JP2018503631A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018503631A5 JP2018503631A5 JP2017535439A JP2017535439A JP2018503631A5 JP 2018503631 A5 JP2018503631 A5 JP 2018503631A5 JP 2017535439 A JP2017535439 A JP 2017535439A JP 2017535439 A JP2017535439 A JP 2017535439A JP 2018503631 A5 JP2018503631 A5 JP 2018503631A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrocarbyl
- alkyl
- cycloalkyl
- alkoxy
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 37
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 125000005842 heteroatom Chemical group 0.000 claims description 16
- 229910052717 sulfur Inorganic materials 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 125000001424 substituent group Chemical group 0.000 claims description 6
- -1 tetrahydropyrenyl Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000005843 halogen group Chemical group 0.000 claims 40
- 125000004093 cyano group Chemical group *C#N 0.000 claims 27
- 125000001188 haloalkyl group Chemical group 0.000 claims 22
- 150000002431 hydrogen Chemical class 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000004438 haloalkoxy group Chemical group 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 7
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 6
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000003106 haloaryl group Chemical group 0.000 claims 4
- 125000004996 haloaryloxy group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021103894A JP7337883B2 (ja) | 2014-12-29 | 2021-06-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
| JP2023135162A JP7771139B2 (ja) | 2014-12-29 | 2023-08-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462097226P | 2014-12-29 | 2014-12-29 | |
| US62/097,226 | 2014-12-29 | ||
| PCT/US2015/067895 WO2016109559A2 (en) | 2014-12-29 | 2015-12-29 | Small molecule inhibitors of lactate dehydrogenase and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103894A Division JP7337883B2 (ja) | 2014-12-29 | 2021-06-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503631A JP2018503631A (ja) | 2018-02-08 |
| JP2018503631A5 true JP2018503631A5 (enExample) | 2021-02-12 |
| JP6903580B2 JP6903580B2 (ja) | 2021-07-14 |
Family
ID=55451544
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017535439A Active JP6903580B2 (ja) | 2014-12-29 | 2015-12-29 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
| JP2021103894A Active JP7337883B2 (ja) | 2014-12-29 | 2021-06-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
| JP2023135162A Active JP7771139B2 (ja) | 2014-12-29 | 2023-08-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103894A Active JP7337883B2 (ja) | 2014-12-29 | 2021-06-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
| JP2023135162A Active JP7771139B2 (ja) | 2014-12-29 | 2023-08-23 | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US10351532B2 (enExample) |
| EP (2) | EP3954685B1 (enExample) |
| JP (3) | JP6903580B2 (enExample) |
| CN (1) | CN107624112B (enExample) |
| AU (2) | AU2015374118B2 (enExample) |
| CA (2) | CA3210002A1 (enExample) |
| DK (1) | DK3240785T3 (enExample) |
| ES (2) | ES3042832T3 (enExample) |
| HU (1) | HUE055662T2 (enExample) |
| PL (1) | PL3240785T3 (enExample) |
| SI (1) | SI3240785T1 (enExample) |
| WO (1) | WO2016109559A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10351532B2 (en) | 2014-12-29 | 2019-07-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Small molecule inhibitors of lactate dehydrogenase and methods of use thereof |
| JP6950897B2 (ja) * | 2016-01-21 | 2021-10-13 | ジーボ・バイオポーラー・チャンシェン・ファーマシューティカル・カンパニー・リミテッドＺｉｂｏ Ｂｉｏｐｏｌａｒ Ｃｈａｎｇｓｈｅｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ． Ｌｔｄ． | ブルトン型チロシンキナーゼ阻害剤 |
| AU2017290233A1 (en) * | 2016-06-29 | 2019-01-24 | The Trustees Of The University Of Pennsylvania | 1 H-pyrazol-1 -YL-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof |
| JP7098630B2 (ja) | 2017-01-10 | 2022-07-11 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としてのヘテロサイクレン誘導体 |
| US11247987B2 (en) | 2017-10-06 | 2022-02-15 | Forma Therapeutics, Inc. | Inhibiting ubiquitin specific peptidase 30 |
| ES2988920T3 (es) | 2018-05-17 | 2024-11-22 | Forma Therapeutics Inc | Compuestos bicíclicos fusionados útiles como inhibidores de la peptidasa 30 específica de ubiquitina |
| WO2020030613A1 (en) | 2018-08-07 | 2020-02-13 | Kemijski Institut | Small molecule-inhibitors of 6-phosphofructo-1-kinase for reducing lactate generation by cancer cells |
| EP3632908A1 (en) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer |
| MX2021002981A (es) | 2018-10-05 | 2021-05-14 | Forma Therapeutics Inc | Pirrolinas fusionadas que actuan como inhibidores de la proteasa 30 especifica de la ubiquitina (usp30). |
| TWI820231B (zh) | 2018-10-11 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於製備經取代咪唑衍生物之方法 |
| CU20210042A7 (es) | 2018-11-22 | 2022-01-13 | Qilu Regor Therapeutics Inc | Compuestos agonistas de glp-1r y composiciones farmacéuticas que lo contienen |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
| US20220289791A1 (en) * | 2019-05-02 | 2022-09-15 | Université Catholique de Louvain | Lactate dehydrogenase inhibitor polypeptides for use in the treatment of cancer |
| US11725026B2 (en) * | 2019-06-28 | 2023-08-15 | The Research Foundation For The State University Of New York | Compositions and methods for inhibiting lactate dehydrogenase a activity |
| US20220331360A1 (en) | 2019-08-07 | 2022-10-20 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | T cells having enhanced anti-tumor activity |
| US20250205203A1 (en) * | 2020-05-18 | 2025-06-26 | Chinook Therapeutics Canada, Inc. | Substituted pyrazolyl compounds and methods of use thereof |
| JP2023528274A (ja) * | 2020-05-18 | 2023-07-04 | チヌーク セラピューティクス カナダ， インコーポレイテッド | 置換ピラゾリル化合物及びその使用方法 |
| US11752138B2 (en) | 2020-05-18 | 2023-09-12 | Vanderbilt University | Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase |
| US20230321135A1 (en) * | 2020-06-08 | 2023-10-12 | Qatar Foundation For Education, Science And Community Development | Targeting of lactate dehydrogenase c, methods of preparing same, and methods of using same in combination with anti-cancer treatments |
| CN116033828B (zh) | 2020-07-02 | 2025-05-16 | 拜耳公司 | 作为害虫防治剂的杂环衍生物 |
| WO2022117882A2 (en) * | 2020-12-03 | 2022-06-09 | Domain Therapeutics | Novel par-2 inhibitors |
| WO2024212024A1 (en) * | 2023-04-09 | 2024-10-17 | Meta Pharmaceuticals (Hk) Limited | Novel substituted pyrrole compounds, compositions comprising the substituted pyrrole compound, and methods of use thereof |
| WO2025011479A1 (en) * | 2023-07-13 | 2025-01-16 | Meta Pharmaceuticals (Hk) Limited | Pyrazole based inhibitors of LDH and their use in immune and inflammatory diseases |
| WO2025026738A1 (en) | 2023-07-31 | 2025-02-06 | Bayer Aktiengesellschaft | 6-[5-(ethylsulfonyl)-1-methyl-1h-imidazol-4-yl]-7-methyl-3-(pentafluoroethyl)-7h-imidazo[4,5-c]pyridazine derivatives as pesticides |
| WO2025241049A1 (en) * | 2024-05-20 | 2025-11-27 | Meta Pharmaceuticals (Hk) Limited | Inhibitors of lactate dehydrogenase, compositions comprising the inhibitor, and methods of use thereof |
| WO2025241048A1 (en) * | 2024-05-20 | 2025-11-27 | Meta Pharmaceuticals (Hk) Limited | Inhibitors of lactate dehydrogenase, compositions comprising the inhibitor, and methods of use thereof |
| WO2025241047A1 (en) * | 2024-05-20 | 2025-11-27 | Meta Pharmaceuticals (Hk) Limited | Inhibitors of lactate dehydrogenase, compositions comprising the inhibitor, and methods of use thereof |
| CN118772058A (zh) * | 2024-06-14 | 2024-10-15 | 济南尚博医药股份有限公司 | 一种2-氯-4-(1h-吡唑-3-基)苯甲腈的合成方法及应用 |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5182289A (en) | 1988-06-14 | 1993-01-26 | Schering Corporation | Heterobicyclic compounds having antiinflammatory activity |
| WO1990008146A1 (en) * | 1989-01-10 | 1990-07-26 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides |
| US5602113A (en) | 1991-02-07 | 1997-02-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyridobenzo- and pyridiothieno-diazepines useful for the treatment of HIV infection |
| MX9205392A (es) | 1991-10-29 | 1993-04-01 | Du Pont | Triazolcarbozamidas herbicidas y procedimiento para su obtencion. |
| JPH0680569A (ja) | 1992-09-03 | 1994-03-22 | Asahi Chem Ind Co Ltd | 血小板凝集阻害剤 |
| US5342851A (en) | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
| DE4405207A1 (de) | 1994-02-18 | 1995-08-24 | Bayer Ag | N-Pyrazolylaniline und N-Pyrazolylaminopyridine |
| US20020028936A1 (en) * | 1999-04-12 | 2002-03-07 | Gerhard Sperl | 1,3-disubstituted indolin-2-ones for neoplasia |
| US6136079A (en) | 1999-04-30 | 2000-10-24 | Eastman Kodak Company | Dye for ink jet ink |
| WO2001005758A2 (en) | 1999-07-15 | 2001-01-25 | Nps Allelix Corp. | Indoles and indazoles for the treatment of migraine |
| US6407238B1 (en) | 1999-10-29 | 2002-06-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
| US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
| JP2002167531A (ja) | 2000-11-29 | 2002-06-11 | Fuji Photo Film Co Ltd | インクジェット記録用インク組成物及び画像形成方法 |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| US7358267B2 (en) | 2001-06-29 | 2008-04-15 | Amgen Inc. | Bis-aryl thiazole derivatives |
| IL159811A0 (en) | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
| EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| DE60309342T2 (de) | 2002-08-09 | 2007-05-16 | Eli Lilly And Co., Indianapolis | Benzimidazole und benzothiazole als inhibitoren der map-kinase |
| EP1534680B1 (en) | 2002-08-14 | 2012-02-22 | Pharmaco Investments, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| US20040166137A1 (en) | 2002-11-08 | 2004-08-26 | Lackey John William | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| CA2520804A1 (en) | 2003-04-03 | 2004-10-28 | Merck & Co., Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
| GB0323845D0 (en) | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| WO2006036748A2 (en) | 2004-09-22 | 2006-04-06 | Symyx Technologies, Inc. | Heterocycle-amine ligands, compositions, complexes, and catalysts, and methods of making and using the same |
| WO2006052546A2 (en) | 2004-11-04 | 2006-05-18 | Neurogen Corporation | Pyrazolylmethyl heteroaryl derivatives |
| US20100197687A1 (en) | 2005-01-19 | 2010-08-05 | Benjamin Pelcman | Indoles Useful in the Treatment of Inflammation |
| JP2008527031A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なピロロピリジン誘導体 |
| EP1838669A1 (en) | 2005-01-19 | 2007-10-03 | Biolipox AB | Indoles useful in the treatment of inflammation |
| KR20070114123A (ko) | 2005-01-19 | 2007-11-29 | 바이올리폭스 에이비 | 염증 치료에 유용한 인돌 |
| US20080249091A1 (en) | 2005-01-19 | 2008-10-09 | Benjamin Pelcman | Indoles Useful in the Treatment of Inflammation |
| WO2006078891A2 (en) | 2005-01-21 | 2006-07-27 | Neurogen Corporation | Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives |
| GB0507198D0 (en) | 2005-04-08 | 2005-05-18 | Sb Pharmco Inc | Process for preparing bicyclic compounds |
| US7456292B2 (en) | 2005-06-30 | 2008-11-25 | Bexel Pharmaceuticals, Inc. | Hydroxamic acid-containing amino acid derivatives |
| WO2007018514A1 (en) | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
| WO2007018508A1 (en) | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetycholine receptor antagonists |
| WO2007021941A2 (en) | 2005-08-16 | 2007-02-22 | Icagen, Inc. | Inhibitors of voltage-gated sodium channels |
| WO2007038571A2 (en) | 2005-09-26 | 2007-04-05 | Smithkline Beecham Corporation | Prolyl hydroxylase antagonists |
| CA2624795A1 (en) | 2005-10-06 | 2007-04-12 | Merck Sharp & Dohme Limited | Use of fused pyrrole carboxylic acids for the treatment of neurodegenerative and psychiatric diseases as d-amino acid oxidase inhibitors |
| BRPI0617446A2 (pt) | 2005-10-17 | 2011-07-26 | Isagro Ricerca Srl | composto anfotÉrico, uso do mesmo, mÉtodos para o controle de fungos e bactÉrias fitopatogÊnicos e/ou a mitigaÇço de estresse abiàtico e biàtico em safras agrÍcolas, e para a estimulaÇço dos sistemas de defesa natural das plantas de estresses abiàticos e biàticos e para a induÇço de resistÊncia nas pràprias plantas em safras agrÍcolas, composiÇço fungicida, e, uso da composiÇço |
| WO2007048732A1 (de) | 2005-10-28 | 2007-05-03 | Basf Aktiengesellschaft | Verwendung von 5-amino-pyrazolen zur bekämpfung pflanzenpathogener schadpilze, neue 5-amino-pyrazole, verfahren zu ihrer herstellung und sie enthaltende mittel |
| EP1998766A2 (en) | 2005-12-16 | 2008-12-10 | Ironwood Pharmaceuticals, Inc. | Useful indole compounds |
| ITMI20052459A1 (it) | 2005-12-22 | 2007-06-23 | Isagro Spa | Sali quaternari e relativo uso per il controllo di fitopatogeni |
| US20080090834A1 (en) | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| GB0614068D0 (en) * | 2006-07-14 | 2006-08-23 | Glaxo Group Ltd | Compounds |
| WO2008009924A2 (en) | 2006-07-18 | 2008-01-24 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7906544B2 (en) | 2007-01-26 | 2011-03-15 | North Carolina State University | Inhibition of bacterial biofilms with imidazole derivatives |
| WO2008121861A2 (en) | 2007-03-28 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Pyrazole and pyrrole compounds useful in treating iron disorders |
| UA103006C2 (ru) | 2007-08-27 | 2013-09-10 | Басф Се | Пиразольные соединения для борьбы с бесхребетными вредителями |
| WO2009076454A2 (en) | 2007-12-12 | 2009-06-18 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2009108551A2 (en) | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| WO2009137291A2 (en) | 2008-05-08 | 2009-11-12 | Merck & Co., Inc. | Spiroazaindoles |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| RU2477281C2 (ru) * | 2008-07-17 | 2013-03-10 | Асахи Касеи Фарма Корпорейшн | Азотсодержащие гетероциклические соединения |
| CA2728098A1 (en) * | 2008-07-17 | 2010-01-21 | Asahi Kasei Pharma Corporation | Pyrazole-containing tricyclic compounds as_antagonits of an ep1 receptor |
| WO2010010186A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| KR101364869B1 (ko) | 2008-09-24 | 2014-02-21 | 바스프 에스이 | 무척추 해충을 방제하기 위한 피라졸 화합물 |
| EP2367798B1 (en) * | 2008-11-20 | 2018-02-28 | Northwestern University | Pyrazolone derivatives useful in the treatment of amyotrophic lateral sclerosis |
| WO2010065067A1 (en) * | 2008-11-20 | 2010-06-10 | Bodymedia, Inc. | Method and apparatus for determining critical care parameters |
| CN101747276B (zh) | 2008-11-28 | 2011-09-07 | 中国中化股份有限公司 | 具有含氮五元杂环的醚类化合物及其应用 |
| AU2009321601B2 (en) | 2008-12-04 | 2012-11-01 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives |
| MX2011006332A (es) | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
| AU2010229144B2 (en) | 2009-03-23 | 2012-07-12 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| CN102448951B (zh) | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
| WO2011057942A1 (en) | 2009-11-12 | 2011-05-19 | Basf Se | Insecticidal methods using pyridine compounds |
| US8742106B2 (en) | 2009-12-21 | 2014-06-03 | Novartis Ag | Disubstituted heteroaryl-fused pyridines |
| WO2011091410A1 (en) | 2010-01-25 | 2011-07-28 | Glaxos Smithkline Llc | Trpv4 antagonists |
| JP2013542255A (ja) | 2010-11-10 | 2013-11-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ミネラルコルチコイド受容体アンタゴニストとしてのピリジル尿素 |
| JPWO2012074022A1 (ja) | 2010-12-01 | 2014-05-19 | 旭硝子株式会社 | イリジウムカチオン錯体および発光組成物 |
| WO2012085167A1 (en) | 2010-12-22 | 2012-06-28 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| WO2012120415A1 (en) | 2011-03-04 | 2012-09-13 | Novartis Ag | Tetrasubstituted cyclohexyl compounds as kinase inhibitors |
| WO2012151440A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| JP5985611B2 (ja) | 2011-05-03 | 2016-09-06 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連用途のための化合物 |
| WO2012154880A1 (en) | 2011-05-09 | 2012-11-15 | Proteostasis Therapeutics, Inc. | Proteostasis regulators for treating cystic fibrosis and other protein misfolding diseases |
| JP2013040240A (ja) | 2011-08-11 | 2013-02-28 | Fujifilm Corp | アゾ化合物、アゾ顔料、顔料分散物、着色組成物、カラーフィルター用着色組成物、カラーフィルター、カラーフィルター用着色組成物の調製方法、インクジェット記録用インク、印刷インク、塗料、染料、及び、レジストインク |
| KR20140060535A (ko) | 2011-08-24 | 2014-05-20 | 깃세이 야쿠힌 고교 가부시키가이샤 | 축합 헤테로환 유도체 및 그 의약용도 |
| ITPI20110143A1 (it) * | 2011-12-20 | 2013-06-21 | Univ Pisa | Agenti terapeutici in grado di ridurre la produzione cellulare di acido lattico e composizioni farmaceutiche che comprendono tali composti |
| CN104203943B (zh) | 2012-01-20 | 2017-12-29 | 盖诺斯克公司 | 取代的嘧啶化合物及其作为syk抑制剂的用途 |
| NZ704147A (en) | 2012-07-30 | 2017-04-28 | Taisho Pharmaceutical Co Ltd | Partially saturated nitrogen-containing heterocyclic compound |
| US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
| EP2934527A4 (en) | 2012-12-20 | 2016-07-13 | Merck Sharp & Dohme | 2-pyridyloxy-4-ESTER-orexin receptor antagonists |
| US9765057B2 (en) | 2012-12-20 | 2017-09-19 | Merck Sharp & Dohme Corp. | 3-ester-4 substituted orexin receptor antagonists |
| EP2934517A4 (en) | 2012-12-20 | 2016-05-25 | Merck Sharp & Dohme | 2-PYRIDYLOXY-3-NITRIL-4-SUBSTITUTED OREXINE RECEPTOR ANTAGONISTS |
| FR3001219A1 (fr) | 2013-01-22 | 2014-07-25 | Centre Nat Rech Scient | Inhibiteurs de kinases |
| KR102178606B1 (ko) | 2013-03-15 | 2020-11-13 | 자임워크스 인코포레이티드 | 세포독성 및 유사분열-억제 화합물, 및 이를 사용하는 방법 |
| EP2980094B1 (en) | 2013-03-29 | 2019-05-01 | Konica Minolta, Inc. | Isomer-mixture metal complex composition, organic electroluminescent element, illuminator, and display device |
| WO2014173880A1 (en) | 2013-04-22 | 2014-10-30 | Syngenta Participations Ag | Novel microbiocides |
| WO2014176475A2 (en) | 2013-04-26 | 2014-10-30 | The Regents Of The University Of Michigan | Egfr inhibitors and uses thereof |
| US9169221B2 (en) | 2013-04-29 | 2015-10-27 | Comsats Institute Of Information Technology | Dihydro 1,4-benzoxazines and method of synthesizing the same using sulfonium salts |
| US10351532B2 (en) * | 2014-12-29 | 2019-07-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Small molecule inhibitors of lactate dehydrogenase and methods of use thereof |
-
2015
- 2015-12-29 US US15/540,893 patent/US10351532B2/en active Active
- 2015-12-29 EP EP21181777.0A patent/EP3954685B1/en active Active
- 2015-12-29 AU AU2015374118A patent/AU2015374118B2/en active Active
- 2015-12-29 ES ES21181777T patent/ES3042832T3/es active Active
- 2015-12-29 PL PL15839113T patent/PL3240785T3/pl unknown
- 2015-12-29 CA CA3210002A patent/CA3210002A1/en active Pending
- 2015-12-29 JP JP2017535439A patent/JP6903580B2/ja active Active
- 2015-12-29 CA CA2978823A patent/CA2978823C/en active Active
- 2015-12-29 HU HUE15839113A patent/HUE055662T2/hu unknown
- 2015-12-29 CN CN201580077097.9A patent/CN107624112B/zh active Active
- 2015-12-29 ES ES15839113T patent/ES2883938T3/es active Active
- 2015-12-29 WO PCT/US2015/067895 patent/WO2016109559A2/en not_active Ceased
- 2015-12-29 EP EP15839113.6A patent/EP3240785B1/en active Active
- 2015-12-29 SI SI201531668T patent/SI3240785T1/sl unknown
- 2015-12-29 DK DK15839113.6T patent/DK3240785T3/da active
-
2019
- 2019-06-28 US US16/455,848 patent/US10961200B2/en active Active
-
2020
- 2020-10-23 AU AU2020257163A patent/AU2020257163B2/en active Active
-
2021
- 2021-01-28 US US17/160,868 patent/US11247971B2/en active Active
- 2021-06-23 JP JP2021103894A patent/JP7337883B2/ja active Active
-
2022
- 2022-01-10 US US17/572,359 patent/US11897845B2/en active Active
-
2023
- 2023-08-23 JP JP2023135162A patent/JP7771139B2/ja active Active
-
2024
- 2024-02-05 US US18/433,099 patent/US12365653B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018503631A5 (enExample) | ||
| JP2020510091A5 (enExample) | ||
| JP2017508789A5 (enExample) | ||
| FI3600282T3 (fi) | Glukokortikoidireseptorien modulaattoreita kohdunkaulan syövän hoitoon | |
| HRP20221412T2 (hr) | Spojevi koji inhibiraju mcl-1 protein | |
| JP2017511815A5 (enExample) | ||
| FI3986890T3 (fi) | Bentsisoksatsolisulfonamidijohdannaisia | |
| MY201239A (en) | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use | |
| JP2019510810A5 (enExample) | ||
| RU2017111200A (ru) | Циклогексилэтилзамещенные диаза- и триаза-трициклические соединения в качестве антагонистов индоламин-2,3-диоксигеназы для лечения рака | |
| RU2018128334A (ru) | Ингибиторы индоламин-2,3-диоксигеназы (ido) | |
| EP4458348A3 (en) | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof | |
| RU2018129308A (ru) | Новые производные аммония, способ их получения и фармацевтические композиции, содержащие их | |
| AR068048A1 (es) | Combinacion de agente antimitotico e inhibidor de aurora quinasa como tratamiento anticancerigeno | |
| RU2012104700A (ru) | Азабициклосоединение и его соль | |
| JP2017507912A5 (enExample) | ||
| JP2018522879A5 (enExample) | ||
| RU2018102372A (ru) | Новые аминокислотные производные, способ их получения и фармацевтические композиции, содержащие их | |
| JP2015520143A5 (enExample) | ||
| JP2005511531A5 (enExample) | ||
| RU2015118647A (ru) | Аминопиримидиновые соединения в качестве ингибиторов содержащих т790м мутантных egfr | |
| JP2020532585A5 (enExample) | ||
| RU2009144848A (ru) | Химические соединения-759 | |
| RU2016110021A (ru) | Алкиниловые спирты и способы их применения | |
| SI3166925T1 (en) | Isoindoline derivatives for use in treating a viral infection |