MX2016009625A - Proteinas quimericas tipo fosfatasa alcalina. - Google Patents

Proteinas quimericas tipo fosfatasa alcalina.

Info

Publication number
MX2016009625A
MX2016009625A MX2016009625A MX2016009625A MX2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A
Authority
MX
Mexico
Prior art keywords
proteins
alkaline phosphatase
chimeric
chimeric alkaline
alkaline phosphatases
Prior art date
Application number
MX2016009625A
Other languages
English (en)
Other versions
MX369041B (es
Inventor
Raaben Willem
Johannes Cornelius Jonk Luigi
Jan VAN DEN BERG Erik
Luis MILLÁN José
Van Elsas Andrea
Original Assignee
Am-Pharma B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Am-Pharma B V filed Critical Am-Pharma B V
Publication of MX2016009625A publication Critical patent/MX2016009625A/es
Publication of MX369041B publication Critical patent/MX369041B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

La invención se refiere a la mejora de las fosfatasas alcalinas, composiciones farmacéuticas que comprenden las fosfatasas alcalinas mejoradas y el uso de las fosfatasas alcalinas mejoradas para la prevención, tratamiento o curación de enfermedades.
MX2016009625A 2014-01-24 2015-01-26 Proteinas quimericas tipo fosfatasa alcalina. MX369041B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14152526 2014-01-24
EP14188158 2014-10-08
PCT/NL2015/050048 WO2015112017A1 (en) 2014-01-24 2015-01-26 Chimeric alkaline phosphatase-like proteins

Publications (2)

Publication Number Publication Date
MX2016009625A true MX2016009625A (es) 2017-05-01
MX369041B MX369041B (es) 2019-10-25

Family

ID=52464544

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009625A MX369041B (es) 2014-01-24 2015-01-26 Proteinas quimericas tipo fosfatasa alcalina.

Country Status (22)

Country Link
US (3) US9926544B2 (es)
EP (2) EP3097189B1 (es)
JP (3) JP6940949B2 (es)
KR (1) KR102166110B1 (es)
CN (2) CN106164262B (es)
AU (1) AU2015209783B2 (es)
BR (1) BR112016017041B1 (es)
CA (1) CA2937328C (es)
DK (1) DK3097189T3 (es)
ES (1) ES2684639T3 (es)
HU (1) HUE039784T2 (es)
IL (1) IL246898B (es)
MX (1) MX369041B (es)
PE (1) PE20161442A1 (es)
PH (1) PH12016501441A1 (es)
PL (1) PL3097189T3 (es)
RU (1) RU2683635C2 (es)
SA (1) SA516371532B1 (es)
SG (1) SG11201606060WA (es)
SI (1) SI3097189T1 (es)
WO (1) WO2015112017A1 (es)
ZA (1) ZA201605028B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9926544B2 (en) 2014-01-24 2018-03-27 Am-Pharma B.V. Chimeric alkaline phosphatase-like proteins
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
JP6787894B2 (ja) 2014-12-05 2020-11-18 アレクシオン ファーマシューティカルズ， インコーポレイテッド 組換えアルカリホスファターゼを用いた発作の処置
AU2016211447B2 (en) 2015-01-28 2021-09-23 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
KR102644116B1 (ko) 2015-08-17 2024-03-05 알렉시온 파마슈티칼스, 인코포레이티드 알칼린 포스파타제의 제조
JP2018533571A (ja) 2015-10-30 2018-11-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド 患者の頭蓋縫合早期癒合症を治療するための方法
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
WO2017173413A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
WO2017214130A1 (en) 2016-06-06 2017-12-14 Alexion Pharmaceuticals, Inc. Metal impact on manufacturing of alkaline phosphatases
EP3345614A1 (en) * 2017-01-05 2018-07-11 Amrif B.V. Composition comprising alkaline phosphatase for use in the treatment of arthritides
CN110719786A (zh) * 2017-03-31 2020-01-21 阿雷克森制药公司 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法
US11338020B2 (en) 2018-01-09 2022-05-24 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
EP4342534A2 (en) * 2018-03-08 2024-03-27 AM-Pharma B.V. Recombinant alkaline phosphatase for use in treating sepsis-associated acute kidney injury
CA3094173A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Intestinal alkaline phosphatase formulations
WO2019183209A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
JP2021519590A (ja) 2018-03-30 2021-08-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド 糖タンパク質の製造
CN110499285A (zh) * 2018-05-17 2019-11-26 西安组织工程与再生医学研究所 Alpl基因在制备预防和/或治疗低碱性磷酸酶症的产品中的应用
WO2022055350A1 (en) 2020-09-09 2022-03-17 Am-Pharma B.V. Recombinant alkaline phosphatase for use in treating acute respiratory distress syndrome

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
EP0441252B1 (en) 1990-02-07 1997-09-03 Abbott Laboratories Alkaline phosphatase enzymes having improved specific activity for use in indicator reagents
EP0867511A1 (en) 1992-03-10 1998-09-30 La Jolla Cancer Research Foundation Recombinant calf intestinal alkaline phosphatase
JPH06284885A (ja) * 1993-04-02 1994-10-11 Tosoh Corp 組換えヒト小腸アルカリフォスファタ−ゼ
WO1994027603A1 (en) 1993-06-01 1994-12-08 Cortex Pharmaceuticals, Inc. Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
AU4835693A (en) 1993-08-13 1995-03-14 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
JPH09509141A (ja) 1993-11-15 1997-09-16 セルトリックス ファーマシューティカルズ，インコーポレイテッド Ｉｇｆ‐ｉおよびｉｇｆｂｐ‐３を投与することによる腎臓疾患処置の方法
WO1996039203A1 (en) 1995-06-06 1996-12-12 Gensci Regeneration Laboratories, Inc. Modified osteogenic materials
FR2736065B1 (fr) 1995-06-29 1997-09-19 Commissariat Energie Atomique Phosphatases alcalines bacteriennes modifiees et leurs applications.
JP3488327B2 (ja) 1995-12-21 2004-01-19 よつ葉乳業株式会社 牛乳脂肪球膜含有画分の製造法
US20020114802A1 (en) 1998-02-10 2002-08-22 Tjellstrom Bo Arthur Einar Oral immunoglobulin treatment for inflammatory bowel disease
DE19819962A1 (de) 1998-05-05 1999-11-11 Roche Diagnostics Gmbh Hochaktive alkalische Phosphatase
WO2000037943A1 (en) 1998-12-21 2000-06-29 Stichting Voor De Technische Wetenschappen Diagnosis of sepsis using the lps-binding moiety of alkaline phosphatase
JP2000350596A (ja) 1999-06-11 2000-12-19 Toyobo Co Ltd 分泌性アルカリフォスファターゼの選択的活性測定方法
DK1132086T3 (da) 2000-01-31 2006-08-28 Pfizer Prod Inc Anvendelse af prostaglandin (PGE2) selektive receptor 4 (EP4) agonister til behandling af akut og kronisk nyresvigt
KR100799192B1 (ko) 2000-07-19 2008-01-31 미쯔비시 웰 파마 가부시키가이샤 히드록삼산계 설폰산 유도체 및 그의 의약 용도
EP1191097A1 (en) 2000-09-21 2002-03-27 Leids Universitair Medisch Centrum Induction of exon skipping in eukaryotic cells
DE10101793A1 (de) 2001-01-17 2002-08-01 Manfred Nilius Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen
EP1370642A2 (en) 2001-01-20 2003-12-17 Cardion AG Pluripotent adult stem cells derived from regenerative tissue
EP1393734A4 (en) 2001-06-01 2006-04-12 Ajinomoto Kk DRUG AGAINST DARMER DISEASES
US7157260B2 (en) 2001-07-26 2007-01-02 Japan Science & Technology Agency Nicotianamine synthase and gene encoding the same
JP4169966B2 (ja) 2001-11-14 2008-10-22 株式会社ヤクルト本社 炎症性腸疾患予防治療剤
CN1425766A (zh) 2001-12-19 2003-06-25 复旦大学 一种多肽——人含碱性磷酸酶活性位点的蛋白－9.24和编码这种多肽的多核苷酸
US20040146907A1 (en) * 2002-11-13 2004-07-29 Genentech, Inc. Methods and compositions for detecting dysplasia
US7048914B2 (en) 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
AU2003295264A1 (en) 2002-12-23 2004-07-14 Rijksuniversiteit Groningen Modulation of the thioredoxin pathway
AU2003225410A1 (en) 2003-03-21 2004-10-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
JP4305071B2 (ja) 2003-06-30 2009-07-29 株式会社ニコン 信号補正方法
JP2005065564A (ja) 2003-08-22 2005-03-17 Hiroshi Ueda センサー蛋白質
US7157261B2 (en) 2003-10-27 2007-01-02 Canji, Inc. Rat secreted embryonic alkaline phosphatase
US20110142817A1 (en) 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
CN1917899B (zh) 2004-02-04 2013-04-17 塞浦西斯阿瓦药物集团 碱性磷酸酶对存在于粘膜屏障的脂多糖解毒的用途
CA2599577A1 (en) 2005-03-04 2006-09-14 Verenium Corporation Nucleic acids and proteins and methods for making and using them
US20070059300A1 (en) 2005-09-12 2007-03-15 Zoltan Laboratories Llc Compounds and compositions to control abnormal cell growth
WO2007075199A1 (en) 2005-12-28 2007-07-05 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals
RU2006103770A (ru) * 2006-02-08 2007-08-20 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) (Ru) Высокоактивная бактериальная щелочная фосфатаза и фрагмент днк, кодирующий щелочную фосфатазу
US20070280922A1 (en) 2006-06-06 2007-12-06 Zoltan Kiss Consulting Combinations of human proteins to enhance viability of stem cells and progenitor cells
US7718170B2 (en) 2006-08-21 2010-05-18 Essential Skincare, Llc Alkaline phosphatase compositions to reduce skin cancer
EP1952823A1 (en) * 2007-01-30 2008-08-06 AM-Pharma B.V. The use of alkaline phosphatase in the treatment of reduced renal function
WO2008104199A1 (en) 2007-03-01 2008-09-04 Gelato Corporation N.V. Use of ecto-phosphatases for the treatment of (acute) myocardial infarction
EP1985697A1 (en) * 2007-04-27 2008-10-29 AM-Pharma B.V. Modified phosphatases
PT2368999E (pt) * 2007-05-11 2014-05-26 Alexion Pharma Holding Fosfatase alcalina dirigida ao osso, kits e métodos para a utilização da mesma
EP2030980A1 (en) 2007-08-28 2009-03-04 AM-Pharma B.V. Mutants of lactoferrin
WO2009106368A1 (en) 2008-02-29 2009-09-03 Gelato Corporation N.V. Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases
AU2009249180A1 (en) 2008-05-19 2009-11-26 Burnham Institute For Medical Research Intestinal Alkaline Phosphatase modulators and uses thereof
AU2009285725A1 (en) 2008-08-29 2010-03-04 The General Hospital Corporation Methods of modulating gastrointestinal tract flora levels with alkaline phosphatase
WO2011134084A1 (en) * 2010-04-30 2011-11-03 Enobia Pharma Inc. Methods, compositions, and kits for the treatment of matrix mineralization disorders
WO2012169892A2 (en) * 2011-06-08 2012-12-13 Am-Pharma B.V. The use of alkaline phosphatase for preserving renal function
US9926544B2 (en) 2014-01-24 2018-03-27 Am-Pharma B.V. Chimeric alkaline phosphatase-like proteins
DK3097188T3 (en) 2014-01-24 2018-10-08 Am Pharma Bv DOWNSTREAM PREPARATION OF AN ALKALIC PHOSPHATASE

Also Published As

Publication number Publication date
WO2015112017A1 (en) 2015-07-30
AU2015209783B2 (en) 2020-10-01
JP6940949B2 (ja) 2021-09-29
US9926544B2 (en) 2018-03-27
BR112016017041B1 (pt) 2023-09-26
CA2937328A1 (en) 2015-07-30
JP2022160503A (ja) 2022-10-19
CN111778228A (zh) 2020-10-16
CA2937328C (en) 2022-09-27
MX369041B (es) 2019-10-25
EP3097189A1 (en) 2016-11-30
SI3097189T1 (sl) 2018-10-30
SA516371532B1 (ar) 2019-02-11
EP3425048A1 (en) 2019-01-09
EP3097189B1 (en) 2018-07-11
IL246898B (en) 2019-09-26
JP2017505128A (ja) 2017-02-16
KR102166110B1 (ko) 2020-10-16
RU2016131879A (ru) 2018-03-01
US10822597B2 (en) 2020-11-03
AU2015209783A1 (en) 2016-08-04
ES2684639T3 (es) 2018-10-03
IL246898A0 (en) 2016-09-29
DK3097189T3 (en) 2018-09-03
CN106164262B (zh) 2020-08-07
PH12016501441A1 (en) 2016-08-22
NZ722253A (en) 2021-11-26
JP7408734B2 (ja) 2024-01-05
US20190024062A1 (en) 2019-01-24
KR20160117487A (ko) 2016-10-10
US20170009216A1 (en) 2017-01-12
US11746340B2 (en) 2023-09-05
US20210163905A1 (en) 2021-06-03
RU2683635C2 (ru) 2019-03-29
CN106164262A (zh) 2016-11-23
ZA201605028B (en) 2020-02-26
HUE039784T2 (hu) 2019-02-28
SG11201606060WA (en) 2016-08-30
PE20161442A1 (es) 2017-01-12
PL3097189T3 (pl) 2018-11-30
RU2016131879A3 (es) 2018-08-16
JP2020058375A (ja) 2020-04-16
BR112016017041A2 (pt) 2017-10-03

Similar Documents

Publication Publication Date Title
PH12016501441A1 (en) Chimeric alkaline phosphate-like proteins
PH12018501378A1 (en) Compositions and methods for the treatment of hemoglobinopathies
PH12018500950A1 (en) Subcutaneous formulations of anti-cd38 antibodies and their uses
MX2023008693A (es) Polinucleotidos moduladores.
PH12017500858A1 (en) Mocrocyclic peptides useful as immunomodulators
TW201613901A (en) New compounds
MY192927A (en) Fused bicyclic compounds for the treatment of disease
IL255509B (en) Compounds as modulators of ccr2, pharmaceutical preparations containing them and their use in the treatment of diseases
PH12017501077A1 (en) Compositions and methods for antibodies targeting bmp6
MX2017008456A (es) Compuestos biciclicos fusionados para el tratamiento de enfermedades.
PH12018501279A1 (en) Compositions comprising 15-hepe and methods of using the same
MX2017004808A (es) Combinaciones que comprenden siponimod y laquinimod para el tratamiento de la esclerosis multiple.
MX2018009325A (es) Compuestos y metodos para tratar enfermedades mediadas por el acido ribonucleico (arn).
ZA201904660B (en) Treatment of aqueous compositions including fines
MY180844A (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
MX2022002635A (es) Anticuerpos anti proteina similar a angiopoyetina 4 y metodos de uso.
TW201613977A (en) Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
IN2014CH00840A (es)
MX2017012342A (es) Compuestos biciclicos fusionados para el tratamiento de enfermedades,.
NZ721832A (en) Solid forms of tenofovir
MX2017003949A (es) Derivados peptidicos novedosos y sus usos.

Legal Events

Date Code Title Description
FG Grant or registration