 2015-05-29 | 2020-12-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｏｘ４０に対する抗体およびその使用 |
| CN108368176B (zh) | 2015-10-01 | 2022-06-07 | 波滕扎治疗公司 | 抗tigit抗原结合蛋白及其使用方法 |
| SG11201804265XA (en) | 2015-12-02 | 2018-06-28 | Agenus Inc | Antibodies and methods of use thereof |
| EP3383914A4 (en) | 2015-12-02 | 2019-10-30 | Agenus Inc. | ANTI-OX40 ANTIBODIES AND METHOD OF USE THEREOF |
| WO2017096182A1 (en) | 2015-12-03 | 2017-06-08 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
| LT3429618T (lt) | 2016-03-16 | 2024-05-10 | Amal Therapeutics Sa | Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje |
| US11596699B2 (en) | 2016-04-29 | 2023-03-07 | CureVac SE | RNA encoding an antibody |
| CA3041340A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
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2016
- 2016-05-06 PH PH1/2017/502013A patent/PH12017502013B1/en unknown
- 2016-05-06 BR BR112017023849A patent/BR112017023849A2/pt not_active IP Right Cessation
- 2016-05-06 MA MA042043A patent/MA42043A/fr unknown
- 2016-05-06 TW TW105114161A patent/TWI716405B/zh not_active IP Right Cessation
- 2016-05-06 WO PCT/US2016/031257 patent/WO2016179517A1/en not_active Ceased
- 2016-05-06 TW TW110100363A patent/TWI820377B/zh not_active IP Right Cessation
- 2016-05-06 CN CN202210581278.7A patent/CN115109158A/zh active Pending
- 2016-05-06 JP JP2017557938A patent/JP6867955B2/ja active Active
- 2016-05-06 US US15/148,720 patent/US10259882B2/en active Active
- 2016-05-06 EP EP16723616.5A patent/EP3292152A1/en active Pending
- 2016-05-06 CN CN201680039426.5A patent/CN108137686B/zh active Active
- 2016-05-06 MX MX2017014188A patent/MX2017014188A/es unknown
- 2016-05-06 MY MYPI2017001627A patent/MY189692A/en unknown
- 2016-05-06 EA EA201792451A patent/EA201792451A1/ru unknown
- 2016-05-06 SG SG11201708804WA patent/SG11201708804WA/en unknown
- 2016-05-06 KR KR1020177035013A patent/KR20180015650A/ko not_active Ceased
- 2016-05-06 AU AU2016256911A patent/AU2016256911B2/en active Active
- 2016-05-06 CA CA2984794A patent/CA2984794A1/en active Pending
- 2016-05-06 HK HK18109884.0A patent/HK1250513A1/zh unknown
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2017
- 2017-10-26 IL IL255278A patent/IL255278A0/en unknown
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2019
- 2019-02-25 US US16/284,811 patent/US11136404B2/en active Active
- 2019-04-15 US US16/384,116 patent/US10626181B2/en active Active
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2020
- 2020-02-07 US US16/784,469 patent/US11332536B2/en active Active
- 2020-03-03 US US16/808,074 patent/US11472883B2/en active Active
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2021
- 2021-04-09 JP JP2021066377A patent/JP7404303B2/ja active Active
- 2021-09-01 US US17/446,706 patent/US20220098316A1/en not_active Abandoned
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2022
- 2022-03-15 AU AU2022201791A patent/AU2022201791A1/en not_active Abandoned
- 2022-09-08 US US17/930,542 patent/US20230167186A1/en active Pending
- 2022-09-08 US US17/930,555 patent/US20230108348A1/en active Pending
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2023
- 2023-07-27 JP JP2023122389A patent/JP2023156367A/ja active Pending
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