JP2018519351A5 - - Google Patents
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- JP2018519351A5 JP2018519351A5 JP2018500417A JP2018500417A JP2018519351A5 JP 2018519351 A5 JP2018519351 A5 JP 2018519351A5 JP 2018500417 A JP2018500417 A JP 2018500417A JP 2018500417 A JP2018500417 A JP 2018500417A JP 2018519351 A5 JP2018519351 A5 JP 2018519351A5
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- Prior art keywords
- compound
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- pharmaceutically acceptable
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- 150000001875 compounds Chemical class 0.000 claims description 193
- 150000003839 salts Chemical class 0.000 claims description 51
- 229910052739 hydrogen Inorganic materials 0.000 claims description 36
- 239000001257 hydrogen Substances 0.000 claims description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
- 150000002431 hydrogen Chemical class 0.000 claims description 28
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 26
- 208000035475 disorder Diseases 0.000 claims description 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 18
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 150000001721 carbon Chemical group 0.000 claims description 12
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 10
- 208000014617 hemorrhoid Diseases 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 claims description 6
- 208000028017 Psychotic disease Diseases 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 6
- 235000003702 sterols Nutrition 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 238000003786 synthesis reaction Methods 0.000 claims description 5
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- 201000011510 cancer Diseases 0.000 claims description 4
- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 3
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- 208000019022 Mood disease Diseases 0.000 claims description 2
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- 208000029726 Neurodevelopmental disease Diseases 0.000 claims description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 201000009916 Postpartum depression Diseases 0.000 claims description 2
- 208000006289 Rett Syndrome Diseases 0.000 claims description 2
- 206010039897 Sedation Diseases 0.000 claims description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 2
- 206010041250 Social phobia Diseases 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- 206010042458 Suicidal ideation Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 208000005298 acute pain Diseases 0.000 claims description 2
- 230000006978 adaptation Effects 0.000 claims description 2
- 230000037005 anaesthesia Effects 0.000 claims description 2
- 208000029560 autism spectrum disease Diseases 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010009887 colitis Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 208000018459 dissociative disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000024732 dysthymic disease Diseases 0.000 claims description 2
- 206010014599 encephalitis Diseases 0.000 claims description 2
- 230000001037 epileptic effect Effects 0.000 claims description 2
- 230000010370 hearing loss Effects 0.000 claims description 2
- 231100000888 hearing loss Toxicity 0.000 claims description 2
- 208000016354 hearing loss disease Diseases 0.000 claims description 2
- 208000007386 hepatic encephalopathy Diseases 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 206010022437 insomnia Diseases 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims description 2
- 230000036407 pain Effects 0.000 claims description 2
- 208000022821 personality disease Diseases 0.000 claims description 2
- 208000014081 polyp of colon Diseases 0.000 claims description 2
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000022610 schizoaffective disease Diseases 0.000 claims description 2
- 201000000980 schizophrenia Diseases 0.000 claims description 2
- 230000036280 sedation Effects 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 125000002328 sterol group Chemical group 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 208000009999 tuberous sclerosis Diseases 0.000 claims description 2
- 230000000007 visual effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 10
- 0 C[C@](CCCC(*)(*)O)[C@@](CC1)[C@@](C)(CC2)[C@]1C(CC1)[C@]2[C@@](C)(CCC(C2)O)C12N Chemical compound C[C@](CCCC(*)(*)O)[C@@](CC1)[C@@](C)(CC2)[C@]1C(CC1)[C@]2[C@@](C)(CCC(C2)O)C12N 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000000069 prophylactic effect Effects 0.000 description 3
- -1 butyl Compound Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189048P | 2015-07-06 | 2015-07-06 | |
| US62/189,048 | 2015-07-06 | ||
| US201662280394P | 2016-01-19 | 2016-01-19 | |
| US62/280,394 | 2016-01-19 | ||
| PCT/US2016/041168 WO2017007836A1 (en) | 2015-07-06 | 2016-07-06 | Oxysterols and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021002172A Division JP2021054864A (ja) | 2015-07-06 | 2021-01-08 | オキシステロールおよびそれらの使用の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018519351A JP2018519351A (ja) | 2018-07-19 |
| JP2018519351A5 true JP2018519351A5 (https=) | 2019-07-25 |
Family
ID=57686105
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500417A Withdrawn JP2018519351A (ja) | 2015-07-06 | 2016-07-06 | オキシステロールおよびそれらの使用の方法 |
| JP2021002172A Withdrawn JP2021054864A (ja) | 2015-07-06 | 2021-01-08 | オキシステロールおよびそれらの使用の方法 |
| JP2022093073A Active JP7602513B2 (ja) | 2015-07-06 | 2022-06-08 | オキシステロールおよびそれらの使用の方法 |
| JP2024213240A Pending JP2025026573A (ja) | 2015-07-06 | 2024-12-06 | オキシステロールおよびそれらの使用の方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021002172A Withdrawn JP2021054864A (ja) | 2015-07-06 | 2021-01-08 | オキシステロールおよびそれらの使用の方法 |
| JP2022093073A Active JP7602513B2 (ja) | 2015-07-06 | 2022-06-08 | オキシステロールおよびそれらの使用の方法 |
| JP2024213240A Pending JP2025026573A (ja) | 2015-07-06 | 2024-12-06 | オキシステロールおよびそれらの使用の方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US10201550B2 (https=) |
| EP (3) | EP3828194B1 (https=) |
| JP (4) | JP2018519351A (https=) |
| KR (2) | KR102703602B1 (https=) |
| CN (2) | CN108135912B (https=) |
| AU (3) | AU2016289967B2 (https=) |
| BR (2) | BR122021005552B1 (https=) |
| CA (1) | CA2991214C (https=) |
| CO (1) | CO2018000660A2 (https=) |
| CY (1) | CY1124496T1 (https=) |
| DK (2) | DK3828194T3 (https=) |
| ES (2) | ES2865258T3 (https=) |
| FI (1) | FI3828194T3 (https=) |
| HR (1) | HRP20210526T8 (https=) |
| HU (1) | HUE053778T2 (https=) |
| IL (2) | IL256710B2 (https=) |
| LT (1) | LT3319611T (https=) |
| MA (2) | MA55097A (https=) |
| MD (1) | MD3319611T2 (https=) |
| MX (2) | MX376833B (https=) |
| PE (1) | PE20180483A1 (https=) |
| PH (2) | PH12021551134A1 (https=) |
| PL (2) | PL3319611T3 (https=) |
| PT (2) | PT3828194T (https=) |
| RS (1) | RS61718B1 (https=) |
| RU (2) | RU2021100620A (https=) |
| SG (1) | SG10202010553XA (https=) |
| SI (1) | SI3319611T1 (https=) |
| SM (1) | SMT202100226T1 (https=) |
| WO (1) | WO2017007836A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20230747T1 (hr) | 2011-09-08 | 2024-01-05 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihova uporaba |
| SMT201800657T1 (it) | 2013-03-13 | 2019-01-11 | Sage Therapeutics Inc | Steroidi neuroattivi e loro metodi di utilizzo |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10238664B2 (en) | 2014-07-09 | 2019-03-26 | Duke University | Compositions and methods for the repair of myelin |
| AU2016289965B2 (en) | 2015-07-06 | 2021-09-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| MX382122B (es) | 2015-07-06 | 2025-03-13 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
| PL3319611T3 (pl) | 2015-07-06 | 2021-07-12 | Sage Therapeutics, Inc. | Oksysterole i sposoby ich stosowania |
| EP3436022B1 (en) * | 2016-04-01 | 2022-03-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2018009867A1 (en) | 2016-07-07 | 2018-01-11 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PT3519422T (pt) | 2016-09-30 | 2022-12-05 | Sage Therapeutics Inc | Oxisteróis substituídos em c7 e métodos como moduladores nmda |
| DK4105223T3 (da) | 2016-10-18 | 2025-07-07 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| CA3041088C (en) | 2016-10-18 | 2024-05-21 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US11458146B2 (en) | 2017-01-13 | 2022-10-04 | Duke University | Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| JP2024520805A (ja) | 2021-06-11 | 2024-05-24 | セージ セラピューティクス， インコーポレイテッド | アルツハイマー病の治療のための神経活性ステロイド |
| CN113667734B (zh) * | 2021-07-16 | 2022-05-24 | 四川大学华西医院 | Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途 |
| JP2024532273A (ja) * | 2021-08-25 | 2024-09-05 | セージ セラピューティクス， インコーポレイテッド | ポジティブｎｍｄａモジュレート化合物及びその使用方法 |
| US20250387409A1 (en) * | 2021-11-10 | 2025-12-25 | Umecrine Cognition Ab | 3-beta-hydroxy-3-alpha-ethyl steroids for modulation of the alpha-3 subtype of the gabaa receptor |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| CN116789726A (zh) * | 2022-01-28 | 2023-09-22 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| EP4704905A1 (en) * | 2023-05-02 | 2026-03-11 | Sage Therapeutics, LLC | Lymphatic system-targeting compounds |
| CN119371475B (zh) * | 2023-07-27 | 2025-11-04 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| WO2025020190A1 (zh) * | 2023-07-27 | 2025-01-30 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| WO2025021195A1 (zh) * | 2023-07-27 | 2025-01-30 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| WO2025221732A1 (en) * | 2024-04-15 | 2025-10-23 | Sage Therapeutics, Inc. | Nmda receptor-modulating compounds and methods of use thereof |
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