PL3097189T3 - Chimeryczne białka podobne do alkalicznej fosfatazy - Google Patents
Chimeryczne białka podobne do alkalicznej fosfatazyInfo
- Publication number
- PL3097189T3 PL3097189T3 PL15703642T PL15703642T PL3097189T3 PL 3097189 T3 PL3097189 T3 PL 3097189T3 PL 15703642 T PL15703642 T PL 15703642T PL 15703642 T PL15703642 T PL 15703642T PL 3097189 T3 PL3097189 T3 PL 3097189T3
- Authority
- PL
- Poland
- Prior art keywords
- proteins
- alkaline phosphatase
- chimeric
- chimeric alkaline
- phosphatase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14152526 | 2014-01-24 | ||
| EP14188158 | 2014-10-08 | ||
| PCT/NL2015/050048 WO2015112017A1 (en) | 2014-01-24 | 2015-01-26 | Chimeric alkaline phosphatase-like proteins |
| EP15703642.7A EP3097189B1 (en) | 2014-01-24 | 2015-01-26 | Chimeric alkaline phosphatase-like proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3097189T3 true PL3097189T3 (pl) | 2018-11-30 |
Family
ID=52464544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15703642T PL3097189T3 (pl) | 2014-01-24 | 2015-01-26 | Chimeryczne białka podobne do alkalicznej fosfatazy |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US9926544B2 (pl) |
| EP (2) | EP3425048A1 (pl) |
| JP (3) | JP6940949B2 (pl) |
| KR (1) | KR102166110B1 (pl) |
| CN (2) | CN111778228A (pl) |
| AU (1) | AU2015209783B2 (pl) |
| BR (1) | BR112016017041B1 (pl) |
| CA (1) | CA2937328C (pl) |
| DK (1) | DK3097189T3 (pl) |
| ES (1) | ES2684639T3 (pl) |
| HU (1) | HUE039784T2 (pl) |
| IL (1) | IL246898B (pl) |
| MX (1) | MX369041B (pl) |
| PE (1) | PE20161442A1 (pl) |
| PH (1) | PH12016501441A1 (pl) |
| PL (1) | PL3097189T3 (pl) |
| RU (1) | RU2683635C2 (pl) |
| SA (1) | SA516371532B1 (pl) |
| SG (1) | SG11201606060WA (pl) |
| SI (1) | SI3097189T1 (pl) |
| WO (1) | WO2015112017A1 (pl) |
| ZA (1) | ZA201605028B (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20161442A1 (es) | 2014-01-24 | 2017-01-12 | Am-Pharma B V | Proteinas quimericas tipo fosfatasa alcalina |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| MX2017007392A (es) | 2014-12-05 | 2019-01-24 | Alexion Pharma Inc | Tratamiento de convulsiones con fosfatasa alcalina recombinante. |
| EP3250227A2 (en) | 2015-01-28 | 2017-12-06 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| RU2745528C2 (ru) | 2015-08-17 | 2021-03-26 | Алексион Фармасьютикалз, Инк. | Производство щелочных фосфатаз |
| JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| RU2754558C2 (ru) | 2016-04-01 | 2021-09-03 | Алексион Фармасьютикалз, Инк. | Лечение мышечной слабости с помощью щелочных фосфатаз |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| EP3345614A1 (en) * | 2017-01-05 | 2018-07-11 | Amrif B.V. | Composition comprising alkaline phosphatase for use in the treatment of arthritides |
| KR20190129058A (ko) | 2017-03-31 | 2019-11-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법 |
| WO2019139891A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| RU2020129445A (ru) * | 2018-03-08 | 2022-04-08 | Ам-Фарма Б.В. | Рекомбинантная щелочная фосфатаза для применения при лечении связанного с сепсисом острого повреждения почек |
| EP3768302A4 (en) | 2018-03-20 | 2021-12-15 | Synthetic Biologics, Inc. | INTESTINAL ALKALINE PHOSPHATASE FORMULATIONS |
| EP3773686B1 (en) | 2018-03-20 | 2023-06-07 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| WO2019190752A1 (en) | 2018-03-30 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
| CN110499283A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备改善低碱性磷酸酯酶症干细胞成骨分化能力异常产品中的应用 |
| CA3190684A1 (en) | 2020-09-09 | 2022-03-17 | Jeroen Elassaiss-Schaap | Recombinant alkaline phosphatase for use in treating acute respiratory distress syndrome |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8328918D0 (en) | 1983-10-28 | 1983-11-30 | Unilever Plc | Alkaline phosphatase |
| EP0441252B1 (en) | 1990-02-07 | 1997-09-03 | Abbott Laboratories | Alkaline phosphatase enzymes having improved specific activity for use in indicator reagents |
| DK0584343T3 (da) | 1992-03-10 | 1999-09-13 | Jolla Cancer Res Found | Rekombinant alkalisk phosphatase fra kalvetarme |
| JPH06284885A (ja) * | 1993-04-02 | 1994-10-11 | Tosoh Corp | 組換えヒト小腸アルカリフォスファタ−ゼ |
| CA2163966A1 (en) | 1993-06-01 | 1994-12-08 | Judith A. Kelleher | Alkaline and acid phosphatase inhibitors in treatment of neurological disorders |
| AU4835693A (en) | 1993-08-13 | 1995-03-14 | Rijksuniversiteit Te Groningen | Pharmaceutical composition comprising phosphatase or a derivative thereof |
| JPH09509141A (ja) | 1993-11-15 | 1997-09-16 | セルトリックス ファーマシューティカルズ，インコーポレイテッド | Ｉｇｆ‐ｉおよびｉｇｆｂｐ‐３を投与することによる腎臓疾患処置の方法 |
| CN1192700A (zh) | 1995-06-06 | 1998-09-09 | 基因科学再生实验室有限公司 | 改性成骨材料 |
| FR2736065B1 (fr) | 1995-06-29 | 1997-09-19 | Commissariat Energie Atomique | Phosphatases alcalines bacteriennes modifiees et leurs applications. |
| JP3488327B2 (ja) | 1995-12-21 | 2004-01-19 | よつ葉乳業株式会社 | 牛乳脂肪球膜含有画分の製造法 |
| US20020114802A1 (en) | 1998-02-10 | 2002-08-22 | Tjellstrom Bo Arthur Einar | Oral immunoglobulin treatment for inflammatory bowel disease |
| DE19819962A1 (de) | 1998-05-05 | 1999-11-11 | Roche Diagnostics Gmbh | Hochaktive alkalische Phosphatase |
| EP1141717A1 (en) | 1998-12-21 | 2001-10-10 | Stichting voor de Technische Wetenschappen | Diagnosis of sepsis using the lps-binding moiety of alkaline phosphatase |
| JP2000350596A (ja) | 1999-06-11 | 2000-12-19 | Toyobo Co Ltd | 分泌性アルカリフォスファターゼの選択的活性測定方法 |
| DE60120007T2 (de) | 2000-01-31 | 2006-11-16 | Pfizer Products Inc., Groton | Verwendung von Aktivatoren des Prostaglandinrezeptores 4 zur Behandlung von akuter oder chronischer Niereninsuffizienz |
| EP1306367B1 (en) | 2000-07-19 | 2007-07-18 | Mitsubishi Pharma Corporation | Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products |
| EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| DE10101793A1 (de) | 2001-01-17 | 2002-08-01 | Manfred Nilius | Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen |
| CA2434362A1 (en) | 2001-01-20 | 2002-07-25 | Cardion Ag | Pluripotent adult stem cells derived from regenerative tissue |
| JP4238726B2 (ja) | 2001-06-01 | 2009-03-18 | 味の素株式会社 | 腸疾患用の薬剤 |
| US7157260B2 (en) | 2001-07-26 | 2007-01-02 | Japan Science & Technology Agency | Nicotianamine synthase and gene encoding the same |
| JP4169966B2 (ja) | 2001-11-14 | 2008-10-22 | 株式会社ヤクルト本社 | 炎症性腸疾患予防治療剤 |
| CN1425766A (zh) | 2001-12-19 | 2003-06-25 | 复旦大学 | 一种多肽——人含碱性磷酸酶活性位点的蛋白－9.24和编码这种多肽的多核苷酸 |
| EP1578940A4 (en) * | 2002-11-13 | 2007-12-12 | Genentech Inc | METHOD AND COMPOSITIONS FOR DYSPLASED DIAGNOSIS |
| US7048914B2 (en) | 2002-12-12 | 2006-05-23 | Zoltan Laboratories | Placental alkaline phosphatase to control diabetes |
| AU2003295264A1 (en) * | 2002-12-23 | 2004-07-14 | Rijksuniversiteit Groningen | Modulation of the thioredoxin pathway |
| WO2004083432A1 (en) | 2003-03-21 | 2004-09-30 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| JP4305071B2 (ja) | 2003-06-30 | 2009-07-29 | 株式会社ニコン | 信号補正方法 |
| JP2005065564A (ja) | 2003-08-22 | 2005-03-17 | Hiroshi Ueda | センサー蛋白質 |
| US7157261B2 (en) | 2003-10-27 | 2007-01-02 | Canji, Inc. | Rat secreted embryonic alkaline phosphatase |
| CA2554683C (en) | 2004-02-04 | 2014-06-10 | Pharmaaware Sepsis B.V. | Use of alkaline phosphatase for the detoxification of lps present at mucosal barriers |
| US20110142817A1 (en) | 2004-02-04 | 2011-06-16 | Pharmaaware Sepsis B.V. | Means and method for treating and/or preventing necrotizing enterocolitis |
| WO2006096527A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Nucleic acids and proteins and methods for making and using them |
| US20070059300A1 (en) | 2005-09-12 | 2007-03-15 | Zoltan Laboratories Llc | Compounds and compositions to control abnormal cell growth |
| WO2007075199A1 (en) | 2005-12-28 | 2007-07-05 | Zoltan Laboratories Llc | Use of alkaline phosphatase to maintain healthy tissue mass in mammals |
| RU2006103770A (ru) * | 2006-02-08 | 2007-08-20 | Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) (Ru) | Высокоактивная бактериальная щелочная фосфатаза и фрагмент днк, кодирующий щелочную фосфатазу |
| US20070280922A1 (en) | 2006-06-06 | 2007-12-06 | Zoltan Kiss Consulting | Combinations of human proteins to enhance viability of stem cells and progenitor cells |
| US7718170B2 (en) | 2006-08-21 | 2010-05-18 | Essential Skincare, Llc | Alkaline phosphatase compositions to reduce skin cancer |
| EP1952823A1 (en) * | 2007-01-30 | 2008-08-06 | AM-Pharma B.V. | The use of alkaline phosphatase in the treatment of reduced renal function |
| WO2008104199A1 (en) | 2007-03-01 | 2008-09-04 | Gelato Corporation N.V. | Use of ecto-phosphatases for the treatment of (acute) myocardial infarction |
| EP1985697A1 (en) * | 2007-04-27 | 2008-10-29 | AM-Pharma B.V. | Modified phosphatases |
| PT2662448T (pt) * | 2007-05-11 | 2017-03-29 | Alexion Pharma Inc | Fosfatase alcalina dirigida ao osso, kits e métodos para a utilização da mesma |
| EP2030980A1 (en) | 2007-08-28 | 2009-03-04 | AM-Pharma B.V. | Mutants of lactoferrin |
| ES2421717T3 (es) | 2008-02-29 | 2013-09-05 | Alloksys Life Science B V | Fosfatasa alcalina para aumentar la actividad del sistema inmune en un mamífero con riesgo de enfermedades inflamatorias |
| US20100016313A1 (en) | 2008-05-19 | 2010-01-21 | Burnham Institute For Medical Research | Intestinal alkaline phosphatase modulators and uses thereof |
| US20110206654A1 (en) | 2008-08-29 | 2011-08-25 | The General Hospital Corporation | Methods of Modulating Gastrointestinal Tract Flora Levels with Alkaline Phosphatase |
| CN103153344A (zh) * | 2010-04-30 | 2013-06-12 | 阿莱克森国际制药有限公司 | 用于治疗基质矿化障碍的方法、组合物、和试剂盒 |
| ES2618794T3 (es) | 2011-06-08 | 2017-06-22 | Am-Pharma B.V. | El uso de fosfatasa alcalina para preservar la función renal |
| PE20161442A1 (es) | 2014-01-24 | 2017-01-12 | Am-Pharma B V | Proteinas quimericas tipo fosfatasa alcalina |
| DK3461891T3 (da) | 2014-01-24 | 2020-08-10 | Am-Pharma Bv | Nedstrømsbehandling af en alkalisk phosphatase |
-
2015
- 2015-01-26 PE PE2016001271A patent/PE20161442A1/es unknown
- 2015-01-26 AU AU2015209783A patent/AU2015209783B2/en active Active
- 2015-01-26 CN CN202010673719.7A patent/CN111778228A/zh active Pending
- 2015-01-26 ES ES15703642.7T patent/ES2684639T3/es active Active
- 2015-01-26 DK DK15703642.7T patent/DK3097189T3/en active
- 2015-01-26 HU HUE15703642A patent/HUE039784T2/hu unknown
- 2015-01-26 JP JP2016548124A patent/JP6940949B2/ja active Active
- 2015-01-26 US US15/113,696 patent/US9926544B2/en active Active
- 2015-01-26 EP EP18174759.3A patent/EP3425048A1/en not_active Withdrawn
- 2015-01-26 CN CN201580016357.1A patent/CN106164262B/zh active Active
- 2015-01-26 SI SI201530345T patent/SI3097189T1/sl unknown
- 2015-01-26 BR BR112016017041-5A patent/BR112016017041B1/pt active IP Right Grant
- 2015-01-26 PL PL15703642T patent/PL3097189T3/pl unknown
- 2015-01-26 MX MX2016009625A patent/MX369041B/es active IP Right Grant
- 2015-01-26 SG SG11201606060WA patent/SG11201606060WA/en unknown
- 2015-01-26 KR KR1020167022726A patent/KR102166110B1/ko active IP Right Grant
- 2015-01-26 EP EP15703642.7A patent/EP3097189B1/en active Active
- 2015-01-26 CA CA2937328A patent/CA2937328C/en active Active
- 2015-01-26 WO PCT/NL2015/050048 patent/WO2015112017A1/en active Application Filing
- 2015-01-26 RU RU2016131879A patent/RU2683635C2/ru active
-
2016
- 2016-07-19 ZA ZA2016/05028A patent/ZA201605028B/en unknown
- 2016-07-20 PH PH12016501441A patent/PH12016501441A1/en unknown
- 2016-07-21 IL IL246898A patent/IL246898B/en active IP Right Grant
- 2016-07-21 SA SA516371532A patent/SA516371532B1/ar unknown
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2018
- 2018-02-07 US US15/891,208 patent/US10822597B2/en active Active
-
2019
- 2019-12-20 JP JP2019230887A patent/JP2020058375A/ja active Pending
-
2020
- 2020-10-16 US US17/072,893 patent/US11746340B2/en active Active
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2022
- 2022-07-22 JP JP2022117484A patent/JP7408734B2/ja active Active
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