JP2011530521A5 - - Google Patents
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- Publication number
- JP2011530521A5 JP2011530521A5 JP2011522195A JP2011522195A JP2011530521A5 JP 2011530521 A5 JP2011530521 A5 JP 2011530521A5 JP 2011522195 A JP2011522195 A JP 2011522195A JP 2011522195 A JP2011522195 A JP 2011522195A JP 2011530521 A5 JP2011530521 A5 JP 2011530521A5
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- JP
- Japan
- Prior art keywords
- substituted
- disorder
- use according
- compound according
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- -1 4-bromo-3,5-dimethoxyphenyl Chemical group 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000027448 Attention Deficit and Disruptive Behavior disease Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000006373 Bell palsy Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010012239 Delusion Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 208000036826 VIIth nerve paralysis Diseases 0.000 claims 1
- 201000007201 aphasia Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 230000019771 cognition Effects 0.000 claims 1
- 231100000868 delusion Toxicity 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035548 disruptive behavior disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000002545 drug psychosis Diseases 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000019899 phobic disease Diseases 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8640608P | 2008-08-05 | 2008-08-05 | |
| US61/086,406 | 2008-08-05 | ||
| US11808808P | 2008-11-26 | 2008-11-26 | |
| US61/118,088 | 2008-11-26 | ||
| US21831109P | 2009-06-18 | 2009-06-18 | |
| US61/218,311 | 2009-06-18 | ||
| PCT/US2009/052754 WO2010017236A1 (en) | 2008-08-05 | 2009-08-04 | Pde10 inhibitors and related compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530521A JP2011530521A (ja) | 2011-12-22 |
| JP2011530521A5 true JP2011530521A5 (https=) | 2012-09-13 |
| JP5759893B2 JP5759893B2 (ja) | 2015-08-05 |
Family
ID=41653504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522195A Active JP5759893B2 (ja) | 2008-08-05 | 2009-08-04 | Ｐｄｅ１０阻害剤ならびに関連する組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8377930B2 (https=) |
| EP (1) | EP2310016B1 (https=) |
| JP (1) | JP5759893B2 (https=) |
| CN (1) | CN102143752B (https=) |
| AU (1) | AU2009279756B2 (https=) |
| CA (1) | CA2733378C (https=) |
| ES (1) | ES2654617T3 (https=) |
| NZ (1) | NZ590951A (https=) |
| WO (1) | WO2010017236A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7786139B2 (en) * | 2006-11-21 | 2010-08-31 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| AU2009279756B2 (en) | 2008-08-05 | 2015-01-29 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| FR2936784B1 (fr) | 2008-10-08 | 2010-10-08 | Gaztransp Et Technigaz | Cuve a membrane ondulee renforcee |
| KR101713453B1 (ko) * | 2010-03-12 | 2017-03-07 | 오메로스 코포레이션 | Pde10 억제제 및 관련 조성물 및 방법 |
| US9132136B2 (en) | 2010-08-02 | 2015-09-15 | Hoffmann-La Roche Inc. | Pharmaceutical combination |
| US8765760B2 (en) | 2011-01-11 | 2014-07-01 | Sunovion Pharmaceuticals, Inc. | [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases |
| CA2827724A1 (en) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| JP5955531B2 (ja) * | 2011-11-07 | 2016-07-20 | 千葉県 | 抗癌剤 |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US10039764B2 (en) | 2013-07-12 | 2018-08-07 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| NZ630803A (en) * | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
| NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| KR20170139074A (ko) | 2015-04-24 | 2017-12-18 | 오메로스 코포레이션 | Pde10 억제제 및 관련 조성물 및 방법 |
| WO2017079678A1 (en) | 2015-11-04 | 2017-05-11 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
| US10927070B2 (en) | 2016-06-09 | 2021-02-23 | Cedars-Sinai Medical Center | Compositions and methods for treating cancer |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2615188B1 (fr) * | 1987-05-14 | 1989-11-17 | Meram Laboratoires Sa | Derives d'hydrazine, procede d'obtention et compositions pharmaceutiques les contenant |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| MXPA02007252A (es) * | 2000-01-28 | 2003-01-29 | Rohm & Haas | Compuestos farmaceuticos con propiedades mejoradas. |
| US20030032579A1 (en) * | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| GB0223665D0 (en) | 2002-10-10 | 2002-11-20 | Syngenta Participations Ag | Organic compounds |
| DE10346913A1 (de) * | 2003-10-09 | 2005-05-04 | Merck Patent Gmbh | Acylhydrazonderivate |
| US9649295B2 (en) * | 2004-01-21 | 2017-05-16 | Cornell Research Foundation, Inc. | Chemical inhibitors of soluble adenylyl cyclase (sAC) |
| AU2005218724A1 (en) | 2004-03-08 | 2005-09-15 | Merck Patent Gmbh | Methods for altering insulin secretion |
| RU2006135653A (ru) | 2004-03-11 | 2008-04-20 | Мерк Патент ГмбХ (DE) | Способы, препятствующие фиброзу |
| KR20070015148A (ko) | 2004-03-11 | 2007-02-01 | 메르크 파텐트 게엠베하 | 혈청 및 글루코코르티코이드 유도가능한 키나아제의조절제의 용도를 포함하는 신경정신학적 장애를 치료하기위한 글루탐산 수용체의 조절 방법 |
| WO2006121684A2 (en) | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International, Gmbh | Acyl hydrazones for treating cardiovascular diseases |
| US7786139B2 (en) | 2006-11-21 | 2010-08-31 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| EP2083819B1 (en) * | 2006-11-21 | 2017-02-22 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009143178A2 (en) * | 2008-05-20 | 2009-11-26 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| AU2009279756B2 (en) | 2008-08-05 | 2015-01-29 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| KR101713453B1 (ko) | 2010-03-12 | 2017-03-07 | 오메로스 코포레이션 | Pde10 억제제 및 관련 조성물 및 방법 |
-
2009
- 2009-08-04 AU AU2009279756A patent/AU2009279756B2/en active Active
- 2009-08-04 WO PCT/US2009/052754 patent/WO2010017236A1/en not_active Ceased
- 2009-08-04 CA CA2733378A patent/CA2733378C/en active Active
- 2009-08-04 CN CN200980134364.6A patent/CN102143752B/zh active Active
- 2009-08-04 NZ NZ590951A patent/NZ590951A/xx unknown
- 2009-08-04 ES ES09805466.1T patent/ES2654617T3/es active Active
- 2009-08-04 US US12/535,598 patent/US8377930B2/en active Active
- 2009-08-04 EP EP09805466.1A patent/EP2310016B1/en active Active
- 2009-08-04 JP JP2011522195A patent/JP5759893B2/ja active Active
-
2013
- 2013-01-15 US US13/742,199 patent/US9783521B2/en active Active
-
2017
- 2017-09-01 US US15/694,342 patent/US20180118711A1/en not_active Abandoned
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