|
CA1271477A
(en)
|
1983-11-18 |
1990-07-10 |
John F. Gerster |
1h-imidazo[4,5-c]quinolin-4-amines
|
|
IL73534A
(en)
|
1983-11-18 |
1990-12-23 |
Riker Laboratories Inc |
1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
IL89220A
(en)
|
1988-02-11 |
1994-02-27 |
Bristol Myers Squibb Co |
Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them
|
|
DE68913658T3
(de)
|
1988-11-11 |
2005-07-21 |
Stratagene, La Jolla |
Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US6399754B1
(en)
|
1991-12-24 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
US5496938A
(en)
|
1990-06-11 |
1996-03-05 |
Nexstar Pharmaceuticals, Inc. |
Nucleic acid ligands to HIV-RT and HIV-1 rev
|
|
US5763177A
(en)
|
1990-06-11 |
1998-06-09 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
|
|
US5789163A
(en)
|
1990-06-11 |
1998-08-04 |
Nexstar Pharmaceuticals, Inc. |
Enzyme linked oligonucleotide assays (ELONAS)
|
|
US5874218A
(en)
|
1990-06-11 |
1999-02-23 |
Nexstar Pharmaceuticals, Inc. |
Method for detecting a target compound in a substance using a nucleic acid ligand
|
|
US5567588A
(en)
|
1990-06-11 |
1996-10-22 |
University Research Corporation |
Systematic evolution of ligands by exponential enrichment: Solution SELEX
|
|
US6465189B1
(en)
|
1990-06-11 |
2002-10-15 |
Gilead Sciences, Inc. |
Systematic evolution of ligands by exponential enrichment: blended selex
|
|
US5270163A
(en)
|
1990-06-11 |
1993-12-14 |
University Research Corporation |
Methods for identifying nucleic acid ligands
|
|
US5475096A
(en)
|
1990-06-11 |
1995-12-12 |
University Research Corporation |
Nucleic acid ligands
|
|
US6716580B2
(en)
|
1990-06-11 |
2004-04-06 |
Somalogic, Inc. |
Method for the automated generation of nucleic acid ligands
|
|
US6001577A
(en)
|
1998-06-08 |
1999-12-14 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
|
|
US6280932B1
(en)
|
1990-06-11 |
2001-08-28 |
Gilead Sciences, Inc. |
High affinity nucleic acid ligands to lectins
|
|
US5660985A
(en)
|
1990-06-11 |
1997-08-26 |
Nexstar Pharmaceuticals, Inc. |
High affinity nucleic acid ligands containing modified nucleotides
|
|
US5853984A
(en)
|
1990-06-11 |
1998-12-29 |
Nexstar Pharmaceuticals, Inc. |
Use of nucleic acid ligands in flow cytometry
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
US5389640A
(en)
|
1991-03-01 |
1995-02-14 |
Minnesota Mining And Manufacturing Company |
1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
US5226575A
(en)
|
1991-11-21 |
1993-07-13 |
Scott Faust |
Pneumatic mortar dispenser with flex release
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
ATE503496T1
(de)
|
1992-02-06 |
2011-04-15 |
Novartis Vaccines & Diagnostic |
Biosynthetisches bindeprotein für tumormarker
|
|
US6608201B2
(en)
|
1992-08-28 |
2003-08-19 |
3M Innovative Properties Company |
Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US5352784A
(en)
|
1993-07-15 |
1994-10-04 |
Minnesota Mining And Manufacturing Company |
Fused cycloalkylimidazopyridines
|
|
US6458539B1
(en)
|
1993-09-17 |
2002-10-01 |
Somalogic, Inc. |
Photoselection of nucleic acid ligands
|
|
US5798340A
(en)
|
1993-09-17 |
1998-08-25 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
US5482936A
(en)
|
1995-01-12 |
1996-01-09 |
Minnesota Mining And Manufacturing Company |
Imidazo[4,5-C]quinoline amines
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5843732A
(en)
|
1995-06-06 |
1998-12-01 |
Nexstar Pharmaceuticals, Inc. |
Method and apparatus for determining consensus secondary structures for nucleic acid sequences
|
|
JP2000503639A
(ja)
|
1995-12-22 |
2000-03-28 |
ブリストル―マイヤーズ スクイブ カンパニー |
分枝ヒドラゾンのリンカー類
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
ATE228529T1
(de)
|
1996-08-30 |
2002-12-15 |
Jens Peter Fuerste |
Spiegelselektion und spiegelevolution von nucleinsäuren
|
|
US6127533A
(en)
|
1997-02-14 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
2'-O-aminooxy-modified oligonucleotides
|
|
UA67760C2
(uk)
|
1997-12-11 |
2004-07-15 |
Міннесота Майнінг Енд Мануфакчурінг Компані |
Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
|
|
US6242246B1
(en)
|
1997-12-15 |
2001-06-05 |
Somalogic, Inc. |
Nucleic acid ligand diagnostic Biochip
|
|
US6110929A
(en)
|
1998-07-28 |
2000-08-29 |
3M Innovative Properties Company |
Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
|
|
US6403779B1
(en)
|
1999-01-08 |
2002-06-11 |
Isis Pharmaceuticals, Inc. |
Regioselective synthesis of 2′-O-modified nucleosides
|
|
US20030054360A1
(en)
|
1999-01-19 |
2003-03-20 |
Larry Gold |
Method and apparatus for the automated generation of nucleic acid ligands
|
|
US6331539B1
(en)
|
1999-06-10 |
2001-12-18 |
3M Innovative Properties Company |
Sulfonamide and sulfamide substituted imidazoquinolines
|
|
US6451810B1
(en)
|
1999-06-10 |
2002-09-17 |
3M Innovative Properties Company |
Amide substituted imidazoquinolines
|
|
CN100482281C
(zh)
|
1999-06-25 |
2009-04-29 |
基因技术股份有限公司 |
抗ErbB抗体-类美坦素偶联物在制备药物中的应用
|
|
US6506887B1
(en)
|
1999-07-29 |
2003-01-14 |
Somalogic, Incorporated |
Conditional-selex
|
|
US6635677B2
(en)
|
1999-08-13 |
2003-10-21 |
Case Western Reserve University |
Methoxyamine combinations in the treatment of cancer
|
|
US6376669B1
(en)
|
1999-11-05 |
2002-04-23 |
3M Innovative Properties Company |
Dye labeled imidazoquinoline compounds
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US20050032733A1
(en)
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
|
US20050020525A1
(en)
|
2002-02-20 |
2005-01-27 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US7097840B2
(en)
|
2000-03-16 |
2006-08-29 |
Genentech, Inc. |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
|
|
DE20014503U1
(de)
|
2000-08-22 |
2001-01-11 |
Siemens AG, 80333 München |
Fertigungsstraßenabschnitt
|
|
US6376190B1
(en)
|
2000-09-22 |
2002-04-23 |
Somalogic, Inc. |
Modified SELEX processes without purified protein
|
|
UA74593C2
(en)
|
2000-12-08 |
2006-01-16 |
3M Innovative Properties Co |
Substituted imidazopyridines
|
|
US6664264B2
(en)
|
2000-12-08 |
2003-12-16 |
3M Innovative Properties Company |
Thioether substituted imidazoquinolines
|
|
WO2006091720A2
(en)
|
2000-12-08 |
2006-08-31 |
3M Innovative Properties Company |
Compositions and methods for targeted delivery of immune response modifiers
|
|
UA75622C2
(en)
|
2000-12-08 |
2006-05-15 |
3M Innovative Properties Co |
Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
|
|
US20060057651A1
(en)
|
2000-12-08 |
2006-03-16 |
Bowdish Katherine S |
Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
|
|
US20030175950A1
(en)
|
2001-05-29 |
2003-09-18 |
Mcswiggen James A. |
RNA interference mediated inhibition of HIV gene expression using short interfering RNA
|
|
ATE452655T1
(de)
|
2001-06-10 |
2010-01-15 |
Noxxon Pharma Ag |
Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
|
|
AU2775402A
(en)
|
2001-06-29 |
2003-01-02 |
Medimolecular Pty Ltd |
Nucleic acid ligands to complex targets
|
|
US20030139364A1
(en)
|
2001-10-12 |
2003-07-24 |
University Of Iowa Research Foundation |
Methods and products for enhancing immune responses using imidazoquinoline compounds
|
|
ATE416771T1
(de)
|
2001-11-16 |
2008-12-15 |
3M Innovative Properties Co |
N-ä4-(4-amino-2-ethyl-1h-imidazoä4,5-cüchinolin 1-yl)butylümethanesulfonamide, diese enthaltende pharmazeutische zusammensetzung und deren verwendung
|
|
HRP20040541A2
(en)
|
2001-11-27 |
2004-10-31 |
Anadys Pharmaceuticals |
3- -D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF
|
|
AU2002360733A1
(en)
|
2001-12-31 |
2003-07-24 |
Guilford Pharmaceuticals Inc. |
SUBSTITUTED 4,9-DIHYDROCYCLOPENTA(imn)PHENANTHRIDINE-5-ONES DERIVATIVES THEREOF AND THEIR USES
|
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
|
US20040092470A1
(en)
|
2002-06-18 |
2004-05-13 |
Leonard Sherry A. |
Dry powder oligonucleotide formualtion, preparation and its uses
|
|
ES2350687T3
(es)
|
2002-07-03 |
2011-01-26 |
Ono Pharmaceutical Co., Ltd. |
Composiciones de inmunopotenciación.
|
|
CA2802205C
(en)
|
2002-07-31 |
2016-01-19 |
Seattle Genetics, Inc. |
Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
|
|
EP1413316A1
(en)
|
2002-09-27 |
2004-04-28 |
Bruno Robert |
Bifunctional conjugates or fusion proteins
|
|
WO2004058759A1
(en)
|
2002-12-20 |
2004-07-15 |
3M Innovative Properties Company |
Aryl / hetaryl substituted imidazoquinolines
|
|
ES2367430T3
(es)
|
2002-12-23 |
2011-11-03 |
Wyeth Llc |
Anticuerpos contra pd-1 y sus usos.
|
|
US20050036951A1
(en)
|
2003-01-09 |
2005-02-17 |
Arizeke Pharmaceuticals, Inc. |
Methods of treating lung diseases
|
|
US9259459B2
(en)
|
2003-01-31 |
2016-02-16 |
Celldex Therapeutics Inc. |
Antibody vaccine conjugates and uses therefor
|
|
JP2006517974A
(ja)
|
2003-02-13 |
2006-08-03 |
スリーエム イノベイティブ プロパティズ カンパニー |
Ｉｒｍ化合物およびトル様受容体８に関する方法および組成物
|
|
EP1594542B1
(en)
|
2003-02-20 |
2010-06-30 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer
|
|
WO2005025583A2
(en)
|
2003-09-05 |
2005-03-24 |
Anadys Pharmaceuticals, Inc. |
Tlr7 ligands for the treatment of hepatitis c
|
|
EP1673087B1
(en)
|
2003-10-03 |
2015-05-13 |
3M Innovative Properties Company |
Alkoxy substituted imidazoquinolines
|
|
BRPI0414867A
(pt)
|
2003-10-03 |
2006-11-21 |
3M Innovative Properties Co |
pirazolopiridinas e seus análogos
|
|
RU2426734C2
(ru)
|
2003-10-03 |
2011-08-20 |
Зм Инновейтив Пропертиз Компани |
Пиразолопиридины и их аналоги
|
|
CA2542099A1
(en)
|
2003-10-11 |
2005-04-21 |
Inex Pharmaceuticals Corporation |
Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
|
|
ITMI20032121A1
(it)
|
2003-11-04 |
2005-05-05 |
Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm |
Procedimento per la preparazione di imiquimod e suoi intermedi
|
|
CN103394083B
(zh)
*
|
2003-11-06 |
2017-07-18 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
WO2005067500A2
(en)
|
2003-12-30 |
2005-07-28 |
3M Innovative Properties Company |
Enhancement of immune responses
|
|
EP1728793B1
(en)
|
2004-03-26 |
2016-02-03 |
Sumitomo Dainippon Pharma Co., Ltd. |
9-substituted 8-oxoadenine compound
|
|
JP2008506683A
(ja)
|
2004-07-18 |
2008-03-06 |
コーリー ファーマシューティカル グループ， リミテッド |
先天免疫応答を誘導するための方法および組成物
|
|
SI1791565T1
(sl)
*
|
2004-09-23 |
2016-08-31 |
Genentech, Inc. |
Cisteinsko konstruirana protitelesa in konjugati
|
|
EP1809671B1
(en)
|
2004-11-09 |
2014-07-16 |
University Of Southern California |
CpG/antibody conjugate against cancer
|
|
EP1830876B1
(en)
*
|
2004-12-30 |
2015-04-08 |
Meda AB |
Use of imiquimod for the treatment of cutaneous metastases derived from a breast cancer tumor
|
|
AU2006216629A1
(en)
|
2005-02-24 |
2006-08-31 |
Janssen Pharmaceutica N.V. |
Novel quinoline derivatives as potassium ion channel openers
|
|
WO2006108627A1
(en)
|
2005-04-14 |
2006-10-19 |
Merck Patent Gmbh |
Anti-egfr antibody therapy based on an increased copy number of the egfr gene in tumor tissues
|
|
EP1871418B1
(en)
|
2005-04-19 |
2014-03-19 |
Seattle Genetics, Inc. |
Humanized anti-cd70 binding agents and uses thereof
|
|
CN101355928B
(zh)
|
2005-04-26 |
2013-05-22 |
卫材R&D管理株式会社 |
用于癌症免疫疗法的组合物和方法
|
|
CN104293780A
(zh)
|
2005-05-04 |
2015-01-21 |
诺松制药股份公司 |
结合hmga的核酸
|
|
AU2006244885B2
(en)
|
2005-05-09 |
2011-03-31 |
E. R. Squibb & Sons, L.L.C. |
Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
|
|
AU2006265108C1
(en)
|
2005-07-01 |
2013-01-17 |
E. R. Squibb & Sons, L.L.C. |
Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
TW201402124A
(zh)
|
2005-08-19 |
2014-01-16 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
|
|
TWI382019B
(zh)
|
2005-08-19 |
2013-01-11 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
|
|
JP2009506790A
(ja)
|
2005-09-07 |
2009-02-19 |
メディミューン，エルエルシー |
毒素とコンジュゲートしたｅｐｈ受容体抗体
|
|
ZA200803029B
(en)
|
2005-09-09 |
2009-02-25 |
Coley Pharm Group Inc |
Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
|
|
EP1940470B1
(en)
*
|
2005-09-26 |
2013-04-17 |
Medarex, Inc. |
Antibody-drug conjugates and their use
|
|
WO2007100634A2
(en)
|
2006-02-22 |
2007-09-07 |
3M Innovative Properties Company |
Immune response modifier conjugates
|
|
WO2007103048A2
(en)
|
2006-03-01 |
2007-09-13 |
Regents Of The University Of Colorado |
Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity
|
|
US20080031887A1
(en)
|
2006-06-30 |
2008-02-07 |
Joseph Lustgarten |
Conjugates for inducing targeted immune responses and methods of making and using same
|
|
EP2041135A4
(en)
|
2006-07-05 |
2010-12-01 |
Astrazeneca Ab |
As TLR7 MODULATORS, 8-OXOADENINE DERIVATIVES WORK
|
|
CA2667019C
(en)
|
2006-10-27 |
2016-03-29 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
PL2125779T3
(pl)
|
2006-12-21 |
2016-11-30 |
|
Polimorfy antagonisty receptora mglur5
|
|
US20080149123A1
(en)
*
|
2006-12-22 |
2008-06-26 |
Mckay William D |
Particulate material dispensing hairbrush with combination bristles
|
|
US20080261913A1
(en)
|
2006-12-28 |
2008-10-23 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of liver disorders
|
|
TWI422594B
(zh)
|
2007-02-02 |
2014-01-11 |
Baylor Res Inst |
經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
|
|
EP2125007B9
(en)
|
2007-02-07 |
2014-04-16 |
The Regents of The University of California |
Conjugates of synthetic tlr agonists and uses therefor
|
|
JP5394246B2
(ja)
*
|
2007-03-30 |
2014-01-22 |
ジェネンテック， インコーポレイテッド |
抗体及びイムノコンジュゲートとこれらの使用方法
|
|
DK2155743T3
(da)
|
2007-05-08 |
2012-11-05 |
Astrazeneca Ab |
Imidazoquinoliner med immunmodulerende egenskaber
|
|
CA2695385A1
(en)
|
2007-07-31 |
2009-02-05 |
Atul Bedi |
Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
|
|
JP6035009B2
(ja)
|
2007-08-22 |
2016-11-30 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
|
|
EA023175B1
(ru)
|
2007-09-28 |
2016-05-31 |
Бинд Терапьютикс, Инк. |
Таргетирование раковых клеток с использованием наночастиц
|
|
EA018579B1
(ru)
|
2008-01-15 |
2013-09-30 |
Меда Аб |
Способ лечения полипов/полипоза и предраковых изменений толстого кишечника
|
|
AU2009207287B2
(en)
|
2008-01-25 |
2014-09-11 |
Gavish-Galilee Bio Applications Ltd |
Targeting of innate immune response to tumor site
|
|
CN102088974A
(zh)
*
|
2008-02-07 |
2011-06-08 |
加利福尼亚大学校务委员会 |
用tlr7活化剂对膀胱疾病的治疗
|
|
NZ621433A
(en)
|
2008-03-18 |
2015-10-30 |
Genentech Inc |
Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
|
|
EP2316032A1
(en)
|
2008-08-20 |
2011-05-04 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
|
|
PL2342226T3
(pl)
|
2008-09-26 |
2017-01-31 |
Dana-Farber Cancer Institute, Inc. |
Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
|
|
US8895702B2
(en)
|
2008-12-08 |
2014-11-25 |
City Of Hope |
Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies
|
|
MX2011006152A
(es)
|
2008-12-09 |
2011-07-28 |
Gilead Sciences Inc |
Moduladores de receptores tipo toll.
|
|
US20100189651A1
(en)
|
2009-01-12 |
2010-07-29 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
|
PT2427485T
(pt)
|
2009-05-07 |
2017-03-13 |
Immunocellular Therapeutics Ltd |
Epitopos cd133
|
|
WO2010132622A2
(en)
|
2009-05-14 |
2010-11-18 |
The Regents Of The University Of California |
Anticd20-cpg conjugates and methods of treating b cell malignancies
|
|
US20110077263A1
(en)
|
2009-09-29 |
2011-03-31 |
University Of Southern California |
Methods and Compositions of Toll-Like Receptor (TLR) Agonists
|
|
WO2011066389A1
(en)
|
2009-11-24 |
2011-06-03 |
Medimmmune, Limited |
Targeted binding agents against b7-h1
|
|
WO2011084725A1
(en)
|
2009-12-21 |
2011-07-14 |
3M Innovative Properties Company |
4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM 1-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS
|
|
WO2011084726A1
(en)
|
2009-12-21 |
2011-07-14 |
3M Innovative Properties Company |
BIS [4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM] 4-[(3-CARBOXYLATO-2-HYDROXYNAPHTHALEN-1-YL)METHYL]-3-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS
|
|
ES2608475T3
(es)
|
2010-04-13 |
2017-04-11 |
Celldex Therapeutics, Inc. |
Anticuerpos que se unen a cd27 humana y usos de los mismos
|
|
PL2575876T3
(pl)
|
2010-05-26 |
2018-07-31 |
Selecta Biosciences, Inc. |
Szczepionki poliwalentne z syntetycznymi nanonośnikami
|
|
AR082686A1
(es)
|
2010-08-13 |
2012-12-26 |
Baylor Res Inst |
Adyuvantes de vacuna que direccionan a los adyuvantes de anticuerpos directamente hacia las celulas presentadoras de antigenos
|
|
RU2603467C2
(ru)
|
2010-10-01 |
2016-11-27 |
Вентиркс Фармасьютикалз, Инк. |
Терапевтическое применение агониста tlr и комбинированная терапия
|
|
CA2818669A1
(en)
*
|
2010-12-09 |
2012-06-14 |
Barbara Klencke |
Treatment of her2-positive cancer with paclitaxel and trastuzumab-mcc-dm1
|
|
HUE032638T2
(en)
|
2011-01-12 |
2017-10-30 |
Ventirx Pharmaceuticals Inc |
Toll receptor modulator substituted benzoazepines
|
|
ES2700514T3
(es)
|
2011-02-01 |
2019-02-18 |
Genmab As |
Anticuerpos humanos y conjugados de anticuerpo-fármaco contra CD74
|
|
AR085633A1
(es)
|
2011-03-08 |
2013-10-16 |
Baylor Res Inst |
Coadyuvantes basados en anticuerpos que son dirigidos directamente a las celulas presentadoras en antigenos
|
|
RS57324B1
(sr)
|
2011-04-20 |
2018-08-31 |
Medimmune Llc |
Antitela i drugi molekuli koji vezuju b7-h1 i pd-1
|
|
AU2012244549B2
(en)
|
2011-04-21 |
2017-04-20 |
Origenis Gmbh |
Heterocyclic compounds as kinase inhibitors
|
|
UY34032A
(es)
|
2011-04-21 |
2012-11-30 |
Origenis Gmbh |
Nuevos inhibidores de quinasa
|
|
US8728486B2
(en)
|
2011-05-18 |
2014-05-20 |
University Of Kansas |
Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
|
|
LT2734551T
(lt)
|
2011-07-24 |
2018-04-10 |
Cure Tech Ltd. |
Humanizuotų imunomoduliuojančių monokloninių antikūnų variantai
|
|
JP6238459B2
(ja)
|
2011-08-01 |
2017-11-29 |
ジェネンテック， インコーポレイテッド |
Ｐｄ−１軸結合アンタゴニストとｍｅｋ阻害剤を使用する癌の治療方法
|
|
JP6046716B2
(ja)
|
2011-08-11 |
2016-12-21 |
ハンツマン・アドバンスド・マテリアルズ・アメリカズ・エルエルシー |
ベンゾオキサジン化合物の生産方法
|
|
CA2849259A1
(en)
|
2011-09-19 |
2013-03-28 |
The Johns Hopkins University |
Cancer immunotherapy
|
|
US9241869B2
(en)
|
2011-10-25 |
2016-01-26 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US10344261B2
(en)
|
2011-11-09 |
2019-07-09 |
Ascend Biopharmaceuticals Ltd |
Immunomodulatory conjugates
|
|
WO2013166110A1
(en)
*
|
2012-05-02 |
2013-11-07 |
Yale University |
Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)
|
|
CA3213528A1
(en)
|
2012-05-15 |
2013-11-21 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
CN112587671A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
US9845356B2
(en)
|
2012-08-03 |
2017-12-19 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use
|
|
SG11201501286PA
(en)
|
2012-08-23 |
2015-05-28 |
Agensys Inc |
Antibody drug conjugates (adc) that bind to 158p1d7 proteins
|
|
US10000482B2
(en)
|
2012-10-19 |
2018-06-19 |
Origenis Gmbh |
Kinase inhibitors
|
|
WO2014060112A1
(en)
|
2012-10-19 |
2014-04-24 |
Origenis Gmbh |
Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
|
|
EP2787005A1
(en)
|
2013-04-02 |
2014-10-08 |
Activartis Biotech GmbH |
Targeted cancer immune therapy
|
|
BR112016014410A2
(pt)
|
2013-12-20 |
2018-02-20 |
The Broad Institute Inc. |
terapia de combinação com vacina de neoantígeno
|
|
CA2936375A1
(en)
|
2014-01-10 |
2015-07-16 |
Shanghai Birdie Biotech, Inc. |
Compounds and compositions for treating her2 positive tumors
|
|
EP3160453A1
(en)
|
2014-06-25 |
2017-05-03 |
Selecta Biosciences, Inc. |
Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
|
|
FI4001311T3
(fi)
|
2014-07-09 |
2026-01-27 |
Birdie Biopharmaceuticals Inc |
Pd-l1/pd-1-vasta-aineiden yhdistelmiä kasvaimien hoitoon
|
|
CN105233291A
(zh)
|
2014-07-09 |
2016-01-13 |
博笛生物科技有限公司 |
用于治疗癌症的联合治疗组合物和联合治疗方法
|
|
CN105440135A
(zh)
|
2014-09-01 |
2016-03-30 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-pd-l1结合物
|
|
CN105732635A
(zh)
|
2014-12-29 |
2016-07-06 |
南京明德新药研发股份有限公司 |
一类Toll样受体7激动剂
|
|
DK3345907T3
(da)
|
2015-09-01 |
2020-06-22 |
Taiho Pharmaceutical Co Ltd |
Pyrazolo[3,4-d]pyrimidinforbindelser eller salte deraf
|
|
US10821127B2
(en)
|
2015-11-09 |
2020-11-03 |
Shaperon Inc. |
Composition for inhibiting myeloid-derived suppressor cells comprising decitabine or its pharmaceutically acceptable salt as active ingredient
|
|
CN106943596A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技（北京）有限公司 |
用于治疗肿瘤的抗-cd20组合
|
|
CN115252792A
(zh)
|
2016-01-07 |
2022-11-01 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-egfr组合
|
|
CN106943598A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技（北京）有限公司 |
用于治疗肿瘤的抗-her2组合
|
|
CN108794467A
(zh)
|
2017-04-27 |
2018-11-13 |
博笛生物科技有限公司 |
2-氨基-喹啉衍生物
|
|
CN110769827A
(zh)
|
2017-06-23 |
2020-02-07 |
博笛生物科技有限公司 |
药物组合物
|
|
CN113164460A
(zh)
|
2018-09-07 |
2021-07-23 |
博笛生物科技有限公司 |
咪唑喹啉化合物及其应用
|
|
EP3902532A4
(en)
|
2018-12-26 |
2022-08-24 |
Birdie Biopharmaceuticals, Inc. |
Immune modulatory combinations and methods for treating cancers
|
|
JP2022525216A
(ja)
|
2019-03-15 |
2022-05-11 |
バーディー バイオファーマシューティカルズ インコーポレイテッド |
癌の治療のための免疫調節組成物および方法
|
|
AU2021332350A1
(en)
|
2020-08-26 |
2023-03-16 |
Birdie Pharmaceuticals, Inc. |
Cancer treatment with TLR agonist
|