JP2018058890A5 - - Google Patents
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- JP2018058890A5 JP2018058890A5 JP2017237313A JP2017237313A JP2018058890A5 JP 2018058890 A5 JP2018058890 A5 JP 2018058890A5 JP 2017237313 A JP2017237313 A JP 2017237313A JP 2017237313 A JP2017237313 A JP 2017237313A JP 2018058890 A5 JP2018058890 A5 JP 2018058890A5
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- Prior art keywords
- disorder
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- schizophrenia
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- 150000001875 compounds Chemical class 0.000 claims 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 201000000980 schizophrenia Diseases 0.000 claims 10
- 208000028017 Psychotic disease Diseases 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 208000028698 Cognitive impairment Diseases 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 208000010877 cognitive disease Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 208000016285 Movement disease Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 208000017194 Affective disease Diseases 0.000 claims 1
- 206010001497 Agitation Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 208000024254 Delusional disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000027465 Psychotic Affective disease Diseases 0.000 claims 1
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 208000030988 Schizoid Personality disease Diseases 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 208000011963 Substance-induced psychotic disease Diseases 0.000 claims 1
- 231100000393 Substance-induced psychotic disorder Toxicity 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims 1
- 208000021017 Weight Gain Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 230000016571 aggressive behavior Effects 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 201000003104 endogenous depression Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000002964 excitative effect Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
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- 208000030159 metabolic disease Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000036651 mood Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 208000024817 paranoid personality disease Diseases 0.000 claims 1
- 208000002851 paranoid schizophrenia Diseases 0.000 claims 1
- 208000022821 personality disease Diseases 0.000 claims 1
- 208000024335 physical disease Diseases 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000000698 schizophrenic effect Effects 0.000 claims 1
- 208000012672 seasonal affective disease Diseases 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 231100000736 substance abuse Toxicity 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 0 C*****(*1)*(C)C(C)NC1C1CCCC1 Chemical compound C*****(*1)*(C)C(C)NC1C1CCCC1 0.000 description 11
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- CATDHNSGUMFFIY-UHFFFAOYSA-N C[n]1c(ccc2ncccc22)c2nc1CCc1nc(cccc2)c2[o]1 Chemical compound C[n]1c(ccc2ncccc22)c2nc1CCc1nc(cccc2)c2[o]1 CATDHNSGUMFFIY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161431769P | 2011-01-11 | 2011-01-11 | |
| US61/431,769 | 2011-01-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016028453A Division JP6261631B2 (ja) | 2011-01-11 | 2016-02-18 | ヘテロアリール化合物及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018058890A JP2018058890A (ja) | 2018-04-12 |
| JP2018058890A5 true JP2018058890A5 (https=) | 2018-05-31 |
Family
ID=46455746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549487A Expired - Fee Related JP6106603B2 (ja) | 2011-01-11 | 2012-01-10 | ヘテロアリール化合物及びその使用方法 |
| JP2016028453A Expired - Fee Related JP6261631B2 (ja) | 2011-01-11 | 2016-02-18 | ヘテロアリール化合物及びその使用方法 |
| JP2017237313A Pending JP2018058890A (ja) | 2011-01-11 | 2017-12-12 | ヘテロアリール化合物及びその使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549487A Expired - Fee Related JP6106603B2 (ja) | 2011-01-11 | 2012-01-10 | ヘテロアリール化合物及びその使用方法 |
| JP2016028453A Expired - Fee Related JP6261631B2 (ja) | 2011-01-11 | 2016-02-18 | ヘテロアリール化合物及びその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8765760B2 (https=) |
| EP (2) | EP3210984B1 (https=) |
| JP (3) | JP6106603B2 (https=) |
| CN (2) | CN107141309A (https=) |
| AU (2) | AU2012205687B2 (https=) |
| CA (1) | CA2824047C (https=) |
| ES (1) | ES2627788T3 (https=) |
| WO (1) | WO2012096929A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107141309A (zh) * | 2011-01-11 | 2017-09-08 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| RU2644558C2 (ru) * | 2012-06-19 | 2018-02-13 | Сановьон Фармасьютикалз Инк. | Гетероарильные соединения и способы их применения |
| US20140045856A1 (en) * | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| WO2014036528A2 (en) * | 2012-08-31 | 2014-03-06 | Ixchel Pharma, Llc | Agents useful for treating obesity, diabetes and related disorders |
| US9163027B2 (en) | 2012-11-21 | 2015-10-20 | Stategics, Inc. | Substituted triazolo-pyrimidine compounds for modulating cell proliferation differentiation and survival |
| CA2889906A1 (en) | 2012-11-29 | 2014-06-05 | Sunovion Pharmaceuticals Inc. | Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system |
| CN105209449B (zh) | 2013-03-14 | 2019-02-01 | 库拉德夫制药私人有限公司 | 犬尿氨酸途径的抑制剂 |
| EP3074387B1 (en) * | 2013-11-28 | 2017-11-08 | F.Hoffmann-La Roche Ag | Imidazole derivatives |
| CN108623619B (zh) * | 2017-03-17 | 2021-11-05 | 江苏豪森药业集团有限公司 | 制备C-Met酪氨酸激酶抑制剂的方法 |
| CN108926528A (zh) * | 2017-05-25 | 2018-12-04 | 北京万全德众医药生物技术有限公司 | 含有氨磺必利树脂酸盐的口服液体组合物 |
| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| US11973194B2 (en) | 2018-03-26 | 2024-04-30 | Kyocera Corporation | Control apparatus, information processing apparatus, and storage cell retrieval system |
| CN108440284A (zh) * | 2018-03-26 | 2018-08-24 | 新沂市中诺新材料科技有限公司 | 一种有机合成中间体丙酮酸乙酯的合成方法 |
| CN109350617A (zh) * | 2018-04-22 | 2019-02-19 | 孙凤兰 | 化合物在制备治疗糖尿病的药物中的用途 |
| WO2019222677A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| GEP20237548B (en) | 2018-07-05 | 2023-10-10 | Incyte Corp | Fused pyrazine derivatives as a2a /a2b inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US11423743B2 (en) * | 2019-10-13 | 2022-08-23 | Everi Games, Inc. | Method, apparatus, and program product for triggering and controlling gaming machine operation in reel-type games |
| CN112138007B (zh) * | 2020-09-23 | 2021-12-28 | 广州中医药大学(广州中医药研究院) | 氧化小檗碱在制备代谢性疾病药物中的应用及包含氧化小檗碱的药物组合物 |
| CN116568302B (zh) * | 2020-10-09 | 2025-04-18 | 上海枢境生物科技有限公司 | 杂环取代的稠合γ-咔啉类衍生物、其制备方法、中间体及应用 |
| CN113797200B (zh) * | 2021-10-21 | 2022-11-04 | 中国人民解放军海军军医大学 | 小分子化合物匹莫范色林在制备抗SARS-CoV-2药物中的应用 |
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-
2012
- 2012-01-10 CN CN201710186503.6A patent/CN107141309A/zh active Pending
- 2012-01-10 EP EP17160357.4A patent/EP3210984B1/en active Active
- 2012-01-10 JP JP2013549487A patent/JP6106603B2/ja not_active Expired - Fee Related
- 2012-01-10 AU AU2012205687A patent/AU2012205687B2/en not_active Ceased
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