JP2010540509A5 - - Google Patents
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- Publication number
- JP2010540509A5 JP2010540509A5 JP2010526364A JP2010526364A JP2010540509A5 JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5 JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- compound according
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 230000002062 proliferating effect Effects 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719038.2 | 2007-09-28 | ||
| GB0719038A GB0719038D0 (en) | 2007-09-28 | 2007-09-28 | Compound |
| GB0806844A GB0806844D0 (en) | 2008-04-15 | 2008-04-15 | Compound |
| GB0806844.7 | 2008-04-15 | ||
| PCT/GB2008/003305 WO2009040556A1 (en) | 2007-09-28 | 2008-09-29 | Pyrimidine derivatives as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Division JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540509A JP2010540509A (ja) | 2010-12-24 |
| JP2010540509A5 true JP2010540509A5 (https=) | 2011-10-06 |
| JP5410432B2 JP5410432B2 (ja) | 2014-02-05 |
Family
ID=40199600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526364A Active JP5410432B2 (ja) | 2007-09-28 | 2008-09-29 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
| JP2013230231A Expired - Fee Related JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Expired - Fee Related JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8563542B2 (https=) |
| EP (2) | EP2610256B1 (https=) |
| JP (2) | JP5410432B2 (https=) |
| CN (1) | CN101878216B (https=) |
| CA (1) | CA2700979C (https=) |
| ES (2) | ES2585110T3 (https=) |
| PL (2) | PL2205603T3 (https=) |
| RU (2) | RU2478100C2 (https=) |
| WO (1) | WO2009040556A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622463B2 (en) | 2006-02-14 | 2009-11-24 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| AU2008287339A1 (en) | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| EP2205241B1 (en) | 2007-09-25 | 2014-05-21 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| PL2205603T3 (pl) | 2007-09-28 | 2014-07-31 | Cyclacel Ltd | Pochodne pirymidyny jako inhibitory kinaz białkowych |
| MX2011000021A (es) | 2008-06-23 | 2011-02-24 | Vertex Pharma | Inhibidores de proteina cinasas. |
| AU2009271658B2 (en) * | 2008-06-23 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| LT3141252T (lt) | 2009-06-17 | 2018-11-12 | Vertex Pharmaceuticals Inc. | Gripo virusų replikacijos inhibitoriai |
| CN103492391A (zh) | 2009-09-25 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
| CN102548994A (zh) | 2009-09-25 | 2012-07-04 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
| ES2577829T3 (es) | 2010-06-04 | 2016-07-19 | F. Hoffmann-La Roche Ag | Derivados de aminopirimidina como moduladores de la LRRK2 |
| NO2638031T3 (https=) | 2010-11-10 | 2018-03-10 | ||
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| GB201205752D0 (en) * | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
| WO2014145909A2 (en) | 2013-03-15 | 2014-09-18 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone compounds and methods of treating disorders |
| US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| JP6618901B2 (ja) | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| LT3068776T (lt) | 2013-11-13 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitoriai |
| EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| KR101517414B1 (ko) * | 2014-04-24 | 2015-05-04 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| EP3546473B1 (en) | 2014-12-16 | 2025-12-10 | Kayla Therapeutics | Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| EP3347021A4 (en) | 2015-09-11 | 2019-07-24 | Dana-Farber Cancer Institute, Inc. | CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF |
| WO2017066428A1 (en) | 2015-10-13 | 2017-04-20 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Brd4-kinase inhibitors as cancer therapeutics |
| MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| MX387025B (es) * | 2016-03-04 | 2025-03-19 | Anhui New Star Pharmaceutical Dev Co Ltd | Compuestos de anillo de siete miembros de pirimidina |
| KR20180132812A (ko) * | 2016-04-07 | 2018-12-12 | 다나-파버 캔서 인스티튜트 인크. | 피리미도-디아제피논 키나아제 스캐폴드 화합물 및 ｐｉ3ｋ-매개된 장애의 치료 방법 |
| US11939320B2 (en) | 2017-11-02 | 2024-03-26 | Abbvie Inc. | Modulators of the integrated stress pathway |
| SG11202004009TA (en) * | 2017-11-02 | 2020-05-28 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| KR20220047822A (ko) * | 2019-08-16 | 2022-04-19 | 싸이클라셀 리미티드 | 피리미디노 디아제핀 유도체의 결정질 형태 |
| US12570660B2 (en) | 2019-08-16 | 2026-03-10 | Cyclacel Pharmaceuticals, Inc | Process for the preparation of a pyrimidino-diazepine derivative |
| US12551563B2 (en) | 2019-09-27 | 2026-02-17 | Dana-Farber Cancer Institute, Inc. | ERK5 degraders as therapeutics in cancer and inflammatory diseases |
| AU2023248848A1 (en) | 2022-04-08 | 2024-10-17 | Inhibrx Biosciences, Inc. | Dr5 agonist and plk1 inhibitor or cdk inhibitor combination therapy |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9117635D0 (en) | 1991-08-15 | 1991-10-02 | British Telecomm | Phase shifter |
| GB0302220D0 (en) | 2003-01-30 | 2003-03-05 | Cyclacel Ltd | Use |
| JP3876265B2 (ja) | 2003-02-26 | 2007-01-31 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | ジヒドロプテリジノン、その製造方法及び薬物形態での使用 |
| US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| WO2005117944A2 (en) | 2004-05-26 | 2005-12-15 | The Texas A & M University System | Hsp20 inhibits amyloidogenesis and neurotoxicity |
| CN102766142A (zh) * | 2004-10-04 | 2012-11-07 | 千禧药品公司 | 有效作为蛋白激酶抑制剂的内酰胺化合物 |
| CA2612723A1 (en) | 2005-06-24 | 2007-01-04 | Eli Lilly And Company | Tetrahydrocarbazole derivatives useful as androgen receptor modulators |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| US7622463B2 (en) * | 2006-02-14 | 2009-11-24 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
| AU2008228303B2 (en) * | 2007-03-22 | 2012-04-19 | Takeda Pharmaceutical Company Limited | Substituted pyrimidodiazepines useful as PLK1 inhibitors |
| EP2205241B1 (en) * | 2007-09-25 | 2014-05-21 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| PL2205603T3 (pl) | 2007-09-28 | 2014-07-31 | Cyclacel Ltd | Pochodne pirymidyny jako inhibitory kinaz białkowych |
| US20090291938A1 (en) * | 2007-11-19 | 2009-11-26 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| US8710068B2 (en) | 2009-01-19 | 2014-04-29 | The Trustees Of The University Of Pennsylvania | Method of treating cancer using a survivin inhibitor |
| GB201205752D0 (en) | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
-
2008
- 2008-09-29 PL PL08806455T patent/PL2205603T3/pl unknown
- 2008-09-29 EP EP13156251.4A patent/EP2610256B1/en active Active
- 2008-09-29 JP JP2010526364A patent/JP5410432B2/ja active Active
- 2008-09-29 PL PL13156251.4T patent/PL2610256T3/pl unknown
- 2008-09-29 US US12/680,353 patent/US8563542B2/en active Active
- 2008-09-29 CN CN2008801182902A patent/CN101878216B/zh active Active
- 2008-09-29 ES ES13156251.4T patent/ES2585110T3/es active Active
- 2008-09-29 ES ES08806455T patent/ES2457394T3/es active Active
- 2008-09-29 WO PCT/GB2008/003305 patent/WO2009040556A1/en not_active Ceased
- 2008-09-29 RU RU2010116759/04A patent/RU2478100C2/ru active
- 2008-09-29 CA CA2700979A patent/CA2700979C/en active Active
- 2008-09-29 EP EP20080806455 patent/EP2205603B1/en active Active
-
2013
- 2013-02-26 RU RU2013108456A patent/RU2623221C2/ru active
- 2013-06-05 US US13/910,349 patent/US9133199B2/en active Active
- 2013-11-06 JP JP2013230231A patent/JP5863196B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-07 US US14/820,711 patent/US9493471B2/en not_active Expired - Fee Related
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