JP2015520151A5 - - Google Patents
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- JP2015520151A5 JP2015520151A5 JP2015511669A JP2015511669A JP2015520151A5 JP 2015520151 A5 JP2015520151 A5 JP 2015520151A5 JP 2015511669 A JP2015511669 A JP 2015511669A JP 2015511669 A JP2015511669 A JP 2015511669A JP 2015520151 A5 JP2015520151 A5 JP 2015520151A5
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- Prior art keywords
- edema
- compound
- compound according
- disease
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 30
- 208000006752 brain edema Diseases 0.000 claims 15
- 206010048962 Brain oedema Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 206010021143 Hypoxia Diseases 0.000 claims 8
- 230000007954 hypoxia Effects 0.000 claims 8
- 206010030113 Oedema Diseases 0.000 claims 7
- 102000010637 Aquaporins Human genes 0.000 claims 6
- 108010063290 Aquaporins Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 4
- 208000006011 Stroke Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 150000003839 salts Chemical group 0.000 claims 4
- 208000009447 Cardiac Edema Diseases 0.000 claims 3
- 206010021036 Hyponatraemia Diseases 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 208000031225 myocardial ischemia Diseases 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 230000008733 trauma Effects 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010019196 Head injury Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000005486 microgravity Effects 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 2
- 208000032253 retinal ischemia Diseases 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 206010053198 Inappropriate antidiuretic hormone secretion Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 206010025130 Lupus encephalitis Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000034388 Mountain sickness acute Diseases 0.000 claims 1
- 201000010183 Papilledema Diseases 0.000 claims 1
- 206010033712 Papilloedema Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010038886 Retinal oedema Diseases 0.000 claims 1
- 206010041549 Spinal cord compression Diseases 0.000 claims 1
- 206010063036 Spinal cord oedema Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 102000002852 Vasopressins Human genes 0.000 claims 1
- 108010004977 Vasopressins Proteins 0.000 claims 1
- 208000005735 Water intoxication Diseases 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 208000018315 acute mountain sickness Diseases 0.000 claims 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 230000008081 blood perfusion Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 201000008284 inappropriate ADH syndrome Diseases 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 201000011195 retinal edema Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229960003726 vasopressin Drugs 0.000 claims 1
- 0 CC(C)(C(C1)=CC(*C(C=C(CCC(*)=*)OI(*)(*)=O)=O)=CC1C(F)(F)F)F Chemical compound CC(C)(C(C1)=CC(*C(C=C(CCC(*)=*)OI(*)(*)=O)=O)=CC1C(F)(F)F)F 0.000 description 2
- UQRLOIYSRFRJKL-UHFFFAOYSA-N OC(c(cc(cc1)Cl)c1OCC(C1O)(C1O)O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 Chemical compound OC(c(cc(cc1)Cl)c1OCC(C1O)(C1O)O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 UQRLOIYSRFRJKL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261644268P | 2012-05-08 | 2012-05-08 | |
| US61/644,268 | 2012-05-08 | ||
| US201261651778P | 2012-05-25 | 2012-05-25 | |
| US61/651,778 | 2012-05-25 | ||
| US201361799606P | 2013-03-15 | 2013-03-15 | |
| US61/799,606 | 2013-03-15 | ||
| PCT/US2013/040194 WO2013169939A2 (en) | 2012-05-08 | 2013-05-08 | New methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017210529A Division JP6570597B2 (ja) | 2012-05-08 | 2017-10-31 | 新規方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520151A JP2015520151A (ja) | 2015-07-16 |
| JP2015520151A5 true JP2015520151A5 (https=) | 2016-06-23 |
| JP6238969B2 JP6238969B2 (ja) | 2017-11-29 |
Family
ID=49551452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511669A Active JP6238969B2 (ja) | 2012-05-08 | 2013-05-08 | 新規方法 |
| JP2017210529A Active JP6570597B2 (ja) | 2012-05-08 | 2017-10-31 | 新規方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017210529A Active JP6570597B2 (ja) | 2012-05-08 | 2017-10-31 | 新規方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9994514B2 (https=) |
| EP (1) | EP2846787B1 (https=) |
| JP (2) | JP6238969B2 (https=) |
| KR (1) | KR102200176B1 (https=) |
| CN (2) | CN109512805B (https=) |
| AU (2) | AU2013259526B2 (https=) |
| BR (1) | BR112014027983B1 (https=) |
| CA (1) | CA2872012C (https=) |
| ES (1) | ES2699646T3 (https=) |
| IL (1) | IL235512B (https=) |
| MX (1) | MX363473B (https=) |
| RU (1) | RU2671495C2 (https=) |
| WO (1) | WO2013169939A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013169939A2 (en) | 2012-05-08 | 2013-11-14 | Aeromics, Llc | New methods |
| US20160279155A1 (en) * | 2013-11-06 | 2016-09-29 | Aeromics, Inc. | Novel formulations |
| AU2015346076A1 (en) * | 2014-11-13 | 2017-06-15 | Aeromics, Inc. | Novel methods |
| CA2968299A1 (en) | 2014-11-18 | 2016-05-26 | Rutgers, The State University Of New Jersey | Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer |
| CZ305738B6 (cs) * | 2014-12-16 | 2016-02-24 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující |
| US10246733B2 (en) | 2015-06-04 | 2019-04-02 | Case Western University | Assay and method for quantitating carbonic anhydrase activity and assessing red blood hemolysis |
| CN105030747B (zh) * | 2015-07-03 | 2017-11-17 | 厦门大学 | 氯硝柳胺在制备防治近视药物中的应用 |
| PE20181295A1 (es) | 2015-09-01 | 2018-08-07 | First Wave Bio Inc | Metodos y composiciones para tratar afecciones asociadas a una respuesta inflamatoria anomala |
| US11117909B2 (en) * | 2016-05-13 | 2021-09-14 | Aeromics, Inc. | Crystals |
| US10227315B2 (en) | 2016-05-18 | 2019-03-12 | Rutgers, The State University Of New Jersey | Mitochondrial uncouplers for treatment of metabolic diseases and cancer |
| WO2018053807A1 (zh) * | 2016-09-23 | 2018-03-29 | 深圳市中医院 | 氯硝柳胺乙醇胺盐在制备1型糖尿病药物中的应用 |
| TWI631944B (zh) * | 2016-10-14 | 2018-08-11 | 長庚大學 | 氯硝柳胺及其衍生物的用途 |
| WO2018211474A1 (en) | 2017-05-19 | 2018-11-22 | Trudell Medical International | Positive expiratory pressure device |
| JP6895165B2 (ja) * | 2017-06-06 | 2021-06-30 | 知和 松浦 | α１−アンチキモトリプシンを含むバイオマーカー |
| WO2019067458A1 (en) * | 2017-09-26 | 2019-04-04 | Deha, Llc | COMPOSITIONS AND METHODS FOR FLUID MOTION TARGETING CANALOPATHY DISORDERS THROUGH MEMBRANES |
| CN108203719A (zh) * | 2017-12-26 | 2018-06-26 | 吉林医药学院 | 用于治疗视神经脊髓炎的小分子化合物及其高通量筛选方法 |
| USD903097S1 (en) | 2018-05-18 | 2020-11-24 | Trudell Medical International | Mask |
| USD874064S1 (en) | 2018-05-18 | 2020-01-28 | Trudell Medical International | Mask |
| US12285182B2 (en) | 2018-10-10 | 2025-04-29 | Innova Vascular, Inc. | Devices and methods for removing an embolus |
| USD893806S1 (en) | 2018-11-09 | 2020-08-18 | Trudell Medical Internationl | Mask and shroud |
| USD902947S1 (en) * | 2019-03-25 | 2020-11-24 | Apple Inc. | Electronic device with graphical user interface |
| CN112107568B (zh) | 2019-06-19 | 2022-03-25 | 北京龙嘉博创医药科技有限公司 | 二芳基酰胺类化合物及其应用 |
| CN110790787B (zh) * | 2019-11-12 | 2022-06-14 | 广东药科大学 | 一类水溶性前药、其制备方法及其作为药物的用途 |
| US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
| EP4192442A4 (en) * | 2020-08-05 | 2025-03-19 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising an aquaporin inhibiter and manufacturing process therefor |
| CN116139116A (zh) * | 2023-03-30 | 2023-05-23 | 中南大学湘雅医院 | 氯硝柳胺在抑制急性肝衰竭中的应用 |
| WO2025075479A1 (ko) * | 2023-10-04 | 2025-04-10 | 이화여자대학교 산학협력단 | 아쿠아포린 4 억제제의 심방세동 치료 용도 |
| EP4559520A1 (en) | 2023-11-21 | 2025-05-28 | Origenis GmbH | Novel aqp4 inhibitors |
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