JP2019031567A5 - - Google Patents

Info

Publication number

JP2019031567A5

JP2019031567A5 JP2018208003A JP2018208003A JP2019031567A5 JP 2019031567 A5 JP2019031567 A5 JP 2019031567A5 JP 2018208003 A JP2018208003 A JP 2018208003A JP 2018208003 A JP2018208003 A JP 2018208003A JP 2019031567 A5 JP2019031567 A5 JP 2019031567A5

Authority

JP

Japan

Prior art keywords

seq

cdr sequences

composition

sclerostin antibody

administering

Prior art date

2018-11-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 210000000988 bone and bone Anatomy 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 229940124597 therapeutic agent Drugs 0.000 claims 3
• 238000012423 maintenance Methods 0.000 claims 2
• 238000005728 strengthening Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
• 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 1
• 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102000003982 Parathyroid hormone Human genes 0.000 claims 1
• 108090000445 Parathyroid hormone Proteins 0.000 claims 1
• 208000005888 Periodontal Pocket Diseases 0.000 claims 1
• 102000014128 RANK Ligand Human genes 0.000 claims 1
• 108010025832 RANK Ligand Proteins 0.000 claims 1
• 108010049264 Teriparatide Proteins 0.000 claims 1
• 150000004663 bisphosphonates Chemical class 0.000 claims 1
• HALQELOKLVRWRI-VDBOFHIQSA-N doxycycline hyclate Chemical compound O.[Cl-].[Cl-].CCO.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]([NH+](C)C)[C@@H]1[C@H]2O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]([NH+](C)C)[C@@H]1[C@H]2O HALQELOKLVRWRI-VDBOFHIQSA-N 0.000 claims 1
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• OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 claims 1
• 229960005460 teriparatide Drugs 0.000 claims 1
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