JP2018501276A - 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法 - Google Patents

非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法 Download PDF

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JP2018501276A
JP2018501276A JP2017535411A JP2017535411A JP2018501276A JP 2018501276 A JP2018501276 A JP 2018501276A JP 2017535411 A JP2017535411 A JP 2017535411A JP 2017535411 A JP2017535411 A JP 2017535411A JP 2018501276 A JP2018501276 A JP 2018501276A
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inhibitor
ring
membered
sulfur
oxygen
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ジェラルディン シー． ハリマン，
ジェラルディン シー． ハリマン，
エイチ． ジェイムズ ハーウッド，
エイチ． ジェイムズ ハーウッド，
ロサーナ カペラー−リーベルマン，
ロサーナ カペラー−リーベルマン，
ウィリアム エフ． ウェストリン，
ウィリアム エフ． ウェストリン，
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ギリアド アポロ， エルエルシー
ギリアド アポロ， エルエルシー
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Publication of JP2018501276A publication Critical patent/JP2018501276A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017535411A 2015-01-09 2016-01-08 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法 Withdrawn JP2018501276A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562101726P 2015-01-09 2015-01-09
US62/101,726 2015-01-09
PCT/US2016/012673 WO2016112305A1 (en) 2015-01-09 2016-01-08 Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease

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JP2020072689A Division JP2020109130A (ja) 2015-01-09 2020-04-15 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法

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JP2018501276A true JP2018501276A (ja) 2018-01-18
JP2018501276A5 JP2018501276A5 (https=) 2019-02-14

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JP2020072689A Pending JP2020109130A (ja) 2015-01-09 2020-04-15 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法

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US (2) US20180021341A1 (https=)
EP (2) EP3242722A4 (https=)
JP (2) JP2018501276A (https=)
KR (1) KR20170102299A (https=)
CN (1) CN107106873A (https=)
AU (1) AU2016205138A1 (https=)
BR (1) BR112017014341A2 (https=)
CA (1) CA2972919A1 (https=)
EA (2) EA201791258A1 (https=)
HK (2) HK1243369A1 (https=)
MX (1) MX2017008844A (https=)
SG (1) SG11201705361PA (https=)
WO (1) WO2016112305A1 (https=)

Cited By (5)

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JP2021522247A (ja) * 2018-04-24 2021-08-30 ピーエイチ・ファーマ・カンパニー・リミテッドＰｈ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． 肝疾患における好中球エラスターゼ阻害薬の使用
WO2021235508A1 (ja) * 2020-05-21 2021-11-25 塩野義製薬株式会社 脂肪性肝疾患の治療用医薬
JP2022513101A (ja) * 2018-11-20 2022-02-07 中国医▲薬▼研究▲開▼▲発▼中心有限公司 スピロ環系化合物及びその医薬用途
JP2022540560A (ja) * 2019-07-02 2022-09-16 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用
JP2023544220A (ja) * 2020-11-17 2023-10-20 インベンティバ 肝疾患を治療するための併用療法

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JP2021522247A (ja) * 2018-04-24 2021-08-30 ピーエイチ・ファーマ・カンパニー・リミテッドＰｈ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． 肝疾患における好中球エラスターゼ阻害薬の使用
JP2022513101A (ja) * 2018-11-20 2022-02-07 中国医▲薬▼研究▲開▼▲発▼中心有限公司 スピロ環系化合物及びその医薬用途
JP2022540560A (ja) * 2019-07-02 2022-09-16 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用
JP7374233B2 (ja) 2019-07-02 2023-11-06 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用
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JP2025060758A (ja) * 2020-11-17 2025-04-10 インベンティバ 肝疾患を治療するための併用療法

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AU2016205138A1 (en) 2017-07-13
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CN107106873A (zh) 2017-08-29
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EP3597271A1 (en) 2020-01-22
WO2016112305A1 (en) 2016-07-14
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US20180021341A1 (en) 2018-01-25
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