CN103153344A - 用于治疗基质矿化障碍的方法、组合物、和试剂盒 - Google Patents
用于治疗基质矿化障碍的方法、组合物、和试剂盒 Download PDFInfo
- Publication number
- CN103153344A CN103153344A CN201180032899XA CN201180032899A CN103153344A CN 103153344 A CN103153344 A CN 103153344A CN 201180032899X A CN201180032899X A CN 201180032899XA CN 201180032899 A CN201180032899 A CN 201180032899A CN 103153344 A CN103153344 A CN 103153344A
- Authority
- CN
- China
- Prior art keywords
- sequence
- amino acid
- salp
- aminoacid sequence
- acid residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
PK参数(NCA) | 单位 | sALP | sALP-Fc |
剂量 | U/kg | 10000 | 2000 |
Cmax/剂量 | U/L/U/kg | 4.32 | 8.54 |
AUC∞/剂量 | U/L*hr/U/kg | 16.0 | 70.6 |
CL | L/hr/kg | 0.0627 | 0.0142 |
半衰期 | hr | 17.6 | 46.9 |
PK参数(NCA) | 单位 | sALP | sALP-Fc |
剂量 | U/kg | 10000 | 2000 |
Cmax/剂量 | U/L/U/kg | 0.0514 | 0.413 |
AUC∞/剂量 | U/L*hr/U/kg | 0.483 | 26.2 |
CL_F | L/hr/kg | 2.07 | 0.0382 |
半衰期 | hr | 24.5 | 43.7 |
生物利用度 | % | 3.02 | 37.1 |
Claims (60)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32987710P | 2010-04-30 | 2010-04-30 | |
US61/329,877 | 2010-04-30 | ||
PCT/CA2011/050258 WO2011134084A1 (en) | 2010-04-30 | 2011-04-29 | Methods, compositions, and kits for the treatment of matrix mineralization disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103153344A true CN103153344A (zh) | 2013-06-12 |
Family
ID=44860717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180032899XA Pending CN103153344A (zh) | 2010-04-30 | 2011-04-29 | 用于治疗基质矿化障碍的方法、组合物、和试剂盒 |
Country Status (14)
Country | Link |
---|---|
US (1) | US9988620B2 (zh) |
EP (1) | EP2563406A4 (zh) |
JP (1) | JP5986986B2 (zh) |
KR (1) | KR20130118203A (zh) |
CN (1) | CN103153344A (zh) |
AU (1) | AU2011245005A1 (zh) |
BR (1) | BR112012027765A2 (zh) |
CA (1) | CA2797865A1 (zh) |
CO (1) | CO6660466A2 (zh) |
EA (1) | EA201291138A1 (zh) |
IL (1) | IL222695A0 (zh) |
MX (1) | MX2012012643A (zh) |
SG (1) | SG185079A1 (zh) |
WO (1) | WO2011134084A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107405390A (zh) * | 2014-12-05 | 2017-11-28 | 阿雷克森制药公司 | 用重组碱性磷酸酶治疗癫痫 |
CN108350440A (zh) * | 2015-08-17 | 2018-07-31 | 阿雷克森制药公司 | 碱性磷酸酯的制造 |
CN109061129A (zh) * | 2018-06-08 | 2018-12-21 | 中山大学附属口腔医院 | 钛表面纳米管仿生矿化方法及用于该方法的试剂盒与溶液 |
CN109152820A (zh) * | 2016-04-01 | 2019-01-04 | 阿雷克森制药公司 | 用碱性磷酸酶治疗肌肉无力 |
CN110719786A (zh) * | 2017-03-31 | 2020-01-21 | 阿雷克森制药公司 | 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法 |
CN111778228A (zh) * | 2014-01-24 | 2020-10-16 | 安-法玛公司 | 嵌合型碱性磷酸酶样蛋白 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005235635B2 (en) | 2004-04-21 | 2010-11-18 | Alexion Pharmaceuticals, Inc. | Bone delivery conjugates and method of using same to target proteins to bone |
US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
EP2563406A4 (en) | 2010-04-30 | 2013-11-13 | Alexion Pharma Internat Sarl | METHOD, COMPOSITIONS AND KITS FOR TREATING MATRIX MINERALIZATION DISORDERS |
AU2011350066A1 (en) | 2010-12-27 | 2013-07-11 | Alexion Pharma International Sarl | Compositions comprising natriuretic peptides and methods of use thereof |
US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
JP6868561B2 (ja) * | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
EP3355904A4 (en) * | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
US11400140B2 (en) | 2015-10-30 | 2022-08-02 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
EP3436020A4 (en) | 2016-04-01 | 2019-12-25 | Alexion Pharmaceuticals, Inc. | METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS |
WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
US11116821B2 (en) | 2016-08-18 | 2021-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
EP3592372A4 (en) * | 2017-03-09 | 2021-01-13 | Alexion Pharmaceuticals, Inc. | GLYCOPROTEIN MANUFACTURING PROCESS |
BR112020007820A2 (pt) * | 2017-10-26 | 2020-10-20 | Shire Human Genetic Therapies, Inc. | formulações compreendendo glucocerebrosidase e isofagomina |
WO2019139891A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
CA3094173A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
WO2019183209A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
WO2019190752A1 (en) | 2018-03-30 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
AU2020398898A1 (en) * | 2019-12-09 | 2022-07-21 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
AU2021337652A1 (en) * | 2020-09-04 | 2023-03-23 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
WO2022173987A1 (en) * | 2021-02-12 | 2022-08-18 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008138131A1 (en) * | 2007-05-11 | 2008-11-20 | Enobia Pharma Inc. | Bone targeted alkaline phosphatase, kits and methods of use thereof |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU662155B2 (en) | 1991-05-10 | 1995-08-24 | Celtrix Pharmaceuticals, Inc. | Targeted delivery of bone growth factors |
WO1995005455A1 (en) | 1993-08-13 | 1995-02-23 | Rijksuniversiteit Te Groningen | Pharmaceutical composition comprising phosphatase or a derivative thereof |
JPH0870875A (ja) | 1994-09-05 | 1996-03-19 | Tosoh Corp | 組換えアルカリフォスファタ−ゼ融合タンパク質 |
US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
WO1998035703A2 (en) | 1997-02-14 | 1998-08-20 | The Salk Institute For Biological Studies | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
CA2245903A1 (en) | 1998-09-28 | 2000-03-28 | Mcgill University | Use of pex in the treatment of metabolic bone diseases |
CA2262056A1 (en) | 1999-02-24 | 2000-08-24 | Guy Boileau | Composition, methods and reagents for the synthesis of a soluble form of human pex |
AU772074B2 (en) | 1999-04-28 | 2004-04-08 | Vectramed, Inc. | Enzymatically activated polymeric drug conjugates |
JP2000327583A (ja) | 1999-05-17 | 2000-11-28 | Medei Sci Puraningu:Kk | 骨指向性ホルモン誘導体 |
ES2284545T3 (es) | 1999-11-16 | 2007-11-16 | Genzyme Corporation | Vectores y transgenes con elementos reguladores para la administracion de genes del higado. |
WO2001044257A1 (en) | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Proton pump inhibitors |
ATE341631T1 (de) | 2000-08-23 | 2006-10-15 | Enobia Pharma Inc | Methode und zusammensetzung zur förderung von osteogenese |
US6436386B1 (en) | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
WO2002068579A2 (en) | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
WO2002092020A2 (en) | 2001-03-23 | 2002-11-21 | The Burnham Institute | Compositions and methods for modulating bone mineral deposition |
US7888372B2 (en) | 2001-03-23 | 2011-02-15 | National Institutes Of Health (Nih) | Compositions and methods for modulating bone mineral deposition |
DE60233047D1 (de) | 2001-05-14 | 2009-09-03 | Gbp Ip Llc | Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie |
US20030158132A1 (en) | 2002-01-22 | 2003-08-21 | Genvec, Inc. | Method for enhancing bone density or formation |
CA2433479A1 (en) | 2002-07-22 | 2004-01-22 | F. Hoffmann-La Roche Ag | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
JP2007501021A (ja) | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
US7431915B2 (en) | 2003-10-31 | 2008-10-07 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
AU2004282984B2 (en) | 2003-11-13 | 2011-07-14 | Hanmi Science Co., Ltd. | Protein complex using immunoglobulin fragment andmethod for the preparation thereof |
AU2005235635B2 (en) | 2004-04-21 | 2010-11-18 | Alexion Pharmaceuticals, Inc. | Bone delivery conjugates and method of using same to target proteins to bone |
US20070081986A1 (en) | 2005-10-07 | 2007-04-12 | Shunji Tomatsu | Beta-glucuronidase with an attached short peptide of acidic amino acids |
US7863238B2 (en) | 2004-06-10 | 2011-01-04 | Saint Louis University | Proteins with an attached short peptide of acidic amino acids |
US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
US7972593B2 (en) | 2004-06-10 | 2011-07-05 | Saint Louis University | Delivery of therapeutic agents to the bone |
US20090142347A1 (en) | 2004-09-29 | 2009-06-04 | The Burnham Institute For Medical Research | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification |
JP2008521575A (ja) | 2004-12-01 | 2008-06-26 | ジェンザイム・コーポレイション | 肝臓を標的とした遺伝物質の送達方法 |
US20070042957A1 (en) | 2005-08-19 | 2007-02-22 | Mayo Foundation For Medical Education And Research | Type v phosphodiesterase inhibitors and natriuretic polypeptides |
US7803901B2 (en) | 2005-09-16 | 2010-09-28 | Mayo Foundation For Medical Education And Research | Polypeptides with natriuresis activity |
US7625564B2 (en) | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
US8784833B2 (en) * | 2006-06-27 | 2014-07-22 | Saint Louis University | Prenatal enzyme replacement therapy for hypophosphatasia |
JP2010501026A (ja) | 2006-06-30 | 2010-01-14 | インターフェース バイオロジクス,インコーポレーテッド | 生体応答性ポリマー |
US7825093B2 (en) | 2006-10-25 | 2010-11-02 | Amgen Inc. | Methods of using OSK1 peptide analogs |
US20080181903A1 (en) | 2006-12-21 | 2008-07-31 | Pdl Biopharma, Inc. | Conjugate of natriuretic peptide and antibody constant region |
EP2162464A1 (en) | 2007-06-06 | 2010-03-17 | Boehringer Ingelheim International GmbH | Natriuretic fusion proteins |
CA2696113A1 (en) | 2007-08-10 | 2009-04-02 | Burnham Institute For Medical Research | Tissue-nonspecific alkaline phosphatase (tnap) activators and uses thereof |
EP2187953A2 (en) | 2007-09-11 | 2010-05-26 | Mondobiotech Laboratories AG | Use of a peptide as a therapeutic agent |
EP3363453A1 (en) * | 2008-06-26 | 2018-08-22 | Acceleron Pharma Inc. | Soluble actriia as activin-actriia antagonist for use in treating anemia or bone-related disorders |
CA2758581C (en) | 2009-05-20 | 2022-06-14 | Biomarin Pharmaceutical Inc. | Variants of c-type natriuretic peptide |
EP2563406A4 (en) | 2010-04-30 | 2013-11-13 | Alexion Pharma Internat Sarl | METHOD, COMPOSITIONS AND KITS FOR TREATING MATRIX MINERALIZATION DISORDERS |
-
2011
- 2011-04-29 EP EP11774253.6A patent/EP2563406A4/en not_active Withdrawn
- 2011-04-29 MX MX2012012643A patent/MX2012012643A/es unknown
- 2011-04-29 EA EA201291138A patent/EA201291138A1/ru unknown
- 2011-04-29 KR KR1020127030261A patent/KR20130118203A/ko active IP Right Grant
- 2011-04-29 BR BR112012027765A patent/BR112012027765A2/pt not_active IP Right Cessation
- 2011-04-29 SG SG2012079869A patent/SG185079A1/en unknown
- 2011-04-29 US US13/695,127 patent/US9988620B2/en active Active
- 2011-04-29 AU AU2011245005A patent/AU2011245005A1/en not_active Abandoned
- 2011-04-29 CA CA2797865A patent/CA2797865A1/en not_active Abandoned
- 2011-04-29 JP JP2013506426A patent/JP5986986B2/ja active Active
- 2011-04-29 CN CN201180032899XA patent/CN103153344A/zh active Pending
- 2011-04-29 WO PCT/CA2011/050258 patent/WO2011134084A1/en active Application Filing
-
2012
- 2012-10-25 IL IL222695A patent/IL222695A0/en unknown
- 2012-11-29 CO CO12217161A patent/CO6660466A2/es not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008138131A1 (en) * | 2007-05-11 | 2008-11-20 | Enobia Pharma Inc. | Bone targeted alkaline phosphatase, kits and methods of use thereof |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111778228A (zh) * | 2014-01-24 | 2020-10-16 | 安-法玛公司 | 嵌合型碱性磷酸酶样蛋白 |
CN107405390A (zh) * | 2014-12-05 | 2017-11-28 | 阿雷克森制药公司 | 用重组碱性磷酸酶治疗癫痫 |
CN108350440A (zh) * | 2015-08-17 | 2018-07-31 | 阿雷克森制药公司 | 碱性磷酸酯的制造 |
CN109152820A (zh) * | 2016-04-01 | 2019-01-04 | 阿雷克森制药公司 | 用碱性磷酸酶治疗肌肉无力 |
CN110719786A (zh) * | 2017-03-31 | 2020-01-21 | 阿雷克森制药公司 | 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法 |
CN109061129A (zh) * | 2018-06-08 | 2018-12-21 | 中山大学附属口腔医院 | 钛表面纳米管仿生矿化方法及用于该方法的试剂盒与溶液 |
CN109061129B (zh) * | 2018-06-08 | 2022-11-29 | 中山大学附属口腔医院 | 钛表面纳米管仿生矿化方法及用于该方法的试剂盒与溶液 |
Also Published As
Publication number | Publication date |
---|---|
EP2563406A4 (en) | 2013-11-13 |
IL222695A0 (en) | 2012-12-31 |
BR112012027765A2 (pt) | 2019-09-24 |
MX2012012643A (es) | 2013-01-22 |
AU2011245005A1 (en) | 2012-11-22 |
JP5986986B2 (ja) | 2016-09-06 |
KR20130118203A (ko) | 2013-10-29 |
JP2013525379A (ja) | 2013-06-20 |
US9988620B2 (en) | 2018-06-05 |
WO2011134084A1 (en) | 2011-11-03 |
CA2797865A1 (en) | 2011-11-03 |
WO2011134084A8 (en) | 2012-12-06 |
US20130108635A1 (en) | 2013-05-02 |
EA201291138A1 (ru) | 2013-05-30 |
EP2563406A1 (en) | 2013-03-06 |
SG185079A1 (en) | 2012-12-28 |
CO6660466A2 (es) | 2013-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103153344A (zh) | 用于治疗基质矿化障碍的方法、组合物、和试剂盒 | |
EP2662448B1 (en) | Bone targeted alkaline phosphatase, kits and methods of use thereof | |
US11224638B2 (en) | Treating seizure with recombinant alkaline phosphatase | |
EP2348114B1 (en) | Bone delivery conjugates and method of using same to target proteins to bone | |
Rowe | The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled | |
Wilson et al. | Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities | |
CN104145015A (zh) | 靶向的溶酶体酶化合物 | |
CN103479994A (zh) | Activin-ActRIIa拮抗剂及其促进骨骼生长的应用 | |
JP2023504208A (ja) | アルカリホスファターゼポリペプチド及びその使用方法 | |
PT1018559E (pt) | Enzimas fosfodiesterases | |
EP2059122B1 (en) | Methods and compositions related to apobec-1 expression | |
Yang et al. | Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function | |
JP2018538008A (ja) | リソソーム酵素の取り込みを中和する抗体または他の因子の検出のための細胞ベースアッセイ | |
CN116710122A (zh) | Enpp1缺乏症和abcc6缺乏症的治疗 | |
AU2013203875A1 (en) | Bone Targeted Alkaline Phosphatase, Kits and Methods of Use Thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: RENASCENCE HOLDING PRIVATE LIMITED COMPANY Free format text: FORMER OWNER: ALEXION PHARMACEUTICAL INTERNATIONAL SARL Effective date: 20140126 Owner name: RENASCENCE PHARMACEUTICAL HOLDING CORP. Free format text: FORMER OWNER: RENASCENCE HOLDING PRIVATE LIMITED COMPANY Effective date: 20140126 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20140126 Address after: Bermuda Hamilton Applicant after: UPS Pharmaceutical Holdings Ltd. Address before: Amsterdam, The Netherlands Applicant before: Credit Holdings Pte. Ltd. Effective date of registration: 20140126 Address after: Amsterdam, The Netherlands Applicant after: Credit Holdings Pte. Ltd. Address before: Lausanne Applicant before: ENOBIA PHARMA Inc. |
|
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130612 |