HK1246232A1 - 用於治療非酒精性脂肪肝病的acc抑制劑組合治療 - Google Patents
用於治療非酒精性脂肪肝病的acc抑制劑組合治療Info
- Publication number
- HK1246232A1 HK1246232A1 HK18105783.0A HK18105783A HK1246232A1 HK 1246232 A1 HK1246232 A1 HK 1246232A1 HK 18105783 A HK18105783 A HK 18105783A HK 1246232 A1 HK1246232 A1 HK 1246232A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- combination therapy
- liver disease
- fatty liver
- alcoholic fatty
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101726P | 2015-01-09 | 2015-01-09 | |
| PCT/US2016/012673 WO2016112305A1 (en) | 2015-01-09 | 2016-01-08 | Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1246232A1 true HK1246232A1 (zh) | 2018-09-07 |
Family
ID=56356482
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18102859.6A HK1243369A1 (zh) | 2015-01-09 | 2018-02-28 | 用於治療非酒精性脂肪肝病的acc抑制劑組合治療 |
| HK18105783.0A HK1246232A1 (zh) | 2015-01-09 | 2018-05-04 | 用於治療非酒精性脂肪肝病的acc抑制劑組合治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18102859.6A HK1243369A1 (zh) | 2015-01-09 | 2018-02-28 | 用於治療非酒精性脂肪肝病的acc抑制劑組合治療 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20180021341A1 (zh) |
| EP (2) | EP3242722A4 (zh) |
| JP (2) | JP2018501276A (zh) |
| KR (1) | KR20170102299A (zh) |
| CN (1) | CN107106873A (zh) |
| AU (1) | AU2016205138A1 (zh) |
| BR (1) | BR112017014341A2 (zh) |
| CA (1) | CA2972919A1 (zh) |
| EA (2) | EA201791258A1 (zh) |
| HK (2) | HK1243369A1 (zh) |
| MX (1) | MX2017008844A (zh) |
| SG (1) | SG11201705361PA (zh) |
| WO (1) | WO2016112305A1 (zh) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2790700T3 (es) | 2005-12-28 | 2020-10-28 | Vertex Pharma | Composiciones farmacéuticas de la forma amorfa de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida |
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| AU2015267148B2 (en) | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| KR102443575B1 (ko) | 2015-07-06 | 2022-09-16 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
| ES2855348T3 (es) | 2015-11-25 | 2021-09-23 | Gilead Apollo Llc | Inhibidores de éster ACC y usos de los mismos |
| JP2019502660A (ja) * | 2015-11-25 | 2019-01-31 | ギリアド アポロ， エルエルシー | ピラゾールａｃｃ阻害剤およびその使用 |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| CA3172549A1 (en) | 2016-03-02 | 2017-09-08 | Gilead Apollo, Llc | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
| ES2929758T3 (es) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo |
| CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| EP3730487B1 (en) | 2016-06-13 | 2022-04-27 | Gilead Sciences, Inc. | Azetidine derivatives as fxr (nr1h4) modulators |
| US10668108B2 (en) | 2016-11-04 | 2020-06-02 | Children's Hospital Medical Center | Compositions and methods of treating liver disease |
| CA3152584C (en) * | 2016-11-10 | 2024-02-13 | Galmed Research And Development Ltd. | Treatment for fibrosis |
| WO2018087600A1 (en) * | 2016-11-10 | 2018-05-17 | Galmed Research And Development Ltd. | Inhibition of fibrosis in non-alcoholic fatty liver disease patients |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| WO2018133858A1 (en) * | 2017-01-22 | 2018-07-26 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| CN110431144B (zh) * | 2017-03-24 | 2022-08-05 | 浙江海正药业股份有限公司 | 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| KR20190126920A (ko) * | 2017-03-28 | 2019-11-12 | 길리애드 사이언시즈, 인코포레이티드 | 간 질환을 치료하기 위한 치료 조합물 |
| US20180311244A1 (en) * | 2017-03-28 | 2018-11-01 | Gilead Sciences, Inc. | Methods of treating liver disease |
| EP3609496A1 (en) * | 2017-04-12 | 2020-02-19 | Gilead Sciences, Inc. | Methods of treating liver disease |
| CN110536682B (zh) * | 2017-04-18 | 2023-01-06 | 基恩菲特公司 | 依拉非诺或其衍生物与抗nash、抗纤维化或抗胆汁淤积药剂的组合 |
| US11583570B2 (en) * | 2017-04-24 | 2023-02-21 | Tsinghua University | Use of autoinducer-related pathway in inducing apoptosis and anti-infective therapy |
| JP2020524181A (ja) * | 2017-06-19 | 2020-08-13 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｎａｆｌｄおよびｎａｓｈの治療のための化合物および方法 |
| US10995099B2 (en) * | 2017-07-17 | 2021-05-04 | Nanjing Ruijie Pharmatech Co., Ltd. | Compounds and their uses as ACC inhibitors |
| TW201910338A (zh) * | 2017-07-26 | 2019-03-16 | 大陸商南京聖和藥業股份有限公司 | 作為acc抑制劑的化合物及其應用 |
| CN109316601B (zh) * | 2017-07-31 | 2021-11-09 | 武汉朗来科技发展有限公司 | 药物组合物及其用途 |
| CA3073956A1 (en) | 2017-09-03 | 2019-03-07 | Angion Biomedica Corp. | Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors |
| US11033601B2 (en) * | 2017-09-14 | 2021-06-15 | The Regents Of The University Of Colorado, A Body Corporate | Selective inhibition of V1b for treating fatty liver |
| CA3077273A1 (en) * | 2017-10-06 | 2019-04-11 | Gilead Sciences, Inc. | Combination therapy comprising an acc inhibitor |
| WO2019085772A1 (zh) * | 2017-11-06 | 2019-05-09 | 深圳市图微安创科技开发有限公司 | 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗胆汁性肝硬化 |
| CN107693514A (zh) * | 2017-12-04 | 2018-02-16 | 威海贯标信息科技有限公司 | 一种鲁格列净组合物 |
| EP3746437A1 (en) | 2018-01-31 | 2020-12-09 | HepaRegeniX GmbH | Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| AU2019254371A1 (en) * | 2018-04-17 | 2020-10-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| SG11202010521VA (en) * | 2018-04-24 | 2020-11-27 | Ph Pharma Co Ltd | Use of neutrophil elastase inhibitors in liver disease |
| US11731968B2 (en) | 2018-06-21 | 2023-08-22 | Heparegenix Gmbh | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL279641B2 (en) | 2018-07-16 | 2024-04-01 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocytic death |
| US20210322324A1 (en) * | 2018-08-14 | 2021-10-21 | Avolynt | Method for treating primary sclerosing cholangitis |
| TWI718644B (zh) | 2018-08-31 | 2021-02-11 | 美商輝瑞股份有限公司 | 用於治療ｎａｓｈ／ｎａｆｌｄ和相關疾病之組合 |
| WO2020049556A1 (en) * | 2018-09-06 | 2020-03-12 | Galmed Research And Development Ltd | Combination therapy for the treatment of liver disease |
| CN110950884B (zh) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| CA3119925A1 (en) * | 2018-11-20 | 2020-05-28 | The National Institutes Of Pharmaceutical Research And Development (Nip) | Spiro compound and medical uses thereof |
| EA202191566A1 (ru) | 2019-01-15 | 2021-11-01 | Джилид Сайенсиз, Инк. | Соединения, модулирующие fxr (nr1h4) |
| CA3129949C (en) | 2019-02-19 | 2024-04-30 | Gilead Sciences, Inc. | Solid forms of fxr agonists |
| CA3130718A1 (en) * | 2019-04-10 | 2020-10-15 | Genfit | Combination therapy comprising compounds of formula (i) and glp-1 receptor agonists |
| PE20220255A1 (es) | 2019-05-08 | 2022-02-16 | Aligos Therapeutics Inc | Moduladores de thr y metodos de uso de estos |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| WO2021000242A1 (zh) * | 2019-07-02 | 2021-01-07 | 广东东阳光药业有限公司 | 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用 |
| KR20220046584A (ko) | 2019-07-29 | 2022-04-14 | 헤파레게닉스 게엠베하 | 간 재생 촉진 또는 간세포 사멸 감소 또는 예방을 위한 헤테로아릴-치환된 피라졸로-피리딘 단백질 키나제 억제제 |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| CN110628810B (zh) * | 2019-08-13 | 2022-06-28 | 浙江大学 | 一种提高植物光合效率的方法 |
| CN114340632A (zh) * | 2019-08-30 | 2022-04-12 | 赛特瑞恩股份有限公司 | 用于治疗或预防非酒精性脂肪性肝炎（nash）的药物组合物 |
| WO2021133948A1 (en) | 2019-12-23 | 2021-07-01 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders |
| JP2023511297A (ja) | 2020-01-15 | 2023-03-17 | ヘパリジェニックス ゲーエムベーハー | 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤 |
| JP2021134211A (ja) | 2020-02-24 | 2021-09-13 | ファイザー・インク | Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ |
| JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ |
| US20230117286A1 (en) * | 2020-03-11 | 2023-04-20 | Dong-A St Co., Ltd. | Pharmaceutical composition for prevention or treatment of nonalcoholic steatohepatitis |
| JP2023520650A (ja) | 2020-03-30 | 2023-05-18 | ギリアード サイエンシーズ， インコーポレイテッド | （Ｓ）－６－（（（１－（ビシクロ［１．１．１］ペンタン－１－イル）－１Ｈ－１，２，３－トリアゾール－４－イル）２－メチル－１－オキソ－１，２－ジヒドロイソキノリン－５－イル）メチル）））アミノ）８－クロロ－（ネオペンチルアミノ）キノリン－３－カルボニトリルＣｏｔ阻害剤化合物の固体形態 |
| KR20220160645A (ko) | 2020-04-02 | 2022-12-06 | 길리애드 사이언시즈, 인코포레이티드 | Cot 저해제 화합물의 제조 방법 |
| CN111407892A (zh) * | 2020-04-08 | 2020-07-14 | 中国药科大学 | Acsl4及其在nash中的应用 |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| WO2021235508A1 (ja) * | 2020-05-21 | 2021-11-25 | 塩野義製薬株式会社 | 脂肪性肝疾患の治療用医薬 |
| EP4000616A1 (en) | 2020-11-17 | 2022-05-25 | Inventiva | Combination therapy for the treatment of a liver disease |
| EP4304711A1 (en) | 2021-03-11 | 2024-01-17 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| EP4313967A1 (en) | 2021-03-29 | 2024-02-07 | Gilead Sciences, Inc. | Khk inhibitors |
| TW202304435A (zh) | 2021-06-04 | 2023-02-01 | 美商基利科學股份有限公司 | 治療ｎａｓｈ之方法 |
| TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑 |
| WO2023034381A1 (en) * | 2021-08-31 | 2023-03-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Quantitative systems pharmacology methods for identifying therapeutics for disease states |
| WO2023047203A1 (en) * | 2021-09-25 | 2023-03-30 | Torrent Pharmaceuticals Ltd | Combination of omzotirome and antidiabetic agent, antihypertensive agent or anti-dyslipidemic agent |
| WO2023090411A1 (ja) | 2021-11-19 | 2023-05-25 | 塩野義製薬株式会社 | 心疾患または骨格筋の疾患の治療用医薬 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009259839A1 (en) * | 2008-06-20 | 2009-12-23 | Kinemed, Inc. | Compositions for the treatment of fibrotic diseases or conditions |
| US20100113473A1 (en) * | 2008-10-30 | 2010-05-06 | Player Mark R | Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor |
| WO2012090219A2 (en) * | 2010-12-31 | 2012-07-05 | Jubilant Biosys Ltd. | Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors |
| AU2012335088B2 (en) * | 2011-11-11 | 2017-08-24 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| AU2014262547A1 (en) * | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| CN105358154A (zh) * | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
| KR20160007598A (ko) * | 2013-05-10 | 2016-01-20 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
| WO2014182950A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
-
2016
- 2016-01-08 AU AU2016205138A patent/AU2016205138A1/en not_active Abandoned
- 2016-01-08 CN CN201680004801.2A patent/CN107106873A/zh active Pending
- 2016-01-08 JP JP2017535411A patent/JP2018501276A/ja not_active Withdrawn
- 2016-01-08 BR BR112017014341-0A patent/BR112017014341A2/pt not_active Application Discontinuation
- 2016-01-08 CA CA2972919A patent/CA2972919A1/en not_active Abandoned
- 2016-01-08 SG SG11201705361PA patent/SG11201705361PA/en unknown
- 2016-01-08 EA EA201791258A patent/EA201791258A1/ru unknown
- 2016-01-08 WO PCT/US2016/012673 patent/WO2016112305A1/en active Application Filing
- 2016-01-08 EA EA201892625A patent/EA201892625A1/ru unknown
- 2016-01-08 US US15/541,008 patent/US20180021341A1/en not_active Abandoned
- 2016-01-08 MX MX2017008844A patent/MX2017008844A/es unknown
- 2016-01-08 KR KR1020177021086A patent/KR20170102299A/ko unknown
- 2016-01-08 EP EP16735485.1A patent/EP3242722A4/en not_active Withdrawn
- 2016-01-08 EP EP19176040.4A patent/EP3597271A1/en not_active Withdrawn
-
2018
- 2018-02-28 HK HK18102859.6A patent/HK1243369A1/zh unknown
- 2018-05-04 HK HK18105783.0A patent/HK1246232A1/zh unknown
-
2019
- 2019-05-13 US US16/410,894 patent/US20190381045A1/en not_active Abandoned
-
2020
- 2020-04-15 JP JP2020072689A patent/JP2020109130A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3242722A4 (en) | 2018-07-11 |
| WO2016112305A1 (en) | 2016-07-14 |
| EA201892625A1 (ru) | 2019-07-31 |
| MX2017008844A (es) | 2018-03-14 |
| US20190381045A1 (en) | 2019-12-19 |
| JP2018501276A (ja) | 2018-01-18 |
| JP2020109130A (ja) | 2020-07-16 |
| KR20170102299A (ko) | 2017-09-08 |
| US20180021341A1 (en) | 2018-01-25 |
| CA2972919A1 (en) | 2016-07-14 |
| CN107106873A (zh) | 2017-08-29 |
| EP3597271A1 (en) | 2020-01-22 |
| SG11201705361PA (en) | 2017-08-30 |
| EA201791258A1 (ru) | 2017-12-29 |
| HK1243369A1 (zh) | 2018-07-13 |
| AU2016205138A1 (en) | 2017-07-13 |
| EP3242722A1 (en) | 2017-11-15 |
| BR112017014341A2 (pt) | 2018-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1246232A1 (zh) | 用於治療非酒精性脂肪肝病的acc抑制劑組合治療 | |
| IL253945A0 (en) | kdm1a inhibitors to treat the disease | |
| HK1247922A1 (zh) | 用於治療癌症的吲哚胺2，3-雙加氧酶抑制劑 | |
| HK1247202A1 (zh) | 用於治療癌症的化合物 | |
| HK1259458A1 (zh) | 用於治療心血管疾病的吉卡賓組合 | |
| ZA201607740B (en) | Treatment of the complications of chronic liver disease with caspase inhibitors | |
| IL254266B (en) | Glucosylceramide synthase inhibitors for the treatment of diseases | |
| EP3132795A4 (en) | Composition for preventing or treating fatty liver diseases | |
| SG11202102684VA (en) | Treatment for non-alcoholic fatty liver disease | |
| EP3362053A4 (en) | TREATMENT OF NON-ALCOHOLIC FATTYLENE OR NON-ALCOHOLIC STEATOHEPATITIS WITH 6-MERCAPTOPURIN WITH DELAYED RELEASE | |
| ZA201805080B (en) | Application of triacetyl-3-hydroxyphenyladenosine in preparation of pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease | |
| SI3302523T1 (sl) | Sestavek za zdravljenje tkivnih lezij | |
| GB201506654D0 (en) | Formulations for inhibition of PCSK9 for the treatment of hypercholesterolemia | |
| PL3484475T3 (pl) | 1-Metylonikotynamid do leczenia choroby układu krążenia | |
| PL3233074T3 (pl) | Leczenie niealkoholowych stłuszczeniowych chorób wątroby | |
| GB201411467D0 (en) | 7-hydroxy cannabidiol (7-oh-cbd) for use in the treatment of non-alcoholic fatty liver disease (nafld) | |
| PT3340975T (pt) | Formulação para o tratamento de acne | |
| ZA201706986B (en) | Compositions for the treatment of kidney and/or liver disease | |
| IL257689B (en) | Pharmaceutical preparations and methods for treating diseases related to lack of oxygen | |
| GB201622116D0 (en) | Treatment of liver disease | |
| HRP20181460T1 (hr) | Derivati 4-okso-n-(4-hidroksifenil)retinamida kao terapeutska sredstva za liječenje karcinoma | |
| PL3273997T3 (pl) | Kompozycja do leczenia nieżytu nosa | |
| GB201509781D0 (en) | Non-alcoholic fatty liver disease |