SG11201705361PA - Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease - Google Patents
Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver diseaseInfo
- Publication number
- SG11201705361PA SG11201705361PA SG11201705361PA SG11201705361PA SG11201705361PA SG 11201705361P A SG11201705361P A SG 11201705361PA SG 11201705361P A SG11201705361P A SG 11201705361PA SG 11201705361P A SG11201705361P A SG 11201705361PA SG 11201705361P A SG11201705361P A SG 11201705361PA
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- combination therapy
- liver disease
- fatty liver
- alcoholic fatty
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562101726P | 2015-01-09 | 2015-01-09 | |
PCT/US2016/012673 WO2016112305A1 (en) | 2015-01-09 | 2016-01-08 | Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201705361PA true SG11201705361PA (en) | 2017-08-30 |
Family
ID=56356482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201705361PA SG11201705361PA (en) | 2015-01-09 | 2016-01-08 | Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease |
Country Status (13)
Country | Link |
---|---|
US (2) | US20180021341A1 (en) |
EP (2) | EP3242722A4 (en) |
JP (2) | JP2018501276A (en) |
KR (1) | KR20170102299A (en) |
CN (1) | CN107106873A (en) |
AU (1) | AU2016205138A1 (en) |
BR (1) | BR112017014341A2 (en) |
CA (1) | CA2972919A1 (en) |
EA (2) | EA201892625A1 (en) |
HK (2) | HK1243369A1 (en) |
MX (1) | MX2017008844A (en) |
SG (1) | SG11201705361PA (en) |
WO (1) | WO2016112305A1 (en) |
Families Citing this family (73)
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AU2015267148B2 (en) | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
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EA201890949A1 (en) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | ESSENTIAL ETHERIC ACETYL-COA-CARBOXYLASE INHIBITORS AND THEIR OPTIONS |
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US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
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SG10202105768WA (en) | 2016-12-05 | 2021-06-29 | Childrens Hospital Med Ct | Colonic organoids and methods of making and using same |
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US11142531B2 (en) | 2017-03-24 | 2021-10-12 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof |
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CN110475556A (en) * | 2017-03-28 | 2019-11-19 | 吉利德科学公司 | The method for treating liver disease |
AU2018250614A1 (en) * | 2017-04-12 | 2019-10-17 | Gilead Sciences, Inc. | Methods of treating liver disease |
WO2018193007A1 (en) * | 2017-04-18 | 2018-10-25 | Genfit | Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor |
EP3609523B1 (en) * | 2017-04-24 | 2022-03-02 | Tsinghua University | Use of autoinducer-related pathway in inducing apoptosis and anti-infective therapy |
JP2020524181A (en) * | 2017-06-19 | 2020-08-13 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Compounds and methods for the treatment of NAFLD and NASH |
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WO2019020041A1 (en) * | 2017-07-26 | 2019-01-31 | 南京圣和药业股份有限公司 | Compound as acc inhibitor and use thereof |
CN109316601B (en) * | 2017-07-31 | 2021-11-09 | 武汉朗来科技发展有限公司 | Pharmaceutical composition and use thereof |
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US11033601B2 (en) * | 2017-09-14 | 2021-06-15 | The Regents Of The University Of Colorado, A Body Corporate | Selective inhibition of V1b for treating fatty liver |
TWI814744B (en) * | 2017-10-06 | 2023-09-11 | 美商基利科學股份有限公司 | Combination therapy comprising an acc inhibitor |
WO2019085772A1 (en) * | 2017-11-06 | 2019-05-09 | 深圳市图微安创科技开发有限公司 | Treatment of biliary cirrhosis based on oxyntomodulin analogue glp-1r/gcgr dual-target agonist peptide |
CN107693514A (en) * | 2017-12-04 | 2018-02-16 | 威海贯标信息科技有限公司 | A kind of glug arranges net composition |
MA51889A (en) | 2018-01-31 | 2021-05-05 | Heparegenix Gmbh | KINASE MKK4 PROTEIN INHIBITORS TO PROMOTE HEPATIC REGENERATION OR TO REDUCE OR PREVENT HEPATOCYTE DEATH |
US20210113561A1 (en) * | 2018-04-17 | 2021-04-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
WO2019209738A1 (en) * | 2018-04-24 | 2019-10-31 | Ph Pharma Co., Ltd. | Use of neutrophil elastase inhibitors in liver disease |
EP3810139A1 (en) | 2018-06-21 | 2021-04-28 | HepaRegeniX GmbH | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
WO2020016243A1 (en) | 2018-07-16 | 2020-01-23 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
WO2020037023A1 (en) * | 2018-08-14 | 2020-02-20 | Avolynt | Method for treating primary sclerosing cholangitis |
MX2021002428A (en) | 2018-08-31 | 2023-01-02 | Pfizer | Combinations for treatment of nash/nafld and related diseases. |
US20210338826A1 (en) * | 2018-09-06 | 2021-11-04 | Galmed Research And Development Ltd | Combination therapy for the treatment of liver disease |
CN110950884B (en) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | Di-ring derivative-containing inhibitor, preparation method and application thereof |
AU2019385438A1 (en) * | 2018-11-20 | 2021-05-27 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
KR20210114457A (en) | 2019-01-15 | 2021-09-23 | 길리애드 사이언시즈, 인코포레이티드 | FXR (NR1H4) modulating compound |
KR20210129128A (en) | 2019-02-19 | 2021-10-27 | 길리애드 사이언시즈, 인코포레이티드 | Solid Forms of FXR Agonists |
AU2020267576A1 (en) | 2019-05-08 | 2021-12-09 | Aligos Therapeutics, Inc. | Modulators of THR-β and methods of use thereof |
TWI770527B (en) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot modulators and methods of use thereof |
JP7374233B2 (en) * | 2019-07-02 | 2023-11-06 | ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 | Thienopyrimidine derivatives with stereoconfiguration and their applications in drugs |
US20220340561A1 (en) | 2019-07-29 | 2022-10-27 | Heparegenix Gmbh | Heteroaryl-substituted pyrazolo-pyridine protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
AR119594A1 (en) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF |
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WO2021040440A1 (en) * | 2019-08-30 | 2021-03-04 | (주)셀트리온 | Pharmaceutical composition for treating or preventing nonalcoholic steatohepatitis (nash) |
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JP2021134211A (en) | 2020-02-24 | 2021-09-13 | ファイザー・インク | Combinations for treating nafld/nash and related diseases |
JP2022058085A (en) | 2020-02-24 | 2022-04-11 | ファイザー・インク | Combination of inhibitors of diacylglycerol acyltransferase 2 and inhibitors of acetyl-coa carboxylase |
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US11655237B2 (en) | 2020-03-30 | 2023-05-23 | Gilead Sciences, Inc. | Solid forms of a Cot inhibitor compound |
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CN111407892A (en) * | 2020-04-08 | 2020-07-14 | 中国药科大学 | ACS L4 and application thereof in NASH |
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TW202345826A (en) | 2021-06-04 | 2023-12-01 | 美商基利科學股份有限公司 | Methods of treating nash |
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WO2023034381A1 (en) * | 2021-08-31 | 2023-03-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Quantitative systems pharmacology methods for identifying therapeutics for disease states |
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Family Cites Families (8)
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WO2009155611A1 (en) * | 2008-06-20 | 2009-12-23 | Kinemed, Inc. | Compositions for the treatment of fibrotic diseases or conditions |
US20100113473A1 (en) * | 2008-10-30 | 2010-05-06 | Player Mark R | Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor |
WO2012090219A2 (en) * | 2010-12-31 | 2012-07-05 | Jubilant Biosys Ltd. | Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors |
EA030264B1 (en) * | 2011-11-11 | 2018-07-31 | Джилид Аполло, Ллс | Acc inhibitors and uses thereof |
JP6417402B2 (en) | 2013-05-10 | 2018-11-07 | ギリアド アポロ, エルエルシー | ACC inhibitors and uses thereof |
CN105358152A (en) * | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc inhibitors and uses thereof |
EA030942B1 (en) | 2013-05-10 | 2018-10-31 | Джилид Аполло, Ллс | Acc inhibitors and uses thereof |
CA2911822A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
-
2016
- 2016-01-08 EP EP16735485.1A patent/EP3242722A4/en not_active Withdrawn
- 2016-01-08 EA EA201892625A patent/EA201892625A1/en unknown
- 2016-01-08 EA EA201791258A patent/EA201791258A1/en unknown
- 2016-01-08 WO PCT/US2016/012673 patent/WO2016112305A1/en active Application Filing
- 2016-01-08 US US15/541,008 patent/US20180021341A1/en not_active Abandoned
- 2016-01-08 BR BR112017014341-0A patent/BR112017014341A2/en not_active Application Discontinuation
- 2016-01-08 AU AU2016205138A patent/AU2016205138A1/en not_active Abandoned
- 2016-01-08 CN CN201680004801.2A patent/CN107106873A/en active Pending
- 2016-01-08 JP JP2017535411A patent/JP2018501276A/en not_active Withdrawn
- 2016-01-08 KR KR1020177021086A patent/KR20170102299A/en unknown
- 2016-01-08 EP EP19176040.4A patent/EP3597271A1/en not_active Withdrawn
- 2016-01-08 SG SG11201705361PA patent/SG11201705361PA/en unknown
- 2016-01-08 MX MX2017008844A patent/MX2017008844A/en unknown
- 2016-01-08 CA CA2972919A patent/CA2972919A1/en not_active Abandoned
-
2018
- 2018-02-28 HK HK18102859.6A patent/HK1243369A1/en unknown
- 2018-05-04 HK HK18105783.0A patent/HK1246232A1/en unknown
-
2019
- 2019-05-13 US US16/410,894 patent/US20190381045A1/en not_active Abandoned
-
2020
- 2020-04-15 JP JP2020072689A patent/JP2020109130A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2018501276A (en) | 2018-01-18 |
JP2020109130A (en) | 2020-07-16 |
HK1246232A1 (en) | 2018-09-07 |
MX2017008844A (en) | 2018-03-14 |
EP3242722A4 (en) | 2018-07-11 |
CA2972919A1 (en) | 2016-07-14 |
AU2016205138A1 (en) | 2017-07-13 |
BR112017014341A2 (en) | 2018-03-27 |
US20180021341A1 (en) | 2018-01-25 |
EP3242722A1 (en) | 2017-11-15 |
EP3597271A1 (en) | 2020-01-22 |
HK1243369A1 (en) | 2018-07-13 |
EA201892625A1 (en) | 2019-07-31 |
WO2016112305A1 (en) | 2016-07-14 |
CN107106873A (en) | 2017-08-29 |
KR20170102299A (en) | 2017-09-08 |
EA201791258A1 (en) | 2017-12-29 |
US20190381045A1 (en) | 2019-12-19 |
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