JP2018104454A5 - - Google Patents
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- JP2018104454A5 JP2018104454A5 JP2018028819A JP2018028819A JP2018104454A5 JP 2018104454 A5 JP2018104454 A5 JP 2018104454A5 JP 2018028819 A JP2018028819 A JP 2018028819A JP 2018028819 A JP2018028819 A JP 2018028819A JP 2018104454 A5 JP2018104454 A5 JP 2018104454A5
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- JP
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- Prior art keywords
- disorder
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 30
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 208000035475 disorder Diseases 0.000 claims 11
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 208000028017 Psychotic disease Diseases 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000004103 aminoalkyl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- -1 nitro, amino, hydroxyl Chemical group 0.000 claims 6
- 201000000980 schizophrenia Diseases 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 208000019022 Mood disease Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- YYPNNBPPDFTQFX-UHFFFAOYSA-N 2-thiophen-3-ylethanol Chemical compound OCCC=1C=CSC=1 YYPNNBPPDFTQFX-UHFFFAOYSA-N 0.000 claims 2
- 208000017194 Affective disease Diseases 0.000 claims 2
- 206010001497 Agitation Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 238000013019 agitation Methods 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 208000022821 personality disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000698 schizophrenic effect Effects 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- DEWAOGITEZGETP-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1-benzothiophen-4-ylmethanamine Chemical compound NCC1CCCC2=C1C=CS2 DEWAOGITEZGETP-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 208000009625 Lesch-Nyhan syndrome Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000027099 Paranoid disease Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 208000019568 Shared Paranoid disease Diseases 0.000 claims 1
- 208000028810 Shared psychotic disease Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- 208000011963 Substance-induced psychotic disease Diseases 0.000 claims 1
- 231100000393 Substance-induced psychotic disorder Toxicity 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000018839 Wilson disease Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000016571 aggressive behavior Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 201000002545 drug psychosis Diseases 0.000 claims 1
- 208000024732 dysthymic disease Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002964 excitative effect Effects 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- IVBHFRNHMUYYEM-UHFFFAOYSA-N methyl 2-formylpyrrolidine-1-carboxylate Chemical compound COC(=O)N1CCCC1C=O IVBHFRNHMUYYEM-UHFFFAOYSA-N 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000036651 mood Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 238000004007 reversed phase HPLC Methods 0.000 claims 1
- 208000012672 seasonal affective disease Diseases 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 231100000872 sexual dysfunction Toxicity 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- 0 *C(*)(CC(*)(c1c2c(*)c(*)[s]1)OC*C*2=C)N(*)* Chemical compound *C(*)(CC(*)(c1c2c(*)c(*)[s]1)OC*C*2=C)N(*)* 0.000 description 2
- SFQWDWPFWSGOEX-UHFFFAOYSA-N Cc1c[s]c2c1C(CNC)CC2 Chemical compound Cc1c[s]c2c1C(CNC)CC2 SFQWDWPFWSGOEX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26688009P | 2009-12-04 | 2009-12-04 | |
| US61/266,880 | 2009-12-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016191898A Division JP6297655B2 (ja) | 2009-12-04 | 2016-09-29 | 多環式化合物及びその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020108727A Division JP7104746B2 (ja) | 2009-12-04 | 2020-06-24 | 多環式化合物及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018104454A JP2018104454A (ja) | 2018-07-05 |
| JP2018104454A5 true JP2018104454A5 (https=) | 2018-11-08 |
Family
ID=44115515
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542219A Active JP5778168B2 (ja) | 2009-12-04 | 2010-12-03 | 多環式化合物及びその使用方法 |
| JP2014253082A Active JP5710064B1 (ja) | 2009-12-04 | 2014-12-15 | 多環式化合物及びその使用方法 |
| JP2015136603A Active JP6005807B2 (ja) | 2009-12-04 | 2015-07-08 | 多環式化合物及びその使用方法 |
| JP2016131247A Active JP6028310B1 (ja) | 2009-12-04 | 2016-07-01 | 多環式化合物及びその使用方法 |
| JP2016191898A Active JP6297655B2 (ja) | 2009-12-04 | 2016-09-29 | 多環式化合物及びその使用方法 |
| JP2018028819A Pending JP2018104454A (ja) | 2009-12-04 | 2018-02-21 | 多環式化合物及びその使用方法 |
| JP2020108727A Active JP7104746B2 (ja) | 2009-12-04 | 2020-06-24 | 多環式化合物及びその使用方法 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542219A Active JP5778168B2 (ja) | 2009-12-04 | 2010-12-03 | 多環式化合物及びその使用方法 |
| JP2014253082A Active JP5710064B1 (ja) | 2009-12-04 | 2014-12-15 | 多環式化合物及びその使用方法 |
| JP2015136603A Active JP6005807B2 (ja) | 2009-12-04 | 2015-07-08 | 多環式化合物及びその使用方法 |
| JP2016131247A Active JP6028310B1 (ja) | 2009-12-04 | 2016-07-01 | 多環式化合物及びその使用方法 |
| JP2016191898A Active JP6297655B2 (ja) | 2009-12-04 | 2016-09-29 | 多環式化合物及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020108727A Active JP7104746B2 (ja) | 2009-12-04 | 2020-06-24 | 多環式化合物及びその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (9) | US8710245B2 (https=) |
| EP (2) | EP3252057B1 (https=) |
| JP (7) | JP5778168B2 (https=) |
| KR (7) | KR102307413B1 (https=) |
| CN (5) | CN106883246B (https=) |
| AU (3) | AU2010325925B2 (https=) |
| BR (2) | BR112012013431B1 (https=) |
| CA (2) | CA2781716A1 (https=) |
| DK (2) | DK3252057T3 (https=) |
| ES (2) | ES2978959T3 (https=) |
| FI (1) | FI3252057T3 (https=) |
| HK (1) | HK1212969A1 (https=) |
| IL (6) | IL272376B2 (https=) |
| MX (3) | MX388468B (https=) |
| NZ (5) | NZ600008A (https=) |
| PT (2) | PT2507245T (https=) |
| RU (3) | RU2557059C2 (https=) |
| SG (3) | SG10201510665WA (https=) |
| WO (1) | WO2011069063A2 (https=) |
| ZA (1) | ZA201203533B (https=) |
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| CA2864085C (en) | 2012-02-08 | 2021-11-23 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| CN103755727B (zh) * | 2013-12-20 | 2015-12-30 | 南京华威医药科技开发有限公司 | 布林佐胺中间体制备方法 |
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| LT3186257T (lt) | 2014-08-27 | 2019-04-25 | Prexton Therapeutics Sa | Nauji chromono oksimo dariniai ir jų panaudojimas kaip metabotropinių gliutamato receptorių alosterinių moduliatorių |
| CN104193722A (zh) * | 2014-08-27 | 2014-12-10 | 湖南华腾制药有限公司 | 一种n-叔丁氧羰基-3-甲胺噻吩的制备方法 |
| PL3256466T3 (pl) * | 2015-02-11 | 2022-05-23 | Sunovion Pharmaceuticals Inc. | Związki 1-heterocykliloizochromanylu i analogi do leczenia zaburzeń oun |
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| RU2018110580A (ru) | 2015-08-27 | 2019-09-30 | Прекстон Терапьютикс Са | Проникающее в мозг производное оксима хромона для терапии леводопа-индуцированной дискинезии |
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| CA3032141A1 (en) | 2016-07-29 | 2018-02-01 | Vadim ALEXANDROV | Compounds and compositions and uses thereof |
| UA125519C2 (uk) | 2016-07-29 | 2022-04-13 | Суновіон Фармасьютікалз Інк. | Сполуки і композиції і їх застосування |
| IL268694B2 (en) * | 2017-02-16 | 2023-10-01 | Sunovion Pharmaceuticals Inc | Treatment of schizophrenia |
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| BR112020001433A2 (pt) | 2017-08-02 | 2020-07-28 | Sunovion Pharmaceuticals Inc. | compostos de isocromano e usos dos mesmos |
| JP2021513972A (ja) * | 2018-02-16 | 2021-06-03 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 社会的機能障害の治療方法 |
| EA202091945A1 (ru) * | 2018-02-16 | 2021-01-18 | Суновион Фармасьютикалз Инк. | Соли, кристаллические формы и способы их получения |
| CN118576586A (zh) | 2018-12-06 | 2024-09-03 | 住友制药美国公司 | 治疗神经和精神疾病的方法 |
| MX2021010880A (es) | 2019-03-14 | 2022-01-18 | Sunovion Pharmaceuticals Inc | Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas. |
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