JP2018508489A5 - - Google Patents

Info

Publication number

JP2018508489A5

JP2018508489A5 JP2017539393A JP2017539393A JP2018508489A5 JP 2018508489 A5 JP2018508489 A5 JP 2018508489A5 JP 2017539393 A JP2017539393 A JP 2017539393A JP 2017539393 A JP2017539393 A JP 2017539393A JP 2018508489 A5 JP2018508489 A5 JP 2018508489A5

Authority

JP

Japan

Prior art keywords

composition

vitamin

use according

alkaline phosphatase

subject

Prior art date

2016-01-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229930003316 Vitamin D Natural products 0.000 claims description 16
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 16
• 235000019166 vitamin D Nutrition 0.000 claims description 16
• 239000011710 vitamin D Substances 0.000 claims description 16
• 150000003710 vitamin D derivatives Chemical class 0.000 claims description 16
• 229940046008 vitamin d Drugs 0.000 claims description 16
• 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 15
• 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 15
• 108090000445 Parathyroid hormone Proteins 0.000 claims description 12
• 102000003982 Parathyroid hormone Human genes 0.000 claims description 10
• 239000000199 parathyroid hormone Substances 0.000 claims description 10
• 229960001319 parathyroid hormone Drugs 0.000 claims description 10
• 239000011575 calcium Substances 0.000 claims description 9
• 230000002092 calcimimetic effect Effects 0.000 claims description 7
• 210000002966 serum Anatomy 0.000 claims description 7
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
• 229960005069 calcium Drugs 0.000 claims description 6
• 229910052791 calcium Inorganic materials 0.000 claims description 6
• 235000001465 calcium Nutrition 0.000 claims description 6
• 239000003814 drug Substances 0.000 claims description 5
• 229940124597 therapeutic agent Drugs 0.000 claims description 5
• 229940122361 Bisphosphonate Drugs 0.000 claims description 4
• 150000004663 bisphosphonates Chemical class 0.000 claims description 4
• VDHAWDNDOKGFTD-MRXNPFEDSA-N cinacalcet Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 VDHAWDNDOKGFTD-MRXNPFEDSA-N 0.000 claims description 4
• 229960003315 cinacalcet Drugs 0.000 claims description 4
• 230000007812 deficiency Effects 0.000 claims description 4
• 238000001990 intravenous administration Methods 0.000 claims description 3
• 102100024321 Alkaline phosphatase, placental type Human genes 0.000 claims description 2
• 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 claims description 2
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
• 101000574445 Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 claims description 2
• 208000037147 Hypercalcaemia Diseases 0.000 claims description 2
• 208000013038 Hypocalcemia Diseases 0.000 claims description 2
• 206010049933 Hypophosphatasia Diseases 0.000 claims description 2
• 102100024319 Intestinal-type alkaline phosphatase Human genes 0.000 claims description 2
• 101710184243 Intestinal-type alkaline phosphatase Proteins 0.000 claims description 2
• 102100036893 Parathyroid hormone Human genes 0.000 claims description 2
• 229930003270 Vitamin B Natural products 0.000 claims description 2
• 229930003448 Vitamin K Natural products 0.000 claims description 2
• 235000010410 calcium alginate Nutrition 0.000 claims description 2
• 239000000648 calcium alginate Substances 0.000 claims description 2
• 229960002681 calcium alginate Drugs 0.000 claims description 2
• 239000001110 calcium chloride Substances 0.000 claims description 2
• 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
• 229960002713 calcium chloride Drugs 0.000 claims description 2
• 235000011148 calcium chloride Nutrition 0.000 claims description 2
• 239000004227 calcium gluconate Substances 0.000 claims description 2
• 235000013927 calcium gluconate Nutrition 0.000 claims description 2
• 229960004494 calcium gluconate Drugs 0.000 claims description 2
• OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 2
• NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical group [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
• 239000002934 diuretic Substances 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• 108020001507 fusion proteins Proteins 0.000 claims description 2
• 102000037865 fusion proteins Human genes 0.000 claims description 2
• 230000000148 hypercalcaemia Effects 0.000 claims description 2
• 208000030915 hypercalcemia disease Diseases 0.000 claims description 2
• 230000000705 hypocalcaemia Effects 0.000 claims description 2
• 238000001802 infusion Methods 0.000 claims description 2
• SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 2
• 108010031345 placental alkaline phosphatase Proteins 0.000 claims description 2
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 2
• 229960004618 prednisone Drugs 0.000 claims description 2
• 229940088594 vitamin Drugs 0.000 claims description 2
• 229930003231 vitamin Natural products 0.000 claims description 2
• 235000013343 vitamin Nutrition 0.000 claims description 2
• 239000011782 vitamin Substances 0.000 claims description 2
• 239000011720 vitamin B Substances 0.000 claims description 2
• 235000019156 vitamin B Nutrition 0.000 claims description 2
• 235000019168 vitamin K Nutrition 0.000 claims description 2
• 239000011712 vitamin K Substances 0.000 claims description 2
• 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
• 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
• 229940046010 vitamin k Drugs 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 18
• 230000003247 decreasing effect Effects 0.000 claims 1
• 229940030606 diuretics Drugs 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000000034 method Methods 0.000 description 19
• 230000018678 bone mineralization Effects 0.000 description 6
• 239000012491 analyte Substances 0.000 description 3
• 238000012544 monitoring process Methods 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 1
• 230000001882 diuretic effect Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1