JP2018510657A5 - - Google Patents
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- JP2018510657A5 JP2018510657A5 JP2018502061A JP2018502061A JP2018510657A5 JP 2018510657 A5 JP2018510657 A5 JP 2018510657A5 JP 2018502061 A JP2018502061 A JP 2018502061A JP 2018502061 A JP2018502061 A JP 2018502061A JP 2018510657 A5 JP2018510657 A5 JP 2018510657A5
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- 210000004027 cell Anatomy 0.000 claims description 322
- 108090000623 proteins and genes Proteins 0.000 claims description 240
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- 108020004414 DNA Proteins 0.000 claims description 113
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- 210000000349 chromosome Anatomy 0.000 claims description 86
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- 238000000034 method Methods 0.000 claims description 80
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- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 66
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- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 62
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 39
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021100691A JP2021137036A (ja) | 2015-03-27 | 2021-06-17 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
| JP2023122393A JP2023129663A (ja) | 2015-03-27 | 2023-07-27 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562139479P | 2015-03-27 | 2015-03-27 | |
| US62/139,479 | 2015-03-27 | ||
| PCT/US2016/024554 WO2016160721A1 (en) | 2015-03-27 | 2016-03-28 | Modified t cells and methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100691A Division JP2021137036A (ja) | 2015-03-27 | 2021-06-17 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510657A JP2018510657A (ja) | 2018-04-19 |
| JP2018510657A5 true JP2018510657A5 (enExample) | 2019-05-09 |
Family
ID=57007260
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502061A Pending JP2018510657A (ja) | 2015-03-27 | 2016-03-28 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
| JP2021100691A Withdrawn JP2021137036A (ja) | 2015-03-27 | 2021-06-17 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
| JP2023122393A Pending JP2023129663A (ja) | 2015-03-27 | 2023-07-27 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100691A Withdrawn JP2021137036A (ja) | 2015-03-27 | 2021-06-17 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
| JP2023122393A Pending JP2023129663A (ja) | 2015-03-27 | 2023-07-27 | 改変ｔ細胞ならびにそれを作製および使用する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20160348073A1 (enExample) |
| EP (2) | EP3273976B1 (enExample) |
| JP (3) | JP2018510657A (enExample) |
| KR (1) | KR20180020125A (enExample) |
| CN (2) | CN107847524A (enExample) |
| AU (3) | AU2016243583B2 (enExample) |
| BR (1) | BR112017020750A2 (enExample) |
| CA (1) | CA2984237A1 (enExample) |
| IL (2) | IL254734B2 (enExample) |
| MX (2) | MX2017012407A (enExample) |
| WO (1) | WO2016160721A1 (enExample) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| SG10201912301XA (en) | 2013-11-04 | 2020-02-27 | Uti Lp | Methods and compositions for sustained immunotherapy |
| EP3241561B1 (en) * | 2014-03-05 | 2025-04-30 | Autolus Limited | Conjugated antibody or bispecific t-cell engager which selectively binds either tcr beta constant region 1 (trbc1) or trbc2 |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| US11982672B2 (en) | 2014-03-05 | 2024-05-14 | Autolus Limited | Methods |
| EP4427809A3 (en) * | 2014-10-31 | 2024-12-04 | The Trustees of The University of Pennsylvania | Altering gene expression in car-t cells and uses thereof |
| WO2016073955A2 (en) * | 2014-11-06 | 2016-05-12 | President And Fellows Of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
| CA3176380A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017020750A2 (pt) * | 2015-03-27 | 2018-06-26 | Harvard College | células t modificadas e métodos de produção e utilização das mesmas |
| US12011480B2 (en) | 2015-05-06 | 2024-06-18 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
| HK1254190A1 (zh) | 2015-05-08 | 2019-07-12 | President And Fellows Of Harvard College | 通用供体干细胞和相关方法 |
| WO2016205703A1 (en) * | 2015-06-17 | 2016-12-22 | The Uab Research Foundation | Crispr/cas9 complex for genomic editing |
| WO2016205680A1 (en) | 2015-06-17 | 2016-12-22 | The Uab Research Foundation | Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage |
| CA2990699A1 (en) | 2015-06-29 | 2017-01-05 | Ionis Pharmaceuticals, Inc. | Modified crispr rna and modified single crispr rna and uses thereof |
| US10906951B2 (en) | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| EP3971284B1 (en) | 2015-07-29 | 2023-11-08 | ONK Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| GB2557123B (en) | 2015-07-31 | 2021-11-03 | Univ Minnesota | Modified cells and methods of therapy |
| EP3344284A1 (en) | 2015-09-04 | 2018-07-11 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
| AU2016333886B2 (en) | 2015-10-05 | 2020-10-08 | Precision Biosciences, Inc. | Engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene |
| EP4108255A1 (en) | 2015-10-05 | 2022-12-28 | Precision Biosciences, Inc. | Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene |
| JP2018536436A (ja) * | 2015-12-04 | 2018-12-13 | ノバルティス アーゲー | 免疫腫瘍学のための組成物および方法 |
| US11648268B2 (en) | 2015-12-09 | 2023-05-16 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of using same |
| SG11201807538PA (en) * | 2016-03-04 | 2018-09-27 | Editas Medicine Inc | Crispr-cpf1-related methods, compositions and components for cancer immunotherapy |
| CA3020923A1 (en) | 2016-04-15 | 2017-10-19 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
| WO2017201476A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| CN109863242A (zh) * | 2016-08-30 | 2019-06-07 | 纪念斯隆-凯特林癌症中心 | 用于治疗病毒感染和其它感染的免疫细胞组合物和使用方法 |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| AU2017347637B2 (en) * | 2016-10-19 | 2024-02-15 | Cellectis | Targeted gene insertion for improved immune cells therapy |
| WO2018073393A2 (en) * | 2016-10-19 | 2018-04-26 | Cellectis | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
| US20230138915A1 (en) * | 2016-10-19 | 2023-05-04 | Cellectis | TAL- effector nuclease (TALEN) -MODIFIED ALLOGENIC CELLS SUITABLE FOR THERAPY |
| CA3044682A1 (en) | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| AU2018224126A1 (en) | 2017-02-23 | 2019-09-12 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| WO2018162696A1 (en) * | 2017-03-10 | 2018-09-13 | Institut Pasteur | Common genetic variations at the tcra-tcrd locus control thymic function in humans |
| MX2019011272A (es) | 2017-03-22 | 2019-10-24 | Novartis Ag | Composiciones y metodos para inmunooncologia. |
| EP3592379B1 (en) * | 2017-03-31 | 2024-04-24 | Cellectis SA | Universal anti-cd22 chimeric antigen receptor engineered immune cells |
| RU2019135533A (ru) * | 2017-04-07 | 2021-05-07 | Ютиай Лимитед Партнершип | Анализ измерения эффективности рецепторно-лигандных взаимодействий в лекарственных нанолекарственных средствах |
| WO2018191490A1 (en) * | 2017-04-13 | 2018-10-18 | The Trustees Of The University Of Pennsylvania | Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy |
| MX389585B (es) | 2017-05-08 | 2025-03-20 | Unilever Ip Holdings B V | Prevencion y/o tratamiento de una enfermedad inflamatoria de la piel |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| MY201573A (en) | 2017-05-12 | 2024-03-02 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| US11725214B2 (en) | 2017-05-25 | 2023-08-15 | Institute Of Genetics And Developmental Biology Chinese Academy Of Sciences | Methods for increasing grain productivity |
| WO2018233596A1 (zh) * | 2017-06-20 | 2018-12-27 | 江苏恒瑞医药股份有限公司 | 体外敲除T细胞中靶基因的方法以及该方法中使用的crRNA |
| SG10201705285SA (en) * | 2017-06-27 | 2019-01-30 | Agency Science Tech & Res | Antisense oligonucleotides |
| WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| AU2018292526A1 (en) * | 2017-06-30 | 2020-01-16 | Precision Biosciences, Inc. | Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene |
| US12104166B2 (en) * | 2017-07-18 | 2024-10-01 | Avectas Limited | Payload delivery across cell membranes using continuous flow fluidic system |
| US20200216805A1 (en) * | 2017-09-18 | 2020-07-09 | Edigene Inc. | Gene editing t cell and use thereof |
| JP7654240B2 (ja) | 2017-09-19 | 2025-04-01 | マサチューセッツ インスティテュート オブ テクノロジー | キメラ抗原受容体ｔ細胞治療のための組成物およびその使用 |
| CN111741746A (zh) | 2017-11-29 | 2020-10-02 | 乌第有限合伙公司 | 治疗自身免疫性疾病的方法 |
| WO2019126555A1 (en) * | 2017-12-20 | 2019-06-27 | Bluebird Bio, Inc. | Ctla4 homing endonuclease variants, compositions, and methods of use |
| CN111788307A (zh) | 2018-03-12 | 2020-10-16 | 南京北恒生物科技有限公司 | 工程化的嵌合向导rna及其用途 |
| JP7611564B2 (ja) * | 2018-03-13 | 2025-01-10 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Ｃａｓ９塩基エディターを使用するリンパ球造血系操作 |
| EP3781196B1 (en) | 2018-03-27 | 2024-03-06 | G+Flas Life Sciences | Sequence-specific in vivo cell targeting |
| CN111989113B (zh) * | 2018-03-27 | 2024-07-12 | G+Flas生命科学有限公司 | 用于治疗癌症的包含向导rna和核酸内切酶作活性成分的药物组合物 |
| SG11202009446TA (en) * | 2018-04-05 | 2020-10-29 | Juno Therapeutics Inc | T cells expressing a recombinant receptor, related polynucleotides and methods |
| WO2019200122A1 (en) | 2018-04-12 | 2019-10-17 | Precision Biosciences, Inc. | Optimized engineered nucleases having specificity for the human t cell receptor alpha constant region gene |
| EP3775213A1 (en) * | 2018-04-13 | 2021-02-17 | Sigma Aldrich Co. LLC | Modification of immune-related genomic loci using paired crispr nickase ribonucleoproteins |
| WO2019204664A2 (en) * | 2018-04-19 | 2019-10-24 | Apdn (B.V.I), Inc. | Engineered lymphocyte compositions, methods and systems |
| JP7542441B2 (ja) | 2018-05-11 | 2024-08-30 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 癌を治療するための方法及び組成物 |
| CN112867498A (zh) * | 2018-05-31 | 2021-05-28 | 华盛顿大学 | 使用嵌合抗原受体基因组编辑和转导t细胞以用于治疗t和b细胞恶性肿瘤的方法 |
| WO2019237381A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 用于人alps5基因编辑的修饰载体、其制备方法及应用 |
| WO2019237394A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 一种应用CRISPR/Cas9系统靶向敲除人ALPS5基因的方法 |
| CN112654245B (zh) * | 2018-09-11 | 2022-05-27 | 得克萨斯州大学系统董事会 | 自身免疫不良事件和免疫检查点阻断治疗的遗传小鼠模型 |
| CN110904045A (zh) * | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| AU2019346335B2 (en) | 2018-09-28 | 2024-07-25 | Massachusetts Institute Of Technology | Collagen-localized immunomodulatory molecules and methods thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| AU2019362879A1 (en) * | 2018-10-16 | 2021-05-27 | Intellia Therapeutics, Inc. | Compositions and methods for immunotherapy |
| EP3877002A4 (en) * | 2018-11-09 | 2022-11-02 | The Board of Trustees of the Leland Stanford Junior University | HYBRID IMMOLATIVE CELL-PENETRATING NUCLEIC ACID DELIVERY COMPLEXES |
| CN109652378B (zh) * | 2018-12-29 | 2020-04-24 | 广州百暨基因科技有限公司 | 一种功能增强的通用型car-t细胞及其制备方法和用途 |
| JP6884450B2 (ja) * | 2019-02-14 | 2021-06-09 | 学校法人獨協学園獨協医科大学 | Ｔ細胞ワクチン |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| EP3981431A4 (en) * | 2019-03-14 | 2023-06-28 | Rena Therapeutics Inc. | Nucleic acid complex for modulating ihh expression |
| US20220249558A1 (en) | 2019-04-30 | 2022-08-11 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| EP3990491A1 (en) | 2019-06-26 | 2022-05-04 | Massachusetts Institute of Technology | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
| AU2020310837A1 (en) * | 2019-07-08 | 2022-02-24 | Inscripta, Inc. | Increased nucleic acid-guided cell editing via a LexA-Rad51 fusion protein |
| WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
| CN110863015B (zh) * | 2019-11-25 | 2023-06-16 | 重庆精准生物产业技术研究院有限公司 | 对t细胞低敏感性的靶细胞及其制备方法和应用 |
| EP4028521A1 (en) * | 2019-12-09 | 2022-07-20 | Caribou Biosciences, Inc. | Crispr abasic restricted nucleotides and crispr accuracy via analogs |
| KR20220142433A (ko) | 2020-01-17 | 2022-10-21 | 사나 바이오테크놀로지, 인크. | 유전자 발현 조절용 안전 스위치 |
| EP4100524A4 (en) * | 2020-02-05 | 2024-12-25 | Danmarks Tekniske Universitet | COMPOSITIONS AND METHODS FOR TARGETING, EDITING OR MODIFYING HUMAN GENES |
| WO2021178924A1 (en) * | 2020-03-05 | 2021-09-10 | Board Of Regents Of The University Of Nebraska | Crispr/cas9 system for multistrain hiv-1 treatment |
| CN115768444A (zh) * | 2020-03-13 | 2023-03-07 | 加利福尼亚大学董事会 | 用于修饰靶核酸的组合物和方法 |
| US20230374454A1 (en) * | 2020-04-06 | 2023-11-23 | Synthekine, Inc. | Human immune cells genomically modified to express orthogonal receptors |
| MX2022015888A (es) * | 2020-06-26 | 2023-03-28 | Carisma Therapeutics Inc | Transfección de ácido ribonucleico mensajero (arnm) de células inmunitarias. |
| KR20220005208A (ko) * | 2020-07-06 | 2022-01-13 | 주식회사 지씨셀 | 면역원성이 감소된 신규한 이식용 세포 |
| MX2023001831A (es) | 2020-08-13 | 2023-06-29 | Sana Biotechnology Inc | Métodos de tratamiento de pacientes sensibilizados con células hipoinmunogénicas y métodos y composiciones asociados. |
| AU2021369840A1 (en) * | 2020-10-30 | 2023-06-01 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting b2m and uses thereof |
| US20240026351A1 (en) * | 2020-10-30 | 2024-01-25 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting trac and uses thereof |
| WO2022094329A1 (en) * | 2020-10-30 | 2022-05-05 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting pdcd1 and uses thereof |
| EP4259160A4 (en) * | 2020-12-14 | 2025-05-14 | Emendobio Inc. | BIALLELIC INACTIVATION OF B2M |
| KR20230137900A (ko) | 2020-12-31 | 2023-10-05 | 사나 바이오테크놀로지, 인크. | Car-t 활성을 조정하기 위한 방법 및 조성물 |
| KR20230160885A (ko) * | 2021-03-24 | 2023-11-24 | 제넨테크, 인크. | T 림프구에서 효율적인 tcr 유전자 편집 |
| US20220315931A1 (en) * | 2021-03-26 | 2022-10-06 | A2 Biotherapeutics, Inc. | Immune cells expressing receptor specific to class i mhc molecule and interfering rna for beta2 microglobulin gene |
| US20240252642A1 (en) | 2021-05-19 | 2024-08-01 | Sana Biotechnology, Inc. | Hypoimmunogenic rhd negative primary t cells |
| KR20240013135A (ko) | 2021-05-27 | 2024-01-30 | 사나 바이오테크놀로지, 인크. | 조작된 hla-e 또는 hla-g를 포함하는 저면역원성 세포 |
| AU2022299551A1 (en) * | 2021-06-23 | 2024-01-18 | Editas Medicine, Inc. | Engineered cells for therapy |
| AU2022309875A1 (en) | 2021-07-14 | 2024-01-25 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
| AU2022325232A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified primary cells for allogeneic cell therapy |
| IL310702A (en) | 2021-08-11 | 2024-04-01 | Sana Biotechnology Inc | Inducible systems for altering gene expression in hypoimmunogenic cells |
| EP4384598A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| EP4384544A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| WO2023019225A2 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| WO2023028348A1 (en) * | 2021-08-27 | 2023-03-02 | Metagenomi, Inc. | Enzymes with ruvc domains |
| WO2023034276A2 (en) * | 2021-09-02 | 2023-03-09 | The Regents Of The University Of California | Materials and methods for targeted genetic manipulations in cells |
| GB202112922D0 (en) * | 2021-09-10 | 2021-10-27 | Ucl Business Ltd | Method |
| EP4419117A1 (en) | 2021-10-22 | 2024-08-28 | Sana Biotechnology, Inc. | Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods |
| IL313660A (en) | 2021-12-22 | 2024-08-01 | Camp4 Therapeutics Corp | Modulation of gene transcription using antisense oligonucleotides targeting regulatory RNAs |
| AU2022422147A1 (en) | 2021-12-23 | 2024-07-04 | Sana Biotechnology, Inc. | Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods |
| EP4479084A1 (en) | 2022-02-14 | 2024-12-25 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
| KR20240155390A (ko) | 2022-02-17 | 2024-10-28 | 사나 바이오테크놀로지, 인크. | 조작된 cd47 단백질 및 이의 용도 |
| WO2023225670A2 (en) * | 2022-05-20 | 2023-11-23 | Tome Biosciences, Inc. | Ex vivo programmable gene insertion |
| WO2023250490A1 (en) * | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of trac expression |
| EP4608979A1 (en) * | 2022-10-28 | 2025-09-03 | CorrectSequence Therapeutics (Shanghai) Co., Ltd | Gene editing systems and methods for reducing immunogenicity and graft versus host response |
| TW202434735A (zh) | 2022-11-04 | 2024-09-01 | 美商烏莫賈生物製藥股份有限公司 | 展示黏著分子融合的顆粒 |
| CN120936714A (zh) * | 2023-01-13 | 2025-11-11 | 拉维洛克治疗有限责任公司 | 使用抑制rna的细胞环境特异性基因调控 |
| WO2025096757A1 (en) | 2023-11-01 | 2025-05-08 | Sana Biotechnology, Inc. | Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas |
Family Cites Families (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4476301A (en) | 1982-04-29 | 1984-10-09 | Centre National De La Recherche Scientifique | Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon |
| US5118800A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | Oligonucleotides possessing a primary amino group in the terminal nucleotide |
| US5550111A (en) | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| FR2567892B1 (fr) | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| US5367066A (en) | 1984-10-16 | 1994-11-22 | Chiron Corporation | Oligonucleotides with selectably cleavable and/or abasic sites |
| FR2575751B1 (fr) | 1985-01-08 | 1987-04-03 | Pasteur Institut | Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5405938A (en) | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5130300A (en) | 1986-03-07 | 1992-07-14 | Monsanto Company | Method for enhancing growth of mammary parenchyma |
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US5264423A (en) | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5276019A (en) | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| DE3851889T2 (de) | 1987-06-24 | 1995-04-13 | Florey Howard Inst | Nukleosid-derivate. |
| US4924624A (en) | 1987-10-22 | 1990-05-15 | Temple University-Of The Commonwealth System Of Higher Education | 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof |
| US5188897A (en) | 1987-10-22 | 1993-02-23 | Temple University Of The Commonwealth System Of Higher Education | Encapsulated 2',5'-phosphorothioate oligoadenylates |
| WO1989009221A1 (en) | 1988-03-25 | 1989-10-05 | University Of Virginia Alumni Patents Foundation | Oligonucleotide n-alkylphosphoramidates |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5175273A (en) | 1988-07-01 | 1992-12-29 | Genentech, Inc. | Nucleic acid intercalating agents |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5134066A (en) | 1989-08-29 | 1992-07-28 | Monsanto Company | Improved probes using nucleosides containing 3-dezauracil analogs |
| US5591722A (en) | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| US5399676A (en) | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| DE69033495T2 (de) | 1989-10-24 | 2000-07-20 | Isis Pharmaceuticals, Inc. | 2'-modifizierte nukleotide |
| US5177198A (en) | 1989-11-30 | 1993-01-05 | University Of N.C. At Chapel Hill | Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates |
| CA2029273A1 (en) | 1989-12-04 | 1991-06-05 | Christine L. Brakel | Modified nucleotide compounds |
| US5670633A (en) | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US5457191A (en) | 1990-01-11 | 1995-10-10 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5852188A (en) | 1990-01-11 | 1998-12-22 | Isis Pharmaceuticals, Inc. | Oligonucleotides having chiral phosphorus linkages |
| US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US5587361A (en) | 1991-10-15 | 1996-12-24 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US5587470A (en) | 1990-01-11 | 1996-12-24 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
| US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
| US5321131A (en) | 1990-03-08 | 1994-06-14 | Hybridon, Inc. | Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| GB9009980D0 (en) | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
| EP0455905B1 (en) | 1990-05-11 | 1998-06-17 | Microprobe Corporation | Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| US5541307A (en) | 1990-07-27 | 1996-07-30 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs and solid phase synthesis thereof |
| US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| CA2088258C (en) | 1990-07-27 | 2004-09-14 | Phillip Dan Cook | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5618704A (en) | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| KR100211552B1 (ko) | 1990-08-03 | 1999-08-02 | 디. 꼬쉬 | 유전자 발현 억제용 화합물 및 방법 |
| US5214134A (en) | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
| US5561225A (en) | 1990-09-19 | 1996-10-01 | Southern Research Institute | Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages |
| JPH06505704A (ja) | 1990-09-20 | 1994-06-30 | ギリアド サイエンシズ，インコーポレイテッド | 改変ヌクレオシド間結合 |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| GB9100304D0 (en) | 1991-01-08 | 1991-02-20 | Ici Plc | Compound |
| US7015315B1 (en) | 1991-12-24 | 2006-03-21 | Isis Pharmaceuticals, Inc. | Gapped oligonucleotides |
| US5571799A (en) | 1991-08-12 | 1996-11-05 | Basco, Ltd. | (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response |
| DE59208572D1 (de) | 1991-10-17 | 1997-07-10 | Ciba Geigy Ag | Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte |
| US5594121A (en) | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| US5359044A (en) | 1991-12-13 | 1994-10-25 | Isis Pharmaceuticals | Cyclobutyl oligonucleotide surrogates |
| US6277603B1 (en) | 1991-12-24 | 2001-08-21 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| DK1695979T3 (da) | 1991-12-24 | 2011-10-10 | Isis Pharmaceuticals Inc | Gappede modificerede oligonukleotider |
| FR2687679B1 (fr) | 1992-02-05 | 1994-10-28 | Centre Nat Rech Scient | Oligothionucleotides. |
| DE4203923A1 (de) | 1992-02-11 | 1993-08-12 | Henkel Kgaa | Verfahren zur herstellung von polycarboxylaten auf polysaccharid-basis |
| US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| EP0577558A2 (de) | 1992-07-01 | 1994-01-05 | Ciba-Geigy Ag | Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte |
| US6346614B1 (en) | 1992-07-23 | 2002-02-12 | Hybridon, Inc. | Hybrid oligonucleotide phosphorothioates |
| US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
| GB9304618D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Chemical compounds |
| CA2159631A1 (en) | 1993-03-30 | 1994-10-13 | Sanofi | Acyclic nucleoside analogs and oligonucleotide sequences containing them |
| WO1994022891A1 (en) | 1993-03-31 | 1994-10-13 | Sterling Winthrop Inc. | Oligonucleotides with amide linkages replacing phosphodiester linkages |
| DE4311944A1 (de) | 1993-04-10 | 1994-10-13 | Degussa | Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung und sie enthaltende Wasch-, Reinigungs- und Bleichmittelzusammensetzungen |
| US5955591A (en) | 1993-05-12 | 1999-09-21 | Imbach; Jean-Louis | Phosphotriester oligonucleotides, amidites and method of preparation |
| US6015886A (en) | 1993-05-24 | 2000-01-18 | Chemgenes Corporation | Oligonucleotide phosphate esters |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| CA2176256A1 (en) | 1993-11-16 | 1995-05-26 | Lyle John Arnold, Jr. | Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages |
| US5457187A (en) | 1993-12-08 | 1995-10-10 | Board Of Regents University Of Nebraska | Oligonucleotides containing 5-fluorouracil |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5596091A (en) | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| US5599922A (en) | 1994-03-18 | 1997-02-04 | Lynx Therapeutics, Inc. | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties |
| US5627053A (en) | 1994-03-29 | 1997-05-06 | Ribozyme Pharmaceuticals, Inc. | 2'deoxy-2'-alkylnucleotide containing nucleic acid |
| US5625050A (en) | 1994-03-31 | 1997-04-29 | Amgen Inc. | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics |
| US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| US5597909A (en) | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
| US6608035B1 (en) | 1994-10-25 | 2003-08-19 | Hybridon, Inc. | Method of down-regulating gene expression |
| US6166197A (en) | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
| EP0813539B1 (en) | 1995-03-06 | 2006-05-24 | Isis Pharmaceuticals, Inc. | Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom |
| US5645620A (en) | 1995-05-25 | 1997-07-08 | Foster Wheeler Development Corp. | System for separating particulates and condensable species from a gas stream |
| US6160109A (en) | 1995-10-20 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Preparation of phosphorothioate and boranophosphate oligomers |
| US6444423B1 (en) | 1996-06-07 | 2002-09-03 | Molecular Dynamics, Inc. | Nucleosides comprising polydentate ligands |
| US6639062B2 (en) | 1997-02-14 | 2003-10-28 | Isis Pharmaceuticals, Inc. | Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom |
| US6172209B1 (en) | 1997-02-14 | 2001-01-09 | Isis Pharmaceuticals Inc. | Aminooxy-modified oligonucleotides and methods for making same |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| US6617438B1 (en) | 1997-11-05 | 2003-09-09 | Sirna Therapeutics, Inc. | Oligoribonucleotides with enzymatic activity |
| US6528640B1 (en) | 1997-11-05 | 2003-03-04 | Ribozyme Pharmaceuticals, Incorporated | Synthetic ribonucleic acids with RNAse activity |
| US7273933B1 (en) | 1998-02-26 | 2007-09-25 | Isis Pharmaceuticals, Inc. | Methods for synthesis of oligonucleotides |
| US7045610B2 (en) | 1998-04-03 | 2006-05-16 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
| US6531590B1 (en) | 1998-04-24 | 2003-03-11 | Isis Pharmaceuticals, Inc. | Processes for the synthesis of oligonucleotide compounds |
| US6867294B1 (en) | 1998-07-14 | 2005-03-15 | Isis Pharmaceuticals, Inc. | Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages |
| US6465628B1 (en) | 1999-02-04 | 2002-10-15 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligomeric compounds |
| US6593466B1 (en) | 1999-07-07 | 2003-07-15 | Isis Pharmaceuticals, Inc. | Guanidinium functionalized nucleotides and precursors thereof |
| US6147200A (en) | 1999-08-19 | 2000-11-14 | Isis Pharmaceuticals, Inc. | 2'-O-acetamido modified monomers and oligomers |
| WO2001053307A1 (en) | 2000-01-21 | 2001-07-26 | Geron Corporation | 2'-arabino-fluorooligonucleotide n3'→p5'phosphoramidates: their synthesis and use |
| US6875904B2 (en) * | 2000-09-20 | 2005-04-05 | The Ohio State University Research Foundation | Animal model for identifying agents that inhibit or enhance CTLA4 signaling |
| US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
| EP1417338A4 (en) | 2001-07-16 | 2005-06-29 | Price Foundation Ltd | SIMPLE NUCLEOTIDE GENES AND POLYMORPHISMS ASSOCIATED WITH FOOD BEHAVIOR DISORDERS |
| US6878805B2 (en) | 2002-08-16 | 2005-04-12 | Isis Pharmaceuticals, Inc. | Peptide-conjugated oligomeric compounds |
| US20040053263A1 (en) | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| US8409861B2 (en) * | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| JP4731324B2 (ja) | 2003-08-28 | 2011-07-20 | 武 今西 | Ｎ−ｏ結合性架橋構造型新規人工核酸 |
| KR100590547B1 (ko) | 2004-02-28 | 2006-06-19 | 삼성전자주식회사 | 복합 질환과 연관된 다중 ｓｎｐ 마커들로부터 최적 마커세트를 선택하는 방법 |
| US20080268436A1 (en) | 2004-08-20 | 2008-10-30 | Jubao Duan | Schizophrenia, Schizoaffective Disorder and Bipolar Disorder Susceptibility Gene Mutation and Applications to Their Diagnosis and Treatment |
| US20060204969A1 (en) | 2005-01-14 | 2006-09-14 | Hoffman Eric P | Genetic variations (SNPs) adjacent to the AKT1 gene locus, and diagnostic and prognostic uses thereof |
| KR101206029B1 (ko) | 2005-04-01 | 2012-11-28 | 삼성전자주식회사 | 대장암 진단용 다중 ｓｎｐ, 그를 포함하는 마이크로어레이및 키트 및 그를 이용한 대장암 진단 방법 |
| WO2006123885A1 (en) | 2005-05-18 | 2006-11-23 | Samsung Electronics Co., Ltd. | Methods and compositions for diagnosing cardiovascular disease |
| US20070269827A1 (en) | 2006-05-18 | 2007-11-22 | Oklahoma Medical Research Foundation | Predicting and Diagnosing Patients With Autoimmune Disease |
| US20080199866A1 (en) | 2006-10-10 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Snp detection and other methods for characterizing and treating bipolar disorder and other ailments |
| WO2009036056A1 (en) | 2007-09-10 | 2009-03-19 | Vanda Pharmaceuticals, Inc. | Antipsychotic treatment based on snp genotype |
| US8563314B2 (en) * | 2007-09-27 | 2013-10-22 | Sangamo Biosciences, Inc. | Methods and compositions for modulating PD1 |
| CA2718392A1 (en) | 2008-03-14 | 2009-09-17 | Genoscreen | Biomarkers for alzheimer's disease |
| AU2010220397A1 (en) | 2009-03-03 | 2011-07-28 | Merck Serono S.A. | BANK1 related SNPS and SLE and/or MS susceptibility |
| WO2010118263A1 (en) | 2009-04-08 | 2010-10-14 | University Of Massachusetts | Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease |
| US8445656B2 (en) | 2009-08-11 | 2013-05-21 | University Of Guelph | Single nucleotide polymorphisms (SNPs) in genes associated with inflammatory diseases |
| EP2483301A1 (en) | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| US8187811B2 (en) | 2009-11-30 | 2012-05-29 | 23Andme, Inc. | Polymorphisms associated with Parkinson's disease |
| WO2011150545A1 (en) | 2010-05-31 | 2011-12-08 | Shandong University | Snps associated with polycystic ovary syndrome, chips comprising the same and use thereof |
| ES2387292B1 (es) | 2010-06-29 | 2013-10-30 | Fundacio Institut De Recerca Hospital Universitari Vall D'hebron | Combinacion de snps para determinar el riesgo de sufrir una enfermedad neurovascular |
| AU2012207356A1 (en) | 2011-01-18 | 2013-08-01 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| EP2535424B1 (en) | 2011-06-16 | 2015-08-05 | Gendiag.exe, S.L. | SNPs associated with thromboemoblic disease |
| WO2013074916A1 (en) * | 2011-11-18 | 2013-05-23 | Board Of Regents, The University Of Texas System | Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| US20150017136A1 (en) * | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
| EP2975942B1 (en) * | 2013-03-21 | 2018-08-08 | Sangamo Therapeutics, Inc. | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
| DK2981607T3 (da) * | 2013-04-03 | 2020-11-16 | Memorial Sloan Kettering Cancer Center | Effektiv generering af tumormålrettede t-celler afledt af pluripotente stamceller |
| AU2014266833B2 (en) * | 2013-05-13 | 2020-07-02 | Cellectis | Methods for engineering highly active T cell for immunotherapy |
| DK3004337T3 (da) * | 2013-05-29 | 2017-11-13 | Cellectis | Fremgangsmåde til konstruktion af T-celler til immunoterapi ved brug af RNA-guidet Cas nuklease-system |
| EP3087101B1 (en) * | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| WO2015161276A2 (en) * | 2014-04-18 | 2015-10-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| GB201418965D0 (enExample) * | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| EP4427809A3 (en) * | 2014-10-31 | 2024-12-04 | The Trustees of The University of Pennsylvania | Altering gene expression in car-t cells and uses thereof |
| WO2016073955A2 (en) * | 2014-11-06 | 2016-05-12 | President And Fellows Of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
| BR112017020750A2 (pt) * | 2015-03-27 | 2018-06-26 | Harvard College | células t modificadas e métodos de produção e utilização das mesmas |
| HK1254190A1 (zh) * | 2015-05-08 | 2019-07-12 | President And Fellows Of Harvard College | 通用供体干细胞和相关方法 |
-
2016
- 2016-03-28 BR BR112017020750A patent/BR112017020750A2/pt not_active Application Discontinuation
- 2016-03-28 EP EP16773942.4A patent/EP3273976B1/en active Active
- 2016-03-28 MX MX2017012407A patent/MX2017012407A/es unknown
- 2016-03-28 WO PCT/US2016/024554 patent/WO2016160721A1/en not_active Ceased
- 2016-03-28 CA CA2984237A patent/CA2984237A1/en active Pending
- 2016-03-28 US US15/083,021 patent/US20160348073A1/en not_active Abandoned
- 2016-03-28 IL IL254734A patent/IL254734B2/en unknown
- 2016-03-28 EP EP23187519.6A patent/EP4269601A3/en active Pending
- 2016-03-28 JP JP2018502061A patent/JP2018510657A/ja active Pending
- 2016-03-28 KR KR1020177031163A patent/KR20180020125A/ko not_active Ceased
- 2016-03-28 CN CN201680031535.2A patent/CN107847524A/zh active Pending
- 2016-03-28 CN CN202210286776.9A patent/CN115537396A/zh active Pending
- 2016-03-28 AU AU2016243583A patent/AU2016243583B2/en active Active
- 2016-03-28 IL IL302341A patent/IL302341A/en unknown
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2017
- 2017-09-27 MX MX2024006041A patent/MX2024006041A/es unknown
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2021
- 2021-06-17 JP JP2021100691A patent/JP2021137036A/ja not_active Withdrawn
- 2021-11-12 US US17/525,644 patent/US20220162554A1/en not_active Abandoned
- 2021-12-02 US US17/540,968 patent/US20220162555A1/en active Pending
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2022
- 2022-06-08 AU AU2022203963A patent/AU2022203963B2/en active Active
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2023
- 2023-07-27 JP JP2023122393A patent/JP2023129663A/ja active Pending
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2025
- 2025-07-30 AU AU2025210797A patent/AU2025210797A1/en active Pending
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