AR068048A1 - Combinacion de agente antimitotico e inhibidor de aurora quinasa como tratamiento anticancerigeno - Google Patents
Combinacion de agente antimitotico e inhibidor de aurora quinasa como tratamiento anticancerigenoInfo
- Publication number
- AR068048A1 AR068048A1 ARP080103276A ARP080103276A AR068048A1 AR 068048 A1 AR068048 A1 AR 068048A1 AR P080103276 A ARP080103276 A AR P080103276A AR P080103276 A ARP080103276 A AR P080103276A AR 068048 A1 AR068048 A1 AR 068048A1
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- Prior art keywords
- nr4c
- nr4r5
- alkyl
- nr4or7
- heterocyclyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Reivindicacion 1: Una composicion farmacéutica para tratar o mejorar cáncer, que comprende en combinacion (a) al menos un agente antimicotico seleccionado del grupo que consiste en un taxano, paclitaxel, docetaxel, un inhibidor de Cenp-E, abraxano, epotilona, monastrol, un inhibidor de KSP, ispinesib y un compuesto de las formulas (A) - (D) mostradas en los puntos a) - d) que figuran más abajo: a) Un compuesto representado por la formula estructural (A) o una de sus sales, solvatos o ésteres farmacéuticamente aceptables, en donde el anillo Y es un arilo de 5 o 6 miembros o un heteroarilo de 5 o 6 miembros fusionado tal como se indica en la formula (A), en donde en dichos arilo y heteroarilo cada carbono del anillo sustituible está sustituido, de modo independiente, con R2 y cada nitrogeno del anillo sustituible está sustituido, de modo independiente, con R6; W es N o C(R12); X es N o N-oxido; Z es S, S(=O) o S(=O)2; R1 es H, alquilo, alcoxi, hidroxi, halo, -CN, -S(O)m-alquilo, -C(O)NR9R10, -(CR9R10)1-6OH o -NR4(CR9R10)1-2OR9; cada R2 está seleccionado, de modo independiente, del grupo que consiste en H, halo, alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, -(CR10R11)0-6-OR7, -C(O)R4, -C(S)R4, -C(O)OR7, -C(S)OR7, -OC(O)R7, -OC(S)R7, -C(O)NR4R5, -C(S)NR4R5, -C(O)NR4OR7, -C(S)NR4OR7, -C(O)NR7NR4R5, -C(S)NR7NR4R5, -C(S)NR4OR7, -C(O)SR7, -NR4R5, -NR4C(O)R5, -NR4C(S)R5, -NR4C(O)OR7, -NR4C(S)OR7, -OC(O)NR4R5, -OC(S)NR4R5, -NR4C(O)NR4R5, -NR4C(S)NR4R5, -NR4C(O)NR4OR7, -NR4C(S)NR4OR7, -(CR10R11)0-6SR7, -SO2R7, -S(O)1-2NR4R5, -N(R7)SO2R7, -S(O)1-2NR5OR7, -CN, -OCF3, -SCF3, -C(=NR7)NR4, -C(O)NR7(CH2)1-10NR4R5, -C(O)NR7(CH2)1-10OR7, -C(S)NR7(CH2)1-10NR4R5, -C(S)NR7(CH2)1-10OR7, haloalquilo y alquilsililo, en donde cada uno de dichos alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo o heteroarilalquilo está opcionalmente sustituido, de modo independiente, con 1-5 restos R9; cada R3 está seleccionado, de modo independiente, del grupo que consiste en H, halo, alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, -(CR10R11)0-6-OR7, -C(O)R4, -C(S)R4, -C(O)OR7, -C(S)OR7, -OC(O)R7, -OC(S)R7, -C(O)NR4R5, -C(S)NR4R5, -C(O)NR4OR7, -C(S)NR4OR7, -C(O)NR7NR4R5, -C(S)NR7NR4R5, -C(S)NR4OR7, -C(O)SR7, -NR4R5, -NR4C(O)R5, -NR4C(S)R5, -NR4C(O)OR7, -NR4C(S)OR7, -OC(O)NR4R5, -OC(S)NR4R5, -NR4C(O)NR4R5, -NR4C(S)NR4R5, -NR4C(O)NR4OR7, -NR4C(S)NR4OR7, -(CR10R11)0-6SR7, SO2R7, -S(O)1-2NR4R5, -N(R7)SO2R7, -S(O)1-2NR5OR7, -CN, -OCF3, -SCF3, -C(=NR7)NR4R5, -C(O)NR7(CH2)1-10NR4R5, -C(O)NR7(CH2)1-10OR7, -C(S)NR7(CH2)1-10NR4R5, -C(S)NR7(CH2)1-10OR7, haloalquilo y alquilsililo, en donde cada uno de dichos alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo o heteroaralquilo está opcionalmente sustituido, de modo independiente, con 1-5 restos R9; cada R4 y R5 está seleccionado, de modo independiente, del grupo que consiste en H, alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, -OR7, -C(O)R7 y -C(O)OR7, en donde cada uno de dichos alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo o heteroaralquilo está opcionalmente sustituido con 1-4 restos R8; o R4 y R5, cuando están unidos al mismo átomo de nitrogeno, se toman opcionalmente juntos con el átomo de nitrogeno al que están unidos para formar un anillo heterocíclico de 3-6 miembros que tiene 0-2 heteroátomos adicionales seleccionados de N, O o S; cada R6 está seleccionado, de modo independiente, del grupo que consiste en H, alquilo, arilo, aralquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, heteroarilo, heteroaralquilo, -(CH2)1-6CF3, -C(O)R7, -C(O)OR7 y -SO2R7; cada R7 está seleccionado, de modo independiente, del grupo que consiste en H, alquilo, arilo, aralquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, heteroarilo y heteroaralquilo, en donde cada miembro de R7 excepto H está opcionalmente sustituido con 1-4 restos R8; cada R8 está seleccionado, de modo independiente, del grupo que consiste en halo, alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, -NO2, -OR10, -(alquil C1-6)-OR10, -CN, -NR10R11, -C(O)R10, -C(O)OR10, -C(O)NR10R11, -CF3, -OCF3, -CF2CF3, -C(=NOH)R10, -N(R10)C(O)R11, -C(=NR10)NR10R11 y -NR10C(O)OR11, en donde cada uno de dichos alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo está opcionalmente sustituido, de modo independiente, con 1-3 restos seleccionados del grupo que consiste en halo, alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, -NO2, -OR10, -(alquil C1-6)-OR10, -CN, -NR10R11, -C(O)OR10, -C(O)NR10R11, -CF3, -OCF3, -NR10C(O)OR11 y -NR10(O)R40; o dos grupos R8, cuando están unidos al mismo átomo de carbono, se toman opcionalmente juntos con el átomo de carbono al que están unidos para formar un grupo C=O o un grupo C=S; cada R9 está seleccionado, de modo independiente, del grupo que consiste en H, alquilo, alcoxi, OH, CN, halo, -(CR10R11)0-4NR4R5, haloalquilo, hidroxialquilo, alcoxialquilo, -C(O)NR4R5, -C(O)OR7, -OC(O)NR4R5, -NR4C(O)R5 y -NR4C(O)NR4R5; cada R10 es, de modo independiente, H o alquilo; o R9 y R10, cuando están unidos al mismo átomo de nitrogeno, se toman opcionalmente juntos con el átomo de nitrogeno al que están unidos para formar un anillo heterocíclico de 3-6 miembros que tiene 0-2 heteroátomos adicionales seleccionados de N, O o S; cada R11 es, de modo independiente, H o alquilo; o R10 y R11 cuando están unidos al mismo átomo de nitrogeno, se toman opcionalmente juntos con el átomo de nitrogeno al que están unidos para formar un anillo heterocíclico de 3-6 miembros que tiene 0-2 heteroátomos adicionales seleccionados de N, O o S; cada R12 está seleccionado, de modo independiente, del grupo que consiste en H, halo, alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, -(CR10R11)0-6-OR7, -C(O)R4, -C(S)R4, -C(O)OR7, -C(S)OR7, -OC(O)R7, -OC(S)R7, -C(O)NR4R5, -C(S)NR4R5, -C(O)NR4OR7, -C(S)NR4OR7, -C(O)NR7NR4R5, -C(S)NR7NR4R5, -C(S)NR4OR7, -C(O)SR7, -NR4R5, -NR4C(O)R5, -NR4C(S)R5, NR4C(O)OR7, -NR4C(S)OR7, -OC(O)NR4R5, -OC(S)NR4R5, -NR4C(O)NR4R5, -NR4C(S)NR4R5, -NR4C(O)NR4OR7, -NR4C(S)NR4OR7, -(CR10R11)0-6SR7, SO2R7, -S(O)1-2NR4R5, -N(R7)SO2R7, -S(O)1-2NR5OR7, -CN, -OCF3, -SCF3, -C(NR7)NR4, -C(O)NR7(CH2)1-10NR4R5, -C(O)NR7(CH2)1-10OR7, -C(S)NR7(CH2)1-10NR4R5, -C(S)NR7(CH2)1-10OR7, haloalquilo y alquilsililo, en donde cada uno de dichos alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, arilo, aralquilo, heteroarilo o heteroarilalquilo está opcionalmente sustituido, de modo independiente, con 1-5 restos R9; y R40 está seleccionado del grupo que consiste en cicloalquilo, heterociclilo, arilo y heteroarilo, en donde cada uno de dichos cicloalquilo, heterociclilo, arilo y heteroarilo está opcionalmente sustituidos, de modo independiente, con 1-3 restos seleccionados, de modo independiente, del grupo que consiste en -CN, -OH, halo, alquilo, haloalquilo, alcoxi y -NR10R11; b) Un compuesto representado por la formula estructural (B) o una de sus sales, solvatos o ésteres farmacéuticamente aceptables, en donde el anillo Y es un anillo de 5 a 7 miembros seleccionado del grupo que consiste en cicloalquilo, cicloalquenilo, heterociclilo o heterociclenilo fusionado tal como se indica en la formula (B), en donde en cada uno de dichos anillos de 5 a 7 miembros, cada carbono del anillo sustituible está sustituido, de modo independiente, con 1-2 restos R2 y cada heteroátomo del anillo sustituible está sustituido, de modo independiente, con R6; W es N o C(R12); X es N o N-oxido; Z es S, S(=O) o S(=O)2; R1 es H, alquilo, alcoxi, hidroxi, halo, -CN, -S(O)m-alquilo, -C(O)NR9R10, -(CR9R10)1-6OH o -NR4(CR9R10)1-2OR9; en donde m es 0 a 2; cada R2 está seleccionado, de modo independiente, del grupo que consiste en H, halo, alquilo, cicloalquilo, alquilsililo, cicloalquenilo, heterociclilo, heterociclenilo, arilo, heteroarilo, -(CR10R11)0-6-OR7, -C(O)R4, -C(S)R4, -C(O)OR7, -C(S)ORT, -OC(O)R7, -OC(S)R7, -C(O)NR4R5, -C(S)NR4R5, -C(O)NR4OR7, -C(S)NR4OR7, -C(O)NR7NR4R5, -C(S)NR7NR4R5, -C(S)NR4OR7, -C(O)SR7, -NR4R5, -NR4C(O)R5, -NR4C(S)R5, -NR4C(O)OR7, -NR4C(S)OR7, -OC(O)NR4R5, -OC(S)NR4R5, -NR4C(O)NR4R5, -NR4C(S)NR4R5, -NR4C(O)NR4OR7, -NR4C(S)NR4OR7, -(CR10R11)0-6SR7, SO2R7, -S(O)1-2NR4R5, -N(R7)SO2R7, -S(O)1-2NR5OR7, -CN, -OCF3, -SCF3, -C(=NR7)NR4, -C(O)NR7(CH2)1-10NR4R5, -C(O)NR7(CH2)1-10OR7, -C(S)NR7(CH2)1-10NR4R5 y -C(S)NR7(CH2)1-10OR7, en donde cada uno de dichos alquilo, cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo, arilo y heteroarilo está opcionalmente sustituido, de modo independiente, con 1-5 restos R9; o dos grupos R2 en el mismo átomo de carbono se toman opcionalmente juntos con el átomo de carbono al que están unidos para formar un grupo C=O, un grupo C=S o un grupo etilendioxi; R3 está seleccionado, de modo independiente, del grupo que consiste en H, halo, alquilo, cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo, arilo, heteroarilo, -(CR10R11)0-6-OR7, -C(O)R4, -C(S)R4, -C(O)OR7, -C(S)OR7, -OC(O)R7, -OC(S)R7, -C(O)NR4R5, -C(S)NR4R, -C(O)NR4OR7, -C(S)NR4OR7, -C(O)NR7NR4R5 -C(S)NR7NR4R5, -C(S)NR4OR7, -C(O)SR7, -NR4R5, -NR4C(O)R5, -NR4C(S)R5, -NR4C(O)OR7, -NR4C(S)OR7, -OC(O)NR4R5, -OC(S)NR4R5, -NR4C(O)NR4R5, -NR4C(S)NR4R5, -NR4C(O)NR4OR7, -NR4C(S)NR4OR7, -(CR10R11)0-6SR7, SO2R7, -S(O)1-2NR4R5, -N(R7)SO2R7, -S(O)1-2NR5OR7, -CN, -C(=NR7)NR4R5, -C(O)N(R7)-(CR40R41)1-5-C(=NR7)NR4R5, -C(O)N(R7)(CR40R41)1-5-NR4R5-C(O)N(R7)(CR40R41)1-5-C(O)-NR4R5, -C(O)N(R7)(CR40R41)1-5-OR7, -C(S)NR7(CH2)1-5NR4R5 y -C(S)NR7(CH2)1-5OR7, en donde cada uno de dichos alquilo, cicloalquilo, cicloalquenilo, heter
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US95308707P | 2007-07-31 | 2007-07-31 | |
US2398508P | 2008-01-28 | 2008-01-28 |
Publications (1)
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AR068048A1 true AR068048A1 (es) | 2009-11-04 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP080103276A AR068048A1 (es) | 2007-07-31 | 2008-07-29 | Combinacion de agente antimitotico e inhibidor de aurora quinasa como tratamiento anticancerigeno |
Country Status (17)
Country | Link |
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US (1) | US20100249030A1 (es) |
EP (1) | EP2182986A2 (es) |
JP (1) | JP2010535201A (es) |
KR (1) | KR20100042287A (es) |
CN (1) | CN101808666A (es) |
AR (1) | AR068048A1 (es) |
AU (1) | AU2008282885A1 (es) |
BR (1) | BRPI0814874A2 (es) |
CA (1) | CA2694218A1 (es) |
CL (1) | CL2008002224A1 (es) |
CO (1) | CO6331446A2 (es) |
EC (1) | ECSP109918A (es) |
MX (1) | MX2010001340A (es) |
PE (1) | PE20090902A1 (es) |
RU (1) | RU2010106878A (es) |
TW (1) | TW200911241A (es) |
WO (1) | WO2009017701A2 (es) |
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CA2668255A1 (en) * | 2006-10-31 | 2008-05-08 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
WO2009097233A1 (en) * | 2008-01-28 | 2009-08-06 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
US8669259B2 (en) * | 2009-08-26 | 2014-03-11 | Merck Sharp & Dohme Corp. | Heterocyclic amide compounds as protein kinase inhibitors |
US8435976B2 (en) * | 2009-09-08 | 2013-05-07 | F. Hoffmann-La Roche | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
SG182629A1 (en) | 2010-02-18 | 2012-08-30 | High Point Pharmaceuticals Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
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- 2008-07-28 CN CN200880109598A patent/CN101808666A/zh active Pending
- 2008-07-28 MX MX2010001340A patent/MX2010001340A/es not_active Application Discontinuation
- 2008-07-28 EP EP08794799A patent/EP2182986A2/en not_active Withdrawn
- 2008-07-28 BR BRPI0814874A patent/BRPI0814874A2/pt not_active IP Right Cessation
- 2008-07-28 KR KR1020107004497A patent/KR20100042287A/ko not_active Application Discontinuation
- 2008-07-28 RU RU2010106878/15A patent/RU2010106878A/ru unknown
- 2008-07-28 JP JP2010519219A patent/JP2010535201A/ja not_active Withdrawn
- 2008-07-28 US US12/670,762 patent/US20100249030A1/en not_active Abandoned
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RU2010106878A (ru) | 2011-09-10 |
KR20100042287A (ko) | 2010-04-23 |
JP2010535201A (ja) | 2010-11-18 |
MX2010001340A (es) | 2010-06-02 |
WO2009017701A3 (en) | 2009-05-07 |
AU2008282885A1 (en) | 2009-02-05 |
BRPI0814874A2 (pt) | 2019-09-24 |
TW200911241A (en) | 2009-03-16 |
CN101808666A (zh) | 2010-08-18 |
WO2009017701A2 (en) | 2009-02-05 |
US20100249030A1 (en) | 2010-09-30 |
CA2694218A1 (en) | 2009-02-05 |
CL2008002224A1 (es) | 2009-07-17 |
ECSP109918A (es) | 2010-02-26 |
EP2182986A2 (en) | 2010-05-12 |
PE20090902A1 (es) | 2009-07-25 |
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