KR102033669B1 - 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법 - Google Patents

항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법 Download PDF

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KR102033669B1
KR102033669B1 KR1020147018792A KR20147018792A KR102033669B1 KR 102033669 B1 KR102033669 B1 KR 102033669B1 KR 1020147018792 A KR1020147018792 A KR 1020147018792A KR 20147018792 A KR20147018792 A KR 20147018792A KR 102033669 B1 KR102033669 B1 KR 102033669B1
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KR20140116089A (ko
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후아 주 케
민 리우
윌리엄 브이. 지아노빌
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암젠 인크
더 리젠츠 오브 더 유니버시티 오브 미시간
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Application filed by 암젠 인크, 더 리젠츠 오브 더 유니버시티 오브 미시간 filed Critical 암젠 인크
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020147018792A 2011-12-28 2012-12-11 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법 Expired - Fee Related KR102033669B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161580964P 2011-12-28 2011-12-28
US61/580,964 2011-12-28
PCT/US2012/068975 WO2013101451A1 (en) 2011-12-28 2012-12-11 Method of treating alvelor bone loss through the use of anti-sclerostin antibodies

Related Child Applications (1)

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KR1020197029949A Division KR20190120401A (ko) 2011-12-28 2012-12-11 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법

Publications (2)

Publication Number Publication Date
KR20140116089A KR20140116089A (ko) 2014-10-01
KR102033669B1 true KR102033669B1 (ko) 2019-10-18

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KR1020147018792A Expired - Fee Related KR102033669B1 (ko) 2011-12-28 2012-12-11 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법
KR1020197029949A Ceased KR20190120401A (ko) 2011-12-28 2012-12-11 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법
KR1020207013720A Ceased KR20200056473A (ko) 2011-12-28 2012-12-11 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법

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KR1020207013720A Ceased KR20200056473A (ko) 2011-12-28 2012-12-11 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법

Country Status (19)

Country Link
US (3) US9657090B2 (enExample)
EP (2) EP2797953B1 (enExample)
JP (3) JP6363954B2 (enExample)
KR (3) KR102033669B1 (enExample)
CN (2) CN107126560A (enExample)
AR (1) AR089509A1 (enExample)
AU (3) AU2012362898B2 (enExample)
BR (1) BR112014016108A2 (enExample)
CA (1) CA2858974A1 (enExample)
CL (1) CL2014001719A1 (enExample)
EA (2) EA036740B1 (enExample)
ES (1) ES2813524T3 (enExample)
IL (2) IL232942B (enExample)
IN (1) IN2014CN04634A (enExample)
MX (1) MX354270B (enExample)
SG (2) SG10201509629QA (enExample)
TW (3) TW202114733A (enExample)
WO (1) WO2013101451A1 (enExample)
ZA (1) ZA201404610B (enExample)

Families Citing this family (13)

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US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
ES2863626T3 (es) * 2010-10-27 2021-10-11 Amgen Inc Anticuerpos DKK1 y métodos de uso
JP2014511842A (ja) 2011-03-25 2014-05-19 アムジエン・インコーポレーテツド 抗スクレロスチン抗体結晶およびその製剤
EA036740B1 (ru) * 2011-12-28 2020-12-15 Эмджен Инк. Способ увеличения высоты альвеолярного отростка посредством применения антител к склеростину
WO2015008491A1 (ja) * 2013-07-19 2015-01-22 株式会社アクシオン・ジャパン パノラマ画像撮影装置及び同装置で用いる画像診断方法
ES2835923T3 (es) * 2015-03-13 2021-06-23 Jiangsu Hengrui Medicine Co Anticuerpo antiesclerostina, fragmento de unión a antígeno y uso médico del mismo
WO2018115879A1 (en) 2016-12-21 2018-06-28 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
WO2019154410A1 (zh) * 2018-02-12 2019-08-15 翼高生物科技有限公司 针对骨硬化蛋白的适体及其用途
US12229964B2 (en) * 2018-10-30 2025-02-18 Diagnocat Inc. Probabilistic segmentation of volumetric images
US12062170B2 (en) * 2018-10-30 2024-08-13 Diagnocat Inc System and method for classifying a tooth condition based on landmarked anthropomorphic measurements
WO2021191903A1 (en) * 2020-03-26 2021-09-30 Bone Sci. Bio Ltd. Pharmaceutical compositions comprising amphiphilic peptides and methods of use thereof
KR102472582B1 (ko) * 2020-08-20 2022-11-30 한림대학교 산학협력단 인공관절 마모편에 의한 활막염과 골용해의 진단 및 치료 방법
CA3193569A1 (en) * 2020-09-28 2022-03-31 Xiaofeng Liu Anti-sclerostin constructs and uses thereof

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