JP2020503332A5 - - Google Patents
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- Publication number
- JP2020503332A5 JP2020503332A5 JP2019535363A JP2019535363A JP2020503332A5 JP 2020503332 A5 JP2020503332 A5 JP 2020503332A5 JP 2019535363 A JP2019535363 A JP 2019535363A JP 2019535363 A JP2019535363 A JP 2019535363A JP 2020503332 A5 JP2020503332 A5 JP 2020503332A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonitrile
- dioxo
- tetrahydroisoquinoline
- phenyl
- trimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)(C(*)(CC*CC1)C1(*)C(*)=C1*)C1=O Chemical compound *C(*)(C(*)(CC*CC1)C1(*)C(*)=C1*)C1=O 0.000 description 4
- IOBYYQVBTCZXEJ-LJQANCHMSA-N CC(C)(C([C@@]1(C=C2C#N)c3ccccc3)=CCN(C)C1=O)C2=O Chemical compound CC(C)(C([C@@]1(C=C2C#N)c3ccccc3)=CCN(C)C1=O)C2=O IOBYYQVBTCZXEJ-LJQANCHMSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662439289P | 2016-12-27 | 2016-12-27 | |
| US62/439,289 | 2016-12-27 | ||
| PCT/US2017/068455 WO2018125880A1 (en) | 2016-12-27 | 2017-12-27 | Nrf2 activator |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503332A JP2020503332A (ja) | 2020-01-30 |
| JP2020503332A5 true JP2020503332A5 (https=) | 2021-02-12 |
| JP7088933B2 JP7088933B2 (ja) | 2022-06-21 |
Family
ID=61007836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535363A Expired - Fee Related JP7088933B2 (ja) | 2016-12-27 | 2017-12-27 | Ｎｒｆ２活性化物質 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10968181B2 (https=) |
| EP (2) | EP3875450A1 (https=) |
| JP (1) | JP7088933B2 (https=) |
| KR (1) | KR20190111949A (https=) |
| CN (1) | CN110382475A (https=) |
| AR (1) | AR110590A1 (https=) |
| AU (1) | AU2017387070B2 (https=) |
| BR (1) | BR112019013341A2 (https=) |
| CA (1) | CA3048849A1 (https=) |
| CL (1) | CL2019001804A1 (https=) |
| CO (1) | CO2019008110A2 (https=) |
| CR (1) | CR20190344A (https=) |
| EA (1) | EA201991595A1 (https=) |
| ES (1) | ES2878102T3 (https=) |
| IL (1) | IL267692B (https=) |
| JO (1) | JOP20190163B1 (https=) |
| MX (1) | MX2019007826A (https=) |
| PE (1) | PE20191488A1 (https=) |
| TW (1) | TW201827406A (https=) |
| UY (1) | UY37551A (https=) |
| WO (1) | WO2018125880A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2963613T3 (es) * | 2018-10-22 | 2024-04-01 | C4X Discovery Ltd | Compuestos terapéuticos |
| MX2021006527A (es) | 2018-12-05 | 2021-07-21 | Scohia Pharma Inc | Compuesto macrociclico y su uso. |
| CN112679328B (zh) * | 2019-10-17 | 2023-09-15 | 南京药石科技股份有限公司 | 一种3-三氟甲基-2-环己烯-1-酮的工业化生产方法 |
| KR102664144B1 (ko) | 2021-08-05 | 2024-05-10 | 주식회사 엘씨에스바이오텍 | 신규한 곡류 발효물, 그 곡류 발효물의 피부 보호 용도, 피부 유용 물질 스크리닝 방법 및 산화적 스트레스로 인한 피부 손상 예측 방법 |
| WO2024091523A1 (en) * | 2022-10-24 | 2024-05-02 | 2A Biosciences, Inc. | Conformationally restricted phenethylamine analogs |
| CN119735636A (zh) * | 2024-09-06 | 2025-04-01 | 五邑大学 | 一种四环肽中间体化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| JP2008110962A (ja) * | 2006-08-02 | 2008-05-15 | Santen Pharmaceut Co Ltd | Ｎｒｆ２活性化物質を有効成分として含む角結膜障害の予防または治療剤 |
| CA2721665C (en) * | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| WO2011156889A1 (en) * | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
| EP2678305A4 (en) * | 2011-02-25 | 2015-11-04 | Univ Johns Hopkins | CHALCONE DERIVATIVES AS NRF2 ACTIVATORS |
| WO2016065264A1 (en) * | 2014-10-24 | 2016-04-28 | Biogen Ma Inc. | Diterpenoid derivatives and methods of use thereof |
| CA2988373A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
-
2017
- 2017-12-26 UY UY0001037551A patent/UY37551A/es unknown
- 2017-12-26 AR ARP170103684A patent/AR110590A1/es unknown
- 2017-12-27 CN CN201780087398.9A patent/CN110382475A/zh active Pending
- 2017-12-27 EP EP21152411.1A patent/EP3875450A1/en not_active Withdrawn
- 2017-12-27 JP JP2019535363A patent/JP7088933B2/ja not_active Expired - Fee Related
- 2017-12-27 BR BR112019013341A patent/BR112019013341A2/pt not_active IP Right Cessation
- 2017-12-27 US US16/473,667 patent/US10968181B2/en active Active
- 2017-12-27 MX MX2019007826A patent/MX2019007826A/es unknown
- 2017-12-27 WO PCT/US2017/068455 patent/WO2018125880A1/en not_active Ceased
- 2017-12-27 CR CR20190344A patent/CR20190344A/es unknown
- 2017-12-27 KR KR1020197022052A patent/KR20190111949A/ko not_active Withdrawn
- 2017-12-27 CA CA3048849A patent/CA3048849A1/en active Pending
- 2017-12-27 ES ES17832681T patent/ES2878102T3/es active Active
- 2017-12-27 TW TW106146033A patent/TW201827406A/zh unknown
- 2017-12-27 PE PE2019001341A patent/PE20191488A1/es unknown
- 2017-12-27 AU AU2017387070A patent/AU2017387070B2/en not_active Ceased
- 2017-12-27 EP EP17832681.5A patent/EP3562816B1/en active Active
- 2017-12-27 EA EA201991595A patent/EA201991595A1/ru unknown
- 2017-12-27 JO JOP/2019/0163A patent/JOP20190163B1/ar active
-
2019
- 2019-06-27 IL IL267692A patent/IL267692B/en unknown
- 2019-06-27 CL CL2019001804A patent/CL2019001804A1/es unknown
- 2019-07-26 CO CONC2019/0008110A patent/CO2019008110A2/es unknown
-
2021
- 2021-04-02 US US17/221,358 patent/US20210340107A1/en not_active Abandoned
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