JP2017535582A5 - - Google Patents
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- JP2017535582A5 JP2017535582A5 JP2017528094A JP2017528094A JP2017535582A5 JP 2017535582 A5 JP2017535582 A5 JP 2017535582A5 JP 2017528094 A JP2017528094 A JP 2017528094A JP 2017528094 A JP2017528094 A JP 2017528094A JP 2017535582 A5 JP2017535582 A5 JP 2017535582A5
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- 230000000694 effects Effects 0.000 claims description 20
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 16
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims description 16
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 16
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 16
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims description 16
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 16
- 206010016654 Fibrosis Diseases 0.000 claims description 13
- 230000004761 fibrosis Effects 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 201000002793 renal fibrosis Diseases 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 3
- 229950004354 phosphorylcholine Drugs 0.000 claims description 3
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 claims description 3
- 208000002260 Keloid Diseases 0.000 claims description 2
- 206010023330 Keloid scar Diseases 0.000 claims description 2
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoserine Chemical compound OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 claims description 2
- JGGNOCUEWOGWPL-MUUNZHRXSA-N [(2R)-2-(4-carboxybutoxy)-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OCCCCC(O)=O)COP([O-])(=O)OCC[N+](C)(C)C JGGNOCUEWOGWPL-MUUNZHRXSA-N 0.000 claims description 2
- 230000002500 effect on skin Effects 0.000 claims description 2
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 2
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 2
- 210000001117 keloid Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 210000001616 monocyte Anatomy 0.000 claims 3
- 230000028327 secretion Effects 0.000 claims 2
- 206010019668 Hepatic fibrosis Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims 1
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 206010050207 Skin fibrosis Diseases 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 125000005309 thioalkoxy group Chemical group 0.000 description 2
- 125000005296 thioaryloxy group Chemical group 0.000 description 2
- GIELSVRJHGSIJE-UHFFFAOYSA-N (oxo-lambda5-phosphanylidyne)methanol Chemical compound P(=O)#CO GIELSVRJHGSIJE-UHFFFAOYSA-N 0.000 description 1
- QQHVEZXEGWKJEP-UHFFFAOYSA-N 2-(oxo-lambda5-phosphanylidyne)ethanol Chemical compound OCC#P=O QQHVEZXEGWKJEP-UHFFFAOYSA-N 0.000 description 1
- OKLITDBMRKBZLC-UHFFFAOYSA-N 3-(oxo-$l^{5}-phosphanylidyne)propan-1-ol Chemical compound OCCC#P=O OKLITDBMRKBZLC-UHFFFAOYSA-N 0.000 description 1
- VDRKXDRYHWOORA-UHFFFAOYSA-N 4-(oxo-$l^{5}-phosphanylidyne)butan-1-ol Chemical compound OCCCC#P=O VDRKXDRYHWOORA-UHFFFAOYSA-N 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 208000001708 Dupuytren contracture Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 239000008777 Glycerylphosphorylcholine Substances 0.000 description 1
- 208000024934 IgG4-related mediastinitis Diseases 0.000 description 1
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 description 1
- 208000002805 Mediastinal fibrosis Diseases 0.000 description 1
- 206010028594 Myocardial fibrosis Diseases 0.000 description 1
- 208000004362 Penile Induration Diseases 0.000 description 1
- 206010034464 Periarthritis Diseases 0.000 description 1
- 208000020758 Peyronie disease Diseases 0.000 description 1
- 206010036805 Progressive massive fibrosis Diseases 0.000 description 1
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- JGENYNHRIOHZOP-UHFFFAOYSA-N ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCOP([O-])(=O)OCC[N+](C)(C)C JGENYNHRIOHZOP-UHFFFAOYSA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N glycerol 1-phosphate Chemical compound OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- -1 hydroxy, thiohydroxy Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 206010028537 myelofibrosis Diseases 0.000 description 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 description 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 208000005069 pulmonary fibrosis Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000005190 thiohydroxy group Chemical group 0.000 description 1
- 125000004953 trihalomethyl group Chemical group 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462085051P | 2014-11-26 | 2014-11-26 | |
| US62/085,051 | 2014-11-26 | ||
| PCT/IB2015/059133 WO2016084023A1 (en) | 2014-11-26 | 2015-11-26 | Oxidized lipids and treatment or prevention of fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535582A JP2017535582A (ja) | 2017-11-30 |
| JP2017535582A5 true JP2017535582A5 (https=) | 2019-01-10 |
| JP6717825B2 JP6717825B2 (ja) | 2020-07-08 |
Family
ID=56073713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528094A Expired - Fee Related JP6717825B2 (ja) | 2014-11-26 | 2015-11-26 | 酸化脂質、および線維症の処置または予防方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10022388B2 (https=) |
| EP (1) | EP3223824B1 (https=) |
| JP (1) | JP6717825B2 (https=) |
| CN (1) | CN106999506A (https=) |
| CA (1) | CA2968790A1 (https=) |
| ES (1) | ES2855299T3 (https=) |
| IL (1) | IL252509B (https=) |
| WO (1) | WO2016084023A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| EP3223824B1 (en) | 2014-11-26 | 2021-01-06 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of fibrosis |
| CN113307824B (zh) | 2021-04-26 | 2022-05-27 | 浙江大学 | 一种双亲性材料及其在制备脂质体中的应用 |
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| EP3223824B1 (en) | 2014-11-26 | 2021-01-06 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of fibrosis |
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2015
- 2015-11-26 EP EP15863247.1A patent/EP3223824B1/en active Active
- 2015-11-26 WO PCT/IB2015/059133 patent/WO2016084023A1/en not_active Ceased
- 2015-11-26 ES ES15863247T patent/ES2855299T3/es active Active
- 2015-11-26 CA CA2968790A patent/CA2968790A1/en active Pending
- 2015-11-26 JP JP2017528094A patent/JP6717825B2/ja not_active Expired - Fee Related
- 2015-11-26 CN CN201580064390.1A patent/CN106999506A/zh active Pending
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2017
- 2017-05-23 US US15/602,435 patent/US10022388B2/en active Active
- 2017-05-25 IL IL252509A patent/IL252509B/en active IP Right Grant
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2018
- 2018-07-16 US US16/036,188 patent/US10206936B2/en active Active
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