MD3319611T2 - Oxisteroli și metode de utilizare a acestora - Google Patents
Oxisteroli și metode de utilizare a acestoraInfo
- Publication number
- MD3319611T2 MD3319611T2 MDE20180512T MDE20180512T MD3319611T2 MD 3319611 T2 MD3319611 T2 MD 3319611T2 MD E20180512 T MDE20180512 T MD E20180512T MD E20180512 T MDE20180512 T MD E20180512T MD 3319611 T2 MD3319611 T2 MD 3319611T2
- Authority
- MD
- Moldova
- Prior art keywords
- oxysterols
- methods
- compounds
- formula
- prevention
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuşii sunt furnizaţi în conformitate cu Formula (I): Formula (I) şi sărurile acceptabile farmaceutic ale acestora şi compoziţiile farmaceutice ale acestora; în care R1, R2, R3, R6, R7, R8 şi n sunt definite aici. Compuşii prezentei invenţii sunt consideraţi utili pentru prevenirea şi tratamentul unei varietăţi de afecţiuni.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562189048P | 2015-07-06 | 2015-07-06 | |
US201662280394P | 2016-01-19 | 2016-01-19 | |
PCT/US2016/041168 WO2017007836A1 (en) | 2015-07-06 | 2016-07-06 | Oxysterols and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3319611T2 true MD3319611T2 (ro) | 2021-06-30 |
Family
ID=57686105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20180512T MD3319611T2 (ro) | 2015-07-06 | 2016-07-06 | Oxisteroli și metode de utilizare a acestora |
Country Status (29)
Country | Link |
---|---|
US (4) | US10201550B2 (ro) |
EP (2) | EP3828194A1 (ro) |
JP (3) | JP2018519351A (ro) |
KR (2) | KR102703602B1 (ro) |
CN (2) | CN113292623A (ro) |
AU (3) | AU2016289967B2 (ro) |
BR (3) | BR112018000129B1 (ro) |
CA (1) | CA2991214C (ro) |
CO (1) | CO2018000660A2 (ro) |
CY (1) | CY1124496T1 (ro) |
DK (1) | DK3319611T3 (ro) |
ES (1) | ES2865258T3 (ro) |
HR (1) | HRP20210526T8 (ro) |
HU (1) | HUE053778T2 (ro) |
IL (2) | IL256710B2 (ro) |
LT (1) | LT3319611T (ro) |
MA (2) | MA55097A (ro) |
MD (1) | MD3319611T2 (ro) |
MX (2) | MX2020011449A (ro) |
NZ (2) | NZ738847A (ro) |
PE (1) | PE20180483A1 (ro) |
PH (1) | PH12018500065A1 (ro) |
PL (1) | PL3319611T3 (ro) |
PT (1) | PT3319611T (ro) |
RS (1) | RS61718B1 (ro) |
RU (2) | RU2021100620A (ro) |
SG (1) | SG10202010553XA (ro) |
SI (1) | SI3319611T1 (ro) |
WO (1) | WO2017007836A1 (ro) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113956315B (zh) | 2011-09-08 | 2024-08-09 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
EP3932932A1 (en) | 2013-03-13 | 2022-01-05 | Sage Therapeutics, Inc. | Neuroactive steriods and methods of use thereof |
US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
US10238664B2 (en) | 2014-07-09 | 2019-03-26 | Duke University | Compositions and methods for the repair of myelin |
MX2020011449A (es) | 2015-07-06 | 2022-02-28 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
US10696712B2 (en) | 2015-07-06 | 2020-06-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
CA2991313C (en) | 2015-07-06 | 2023-12-19 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
AU2017240157B2 (en) * | 2016-04-01 | 2022-10-20 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
MD3481846T2 (ro) | 2016-07-07 | 2021-11-30 | Sage Therapeutics Inc | 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA |
CA3038900A1 (en) | 2016-09-30 | 2018-04-05 | Sage Therapeutics, Inc. | C7 substituted oxysterols and methods as nmda modulators |
AU2017345399B2 (en) | 2016-10-18 | 2022-02-24 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
NZ752732A (en) | 2016-10-18 | 2024-08-30 | Sage Therapeutics Inc | Oxysterols and methods of use thereof |
US11458146B2 (en) | 2017-01-13 | 2022-10-04 | Duke University | Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders |
US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
KR20240035444A (ko) | 2021-06-11 | 2024-03-15 | 세이지 테라퓨틱스, 인크. | 알츠하이머병 치료를 위한 신경활성 스테로이드 |
CN113667734B (zh) * | 2021-07-16 | 2022-05-24 | 四川大学华西医院 | Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途 |
JP2024532273A (ja) * | 2021-08-25 | 2024-09-05 | セージ セラピューティクス, インコーポレイテッド | ポジティブnmdaモジュレート化合物及びその使用方法 |
EP4430056A1 (en) * | 2021-11-10 | 2024-09-18 | Umecrine AB | 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor |
EP4447953A1 (en) | 2021-12-13 | 2024-10-23 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2594323A (en) | 1948-07-22 | 1952-04-29 | Upjohn Co | 24-substituted delta 5-cholene-3, 24-diols |
US3079385A (en) | 1961-01-24 | 1963-02-26 | Roussel Uclaf | Novel process of preparation of polyhydroxylated pregnanes |
US3206459A (en) | 1962-10-19 | 1965-09-14 | Syntex Corp | 10alpha-pregnan-19-ol derivatives |
US4071625A (en) | 1974-05-13 | 1978-01-31 | Richardson-Merrell Inc. | 19-Oxygenated-5α-androstanes for the enhancement of libido |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
AU698834B2 (en) | 1993-05-24 | 1998-11-12 | Purdue Pharma Ltd. | Methods and compositions for inducing sleep |
IL110309A0 (en) | 1993-07-15 | 1994-10-21 | Univ Kentucky Res Found | A method of protecting against neuron loss |
IL112638A (en) | 1994-02-14 | 2003-10-31 | Cocensys Inc | 3alpha-HYDROXYLATED PREGNANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
US5595996A (en) | 1994-10-25 | 1997-01-21 | Merck & Co., Inc. | 7-substituted 4-aza cholanic acid derivatives and their use |
JPH08268917A (ja) | 1995-03-31 | 1996-10-15 | D D S Kenkyusho:Kk | 癌組織への移行性の高い制癌剤 |
CZ394197A3 (cs) | 1995-06-06 | 1998-06-17 | Cocensys, Inc. | Neuroaktivní steroidy androstanové a pregnanové řady |
US6645953B2 (en) | 1995-06-23 | 2003-11-11 | Novo Nordisk A/S | Meiosis regulating compounds |
US5888996A (en) | 1995-07-26 | 1999-03-30 | Trustees Of Boston University | Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity |
US5841272A (en) | 1995-12-20 | 1998-11-24 | Sundstrand Corporation | Frequency-insensitive current sensor |
US6122371A (en) | 1997-07-22 | 2000-09-19 | Atwell; Ronald C. | Apparatus for protecting coin-operated telephones from vandalism and larceny |
IL139241A0 (en) | 1998-05-13 | 2001-11-25 | Novo Nordisk As | Meiosis regulating compounds |
US8541600B2 (en) | 1998-11-24 | 2013-09-24 | Harbor Therapeutics, Inc. | 11-aza, 11-thia and 11-oxa sterol compounds and compositions |
US6376530B1 (en) * | 1999-05-10 | 2002-04-23 | Merck & Co., Inc. | Cyclic amidines useful as NMDA NR2B antagonists |
GB9910934D0 (en) | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
GB0000228D0 (en) | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
GB0019290D0 (en) | 2000-08-04 | 2000-09-27 | Symphar Sa | Methods for inducing apolipoprotein E secretion |
GR1003861B (el) | 2000-12-29 | 2002-04-11 | Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa. | |
GB0107822D0 (en) | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
US20070197484A1 (en) | 2001-05-03 | 2007-08-23 | Ching Song | Method of treating disorder related to high cholesterol concentration |
WO2003039480A2 (en) | 2001-11-08 | 2003-05-15 | The University Of Chicago | Method of treating disorder related to high cholesterol concentration |
AU2002360489A1 (en) | 2001-12-07 | 2003-06-23 | The Regents Of The University Of California | Treatment for age-related macular degeneration |
CN102727501A (zh) | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
KR20100093621A (ko) | 2002-03-27 | 2010-08-25 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 용도 |
GB0216621D0 (en) * | 2002-07-17 | 2002-08-28 | Imaging Res Solutions Ltd | Imaging compounds |
EP1565453A4 (en) * | 2002-11-22 | 2007-10-10 | Merck & Co Inc | USE OF 2- (4-BENZYL) -1-PIPERIDINYL) METHYL | BENZIMIDAZOLE-5-OL DERIVATIVES AS ANTAGONISTS OF NR2B RECEPTORS |
WO2004055201A2 (en) | 2002-12-13 | 2004-07-01 | Bayer Healthcare Ag | Cholesterol 24-hydroxylase (cyp46) as therapeutic target for the treatment of alzheimer's disease |
FR2850023B1 (fr) | 2003-01-17 | 2007-04-06 | Mapreg | Medicaments pour le systeme nerveux |
GB0403889D0 (en) | 2004-02-21 | 2004-03-24 | Univ Edinburgh | Uses of er-beta modulators |
US8604011B2 (en) | 2004-09-27 | 2013-12-10 | The Regents Of The University Of California | Therapy for treatment of chronic degenerative brain diseases and nervous system injury |
WO2007098281A2 (en) | 2006-02-27 | 2007-08-30 | Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
KR101767849B1 (ko) | 2007-06-20 | 2017-08-11 | 오스펙스 파마슈티칼스, 인코포레이티드 | 섬유증 저해제로서의 치환된 n-아릴 피리디논 |
GB0712494D0 (en) | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
EP2207542A2 (en) | 2007-11-06 | 2010-07-21 | N.V. Organon | A method of hormone suppression in humans |
WO2009090063A1 (en) | 2008-01-16 | 2009-07-23 | Jado Technologies Gmbh | Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases |
BRPI0912362A2 (pt) | 2008-05-09 | 2015-10-06 | Univ Emory | antagonista do receptor nmda para o tratamento de transtornos neuropsiquiátricos |
WO2010065709A2 (en) | 2008-12-03 | 2010-06-10 | Amin Khan | Hydroxamic acid derivatives, preparation and therapeutic uses thereof |
US20120040916A1 (en) | 2008-12-22 | 2012-02-16 | Massachusetts Institute Of Technology | Molecular inhibitors of the wnt/beta-catenin pathway |
US20110319416A1 (en) | 2009-01-28 | 2011-12-29 | Emory University | Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions |
JP2013500986A (ja) | 2009-07-29 | 2013-01-10 | ザ・ユニバーシティ・オブ・シカゴ | 肝臓x受容体アゴニスト |
WO2011028794A2 (en) | 2009-09-01 | 2011-03-10 | Lazarus Therapeutics, Inc. | Treatment of huntington's disease with cycloserine and an nmda receptor antagonist |
FR2953138B1 (fr) | 2009-12-02 | 2015-10-16 | Assist Publ Hopitaux Marseille | Composes aminosteroidiens pour une application topique locale pour la decolonisation cutaneo-muqueuse de staphylococcus aureus |
KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
GB201008047D0 (en) * | 2010-05-14 | 2010-06-30 | Ge Healthcare Ltd | Method of synthesis |
US20120035156A1 (en) | 2010-08-09 | 2012-02-09 | Daniela Alberati | Combination of glyt1 compound with antipsychotics |
US8969525B2 (en) | 2010-11-09 | 2015-03-03 | Enzo Life Sciences, Inc. | Hydroxycholesterol immunoassay |
WO2012142039A1 (en) | 2011-04-15 | 2012-10-18 | University Of North Dakota | Combination of liver x receptor modulator and estrogen receptor modulator for the treatment of age-related diseases |
AU2012262520A1 (en) | 2011-05-27 | 2014-01-23 | Cytocure Llc | Methods, compositions, and kits for the treatment of cancer |
CA2843436A1 (en) | 2011-07-29 | 2013-02-07 | The Regents Of The University Of California | Novel 17.beta.-heteroaryl-substituted steroids as modulators of gaba a receptors |
CN113956315B (zh) * | 2011-09-08 | 2024-08-09 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
CN108976272B (zh) | 2011-10-14 | 2021-05-25 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
EP2841067A4 (en) | 2012-04-25 | 2016-04-13 | Univ California | MEDICINAL SCREENING PLATFORM FOR THE RETT SYNDROME |
US20140149272A1 (en) | 2012-08-17 | 2014-05-29 | Trueex Group Llc | Interoffice bank offered rate financial product and implementation |
TR201808616T4 (tr) | 2012-12-18 | 2018-07-23 | Sage Therapeutics Inc | Nöroaktif 19-alkoksi-17-ikameli steroidler, bunların ön ilaçları ve bunları kullanan tedavi yöntemleri. |
WO2014115167A2 (en) | 2013-01-23 | 2014-07-31 | Sphaera Pharma Pvt. Ltd. | Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion |
KR20150110787A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
MX2015012437A (es) * | 2013-03-13 | 2016-04-15 | Sage Therapeutics Inc | Esteroides neuroactivos, composiciones, y usos de los mismos. |
EP3932932A1 (en) * | 2013-03-13 | 2022-01-05 | Sage Therapeutics, Inc. | Neuroactive steriods and methods of use thereof |
US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
US10238664B2 (en) | 2014-07-09 | 2019-03-26 | Duke University | Compositions and methods for the repair of myelin |
US10016095B2 (en) * | 2014-10-03 | 2018-07-10 | Progressive International Corporation | Salad spinner |
JP2017530982A (ja) | 2014-10-07 | 2017-10-19 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性化合物およびその使用方法 |
MX2020011449A (es) | 2015-07-06 | 2022-02-28 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
CA2991313C (en) | 2015-07-06 | 2023-12-19 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
US10696712B2 (en) | 2015-07-06 | 2020-06-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
GB2557875A (en) | 2015-09-02 | 2018-07-04 | Univ Swansea | Diagnostic methods and kits |
WO2018170336A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
KR20200020877A (ko) | 2017-06-23 | 2020-02-26 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 유도체 제조를 위한 방법 및 중간체 |
SG10202110563YA (en) | 2017-11-10 | 2021-11-29 | Marinus Pharmaceuticals Inc | Ganaxolone for use in treating genetic epileptic disoders |
-
2016
- 2016-07-06 MX MX2020011449A patent/MX2020011449A/es unknown
- 2016-07-06 KR KR1020187003210A patent/KR102703602B1/ko active IP Right Grant
- 2016-07-06 BR BR112018000129-5A patent/BR112018000129B1/pt active IP Right Grant
- 2016-07-06 BR BR122023021450-1A patent/BR122023021450A2/pt unknown
- 2016-07-06 WO PCT/US2016/041168 patent/WO2017007836A1/en active Application Filing
- 2016-07-06 CA CA2991214A patent/CA2991214C/en active Active
- 2016-07-06 PT PT168219244T patent/PT3319611T/pt unknown
- 2016-07-06 IL IL256710A patent/IL256710B2/en unknown
- 2016-07-06 PL PL16821924T patent/PL3319611T3/pl unknown
- 2016-07-06 LT LTEP16821924.4T patent/LT3319611T/lt unknown
- 2016-07-06 MA MA055097A patent/MA55097A/fr unknown
- 2016-07-06 SG SG10202010553XA patent/SG10202010553XA/en unknown
- 2016-07-06 AU AU2016289967A patent/AU2016289967B2/en active Active
- 2016-07-06 KR KR1020247029533A patent/KR20240137111A/ko active Search and Examination
- 2016-07-06 RU RU2021100620A patent/RU2021100620A/ru unknown
- 2016-07-06 IL IL305404A patent/IL305404A/en unknown
- 2016-07-06 CN CN202110670292.XA patent/CN113292623A/zh active Pending
- 2016-07-06 DK DK16821924.4T patent/DK3319611T3/da active
- 2016-07-06 ES ES16821924T patent/ES2865258T3/es active Active
- 2016-07-06 SI SI201631146T patent/SI3319611T1/sl unknown
- 2016-07-06 US US15/742,425 patent/US10201550B2/en active Active
- 2016-07-06 MD MDE20180512T patent/MD3319611T2/ro unknown
- 2016-07-06 NZ NZ738847A patent/NZ738847A/en unknown
- 2016-07-06 MA MA42410A patent/MA42410B1/fr unknown
- 2016-07-06 HU HUE16821924A patent/HUE053778T2/hu unknown
- 2016-07-06 EP EP21151891.5A patent/EP3828194A1/en active Pending
- 2016-07-06 RU RU2018104278A patent/RU2744267C2/ru active
- 2016-07-06 CN CN201680051035.5A patent/CN108135912B/zh active Active
- 2016-07-06 MX MX2018000282A patent/MX2018000282A/es active IP Right Grant
- 2016-07-06 JP JP2018500417A patent/JP2018519351A/ja not_active Withdrawn
- 2016-07-06 PE PE2018000034A patent/PE20180483A1/es unknown
- 2016-07-06 RS RS20210461A patent/RS61718B1/sr unknown
- 2016-07-06 BR BR122021005552-1A patent/BR122021005552B1/pt active IP Right Grant
- 2016-07-06 EP EP16821924.4A patent/EP3319611B1/en active Active
- 2016-07-06 NZ NZ777726A patent/NZ777726A/en unknown
-
2018
- 2018-01-05 PH PH12018500065A patent/PH12018500065A1/en unknown
- 2018-01-24 CO CONC2018/0000660A patent/CO2018000660A2/es unknown
- 2018-12-20 US US16/227,099 patent/US10765685B2/en active Active
-
2020
- 2020-07-29 US US16/942,245 patent/US20210145848A1/en not_active Abandoned
-
2021
- 2021-01-08 JP JP2021002172A patent/JP2021054864A/ja not_active Withdrawn
- 2021-03-31 HR HRP20210526TT patent/HRP20210526T8/hr unknown
- 2021-04-13 CY CY20211100316T patent/CY1124496T1/el unknown
- 2021-08-20 AU AU2021218228A patent/AU2021218228B2/en active Active
-
2022
- 2022-06-08 JP JP2022093073A patent/JP2022120062A/ja active Pending
-
2024
- 2024-01-16 AU AU2024200268A patent/AU2024200268A1/en active Pending
- 2024-03-13 US US18/603,816 patent/US20240277733A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD3319611T2 (ro) | Oxisteroli și metode de utilizare a acestora | |
MD3319612T2 (ro) | Oxisteroli și metode de utilizare a acestora | |
CY1122585T1 (el) | Συνδυασμοι που περιλαμβανουν παραγωγα 5-φαινοξυ-3η-πυριμιδιν-4-ονης και η χρηση αυτων για την προφυλαξη ή αγωγη λοιμωξης απο ηiv | |
MX2021013075A (es) | Oxisteroles y metodos de uso de los mismos. | |
MD3377488T2 (ro) | Compuși heterociclici ca imunomodulatori | |
MD3481846T2 (ro) | 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA | |
MD3472167T2 (ro) | Compuși heterociclici ca imunomodulatori | |
MD3394033T2 (ro) | Compuși heterociclici ca imunomodulatori | |
EA201792259A1 (ru) | Бензимидазольные и имидазопиридиновые карбоксимидамидные соединения | |
MX2022005160A (es) | Oxisteroles y metodos de uso de los mismos. | |
MD3313817T2 (ro) | Derivați biciclici, un procedeu pentru prepararea lor și compozițiile farmaceutice care îi conțin | |
NZ746825A (en) | Oxysterols and methods of use thereof | |
MD3442972T2 (ro) | Inhibitori ai bromodomeniului | |
MD3313850T2 (ro) | Noi derivaţi de aminoacizi, procedeu pentru prepararea acestora şi compoziţii farmaceutice care îi conţin | |
EP4316591A3 (en) | Oxysterols and methods of use thereof | |
EA201790766A1 (ru) | Новые соединения метилпиперидина, подходящие для ингибирования микросомальной простагландин-e2-синтазы 1 | |
TR201901312T4 (tr) | Mcl-1 proteinini inhibe eden tetrahidronaftalen türevleri. | |
EA201791955A1 (ru) | ИНГИБИТОРЫ TGF-β | |
PH12016500170A1 (en) | Formulation of syk inhibitors | |
EA201891063A1 (ru) | Производные дигидроимидазопиразинона, применимые в лечении рака | |
EA201790627A1 (ru) | СТИМУЛЯТОРЫ рГЦ | |
MD3532459T2 (ro) | Inhibitori ai LSD1 și utilizările medicale ale acestora | |
MA39956A (fr) | Analogues du benzomorphane et leur utilisation | |
MD3288940T2 (ro) | Azabenzimidazoli și utilizarea lor ca modulatori ai receptorilor AMPA | |
CY1121693T1 (el) | Θετικοι αλλοστερικοι διαμορφωτες μουσκαρινικου υποδοχεα μ1 |