JP2020517607A5 - - Google Patents
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- JP2020517607A5 JP2020517607A5 JP2019556587A JP2019556587A JP2020517607A5 JP 2020517607 A5 JP2020517607 A5 JP 2020517607A5 JP 2019556587 A JP2019556587 A JP 2019556587A JP 2019556587 A JP2019556587 A JP 2019556587A JP 2020517607 A5 JP2020517607 A5 JP 2020517607A5
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- JP
- Japan
- Prior art keywords
- item
- compound according
- pharmaceutically acceptable
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- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762487413P | 2017-04-19 | 2017-04-19 | |
| US62/487,413 | 2017-04-19 | ||
| US201862652837P | 2018-04-04 | 2018-04-04 | |
| US62/652,837 | 2018-04-04 | ||
| PCT/US2018/028031 WO2018195121A1 (en) | 2017-04-19 | 2018-04-17 | Vmat2 inhibitor compounds and compositions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517607A JP2020517607A (ja) | 2020-06-18 |
| JP2020517607A5 true JP2020517607A5 (https=) | 2021-05-27 |
| JP7170662B2 JP7170662B2 (ja) | 2022-11-14 |
Family
ID=62111264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556587A Active JP7170662B2 (ja) | 2017-04-19 | 2018-04-17 | Ｖｍａｔ２インヒビター化合物およびその組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11040970B2 (https=) |
| EP (1) | EP3612532B1 (https=) |
| JP (1) | JP7170662B2 (https=) |
| KR (1) | KR20190140968A (https=) |
| CN (1) | CN110770236B (https=) |
| AU (1) | AU2018254429A1 (https=) |
| BR (1) | BR112019021853A2 (https=) |
| CA (1) | CA3060251A1 (https=) |
| CL (1) | CL2019002919A1 (https=) |
| CO (1) | CO2019011604A2 (https=) |
| ES (1) | ES2971230T3 (https=) |
| JO (1) | JOP20190239A1 (https=) |
| MA (1) | MA50145A (https=) |
| MX (1) | MX2019012336A (https=) |
| PE (1) | PE20191784A1 (https=) |
| TW (1) | TW201841913A (https=) |
| WO (1) | WO2018195121A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018140092A1 (en) | 2017-01-27 | 2018-08-02 | Obrien Christopher F | Methods for the administration of certain vmat2 inhibitors |
| ES3024958T3 (en) | 2017-09-21 | 2025-06-05 | Neurocrine Biosciences Inc | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
| JP2021502959A (ja) | 2017-10-10 | 2021-02-04 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| MX2020013004A (es) * | 2018-06-14 | 2021-02-17 | Neurocrine Biosciences Inc | Compuestos inhibidores del transportador de monoamina 2 (vmat2), composiciones, y metodos relacionados con los mismos. |
| SG11202100303QA (en) | 2018-08-15 | 2021-02-25 | Neurocrine Biosciences Inc | Methods for the administration of certain vmat2 inhibitors |
| WO2020086765A1 (en) * | 2018-10-24 | 2020-04-30 | Neurocrine Biosciences, Inc. | Processes for preparing a vmat2 inhibitor |
| WO2021067217A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| PT4168409T (pt) | 2021-03-22 | 2025-06-12 | Neurocrine Biosciences Inc | Inibidores de vmat2 e métodos de utilização |
| WO2022232380A1 (en) | 2021-04-29 | 2022-11-03 | Neurocrine Biosciences, Inc. | Processes for preparing a vmat2 inhibitor |
| US20250064990A1 (en) | 2021-08-20 | 2025-02-27 | Neurocrine Biosciences, Inc. | Methods of screening for vmat2 inhibitors |
| WO2026050236A1 (en) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Muscarinic receptor agonist in combination with a vesicular monoamine transporter 2 inhibitor, for use in the treatment of a neurological or psychiatric disorder |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798119A (en) | 1995-06-13 | 1998-08-25 | S. C. Johnson & Son, Inc. | Osmotic-delivery devices having vapor-permeable coatings |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| RU2339636C2 (ru) | 2003-06-20 | 2008-11-27 | Ф.Хоффманн-Ля Рош Аг | Гексагидропиридоизохинолины в качестве ингибиторов дипептидилпептидазы iv (dpp-iv) |
| AU2005272773A1 (en) | 2004-08-13 | 2006-02-23 | Omeros Corporation | Novel serotonin receptor ligands and their uses thereof |
| PL2081929T3 (pl) | 2006-11-08 | 2013-06-28 | Neurocrine Biosciences Inc | Podstawione związki 3-izobutylo-9,10-dimetoksy-1,3,4,6,7,11b-heksahydro-2H-pirydo[2,1-a]izochinolin-2-olowe i ich wytwarzania |
| FR2912145B1 (fr) | 2007-02-02 | 2009-03-06 | Servier Lab | Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2009126305A1 (en) | 2008-04-11 | 2009-10-15 | The Trustees Of Columbia University | Glucose metabolism modulating compounds |
| WO2010044981A2 (en) | 2008-09-18 | 2010-04-22 | Auspex Pharmaceutical ,Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CA2784830C (en) | 2009-12-18 | 2018-03-27 | Sunovion Pharmaceuticals Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| CN102285984B (zh) | 2010-11-25 | 2012-10-10 | 江苏威凯尔医药科技有限公司 | (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法 |
| WO2014043866A1 (zh) | 2012-09-19 | 2014-03-27 | 中国科学院福建物质结构研究所 | 噻吩[2,3-d]嘧啶衍生物、其制备方法及其用途 |
| NZ760790A (en) | 2014-02-07 | 2022-11-25 | Neurocrine Biosciences Inc | Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof |
| CA2974540C (en) * | 2015-02-06 | 2023-09-26 | Neurocrine Biosciences, Inc. | [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto |
| EP3558990B1 (en) | 2016-12-22 | 2022-08-10 | Incyte Corporation | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
| AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
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2017
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- 2018-04-17 CA CA3060251A patent/CA3060251A1/en active Pending
- 2018-04-17 ES ES18722357T patent/ES2971230T3/es active Active
- 2018-04-17 KR KR1020197033620A patent/KR20190140968A/ko not_active Withdrawn
- 2018-04-17 BR BR112019021853-0A patent/BR112019021853A2/pt not_active Application Discontinuation
- 2018-04-17 JP JP2019556587A patent/JP7170662B2/ja active Active
- 2018-04-17 CN CN201880040884.XA patent/CN110770236B/zh active Active
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- 2018-04-17 WO PCT/US2018/028031 patent/WO2018195121A1/en not_active Ceased
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