MX2022011366A - Composiciones y métodos para modificar un ácido nucleico diana. - Google Patents

Composiciones y métodos para modificar un ácido nucleico diana.

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Publication number
MX2022011366A
MX2022011366A MX2022011366A MX2022011366A MX2022011366A MX 2022011366 A MX2022011366 A MX 2022011366A MX 2022011366 A MX2022011366 A MX 2022011366A MX 2022011366 A MX2022011366 A MX 2022011366A MX 2022011366 A MX2022011366 A MX 2022011366A
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MX
Mexico
Prior art keywords
modifying
methods
compositions
nucleic acid
target nucleic
Prior art date
Application number
MX2022011366A
Other languages
English (en)
Inventor
Alexander Marson
Vivasvan Vykunta
Justin Eyquem
Brian Shy
Original Assignee
Univ California
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Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2022011366A publication Critical patent/MX2022011366A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2319/00—Fusion polypeptide
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La descripción proporciona composiciones y métodos para modificar una proteína de superficie celular endógena (por ejemplo, un TCR endógeno) en una célula (por ejemplo, una célula T) con un CAR o una proteína exógena (por ejemplo, una proteína intracelular exógena o de superficie celular (por ejemplo, un TCR exógeno)).
MX2022011366A 2020-03-13 2021-03-12 Composiciones y métodos para modificar un ácido nucleico diana. MX2022011366A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062989505P 2020-03-13 2020-03-13
PCT/US2021/022102 WO2021183884A1 (en) 2020-03-13 2021-03-12 Compositions and methods for modifying a target nucleic acid

Publications (1)

Publication Number Publication Date
MX2022011366A true MX2022011366A (es) 2023-03-03

Family

ID=77671980

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022011366A MX2022011366A (es) 2020-03-13 2021-03-12 Composiciones y métodos para modificar un ácido nucleico diana.

Country Status (11)

Country Link
US (1) US20230112075A1 (es)
EP (1) EP4117690A1 (es)
JP (1) JP2023519819A (es)
KR (1) KR20230036059A (es)
CN (1) CN115768444A (es)
AU (1) AU2021236320A1 (es)
BR (1) BR112022018218A2 (es)
CA (1) CA3175106A1 (es)
IL (1) IL296321A (es)
MX (1) MX2022011366A (es)
WO (1) WO2021183884A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023126458A1 (en) 2021-12-28 2023-07-06 Mnemo Therapeutics Immune cells with inactivated suv39h1 and modified tcr
EP4279085A1 (en) 2022-05-20 2023-11-22 Mnemo Therapeutics Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7374927B2 (en) * 2004-05-03 2008-05-20 Affymetrix, Inc. Methods of analysis of degraded nucleic acid samples
BR112017020750A2 (pt) * 2015-03-27 2018-06-26 Harvard College células t modificadas e métodos de produção e utilização das mesmas
WO2017180711A1 (en) * 2016-04-13 2017-10-19 Editas Medicine, Inc. Grna fusion molecules, gene editing systems, and methods of use thereof
US10934336B2 (en) * 2017-04-13 2021-03-02 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal TCR re-directed T cells for adoptive immunotherapy
AU2018355587B2 (en) * 2017-10-27 2023-02-02 The Regents Of The University Of California Targeted replacement of endogenous T cell receptors

Also Published As

Publication number Publication date
IL296321A (en) 2022-11-01
KR20230036059A (ko) 2023-03-14
EP4117690A1 (en) 2023-01-18
JP2023519819A (ja) 2023-05-15
CA3175106A1 (en) 2021-09-16
BR112022018218A2 (pt) 2022-12-20
WO2021183884A1 (en) 2021-09-16
AU2021236320A1 (en) 2022-11-10
CN115768444A (zh) 2023-03-07
US20230112075A1 (en) 2023-04-13

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