JP2018076350A5 - - Google Patents
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- JP2018076350A5 JP2018076350A5 JP2017243830A JP2017243830A JP2018076350A5 JP 2018076350 A5 JP2018076350 A5 JP 2018076350A5 JP 2017243830 A JP2017243830 A JP 2017243830A JP 2017243830 A JP2017243830 A JP 2017243830A JP 2018076350 A5 JP2018076350 A5 JP 2018076350A5
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- Prior art keywords
- formulation
- antibody
- cancer
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000009472 formulation Methods 0.000 claims 45
- 239000000203 mixture Substances 0.000 claims 45
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000000872 buffer Substances 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 229920005862 polyol Polymers 0.000 claims 9
- 150000003077 polyols Chemical class 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 9
- 206010064930 age-related macular degeneration Diseases 0.000 claims 8
- 208000002780 macular degeneration Diseases 0.000 claims 8
- 238000001542 size-exclusion chromatography Methods 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 6
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 5
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 5
- 239000000178 monomer Substances 0.000 claims 5
- 239000000600 sorbitol Substances 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000006172 buffering agent Substances 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 229940071643 prefilled syringe Drugs 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
- 150000001242 acetic acid derivatives Chemical class 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001155 isoelectric focusing Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697111P | 2012-09-05 | 2012-09-05 | |
| US61/697,111 | 2012-09-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531196A Division JP2015532657A (ja) | 2012-09-05 | 2013-09-05 | 抗体製剤及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018223128A Division JP6602446B2 (ja) | 2012-09-05 | 2018-11-29 | 抗体製剤及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018076350A JP2018076350A (ja) | 2018-05-17 |
| JP2018076350A5 true JP2018076350A5 (enExample) | 2018-10-11 |
| JP6445671B2 JP6445671B2 (ja) | 2018-12-26 |
Family
ID=50237600
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531196A Pending JP2015532657A (ja) | 2012-09-05 | 2013-09-05 | 抗体製剤及びその使用 |
| JP2017243830A Expired - Fee Related JP6445671B2 (ja) | 2012-09-05 | 2017-12-20 | 抗体製剤及びその使用 |
| JP2018223128A Expired - Fee Related JP6602446B2 (ja) | 2012-09-05 | 2018-11-29 | 抗体製剤及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531196A Pending JP2015532657A (ja) | 2012-09-05 | 2013-09-05 | 抗体製剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018223128A Expired - Fee Related JP6602446B2 (ja) | 2012-09-05 | 2018-11-29 | 抗体製剤及びその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10195281B2 (enExample) |
| EP (1) | EP2892559A4 (enExample) |
| JP (3) | JP2015532657A (enExample) |
| KR (2) | KR20180007014A (enExample) |
| CN (2) | CN104684580A (enExample) |
| AU (2) | AU2013312536B2 (enExample) |
| BR (1) | BR112015004875A2 (enExample) |
| CA (1) | CA2883343A1 (enExample) |
| EA (1) | EA029214B1 (enExample) |
| GE (1) | GEP201706789B (enExample) |
| HK (1) | HK1210714A1 (enExample) |
| IL (1) | IL237287A0 (enExample) |
| MX (1) | MX368996B (enExample) |
| MY (1) | MY180157A (enExample) |
| NZ (1) | NZ705109A (enExample) |
| PH (1) | PH12015500480B1 (enExample) |
| SG (2) | SG10201705070PA (enExample) |
| UA (1) | UA115789C2 (enExample) |
| WO (1) | WO2014039682A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA035619B1 (ru) | 2005-06-01 | 2020-07-16 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Композиции для использования в способе лечения митохондриальных нарушений |
| EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| US8221753B2 (en) | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
| UA115789C2 (uk) | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
| AU2015346444A1 (en) | 2014-11-12 | 2017-05-04 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
| US9926375B2 (en) | 2014-11-12 | 2018-03-27 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
| EP3389646A1 (en) | 2015-12-17 | 2018-10-24 | BioElectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| CN106928355B (zh) * | 2015-12-30 | 2020-09-29 | 广西医科大学 | 一种CD105纳米抗体Nb184 |
| CN106928359B (zh) * | 2015-12-30 | 2020-10-13 | 广西医科大学 | 一种CD105纳米抗体Nb59 |
| CN106478820A (zh) * | 2016-10-10 | 2017-03-08 | 米度（南京）生物技术有限公司 | 一种肝癌pet诊断示踪剂及其制备方法与用途 |
| WO2019099921A2 (en) * | 2017-11-17 | 2019-05-23 | Amgen Inc. | Vegfr-fc fusion protein formulations |
| BR112020015052A2 (pt) * | 2018-02-09 | 2020-12-08 | Genmab A/S | Composição farmacêutica, uso da composição farmacêutica, métodos para tratar câncer em um sujeito, para preparar uma composição farmacêutica e para preparar uma forma de dosagem unitária, forma de dosagem unitária, recipiente, e, kit-de-partes |
| PE20212185A1 (es) | 2019-02-18 | 2021-11-11 | Lilly Co Eli | Formulacion de anticuerpos terapeuticos |
| CN112717129A (zh) * | 2019-10-14 | 2021-04-30 | 百奥泰生物制药股份有限公司 | 抗vegf抗体制剂 |
| KR20230008775A (ko) | 2020-05-08 | 2023-01-16 | 젠맵 에이/에스 | Cd3 및 cd20에 대한 이중특이적 항체 |
| EP4168038A1 (en) | 2020-06-18 | 2023-04-26 | Regeneron Pharmaceuticals, Inc. | Activin a antibody formulations and methods of use thereof |
| CN116437956A (zh) | 2020-09-10 | 2023-07-14 | 健玛保 | 用于治疗慢性淋巴细胞白血病的针对cd3和cd20的双特异性抗体 |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| IL322368A (en) | 2023-02-03 | 2025-09-01 | Genzyme Corp | HSC-specific antibody-conjugated lipid nanoparticles and their uses |
| WO2025217334A1 (en) * | 2024-04-09 | 2025-10-16 | Regeneron Pharmaceuticals, Inc. | Low concentration vegf receptor fusion protein containing formulations |
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2013
- 2013-05-09 UA UAA201501709A patent/UA115789C2/uk unknown
- 2013-09-05 EP EP13834890.9A patent/EP2892559A4/en not_active Withdrawn
- 2013-09-05 CA CA2883343A patent/CA2883343A1/en not_active Abandoned
- 2013-09-05 AU AU2013312536A patent/AU2013312536B2/en not_active Ceased
- 2013-09-05 CN CN201380046405.2A patent/CN104684580A/zh active Pending
- 2013-09-05 BR BR112015004875A patent/BR112015004875A2/pt not_active Application Discontinuation
- 2013-09-05 US US14/421,108 patent/US10195281B2/en active Active - Reinstated
- 2013-09-05 CN CN201810659773.9A patent/CN108785669A/zh active Pending
- 2013-09-05 MY MYPI2015000556A patent/MY180157A/en unknown
- 2013-09-05 KR KR1020187001035A patent/KR20180007014A/ko not_active Abandoned
- 2013-09-05 WO PCT/US2013/058265 patent/WO2014039682A1/en not_active Ceased
- 2013-09-05 SG SG10201705070PA patent/SG10201705070PA/en unknown
- 2013-09-05 HK HK15111622.6A patent/HK1210714A1/xx unknown
- 2013-09-05 JP JP2015531196A patent/JP2015532657A/ja active Pending
- 2013-09-05 MX MX2015002840A patent/MX368996B/es active IP Right Grant
- 2013-09-05 KR KR1020157008487A patent/KR101820582B1/ko not_active Expired - Fee Related
- 2013-09-05 SG SG11201501659SA patent/SG11201501659SA/en unknown
- 2013-09-05 NZ NZ705109A patent/NZ705109A/en not_active IP Right Cessation
- 2013-09-05 EA EA201590412A patent/EA029214B1/ru not_active IP Right Cessation
- 2013-09-05 GE GEAP201313760A patent/GEP201706789B/en unknown
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2015
- 2015-02-17 IL IL237287A patent/IL237287A0/en unknown
- 2015-03-05 PH PH12015500480A patent/PH12015500480B1/en unknown
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2017
- 2017-12-20 JP JP2017243830A patent/JP6445671B2/ja not_active Expired - Fee Related
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2018
- 2018-06-07 AU AU2018204044A patent/AU2018204044A1/en not_active Abandoned
- 2018-07-13 US US16/034,658 patent/US20180311359A1/en not_active Abandoned
- 2018-11-29 JP JP2018223128A patent/JP6602446B2/ja not_active Expired - Fee Related
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