JP2013543501A5 - - Google Patents
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- JP2013543501A5 JP2013543501A5 JP2013532213A JP2013532213A JP2013543501A5 JP 2013543501 A5 JP2013543501 A5 JP 2013543501A5 JP 2013532213 A JP2013532213 A JP 2013532213A JP 2013532213 A JP2013532213 A JP 2013532213A JP 2013543501 A5 JP2013543501 A5 JP 2013543501A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antibody
- seq
- patient
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000013691 Interleukin-17 Human genes 0.000 claims 62
- 239000008194 pharmaceutical composition Substances 0.000 claims 47
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 16
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 16
- 201000004681 Psoriasis Diseases 0.000 claims 12
- 230000006698 induction Effects 0.000 claims 11
- 238000012423 maintenance Methods 0.000 claims 9
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 4
- 239000000710 homodimer Substances 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000009885 systemic effect Effects 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 229960005339 acitretin Drugs 0.000 claims 1
- 229960002459 alefacept Drugs 0.000 claims 1
- IHUNBGSDBOWDMA-AQFIFDHZSA-N all-trans-acitretin Chemical compound COC1=CC(C)=C(\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O)C(C)=C1C IHUNBGSDBOWDMA-AQFIFDHZSA-N 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 229960000284 efalizumab Drugs 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 229960001743 golimumab Drugs 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39138810P | 2010-10-08 | 2010-10-08 | |
| US61/391,388 | 2010-10-08 | ||
| PCT/EP2011/067522 WO2012045848A1 (en) | 2010-10-08 | 2011-10-07 | Methods of treating psoriasis using il-17 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013253745A Division JP2014114288A (ja) | 2010-10-08 | 2013-12-09 | Ｉｌ−１７アンタゴニストを用いて乾癬を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543501A JP2013543501A (ja) | 2013-12-05 |
| JP2013543501A5 true JP2013543501A5 (enExample) | 2014-03-27 |
| JP5537740B2 JP5537740B2 (ja) | 2014-07-02 |
Family
ID=44759699
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532213A Active JP5537740B2 (ja) | 2010-10-08 | 2011-10-07 | Ｉｌ−１７アンタゴニストを用いて乾癬を治療する方法 |
| JP2013253745A Withdrawn JP2014114288A (ja) | 2010-10-08 | 2013-12-09 | Ｉｌ−１７アンタゴニストを用いて乾癬を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013253745A Withdrawn JP2014114288A (ja) | 2010-10-08 | 2013-12-09 | Ｉｌ−１７アンタゴニストを用いて乾癬を治療する方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US9717791B2 (enExample) |
| EP (4) | EP2625199B1 (enExample) |
| JP (2) | JP5537740B2 (enExample) |
| KR (3) | KR20130110179A (enExample) |
| CN (2) | CN103154031A (enExample) |
| AU (1) | AU2011311482B2 (enExample) |
| BR (1) | BR112013008501A2 (enExample) |
| CA (1) | CA2813900C (enExample) |
| CL (1) | CL2013000930A1 (enExample) |
| CY (1) | CY1119942T1 (enExample) |
| DK (1) | DK2625199T3 (enExample) |
| ES (1) | ES2660770T3 (enExample) |
| HK (1) | HK1247932A1 (enExample) |
| HR (1) | HRP20180301T1 (enExample) |
| HU (1) | HUE038334T2 (enExample) |
| IL (1) | IL225310A (enExample) |
| LT (1) | LT2625199T (enExample) |
| MA (1) | MA34646B1 (enExample) |
| MX (1) | MX356279B (enExample) |
| NO (1) | NO2625199T3 (enExample) |
| PH (1) | PH12013500660B1 (enExample) |
| PL (1) | PL2625199T3 (enExample) |
| PT (1) | PT2625199T (enExample) |
| RU (2) | RU2591083C2 (enExample) |
| SG (1) | SG188979A1 (enExample) |
| SI (1) | SI2625199T1 (enExample) |
| TW (2) | TWI548419B (enExample) |
| WO (1) | WO2012045848A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| IN2012DN06720A (enExample) | 2010-01-15 | 2015-10-23 | Kirin Amgen Inc | |
| SG185354A1 (en) | 2010-05-20 | 2012-12-28 | Ablynx Nv | Biological materials related to her3 |
| HRP20251174T1 (hr) | 2010-11-05 | 2025-11-21 | Novartis Ag | Postupci za liječenje psorijatičnog artritisa uporabom il-17 antagonista |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| EP2783014A1 (en) * | 2011-11-21 | 2014-10-01 | Novartis AG | Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles |
| AU2014228553B2 (en) * | 2013-03-15 | 2019-01-24 | Amgen Inc. | Methods for treating Crohn's disease using an anti-IL23 antibody |
| HK1219425A1 (zh) * | 2013-03-15 | 2017-04-07 | Amgen Inc. | 使用抗il-23抗体治疗银屑病的方法 |
| US10434172B2 (en) * | 2013-08-15 | 2019-10-08 | Novartis Ag | Methods of treating generalized pustular psoriasis (GPP) using IL-17 antagonists |
| CA2935046C (en) * | 2013-12-27 | 2021-04-13 | Osaka University | Vaccine targeting il-17a |
| RU2577228C2 (ru) * | 2014-03-14 | 2016-03-10 | Закрытое Акционерное Общество "Биокад" | Анти-il-17-антитела, способ их получения и способ применения |
| SG11201607881SA (en) * | 2014-03-31 | 2016-10-28 | Kirin Amgen Inc | Methods of treating nail and scalp psoriasis |
| EP3142645A4 (en) | 2014-05-15 | 2017-12-27 | Rani Therapeutics, LLC | Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins |
| US11548940B2 (en) * | 2014-05-15 | 2023-01-10 | Rani Therapeutics, Llc | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| SG11201701276SA (en) * | 2014-08-26 | 2017-03-30 | Kirin Amgen Inc | Method for treating psoriasis patient which received anti-tnf-alpha antibody therapy |
| CA2960754A1 (en) * | 2014-09-10 | 2016-03-17 | Novartis Ag | Use of il-17 antagonists to inhibit the progression of structural damage in psoriatic arthritis patients |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| AR103172A1 (es) | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
| CA2978449A1 (en) | 2015-03-02 | 2016-09-09 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using an il-33 antagonist |
| EP3167892A1 (en) | 2015-11-10 | 2017-05-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for preventing or treating imflammatory bowel diseases |
| JP6931648B2 (ja) * | 2015-10-27 | 2021-09-08 | ユーシービー バイオファルマ エスアールエル | 抗ｉｌ−１７ａ／ｆ抗体を用いた治療方法 |
| US20190194311A1 (en) * | 2016-07-19 | 2019-06-27 | Novartis Ag | Methods of treating new-onset plaque type psoriasis using il-17 antagonists |
| JP2019505516A (ja) * | 2016-11-28 | 2019-02-28 | ノバルティス アーゲー | インターロイキン−１７（ｉｌ−１７）アンタゴニストを使用してざ瘡を治療する方法 |
| WO2018158741A1 (en) * | 2017-03-03 | 2018-09-07 | Novartis Ag | Psoriasis disease modification following long-term treatment with an il-17 antagonist |
| CA3073597A1 (en) * | 2017-08-23 | 2019-02-28 | Eli Lilly And Company | Treatment of genital psoriasis |
| TWI808397B (zh) * | 2018-09-11 | 2023-07-11 | 美商美國禮來大藥廠 | 治療牛皮癬之方法 |
| EP4006053A4 (en) | 2019-07-30 | 2022-10-26 | Jiangsu Hengrui Medicine Co., Ltd. | METHOD OF TREATMENT OF AN AUTOIMMUNE DISEASE WITH AN IL-17 ANTAGONIST |
| CN116685605A (zh) * | 2020-12-17 | 2023-09-01 | 上海华奥泰生物药业股份有限公司 | 靶向il-17a和il-36r的双特异性抗体及其应用 |
| TW202246329A (zh) * | 2021-03-03 | 2022-12-01 | 大陸商蘇州盛迪亞生物醫藥有限公司 | 抗il-17抗體治療自體免疫性疾病和炎症的方法 |
| WO2023186174A1 (en) * | 2022-04-01 | 2023-10-05 | Zai Lab (Shanghai) Co., Ltd. | Topical formulation comprising an il-17a binding molecule and uses thereof |
| CN116593718B (zh) * | 2023-07-18 | 2023-09-15 | 军科正源（北京）药物研究有限责任公司 | 用于检测司库奇尤单抗抗药性抗体的试剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9422306D0 (en) * | 1994-11-04 | 1994-12-21 | Sandoz Ltd | Organic compounds |
| US6093745A (en) * | 1997-11-25 | 2000-07-25 | Psorx, L.L.C. | Methods and composition for treating skin proliferative diseases |
| AU2002224417A1 (en) * | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| TW201705980A (zh) * | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| CN101296706B (zh) * | 2005-09-01 | 2011-11-30 | 先灵公司 | Il-23和il-17拮抗剂治疗自身免疫性眼部炎性疾病的用途 |
| DK1963368T6 (da) | 2005-12-13 | 2020-06-29 | Lilly Co Eli | Anti-il-17-antistoffer |
| TW200815469A (en) * | 2006-06-23 | 2008-04-01 | Astrazeneca Ab | Compounds |
| RU2367429C2 (ru) | 2007-01-30 | 2009-09-20 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Способ лечения псориаза |
| EP2152318A4 (en) * | 2007-06-01 | 2011-12-07 | Abbott Biotech Ltd | COMPOSITIONS AND USES FOR THE TREATMENT OF PSORIASIS AND CROHN'S DISEASE |
| RU2341272C1 (ru) | 2007-10-22 | 2008-12-20 | Левон Никитович Мкртчян | Средство для неспецифической иммунотерапии |
| WO2010034443A1 (en) * | 2008-09-29 | 2010-04-01 | F. Hoffmann-La Roche Ag | Antibodies against human il 17 and uses thereof |
-
2011
- 2011-10-07 EP EP11764764.4A patent/EP2625199B1/en active Active
- 2011-10-07 KR KR1020137011792A patent/KR20130110179A/ko not_active Ceased
- 2011-10-07 RU RU2013120957/15A patent/RU2591083C2/ru active
- 2011-10-07 ES ES11764764.4T patent/ES2660770T3/es active Active
- 2011-10-07 US US13/876,367 patent/US9717791B2/en active Active
- 2011-10-07 WO PCT/EP2011/067522 patent/WO2012045848A1/en not_active Ceased
- 2011-10-07 PT PT117647644T patent/PT2625199T/pt unknown
- 2011-10-07 SI SI201131408T patent/SI2625199T1/en unknown
- 2011-10-07 CN CN2011800487322A patent/CN103154031A/zh active Pending
- 2011-10-07 EP EP17195148.6A patent/EP3299390A1/en not_active Withdrawn
- 2011-10-07 KR KR1020147018691A patent/KR101620771B1/ko active Active
- 2011-10-07 RU RU2016120615A patent/RU2665954C1/ru active
- 2011-10-07 EP EP22186296.4A patent/EP4137514A1/en active Pending
- 2011-10-07 EP EP20187002.9A patent/EP3792281A1/en not_active Ceased
- 2011-10-07 LT LTEP11764764.4T patent/LT2625199T/lt unknown
- 2011-10-07 BR BR112013008501A patent/BR112013008501A2/pt active Search and Examination
- 2011-10-07 CN CN201710261381.2A patent/CN107029234A/zh active Pending
- 2011-10-07 CA CA2813900A patent/CA2813900C/en active Active
- 2011-10-07 DK DK11764764.4T patent/DK2625199T3/en active
- 2011-10-07 TW TW100136608A patent/TWI548419B/zh active
- 2011-10-07 AU AU2011311482A patent/AU2011311482B2/en active Active
- 2011-10-07 JP JP2013532213A patent/JP5537740B2/ja active Active
- 2011-10-07 PH PH1/2013/500660A patent/PH12013500660B1/en unknown
- 2011-10-07 MX MX2013003916A patent/MX356279B/es active IP Right Grant
- 2011-10-07 SG SG2013018486A patent/SG188979A1/en unknown
- 2011-10-07 PL PL11764764T patent/PL2625199T3/pl unknown
- 2011-10-07 HU HUE11764764A patent/HUE038334T2/hu unknown
- 2011-10-07 NO NO11764764A patent/NO2625199T3/no unknown
- 2011-10-07 HR HRP20180301TT patent/HRP20180301T1/hr unknown
- 2011-10-07 TW TW105116323A patent/TWI564022B/zh active
- 2011-10-07 KR KR1020147036815A patent/KR20150018595A/ko not_active Withdrawn
-
2013
- 2013-03-18 IL IL225310A patent/IL225310A/en active IP Right Grant
- 2013-04-05 CL CL2013000930A patent/CL2013000930A1/es unknown
- 2013-05-03 MA MA35872A patent/MA34646B1/fr unknown
- 2013-12-09 JP JP2013253745A patent/JP2014114288A/ja not_active Withdrawn
-
2017
- 2017-06-22 US US15/630,577 patent/US10583190B2/en active Active
-
2018
- 2018-02-22 CY CY20181100220T patent/CY1119942T1/el unknown
- 2018-06-01 HK HK18107225.2A patent/HK1247932A1/en unknown
-
2019
- 2019-12-19 US US16/720,351 patent/US11534490B2/en active Active
-
2020
- 2020-12-18 US US17/127,738 patent/US20210113688A1/en not_active Abandoned
-
2021
- 2021-02-02 US US17/165,724 patent/US20210162044A1/en not_active Abandoned
-
2022
- 2022-12-02 US US18/061,227 patent/US20230321231A1/en active Pending
-
2024
- 2024-12-16 US US18/983,034 patent/US20250161444A1/en active Pending
- 2024-12-16 US US18/983,030 patent/US20250161443A1/en active Pending
- 2024-12-16 US US18/983,037 patent/US20250161445A1/en active Pending
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