DK3461891T3 - Nedstrømsbehandling af en alkalisk phosphatase - Google Patents

Nedstrømsbehandling af en alkalisk phosphatase Download PDF

Info

Publication number
DK3461891T3
DK3461891T3 DK18190484.8T DK18190484T DK3461891T3 DK 3461891 T3 DK3461891 T3 DK 3461891T3 DK 18190484 T DK18190484 T DK 18190484T DK 3461891 T3 DK3461891 T3 DK 3461891T3
Authority
DK
Denmark
Prior art keywords
downtower
treatment
alkaline phosphatase
phosphatase
alkaline
Prior art date
Application number
DK18190484.8T
Other languages
English (en)
Inventor
Luigi Johannes Cornelius Jonk
Stephen Edward Connor
Den Berg Erik Jan Van
Elsas Andrea Van
Abhinav Alok Shukla
Heather Bethea Horne
Susan Cook
Timothy Martin Kelly
Victoria Anne Dowling
Mialy Fanjamalala Ramaroson
Original Assignee
Am-Pharma Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Am-Pharma Bv filed Critical Am-Pharma Bv
Application granted granted Critical
Publication of DK3461891T3 publication Critical patent/DK3461891T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/03Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001Alkaline phosphatase (3.1.3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
DK18190484.8T 2014-01-24 2015-01-26 Nedstrømsbehandling af en alkalisk phosphatase DK3461891T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14152542 2014-01-24
EP15703640.1A EP3097188B1 (en) 2014-01-24 2015-01-26 Downstream processing of an alkaline phosphatase

Publications (1)

Publication Number Publication Date
DK3461891T3 true DK3461891T3 (da) 2020-08-10

Family

ID=49989634

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18190484.8T DK3461891T3 (da) 2014-01-24 2015-01-26 Nedstrømsbehandling af en alkalisk phosphatase
DK15703640.1T DK3097188T3 (da) 2014-01-24 2015-01-26 Nedstrømsforarbejdning af en alkalisk phosphatase

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK15703640.1T DK3097188T3 (da) 2014-01-24 2015-01-26 Nedstrømsforarbejdning af en alkalisk phosphatase

Country Status (12)

Country Link
US (2) US10570380B2 (da)
EP (2) EP3097188B1 (da)
JP (3) JP6713147B2 (da)
CN (3) CN106459143A (da)
CA (1) CA2936829A1 (da)
DK (2) DK3461891T3 (da)
ES (2) ES2810813T3 (da)
HU (2) HUE040230T2 (da)
PL (2) PL3097188T3 (da)
PT (1) PT3461891T (da)
SI (2) SI3097188T1 (da)
WO (1) WO2015112015A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3404102B1 (en) 2004-04-21 2021-08-11 Alexion Pharmaceuticals, Inc. Bone delivery conjugates and method of using same to target proteins to bone
DK3097189T3 (da) 2014-01-24 2018-09-03 Am Pharma Bv Kimæriske alkalisk phosphatase-lignende proteiner
US10822596B2 (en) 2014-07-11 2020-11-03 Alexion Pharmaceuticals, Inc. Compositions and methods for treating craniosynostosis
AU2015357551B2 (en) 2014-12-05 2021-02-25 Alexion Pharmaceuticals, Inc. Treating seizure with recombinant alkaline phosphatase
CA2973883A1 (en) 2015-01-28 2016-08-04 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
EP3337894A1 (en) 2015-08-17 2018-06-27 Alexion Pharmaceuticals, Inc. Manufacturing of alkaline phosphatases
EP3355904A4 (en) 2015-09-28 2019-06-12 Alexion Pharmaceuticals, Inc. IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA
EP3368062A4 (en) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT
US11065306B2 (en) 2016-03-08 2021-07-20 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
US10898549B2 (en) 2016-04-01 2021-01-26 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
MX2018011833A (es) 2016-04-01 2019-02-13 Alexion Pharma Inc Tratamiento para la debilidad muscular con fosfatasas alcalinas.
WO2017214130A1 (en) * 2016-06-06 2017-12-14 Alexion Pharmaceuticals, Inc. Metal impact on manufacturing of alkaline phosphatases
US11116821B2 (en) 2016-08-18 2021-09-14 Alexion Pharmaceuticals, Inc. Methods for treating tracheobronchomalacia
CA3057502A1 (en) 2017-03-31 2018-10-04 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia (hpp) in adults and adolescents
US11338020B2 (en) 2018-01-09 2022-05-24 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
EP3773686B1 (en) 2018-03-20 2023-06-07 Theriva Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
EP3768302A4 (en) 2018-03-20 2021-12-15 Synthetic Biologics, Inc. INTESTINAL ALKALINE PHOSPHATASE FORMULATIONS
JP2021519590A (ja) 2018-03-30 2021-08-12 アレクシオン ファーマシューティカルズ, インコーポレイテッド 糖タンパク質の製造
CN114126715A (zh) 2019-05-31 2022-03-01 罗根生物技术有限公司 组合物以及解除细菌内毒素毒性的方法
US20240052327A1 (en) * 2020-10-23 2024-02-15 Alexion Pharmaceuticals, Inc. Method of controlling total sialic acid content (tsac) during manufacturing of alkaline phosphatase

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
ATE157702T1 (de) 1990-02-07 1997-09-15 Abbott Lab Alkalische phosphatase mit verbesserter spezifischer aktivität zur verwendung in indikatorreagenzien
CA2102294A1 (en) 1992-03-10 1993-09-11 Jose L. Millan Recombinant calf intestinal alkaline phosphatase
AU698101B2 (en) 1993-06-01 1998-10-22 Cortex Pharmaceuticals, Inc. Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
WO1995005455A1 (en) 1993-08-13 1995-02-23 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
AU690941B2 (en) 1993-11-15 1998-05-07 Celtrix Pharmaceuticals, Inc. Method of treating renal disease by administering IGF-I and IGFBP-3
US20020055098A1 (en) 1994-04-18 2002-05-09 Joseph Szasz Thermostable alkaline phosphatases
JP3625503B2 (ja) * 1994-11-11 2005-03-02 旭化成ファーマ株式会社 臨床検査用複合酵素含有組成物
EP0851772A1 (en) 1995-06-06 1998-07-08 Gensci Regeneration Laboratories, Inc. Modified osteogenic materials
FR2736065B1 (fr) 1995-06-29 1997-09-19 Commissariat Energie Atomique Phosphatases alcalines bacteriennes modifiees et leurs applications.
EP0770678B1 (en) * 1995-10-27 2003-01-22 Amersham Biosciences Corp. Thermostable alkaline phosphatase of Rhodothermus marinus
JP3488327B2 (ja) 1995-12-21 2004-01-19 よつ葉乳業株式会社 牛乳脂肪球膜含有画分の製造法
US20020114802A1 (en) 1998-02-10 2002-08-22 Tjellstrom Bo Arthur Einar Oral immunoglobulin treatment for inflammatory bowel disease
DE19819962A1 (de) 1998-05-05 1999-11-11 Roche Diagnostics Gmbh Hochaktive alkalische Phosphatase
AU764247B2 (en) 1998-12-21 2003-08-14 Pharmaaware Ip B.V. Diagnosis of sepsis using the LPS-binding moiety of alkaline phosphatase
JP2000350596A (ja) 1999-06-11 2000-12-19 Toyobo Co Ltd 分泌性アルカリフォスファターゼの選択的活性測定方法
PT1132086E (pt) 2000-01-31 2006-09-29 Pfizer Prod Inc Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica
ATE367374T1 (de) 2000-07-19 2007-08-15 Mitsubishi Pharma Corp Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten
EP1191097A1 (en) 2000-09-21 2002-03-27 Leids Universitair Medisch Centrum Induction of exon skipping in eukaryotic cells
DE10101793A1 (de) 2001-01-17 2002-08-01 Manfred Nilius Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen
WO2002057430A2 (en) 2001-01-20 2002-07-25 Cardion Ag Pluripotent adult stem cells derived from regenerative tissue
WO2002098433A1 (fr) 2001-06-01 2002-12-12 Ajinomoto Co., Inc. Medicaments pour les maladies intestinales
JP3507890B2 (ja) 2001-06-07 2004-03-15 大阪大学長 Shewanellasp.SIB1株由来の新規なアルカリフォスファターゼ
US7157260B2 (en) 2001-07-26 2007-01-02 Japan Science & Technology Agency Nicotianamine synthase and gene encoding the same
JP4169966B2 (ja) 2001-11-14 2008-10-22 株式会社ヤクルト本社 炎症性腸疾患予防治療剤
CN1425766A (zh) 2001-12-19 2003-06-25 复旦大学 一种多肽——人含碱性磷酸酶活性位点的蛋白-9.24和编码这种多肽的多核苷酸
CA2503621A1 (en) 2002-11-13 2004-05-27 Genentech, Inc. Methods and compositions for diagnosing dysplasia
US7048914B2 (en) 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
AU2003295264A1 (en) 2002-12-23 2004-07-14 Rijksuniversiteit Groningen Modulation of the thioredoxin pathway
WO2004083432A1 (en) 2003-03-21 2004-09-30 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
JP4305071B2 (ja) 2003-06-30 2009-07-29 株式会社ニコン 信号補正方法
JP2005065564A (ja) 2003-08-22 2005-03-17 Hiroshi Ueda センサー蛋白質
US20110142817A1 (en) 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
ES2624905T3 (es) 2004-02-04 2017-07-18 Am-Pharma B.V. Uso de fosfatasa alcalina para la desintoxicación de LPS
EP1856291A4 (en) 2005-03-04 2009-04-01 Verenium Corp NUCLEIC ACIDS AND PROTEINS, AND METHODS OF MAKING AND USING SAME
US20070059300A1 (en) 2005-09-12 2007-03-15 Zoltan Laboratories Llc Compounds and compositions to control abnormal cell growth
EP1965830B1 (en) 2005-12-28 2014-05-14 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals
US20070280922A1 (en) 2006-06-06 2007-12-06 Zoltan Kiss Consulting Combinations of human proteins to enhance viability of stem cells and progenitor cells
US7718170B2 (en) 2006-08-21 2010-05-18 Essential Skincare, Llc Alkaline phosphatase compositions to reduce skin cancer
EP1952823A1 (en) 2007-01-30 2008-08-06 AM-Pharma B.V. The use of alkaline phosphatase in the treatment of reduced renal function
WO2008104199A1 (en) 2007-03-01 2008-09-04 Gelato Corporation N.V. Use of ecto-phosphatases for the treatment of (acute) myocardial infarction
EP1985697A1 (en) * 2007-04-27 2008-10-29 AM-Pharma B.V. Modified phosphatases
EP2030980A1 (en) 2007-08-28 2009-03-04 AM-Pharma B.V. Mutants of lactoferrin
CA2716400C (en) 2008-02-29 2017-05-09 Alloksys Life Sciences B.V. Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases
JP2011521916A (ja) 2008-05-19 2011-07-28 バーナム インスティテュート フォー メディカル リサーチ 腸アルカリホスファターゼモジュレーターおよびそれの使用
AU2009285725A1 (en) 2008-08-29 2010-03-04 The General Hospital Corporation Methods of modulating gastrointestinal tract flora levels with alkaline phosphatase
KR101951446B1 (ko) 2010-03-30 2019-02-22 옥타파마 아게 성장 인자 단백질을 정제하는 방법
JP2012196170A (ja) * 2011-03-22 2012-10-18 Sanyo Chem Ind Ltd セルラーゼ組成物及びこのセルラーゼ組成物を含有する洗剤組成物
EP2717906B1 (en) * 2011-06-08 2017-03-01 AM-Pharma B.V. The use of alkaline phosphatase for preserving renal function
AU2012290379A1 (en) * 2011-07-29 2014-02-06 Eleven Biotherapeutics, Inc. Purified proteins

Also Published As

Publication number Publication date
JP6713147B2 (ja) 2020-06-24
ES2810813T3 (es) 2021-03-09
JP2017505613A (ja) 2017-02-23
EP3461891B1 (en) 2020-07-01
EP3461891A1 (en) 2019-04-03
CN112029753A (zh) 2020-12-04
WO2015112015A8 (en) 2016-03-03
EP3097188B1 (en) 2018-08-29
US20170009217A1 (en) 2017-01-12
PT3461891T (pt) 2020-07-30
HUE040230T2 (hu) 2019-02-28
JP2020127427A (ja) 2020-08-27
US20200063112A1 (en) 2020-02-27
JP2022001061A (ja) 2022-01-06
WO2015112015A1 (en) 2015-07-30
EP3097188A1 (en) 2016-11-30
SI3097188T1 (sl) 2018-10-30
CN112048491A (zh) 2020-12-08
US10570380B2 (en) 2020-02-25
CN106459143A (zh) 2017-02-22
HUE051470T2 (hu) 2021-03-01
JP7039645B2 (ja) 2022-03-22
DK3097188T3 (da) 2018-10-08
SI3461891T1 (sl) 2020-09-30
CA2936829A1 (en) 2015-07-30
JP7449266B2 (ja) 2024-03-13
PL3461891T3 (pl) 2020-11-16
PL3097188T3 (pl) 2018-11-30
ES2688066T3 (es) 2018-10-30

Similar Documents

Publication Publication Date Title
DK3461891T3 (da) Nedstrømsbehandling af en alkalisk phosphatase
DK3134530T3 (da) Behandling af hyperbilirubinæmi
DK3137169T3 (da) Hæmmere af lysin-specifik demethylase-1
DK3102576T3 (da) Dihydropyrrolopyridininhibitorer af ror-gamma
DK3466432T3 (da) Fremgangsmåder til behandling af pulmonale non-tuberkuløse mykobakterielle infektioner
DK3160956T3 (da) Inhibitorer af lysin-specifik demethylase-1
DK3164380T3 (da) Hæmmere af lysinspecifik demethylase-1
DK3180331T3 (da) Polymorfer af selinexor
DK2947898T3 (da) Høreanordning
DK3307267T3 (da) Behandling af multipel sklerose
DK3229995T3 (da) Fremgangsmåde for fremstilling af et endestykke
DK3283210T3 (da) Fremgangsmåde
DK3001700T3 (da) Positioneret høresystem
DK3132009T3 (da) Fremgangsmåde
DK3220891T3 (da) Sublingual formulering af riluzol
DK3368044T3 (da) Behandling af hepatisk steatose-relateret oligo-ovulation
DK3204352T3 (da) Hæmmere af lysin-gingipain
DK3201323T3 (da) Modificering af bakteriofag
DK2897382T3 (da) Forbedring af binaural kilde
DK3297619T3 (da) Terapeutiske anvendelser af L-4-chlorkynurenin
DK3418273T3 (da) Derivater af flavagliner
DK3113773T3 (da) Krystallinske former af grapiprant
DK3430004T3 (da) Faststofformer af nilotinibsalte
FR3022129B1 (fr) Baignoire de puericulture
DK3200783T3 (da) Behandling af erytromelalgi