|
JP2002532729A
(ja)
|
1998-12-23 |
2002-10-02 |
グラクソ グループ リミテッド |
核内受容体のリガンドのアッセイ
|
|
IL146732A0
(en)
|
1999-06-03 |
2002-07-25 |
Nippon Suisan Kaisha Ltd |
Tricyclic fused heterocycle compounds, process for preparing the same and use thereof
|
|
ATE381542T1
(de)
|
2001-08-13 |
2008-01-15 |
Phenex Pharmaceuticals Ag |
Nr1h4-kern-rezeptor-bindende verbindungen
|
|
EP1538906A2
(en)
*
|
2002-09-18 |
2005-06-15 |
Fmc Corporation |
Insecticidal tricyclic derivatives
|
|
JP2006515838A
(ja)
|
2002-11-22 |
2006-06-08 |
スミスクライン ビーチャム コーポレーション |
ファルネソイドｘ受容体アゴニスト
|
|
JP5081161B2
(ja)
|
2005-12-19 |
2012-11-21 |
スミスクライン ビーチャム コーポレーション |
ファルネソイドｘ受容体アゴニスト
|
|
CA2640476A1
(en)
|
2006-02-03 |
2007-08-16 |
Eli Lilly And Company |
Compounds and methods for modulating fx-receptors
|
|
JP2007230909A
(ja)
|
2006-03-01 |
2007-09-13 |
Univ Of Tokyo |
置換イソキサゾール誘導体
|
|
US8106077B2
(en)
|
2006-05-24 |
2012-01-31 |
Eli Lilly And Company |
Compounds and methods for modulating FXR
|
|
BRPI0712262A2
(pt)
|
2006-05-24 |
2012-07-10 |
Lilly Co Eli |
agonistas de fxr
|
|
EP1894924A1
(en)
|
2006-08-29 |
2008-03-05 |
Phenex Pharmaceuticals AG |
Heterocyclic FXR binding compounds
|
|
EP1894928A1
(en)
|
2006-08-29 |
2008-03-05 |
PheneX Pharmaceuticals AG |
Heterocyclic fxr binding compounds
|
|
CL2007003035A1
(es)
|
2006-10-24 |
2008-05-16 |
Smithkline Beechman Corp |
Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos,
|
|
WO2008157270A1
(en)
|
2007-06-13 |
2008-12-24 |
Smithkline Beecham Corporation |
Farnesoid x receptor agonists
|
|
CA2690406A1
(en)
|
2007-07-02 |
2009-01-08 |
Glaxosmithkline Llc |
Farnesoid x receptor agonists
|
|
TW200906823A
(en)
|
2007-07-16 |
2009-02-16 |
Lilly Co Eli |
Compounds and methods for modulating FXR
|
|
EP2128158A1
(en)
*
|
2008-05-26 |
2009-12-02 |
Phenex Pharmaceuticals AG |
Heterocyclic cyclopropyl-substituted FXR binding compounds
|
|
EP2289883A1
(en)
|
2009-08-19 |
2011-03-02 |
Phenex Pharmaceuticals AG |
Novel FXR (NR1H4) binding and activity modulating compounds
|
|
JP2014500319A
(ja)
|
2010-12-20 |
2014-01-09 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
ファルネソイドｘ受容体を調節するための組成物および方法
|
|
CU24152B1
(es)
|
2010-12-20 |
2016-02-29 |
Irm Llc |
1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
|
|
WO2012087520A1
(en)
|
2010-12-20 |
2012-06-28 |
Irm Llc |
Compositions and methods for modulating farnesoid x receptors
|
|
EP2545964A1
(en)
|
2011-07-13 |
2013-01-16 |
Phenex Pharmaceuticals AG |
Novel FXR (NR1H4) binding and activity modulating compounds
|
|
SI3043865T1
(sl)
|
2013-09-11 |
2021-04-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Metode in farmacevtski sestavki za zdravljenje virusne okužbe s hepatitisom B
|
|
CN104513213A
(zh)
|
2013-09-28 |
2015-04-15 |
山东亨利医药科技有限责任公司 |
Fxr激动剂
|
|
KR102350357B1
(ko)
*
|
2013-11-05 |
2022-01-14 |
노파르티스 아게 |
파르네소이드 x 수용체의 조정을 위한 조성물 및 방법
|
|
CN104045635A
(zh)
|
2014-06-23 |
2014-09-17 |
华东理工大学 |
3,4,5-三取代异恶唑类化合物及其用途
|
|
EP3034501A1
(en)
|
2014-12-17 |
2016-06-22 |
Gilead Sciences, Inc. |
Hydroxy containing FXR (NR1H4) modulating compounds
|
|
EP3034499A1
(en)
|
2014-12-17 |
2016-06-22 |
Gilead Sciences, Inc. |
Novel FXR (NR1H4) modulating compounds
|
|
US20170368038A1
(en)
|
2014-12-18 |
2017-12-28 |
Novartis Ag |
Azabicyclooctane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases
|
|
WO2016103037A1
(en)
*
|
2014-12-22 |
2016-06-30 |
Akarna Therapeutics, Ltd. |
Fused bicyclic compounds for the treatment of disease
|
|
TWI698430B
(zh)
|
2015-02-13 |
2020-07-11 |
南北兄弟藥業投資有限公司 |
三環化合物及其在藥物中的應用
|
|
CN106146483A
(zh)
|
2015-04-23 |
2016-11-23 |
上海迪诺医药科技有限公司 |
杂环类法尼酯衍生物x受体调节剂
|
|
CN106946867B
(zh)
|
2016-01-06 |
2019-11-12 |
广州市恒诺康医药科技有限公司 |
Fxr受体调节剂及其制备方法和用途
|
|
WO2017128896A1
(zh)
|
2016-01-26 |
2017-08-03 |
江苏豪森药业集团有限公司 |
Fxr激动剂及其制备方法和应用
|
|
CN107021958A
(zh)
*
|
2016-02-01 |
2017-08-08 |
山东轩竹医药科技有限公司 |
Fxr受体激动剂
|
|
WO2017133521A1
(zh)
|
2016-02-01 |
2017-08-10 |
山东轩竹医药科技有限公司 |
Fxr受体激动剂
|
|
CN107021957A
(zh)
|
2016-02-01 |
2017-08-08 |
山东轩竹医药科技有限公司 |
Fxr受体激动剂
|
|
TW201741307A
(zh)
|
2016-02-22 |
2017-12-01 |
艾洛斯生物製藥公司 |
Ｆｘｒ調節劑及其使用方法
|
|
WO2017189651A1
(en)
|
2016-04-26 |
2017-11-02 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as fxr agonists and methods of use thereof
|
|
WO2017189663A1
(en)
|
2016-04-26 |
2017-11-02 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as fxr agonists and methods of use thereof
|
|
US10080741B2
(en)
|
2016-04-26 |
2018-09-25 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as FXR agonists and methods of use thereof
|
|
WO2017201152A1
(en)
|
2016-05-18 |
2017-11-23 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as fxr agonists and methods of use thereof
|
|
WO2017201155A1
(en)
|
2016-05-18 |
2017-11-23 |
Enanta Pharmaceuticals, Inc. |
lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
|
|
US10144729B2
(en)
|
2016-05-18 |
2018-12-04 |
Enanta Pharmaceuticals, Inc. |
Isoxazole analogs as FXR agonists and methods of use thereof
|
|
AR108711A1
(es)
|
2016-06-13 |
2018-09-19 |
Gilead Sciences Inc |
Compuestos moduladores de fxr (nr1h4)
|
|
NZ748641A
(en)
|
2016-06-13 |
2020-04-24 |
Gilead Sciences Inc |
Fxr (nr1h4) modulating compounds
|
|
TW201808283A
(zh)
|
2016-08-05 |
2018-03-16 |
廣東東陽光藥業有限公司 |
含氮三環化合物及其在藥物中的應用
|
|
US11091482B2
(en)
|
2016-08-23 |
2021-08-17 |
Ardelyx, Inc. |
Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
|
|
MA55632A
(fr)
|
2016-08-23 |
2022-02-16 |
Ardelyx Inc |
Procédé de preparation de modulateurs du récepteur hormonal pour le traitement d'états et de troubles métaboliques
|
|
CN108430998B
(zh)
|
2016-09-28 |
2021-07-09 |
四川科伦博泰生物医药股份有限公司 |
氮杂双环衍生物及其制备方法和用途
|
|
MX2019003790A
(es)
|
2016-10-04 |
2019-09-26 |
Enanta Pharm Inc |
Analogos de isoxazol como agonistas de fxr y metodos de uso de los mismos.
|
|
CN107973790A
(zh)
|
2016-10-22 |
2018-05-01 |
合帕吉恩治疗公司 |
杂环fxr调节剂
|
|
WO2018081285A1
(en)
|
2016-10-26 |
2018-05-03 |
Enanta Pharmaceuticals, Inc. |
Urea-containing isoxazole derivatives as fxr agonists and methods of use thereof
|
|
CN108017636A
(zh)
|
2016-11-04 |
2018-05-11 |
合帕吉恩治疗公司 |
作为fxr调节剂的含氮杂环化合物
|
|
CN108218852A
(zh)
|
2016-12-15 |
2018-06-29 |
宁波百纳西药业有限公司 |
一种螺环化合物、其制备方法、组合物及用途
|
|
CN106632294A
(zh)
|
2016-12-15 |
2017-05-10 |
宁波百纳西药业有限公司 |
一种螺环化合物及其药物用途
|
|
CN109071468B
(zh)
|
2017-01-20 |
2022-09-02 |
四川科伦博泰生物医药股份有限公司 |
一种杂环化合物及其制备方法和用途
|
|
CN108341822B
(zh)
|
2017-01-23 |
2021-04-16 |
广州市恒诺康医药科技有限公司 |
Fxr受体调节剂及其制备方法和应用
|
|
MX394743B
(es)
|
2017-04-12 |
2025-03-04 |
Il Dong Pharma |
Derivados de isoxazol como agonistas del receptor nuclear y usos de los mismos
|
|
US11339147B2
(en)
|
2017-05-26 |
2022-05-24 |
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. |
Lactam compound as FXR receptor agonist
|
|
KR102400183B1
(ko)
|
2017-07-06 |
2022-05-18 |
수안주 바이오파마슈티컬 컴퍼니 리미티드 |
Fxr 작용제
|
|
CN109320517B
(zh)
|
2017-07-31 |
2021-08-17 |
轩竹生物科技有限公司 |
Fxr受体激动剂
|
|
CN109320509B
(zh)
|
2017-07-31 |
2022-02-08 |
轩竹生物科技股份有限公司 |
Fxr受体激动剂
|
|
JP7271513B2
(ja)
|
2017-09-14 |
2023-05-11 |
アルデリックス， インコーポレイテッド |
代謝関連の突然変異誘発性及び線維性の症状及び障害を治療するためのホルモン受容体調節薬
|
|
CN111278817B
(zh)
|
2017-11-01 |
2023-05-16 |
百时美施贵宝公司 |
作为法尼醇x受体调节剂的多环化合物
|
|
CN111630051B
(zh)
|
2017-11-01 |
2023-12-26 |
百时美施贵宝公司 |
作为法尼醇x受体调节剂的烯烃螺环化合物
|
|
PE20201170A1
(es)
|
2017-11-01 |
2020-10-28 |
Bristol Myers Squibb Co |
Compuestos biciclicos en puente como moduladores del receptor farnesoide x
|
|
JP7264906B2
(ja)
|
2017-11-01 |
2023-04-25 |
ブリストル－マイヤーズ スクイブ カンパニー |
ファルネソイドｘ受容体モジュレーターとしてのアルケン化合物
|
|
US10689391B2
(en)
|
2017-12-12 |
2020-06-23 |
Enanta Pharmaceuticals, Inc. |
Isoxazole analogs as FXR agonists and methods of use thereof
|
|
US11667629B2
(en)
|
2017-12-22 |
2023-06-06 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Isoxazole derivative, preparation method therefor, and use thereof
|
|
CN108264506B
(zh)
|
2018-01-17 |
2021-01-26 |
中国药科大学 |
异黄酮衍生物、其制备方法和医药用途
|