JP2017537094A5 - - Google Patents
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- JP2017537094A5 JP2017537094A5 JP2017528088A JP2017528088A JP2017537094A5 JP 2017537094 A5 JP2017537094 A5 JP 2017537094A5 JP 2017528088 A JP2017528088 A JP 2017528088A JP 2017528088 A JP2017528088 A JP 2017528088A JP 2017537094 A5 JP2017537094 A5 JP 2017537094A5
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- 150000001875 compounds Chemical class 0.000 claims description 78
- 238000000034 method Methods 0.000 claims description 43
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 125000001072 heteroaryl group Chemical group 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 206010016654 Fibrosis Diseases 0.000 claims description 16
- 208000027866 inflammatory disease Diseases 0.000 claims description 16
- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 230000004761 fibrosis Effects 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 12
- 239000007795 chemical reaction product Substances 0.000 claims description 12
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 9
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 9
- 125000004104 aryloxy group Chemical group 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 9
- 239000010452 phosphate Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 9
- 125000005296 thioaryloxy group Chemical group 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 8
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 229910052698 phosphorus Inorganic materials 0.000 claims description 8
- 239000011574 phosphorus Substances 0.000 claims description 8
- 239000000376 reactant Substances 0.000 claims description 8
- 229910052710 silicon Inorganic materials 0.000 claims description 8
- 239000010703 silicon Substances 0.000 claims description 8
- HJKGBRPNSJADMB-UHFFFAOYSA-N 3-phenylpyridine Chemical compound C1=CC=CC=C1C1=CC=CN=C1 HJKGBRPNSJADMB-UHFFFAOYSA-N 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 6
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 6
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 6
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 claims description 6
- 150000001408 amides Chemical class 0.000 claims description 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 claims description 5
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000001424 substituent group Chemical group 0.000 claims description 5
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 5
- 229940124530 sulfonamide Drugs 0.000 claims description 5
- 150000003456 sulfonamides Chemical class 0.000 claims description 5
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 5
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims description 5
- 125000005190 thiohydroxy group Chemical group 0.000 claims description 5
- 125000004953 trihalomethyl group Chemical group 0.000 claims description 5
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 4
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 4
- 230000003301 hydrolyzing effect Effects 0.000 claims description 4
- -1 hydroxy, thiohydroxy Chemical group 0.000 claims description 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 4
- 125000004043 oxo group Chemical group O=* 0.000 claims description 4
- 201000002793 renal fibrosis Diseases 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- CELKOWQJPVJKIL-UHFFFAOYSA-N 3-fluoropyridine Chemical compound FC1=CC=CN=C1 CELKOWQJPVJKIL-UHFFFAOYSA-N 0.000 claims description 3
- 201000001320 Atherosclerosis Diseases 0.000 claims description 3
- 230000002757 inflammatory effect Effects 0.000 claims description 3
- 208000010125 myocardial infarction Diseases 0.000 claims description 3
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 2
- 208000004930 Fatty Liver Diseases 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 208000024934 IgG4-related mediastinitis Diseases 0.000 claims description 2
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000002260 Keloid Diseases 0.000 claims description 2
- 206010023330 Keloid scar Diseases 0.000 claims description 2
- 208000002805 Mediastinal fibrosis Diseases 0.000 claims description 2
- 206010028594 Myocardial fibrosis Diseases 0.000 claims description 2
- 208000004362 Penile Induration Diseases 0.000 claims description 2
- 208000020758 Peyronie disease Diseases 0.000 claims description 2
- 206010036805 Progressive massive fibrosis Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 230000001746 atrial effect Effects 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 230000002500 effect on skin Effects 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- 210000001117 keloid Anatomy 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 206010028537 myelofibrosis Diseases 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 description 5
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 4
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 4
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 4
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 4
- 102100024333 Toll-like receptor 2 Human genes 0.000 description 4
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 0 C*C(C)(C)CC(C)(C)OP(C)(C(F)(F)F)=O Chemical compound C*C(C)(C)CC(C)(C)OP(C)(C(F)(F)F)=O 0.000 description 2
- 206010018364 Glomerulonephritis Diseases 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000005784 autoimmunity Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 1
- 206010001935 American trypanosomiasis Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 208000024699 Chagas disease Diseases 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 208000013600 Diabetic vascular disease Diseases 0.000 description 1
- 206010017711 Gangrene Diseases 0.000 description 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000011200 Kawasaki disease Diseases 0.000 description 1
- 241000272534 Struthio camelus Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 208000001106 Takayasu Arteritis Diseases 0.000 description 1
- 206010043561 Thrombocytopenic purpura Diseases 0.000 description 1
- 241000223109 Trypanosoma cruzi Species 0.000 description 1
- 206010047124 Vasculitis necrotising Diseases 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 208000027744 congestion Diseases 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 201000009101 diabetic angiopathy Diseases 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 201000002249 diabetic peripheral angiopathy Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 208000018578 heart valve disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000023569 ischemic bowel disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 206010063344 microscopic polyangiitis Diseases 0.000 description 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000002956 necrotizing effect Effects 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 210000002385 vertebral artery Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462085153P | 2014-11-26 | 2014-11-26 | |
| US62/085,153 | 2014-11-26 | ||
| PCT/IB2015/059134 WO2016084024A1 (en) | 2014-11-26 | 2015-11-26 | Oxidized lipids and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537094A JP2017537094A (ja) | 2017-12-14 |
| JP2017537094A5 true JP2017537094A5 (https=) | 2019-01-10 |
| JP6637044B2 JP6637044B2 (ja) | 2020-01-29 |
Family
ID=56073714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528088A Expired - Fee Related JP6637044B2 (ja) | 2014-11-26 | 2015-11-26 | 酸化脂質およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9771385B2 (https=) |
| EP (1) | EP3223806B1 (https=) |
| JP (1) | JP6637044B2 (https=) |
| CN (1) | CN106999447B (https=) |
| CA (1) | CA2968504A1 (https=) |
| ES (1) | ES2777533T3 (https=) |
| IL (1) | IL252508A0 (https=) |
| WO (1) | WO2016084024A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| EP3223824B1 (en) | 2014-11-26 | 2021-01-06 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of fibrosis |
| WO2021199003A1 (en) * | 2020-04-02 | 2021-10-07 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of inflammation or infectious disease caused by coronavirus infection |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5638578B2 (https=) | 1973-05-18 | 1981-09-08 | ||
| US4166132A (en) | 1977-08-18 | 1979-08-28 | Pfizer Inc. | Antiviral amine derivatives of glycerol and propanediols |
| GB1572226A (en) | 1977-11-03 | 1980-07-30 | Hoechst Uk Ltd | Pharmaceutical preparations in solid unit dosage form |
| CH642665A5 (en) | 1979-02-08 | 1984-04-30 | Rudolf Berchtold | Process for the preparation of 1-(omega-carboxyalkyl)-2-alkyl- glycero-3-phosphatides |
| US4329302A (en) | 1980-06-27 | 1982-05-11 | Board Of Regents, The University Of Texas System | Synthetic phosphoglycerides possessing platelet activating properties |
| JPS58154512A (ja) | 1982-03-09 | 1983-09-14 | Takeda Chem Ind Ltd | 血小板活性化因子抑制剤 |
| JPS58164596A (ja) * | 1982-03-22 | 1983-09-29 | Fujisawa Pharmaceut Co Ltd | 燐脂質誘導体、その製造法およびそれを含有する抗腫瘍剤 |
| DK104583A (da) * | 1982-03-22 | 1983-09-23 | Fujisawa Pharmaceutical Co | Fremgangsmaade til fremstilling af phospholipider |
| JPS58192825A (ja) * | 1982-05-06 | 1983-11-10 | Takeda Chem Ind Ltd | グリセロール誘導体 |
| JPS5993022A (ja) | 1982-11-16 | 1984-05-29 | Kao Corp | ポリオ−ルエ−テル化合物およびその製造法ならびにこれを含有する化粧料 |
| DE3307925A1 (de) | 1983-03-05 | 1984-09-06 | A. Nattermann & Cie GmbH, 5000 Köln | Neue 0-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4614796A (en) | 1983-03-25 | 1986-09-30 | Nippon Shinyaku Co., Ltd. | Liposome and method of manufacture therefor |
| JPS60100544A (ja) | 1983-11-08 | 1985-06-04 | Ono Pharmaceut Co Ltd | 新規なグリセリン誘導体，その製造方法及びその誘導体を含有する薬剤 |
| JPS60104066A (ja) | 1983-11-10 | 1985-06-08 | Ono Pharmaceut Co Ltd | グリセリン誘導体 |
| AT383130B (de) | 1984-05-15 | 1987-05-25 | Chemie Linz Ag | Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin |
| US4710579A (en) | 1984-11-09 | 1987-12-01 | Takeda Chemical Industries, Ltd. | 2-(acetoacetyloxy)-3-(octadecyloxy)propyl-3-trimethylammoniopropyl phosphate or a pharmaceutically acceptable salt thereof |
| JPH0617307B2 (ja) | 1984-11-09 | 1994-03-09 | 武田薬品工業株式会社 | 抗腫瘍剤 |
| US4827011A (en) | 1984-12-10 | 1989-05-02 | American Cyanamid Company | Antihypertensive phosphate derivatives |
| EP0225129B1 (en) | 1985-11-29 | 1989-05-24 | Takeda Chemical Industries, Ltd. | Phospholipid derivatives, their production and use |
| WO1987005904A1 (en) | 1986-03-24 | 1987-10-08 | The University Of Sydney | Antigenic analogues of platelet activating factor (paf) |
| JPH01502022A (ja) | 1986-04-07 | 1989-07-13 | ジ・アップジョン・カンパニー | 駆虫薬第４級アルキルアシルヒドラゾン、使用方法および組成物 |
| JPS6294A (ja) | 1986-05-09 | 1987-01-06 | Toyama Chem Co Ltd | 新規なグリセロリン酸誘導体およびその塩並びにそれらの製造法 |
| ES2036210T3 (es) | 1986-07-14 | 1993-05-16 | Nippon Chemiphar Co., Ltd. | Un procedimiento para la preparacion de un derivado de glicerol. |
| JPS6354386A (ja) | 1986-08-26 | 1988-03-08 | Takeda Chem Ind Ltd | リン脂質およびその用途 |
| JPS63135395A (ja) | 1986-11-28 | 1988-06-07 | Nippon Oil & Fats Co Ltd | リン脂質誘導体及びその製造方法 |
| DE3807123A1 (de) | 1988-03-04 | 1989-09-14 | Boehringer Mannheim Gmbh | Substrate fuer phospholipasen |
| JPH01258691A (ja) | 1988-04-06 | 1989-10-16 | Nippon Oil & Fats Co Ltd | リン脂質誘導体及びその製造方法 |
| JP2534894B2 (ja) | 1988-06-24 | 1996-09-18 | 日本ケミファ株式会社 | 新規なグリセリン誘導体およびその誘導体を含有する血圧降下剤 |
| JPH0248585A (ja) | 1988-08-10 | 1990-02-19 | Nippon Oil & Fats Co Ltd | リン脂質誘導体及びその製造方法 |
| CA2001401A1 (en) | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
| JPH03258740A (ja) | 1990-03-06 | 1991-11-19 | Kao Corp | 液体油、その製造法及びこれを含有する化粧料 |
| ES2019552A6 (es) | 1990-04-11 | 1991-06-16 | Menarini Lab | Procedimiento para la preparacion de glicerofosfolipidos. |
| JP2869572B2 (ja) | 1990-05-14 | 1999-03-10 | 和光純薬工業株式会社 | ホスファチジルコリン誘導体の製造方法 |
| JP3128782B2 (ja) | 1992-06-12 | 2001-01-29 | 科学技術振興事業団 | 架橋高分子薄膜の製造方法 |
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-
2015
- 2015-11-25 US US14/952,827 patent/US9771385B2/en not_active Expired - Fee Related
- 2015-11-26 JP JP2017528088A patent/JP6637044B2/ja not_active Expired - Fee Related
- 2015-11-26 ES ES15862487T patent/ES2777533T3/es active Active
- 2015-11-26 CA CA2968504A patent/CA2968504A1/en not_active Abandoned
- 2015-11-26 CN CN201580064405.4A patent/CN106999447B/zh not_active Expired - Fee Related
- 2015-11-26 WO PCT/IB2015/059134 patent/WO2016084024A1/en not_active Ceased
- 2015-11-26 EP EP15862487.4A patent/EP3223806B1/en active Active
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2017
- 2017-05-25 IL IL252508A patent/IL252508A0/en active IP Right Grant
- 2017-08-16 US US15/678,228 patent/US10464957B2/en not_active Expired - Fee Related
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