JP2018509390A5 - - Google Patents
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- JP2018509390A5 JP2018509390A5 JP2017540167A JP2017540167A JP2018509390A5 JP 2018509390 A5 JP2018509390 A5 JP 2018509390A5 JP 2017540167 A JP2017540167 A JP 2017540167A JP 2017540167 A JP2017540167 A JP 2017540167A JP 2018509390 A5 JP2018509390 A5 JP 2018509390A5
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- Prior art keywords
- seq
- sequence
- binding fragment
- antigen
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000027455 binding Effects 0.000 claims description 40
- 239000012634 fragment Substances 0.000 claims description 39
- 239000000427 antigen Substances 0.000 claims description 30
- 102000036639 antigens Human genes 0.000 claims description 30
- 108091007433 antigens Proteins 0.000 claims description 30
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 6
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 206010004593 Bile duct cancer Diseases 0.000 claims description 2
- 206010005949 Bone cancer Diseases 0.000 claims description 2
- 208000018084 Bone neoplasm Diseases 0.000 claims description 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims description 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 208000003445 Mouth Neoplasms Diseases 0.000 claims description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 102000012086 alpha-L-Fucosidase Human genes 0.000 claims description 2
- 108010061314 alpha-L-Fucosidase Proteins 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- GRHWEVYJIHXESA-HBHDJDHDSA-N beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->3)-[beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)-beta-D-GlcpNAc Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@H]4[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O4)O)[C@@H](CO)O3)NC(C)=O)[C@H](O)[C@@H](CO[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@H]4[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O4)O)[C@@H](CO)O3)NC(C)=O)O2)O)[C@@H](CO)O1 GRHWEVYJIHXESA-HBHDJDHDSA-N 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 description 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562110338P | 2015-01-30 | 2015-01-30 | |
| US62/110,338 | 2015-01-30 | ||
| US14/723,297 | 2015-05-27 | ||
| US14/723,297 US10023892B2 (en) | 2014-05-27 | 2015-05-27 | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| US14/798,312 | 2015-07-13 | ||
| US14/798,312 US10150818B2 (en) | 2014-01-16 | 2015-07-13 | Compositions and methods for treatment and detection of cancers |
| PCT/US2016/015858 WO2016123593A1 (en) | 2015-01-30 | 2016-01-30 | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509390A JP2018509390A (ja) | 2018-04-05 |
| JP2018509390A5 true JP2018509390A5 (enExample) | 2019-02-28 |
| JP6942633B2 JP6942633B2 (ja) | 2021-09-29 |
Family
ID=56544456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540167A Active JP6942633B2 (ja) | 2015-01-30 | 2016-01-30 | 抗体の増強された有効性のための普遍的グリコフォームに関する組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3250590B1 (enExample) |
| JP (1) | JP6942633B2 (enExample) |
| KR (1) | KR102620346B1 (enExample) |
| CN (2) | CN107614521B (enExample) |
| AU (1) | AU2016211176B2 (enExample) |
| CA (1) | CA2973886A1 (enExample) |
| DK (1) | DK3250590T3 (enExample) |
| ES (1) | ES2901173T3 (enExample) |
| IL (1) | IL253497B2 (enExample) |
| TW (1) | TWI717333B (enExample) |
| WO (2) | WO2016123591A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015267051B2 (en) * | 2014-05-27 | 2022-03-17 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ，インコーポレイテッド | グリカンアレイおよび使用の方法 |
| KR20180121786A (ko) | 2016-03-29 | 2018-11-08 | 오비아이 파머 인코퍼레이티드 | 항체, 제약 조성물 및 방법 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20250048399A (ko) | 2016-04-22 | 2025-04-08 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법 |
| US11642400B2 (en) | 2016-07-27 | 2023-05-09 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ，インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
| CN107778372B (zh) * | 2016-08-22 | 2019-11-26 | 中国科学院上海药物研究所 | 一种寡糖连接子以及利用该寡糖连接子制备的定点连接的抗体-药物偶联物 |
| JP7373998B2 (ja) | 2017-05-02 | 2023-11-06 | コーネル・ユニバーシティー | 有効性がより大きくかつ毒性がより少ない腫瘍標的指向方法及び試薬 |
| AU2019276647A1 (en) * | 2018-06-01 | 2020-12-24 | Obi Pharma, Inc. | Combination therapy by using anti-Globo H or anti-SSEA-4 antibody with anti-negative immune check points antibody |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| CN109620970A (zh) * | 2018-11-13 | 2019-04-16 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 一种胸腔镜下内乳区前哨淋巴结纳米碳示踪活检及内乳淋巴结清扫方法 |
| EP4010470A4 (en) * | 2019-08-05 | 2023-08-09 | Cho Pharma Inc | FUSION PROTEIN FOR ANTIBODY GLYCOFORM REMODELING |
| AU2021376384A1 (en) | 2020-11-06 | 2023-06-08 | Cho Pharma, Inc. | Immune composition comprising antigen and glycoengineered antibody thereof |
| US12421305B2 (en) | 2020-11-30 | 2025-09-23 | Cho Pharma, Inc. | Antibody for enrichment of cells |
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| JPWO2011074621A1 (ja) * | 2009-12-18 | 2013-04-25 | 株式会社医学生物学研究所 | メソセリン（ｍｓｌｎ）に対する抗体及びその用途 |
| SG182823A1 (en) * | 2010-02-11 | 2012-09-27 | Alexion Pharma Inc | Therapeutic methods using an ti-cd200 antibodies |
| GB201015569D0 (en) * | 2010-09-16 | 2010-10-27 | Medical Res Council | Blood assay for prions |
| EP2714732A4 (en) * | 2011-05-25 | 2014-12-10 | Merck Sharp & Dohme | PROCESS FOR PREPARING FC-CONTAINING POLYPEPTIDES WITH IMPROVED PROPERTIES |
| IN2014DN06806A (enExample) * | 2012-02-10 | 2015-05-22 | Univ Maryland | |
| WO2013151649A1 (en) * | 2012-04-04 | 2013-10-10 | Sialix Inc | Glycan-interacting compounds |
| TWI510627B (zh) | 2012-08-20 | 2015-12-01 | 中央研究院 | 寡醣之大規模酵素合成 |
| WO2014078373A1 (en) * | 2012-11-13 | 2014-05-22 | Iogenetics, Llc | Antimicrobial compositions |
| WO2016114819A1 (en) * | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| TW201620939A (zh) * | 2014-01-16 | 2016-06-16 | 中央研究院 | 治療及檢測癌症之組合物及方法 |
| US10118969B2 (en) * | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| AU2015267051B2 (en) * | 2014-05-27 | 2022-03-17 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| US10273295B2 (en) * | 2014-08-19 | 2019-04-30 | Miltenyi Biotec Gmbh | Chimeric antigen receptor specific for SSEA4 antigen |
| US9975965B2 (en) * | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
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2016
- 2016-01-30 ES ES16744256T patent/ES2901173T3/es active Active
- 2016-01-30 WO PCT/US2016/015856 patent/WO2016123591A2/en not_active Ceased
- 2016-01-30 JP JP2017540167A patent/JP6942633B2/ja active Active
- 2016-01-30 EP EP16744256.5A patent/EP3250590B1/en active Active
- 2016-01-30 AU AU2016211176A patent/AU2016211176B2/en active Active
- 2016-01-30 WO PCT/US2016/015858 patent/WO2016123593A1/en not_active Ceased
- 2016-01-30 CN CN201680008450.2A patent/CN107614521B/zh active Active
- 2016-01-30 TW TW105103073A patent/TWI717333B/zh active
- 2016-01-30 KR KR1020177024323A patent/KR102620346B1/ko active Active
- 2016-01-30 CN CN202210185767.0A patent/CN114702581B/zh active Active
- 2016-01-30 CA CA2973886A patent/CA2973886A1/en active Pending
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- 2017-07-16 IL IL253497A patent/IL253497B2/en unknown
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