JP2022513933A5 - - Google Patents

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Publication number
JP2022513933A5
JP2022513933A5 JP2021534641A JP2021534641A JP2022513933A5 JP 2022513933 A5 JP2022513933 A5 JP 2022513933A5 JP 2021534641 A JP2021534641 A JP 2021534641A JP 2021534641 A JP2021534641 A JP 2021534641A JP 2022513933 A5 JP2022513933 A5 JP 2022513933A5
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JP
Japan
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JP2021534641A
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Japanese (ja)
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JP7645797B2 (ja
JP2022513933A (ja
JPWO2020131918A5 (https=
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Priority claimed from PCT/US2019/066923 external-priority patent/WO2020131918A1/en
Publication of JP2022513933A publication Critical patent/JP2022513933A/ja
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Publication of JPWO2020131918A5 publication Critical patent/JPWO2020131918A5/ja
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JP2021534641A 2018-12-17 2019-12-17 有機化合物 Active JP7645797B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862780703P 2018-12-17 2018-12-17
US62/780,703 2018-12-17
PCT/US2019/066923 WO2020131918A1 (en) 2018-12-17 2019-12-17 Organic compounds

Publications (4)

Publication Number Publication Date
JP2022513933A JP2022513933A (ja) 2022-02-09
JP2022513933A5 true JP2022513933A5 (https=) 2022-12-23
JPWO2020131918A5 JPWO2020131918A5 (https=) 2022-12-23
JP7645797B2 JP7645797B2 (ja) 2025-03-14

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ID=71100855

Family Applications (1)

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JP2021534641A Active JP7645797B2 (ja) 2018-12-17 2019-12-17 有機化合物

Country Status (11)

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US (1) US12325726B2 (https=)
EP (1) EP3897656A4 (https=)
JP (1) JP7645797B2 (https=)
KR (1) KR102931436B1 (https=)
CN (1) CN113226326B (https=)
AU (1) AU2019406803B2 (https=)
BR (1) BR112021011765A2 (https=)
CA (1) CA3121636A1 (https=)
IL (1) IL283960B2 (https=)
MX (1) MX2021007142A (https=)
WO (1) WO2020131918A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10562930B1 (en) 2018-08-31 2020-02-18 Praxis Precision Medicines, Inc. Salts and crystal forms of GABAA positive allosteric modulator
AU2019406803B2 (en) 2018-12-17 2025-04-24 Intra-Cellular Therapies, Inc. Organic compounds
WO2021168106A1 (en) * 2020-02-18 2021-08-26 Praxis Precision Medicines, Inc. Deuterated neurosteroid
JP2023539125A (ja) * 2020-08-20 2023-09-13 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
WO2023159094A2 (en) * 2022-02-16 2023-08-24 Praxis Precision Medicines, Inc. PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232917A (en) 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
KR100338287B1 (ko) 1994-02-14 2002-11-30 푸르듀 파머 리미티드 감마-아미노부티르산a수용체의알로오스테리조절용안드로스탄및프레그난
US5939545A (en) 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
CN1087725C (zh) * 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
UA73736C2 (en) * 1999-04-29 2005-09-15 Euro Celtic S A Method for alleviating or preventing insomnia and inducing anesthesia
WO2005105822A2 (en) 2004-04-23 2005-11-10 Euro-Celtique S.A. 3-alpha-hydroxy 21-n- heteroaryl-pregnane derivatives for modulation of brain excitability and a process for the production thereof
US20060074059A1 (en) 2004-08-26 2006-04-06 Goliber Philip A Isomorphic crystalline habits of 3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha-pregnane-20-one
RS51304B (sr) * 2005-06-09 2010-12-31 Euro-Celtique S.A. Farmaceutske kompozicije neuroaktivnog steroida i njihova upotreba
JP6470258B2 (ja) 2013-04-17 2019-02-13 セージ セラピューティクス, インコーポレイテッド 19−ノルc3,3−ジ置換c21−n−ピラゾリルステロイドおよびその使用方法
US10577390B2 (en) * 2014-10-16 2020-03-03 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
ME03809B (me) * 2014-10-16 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
CN105985396A (zh) * 2015-02-16 2016-10-05 苏州泽璟生物制药有限公司 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物
EP4155314A1 (en) * 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
EP3720867A1 (en) 2017-12-08 2020-10-14 Sage Therapeutics, Inc. Deuterated 21 -[4-cyano-pyrazol-1 -yl]-19-nor-pregan-3. alpha-ol-20-one derivatives for treating cns disorders
AU2019406803B2 (en) 2018-12-17 2025-04-24 Intra-Cellular Therapies, Inc. Organic compounds
JP2023539125A (ja) 2020-08-20 2023-09-13 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物

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