PL3097189T3 - Chimeryczne białka podobne do alkalicznej fosfatazy - Google Patents
Chimeryczne białka podobne do alkalicznej fosfatazyInfo
- Publication number
- PL3097189T3 PL3097189T3 PL15703642T PL15703642T PL3097189T3 PL 3097189 T3 PL3097189 T3 PL 3097189T3 PL 15703642 T PL15703642 T PL 15703642T PL 15703642 T PL15703642 T PL 15703642T PL 3097189 T3 PL3097189 T3 PL 3097189T3
- Authority
- PL
- Poland
- Prior art keywords
- alkaline phosphatase
- chimeric proteins
- proteins similar
- similar
- chimeric
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14152526 | 2014-01-24 | ||
| EP14188158 | 2014-10-08 | ||
| EP15703642.7A EP3097189B1 (en) | 2014-01-24 | 2015-01-26 | Chimeric alkaline phosphatase-like proteins |
| PCT/NL2015/050048 WO2015112017A1 (en) | 2014-01-24 | 2015-01-26 | Chimeric alkaline phosphatase-like proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3097189T3 true PL3097189T3 (pl) | 2018-11-30 |
Family
ID=52464544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15703642T PL3097189T3 (pl) | 2014-01-24 | 2015-01-26 | Chimeryczne białka podobne do alkalicznej fosfatazy |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9926544B2 (pl) |
| EP (2) | EP3425048A1 (pl) |
| JP (3) | JP6940949B2 (pl) |
| KR (1) | KR102166110B1 (pl) |
| CN (2) | CN111778228A (pl) |
| AU (1) | AU2015209783B2 (pl) |
| BR (1) | BR112016017041B1 (pl) |
| CA (1) | CA2937328C (pl) |
| DK (1) | DK3097189T3 (pl) |
| ES (1) | ES2684639T3 (pl) |
| HU (1) | HUE039784T2 (pl) |
| IL (1) | IL246898B (pl) |
| MX (1) | MX369041B (pl) |
| PE (1) | PE20161442A1 (pl) |
| PH (1) | PH12016501441B1 (pl) |
| PL (1) | PL3097189T3 (pl) |
| RU (1) | RU2683635C2 (pl) |
| SA (1) | SA516371532B1 (pl) |
| SG (1) | SG11201606060WA (pl) |
| SI (1) | SI3097189T1 (pl) |
| WO (1) | WO2015112017A1 (pl) |
| ZA (1) | ZA201605028B (pl) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12016501441B1 (en) | 2014-01-24 | 2023-02-22 | Am Pharma Bv | Chimeric alkaline phosphatase-like proteins |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| BR112017011900A2 (pt) | 2014-12-05 | 2018-02-27 | Alexion Pharma Inc | tratamento de ataques com fosfatase alcalina recombinante |
| CA2973883A1 (en) | 2015-01-28 | 2016-08-04 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| AU2016308624B2 (en) * | 2015-08-17 | 2022-06-23 | Alexion Pharmaceuticals, Inc. | Manufacturing of alkaline phosphatases |
| WO2017074466A1 (en) | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US11186832B2 (en) | 2016-04-01 | 2021-11-30 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
| US10988744B2 (en) | 2016-06-06 | 2021-04-27 | Alexion Pharmaceuticals, Inc. | Method of producing alkaline phosphatase |
| EP3345614A1 (en) * | 2017-01-05 | 2018-07-11 | Amrif B.V. | Composition comprising alkaline phosphatase for use in the treatment of arthritides |
| CN110719786A (zh) | 2017-03-31 | 2020-01-21 | 阿雷克森制药公司 | 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法 |
| US11338020B2 (en) | 2018-01-09 | 2022-05-24 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| PT3762018T (pt) | 2018-03-08 | 2024-05-07 | Am Pharma Bv | Fosfatase alcalina recombinante para utilização no tratamento de lesão renal aguda associada a septicemia |
| ES3032290T3 (en) | 2018-03-20 | 2025-07-16 | Theriva Biologics Inc | Intestinal alkaline phosphatase formulations |
| EP3773686B1 (en) | 2018-03-20 | 2023-06-07 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| CN110499284A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备治疗基因ALPL敲除小鼠牙硬组织矿化异常产品中的应用 |
| EP3833377B1 (en) | 2018-08-10 | 2023-11-22 | Alexion Pharmaceuticals, Inc. | Bone healing at implants using alkaline phosphatase |
| CN113993541A (zh) | 2019-05-06 | 2022-01-28 | 合成生物制品有限公司 | 基于碱性磷酸酶的肿瘤学治疗 |
| MX2022007114A (es) | 2019-12-09 | 2022-07-11 | Alexion Pharma Inc | Polipeptidos de fosfatasa alcalina y metodos de uso de los mismos. |
| JP2023510195A (ja) * | 2020-01-03 | 2023-03-13 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 歯周の健康を促進するために局所投与されるｔｎａｐ |
| CN111110835A (zh) * | 2020-01-22 | 2020-05-08 | 李鑫荣 | 一种肠碱性磷酸酶的新应用及其制剂的细胞活性检测方法 |
| EP4210731A1 (en) | 2020-09-09 | 2023-07-19 | AM-Pharma B.V. | Recombinant alkaline phosphatase for use in treating acute respiratory distress syndrome |
| BR112023016048A2 (pt) | 2021-02-12 | 2023-11-14 | Alexion Pharma Inc | Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos |
| CN118580341B (zh) * | 2024-06-24 | 2025-03-18 | 浙江大学 | 一种寄生线虫spi-i8蛋白及其在防治炎症疾病中的应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8328918D0 (en) | 1983-10-28 | 1983-11-30 | Unilever Plc | Alkaline phosphatase |
| EP0441252B1 (en) | 1990-02-07 | 1997-09-03 | Abbott Laboratories | Alkaline phosphatase enzymes having improved specific activity for use in indicator reagents |
| WO1993018139A1 (en) | 1992-03-10 | 1993-09-16 | La Jolla Cancer Research Foundation | Recombinant calf intestinal alkaline phosphatase |
| JPH06284885A (ja) * | 1993-04-02 | 1994-10-11 | Tosoh Corp | 組換えヒト小腸アルカリフォスファタ−ゼ |
| AU698101B2 (en) | 1993-06-01 | 1998-10-22 | Cortex Pharmaceuticals, Inc. | Alkaline and acid phosphatase inhibitors in treatment of neurological disorders |
| WO1995005455A1 (en) | 1993-08-13 | 1995-02-23 | Rijksuniversiteit Te Groningen | Pharmaceutical composition comprising phosphatase or a derivative thereof |
| ATE225666T1 (de) | 1993-11-15 | 2002-10-15 | Celtrix Pharma | Verwendung von igf-1 und igfbp-3 zur herstellung eines arzneimittels zur behandlung von einer nierenerkrankung |
| CA2222626A1 (en) | 1995-06-06 | 1996-12-12 | Biocoll Laboratories, Inc. | Modified osteogenic materials |
| FR2736065B1 (fr) | 1995-06-29 | 1997-09-19 | Commissariat Energie Atomique | Phosphatases alcalines bacteriennes modifiees et leurs applications. |
| JP3488327B2 (ja) | 1995-12-21 | 2004-01-19 | よつ葉乳業株式会社 | 牛乳脂肪球膜含有画分の製造法 |
| US20020114802A1 (en) | 1998-02-10 | 2002-08-22 | Tjellstrom Bo Arthur Einar | Oral immunoglobulin treatment for inflammatory bowel disease |
| DE19819962A1 (de) | 1998-05-05 | 1999-11-11 | Roche Diagnostics Gmbh | Hochaktive alkalische Phosphatase |
| JP2002533679A (ja) | 1998-12-21 | 2002-10-08 | フアーマアウエア・アイピー・ベー・ブイ | アルカリホスファターゼのｌｐｓ−結合部分を使用する敗血症の診断 |
| JP2000350596A (ja) | 1999-06-11 | 2000-12-19 | Toyobo Co Ltd | 分泌性アルカリフォスファターゼの選択的活性測定方法 |
| ATE327751T1 (de) | 2000-01-31 | 2006-06-15 | Pfizer Prod Inc | Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz |
| KR100799192B1 (ko) | 2000-07-19 | 2008-01-31 | 미쯔비시 웰 파마 가부시키가이샤 | 히드록삼산계 설폰산 유도체 및 그의 의약 용도 |
| EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| DE10101793A1 (de) | 2001-01-17 | 2002-08-01 | Manfred Nilius | Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen |
| EP1370642A2 (en) | 2001-01-20 | 2003-12-17 | Cardion AG | Pluripotent adult stem cells derived from regenerative tissue |
| JP4238726B2 (ja) | 2001-06-01 | 2009-03-18 | 味の素株式会社 | 腸疾患用の薬剤 |
| US7157260B2 (en) | 2001-07-26 | 2007-01-02 | Japan Science & Technology Agency | Nicotianamine synthase and gene encoding the same |
| JP4169966B2 (ja) | 2001-11-14 | 2008-10-22 | 株式会社ヤクルト本社 | 炎症性腸疾患予防治療剤 |
| CN1425766A (zh) | 2001-12-19 | 2003-06-25 | 复旦大学 | 一种多肽——人含碱性磷酸酶活性位点的蛋白－9.24和编码这种多肽的多核苷酸 |
| US20040146907A1 (en) * | 2002-11-13 | 2004-07-29 | Genentech, Inc. | Methods and compositions for detecting dysplasia |
| US7048914B2 (en) | 2002-12-12 | 2006-05-23 | Zoltan Laboratories | Placental alkaline phosphatase to control diabetes |
| WO2004056987A1 (en) * | 2002-12-23 | 2004-07-08 | Rijksuniversiteit Groningen | Modulation of the thioredoxin pathway |
| AU2003225410A1 (en) | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| JP4305071B2 (ja) | 2003-06-30 | 2009-07-29 | 株式会社ニコン | 信号補正方法 |
| JP2005065564A (ja) | 2003-08-22 | 2005-03-17 | Hiroshi Ueda | センサー蛋白質 |
| US7157261B2 (en) | 2003-10-27 | 2007-01-02 | Canji, Inc. | Rat secreted embryonic alkaline phosphatase |
| JP4999467B2 (ja) | 2004-02-04 | 2012-08-15 | ファルマアウェア セプシス ビー．ブイ． | 粘膜関門に存在するｌｐｓを解毒するためのアルカリホスファターゼの使用 |
| US20110142817A1 (en) | 2004-02-04 | 2011-06-16 | Pharmaaware Sepsis B.V. | Means and method for treating and/or preventing necrotizing enterocolitis |
| WO2006096527A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Nucleic acids and proteins and methods for making and using them |
| US20070059300A1 (en) | 2005-09-12 | 2007-03-15 | Zoltan Laboratories Llc | Compounds and compositions to control abnormal cell growth |
| WO2007075199A1 (en) | 2005-12-28 | 2007-07-05 | Zoltan Laboratories Llc | Use of alkaline phosphatase to maintain healthy tissue mass in mammals |
| RU2006103770A (ru) * | 2006-02-08 | 2007-08-20 | Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) (Ru) | Высокоактивная бактериальная щелочная фосфатаза и фрагмент днк, кодирующий щелочную фосфатазу |
| US20070280922A1 (en) | 2006-06-06 | 2007-12-06 | Zoltan Kiss Consulting | Combinations of human proteins to enhance viability of stem cells and progenitor cells |
| US7718170B2 (en) | 2006-08-21 | 2010-05-18 | Essential Skincare, Llc | Alkaline phosphatase compositions to reduce skin cancer |
| EP1952823A1 (en) * | 2007-01-30 | 2008-08-06 | AM-Pharma B.V. | The use of alkaline phosphatase in the treatment of reduced renal function |
| WO2008104199A1 (en) | 2007-03-01 | 2008-09-04 | Gelato Corporation N.V. | Use of ecto-phosphatases for the treatment of (acute) myocardial infarction |
| EP1985697A1 (en) | 2007-04-27 | 2008-10-29 | AM-Pharma B.V. | Modified phosphatases |
| AU2008250945B2 (en) * | 2007-05-11 | 2013-12-12 | Alexion Pharmaceuticals, Inc. | Bone targeted alkaline phosphatase, kits and methods of use thereof |
| EP2030980A1 (en) | 2007-08-28 | 2009-03-04 | AM-Pharma B.V. | Mutants of lactoferrin |
| WO2009106368A1 (en) | 2008-02-29 | 2009-09-03 | Gelato Corporation N.V. | Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases |
| JP2011521916A (ja) | 2008-05-19 | 2011-07-28 | バーナム インスティテュート フォー メディカル リサーチ | 腸アルカリホスファターゼモジュレーターおよびそれの使用 |
| CA2732438A1 (en) | 2008-08-29 | 2010-03-04 | The General Hospital Corporation | Methods of modulating gastrointestinal tract flora levels with alkaline phosphatase |
| BR112012027765A2 (pt) * | 2010-04-30 | 2019-09-24 | Enobia Pharma Inc | métodos, composições e kits para tratamento de distúrbios de mineralização da matriz. |
| HUE052383T2 (hu) * | 2011-06-08 | 2021-04-28 | Am Pharma Bv | Az alkalikus foszfatáz alkalmazása a vesemûködés megõrzésére |
| PH12016501441B1 (en) | 2014-01-24 | 2023-02-22 | Am Pharma Bv | Chimeric alkaline phosphatase-like proteins |
| PT3461891T (pt) | 2014-01-24 | 2020-07-30 | Am Pharma Bv | Processamento a jusante de uma fosfatase alcalina |
-
2015
- 2015-01-26 PH PH1/2016/501441A patent/PH12016501441B1/en unknown
- 2015-01-26 JP JP2016548124A patent/JP6940949B2/ja active Active
- 2015-01-26 RU RU2016131879A patent/RU2683635C2/ru active
- 2015-01-26 ES ES15703642.7T patent/ES2684639T3/es active Active
- 2015-01-26 SI SI201530345T patent/SI3097189T1/sl unknown
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