JP2021512114A5 - - Google Patents

Download PDF

Info

Publication number
JP2021512114A5
JP2021512114A5 JP2020541888A JP2020541888A JP2021512114A5 JP 2021512114 A5 JP2021512114 A5 JP 2021512114A5 JP 2020541888 A JP2020541888 A JP 2020541888A JP 2020541888 A JP2020541888 A JP 2020541888A JP 2021512114 A5 JP2021512114 A5 JP 2021512114A5
Authority
JP
Japan
Prior art keywords
disease
alkoxy
alkyl
independently
bile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020541888A
Other languages
English (en)
Japanese (ja)
Other versions
JP7237078B2 (ja
JP2021512114A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2019/073303 external-priority patent/WO2019149158A1/en
Publication of JP2021512114A publication Critical patent/JP2021512114A/ja
Publication of JP2021512114A5 publication Critical patent/JP2021512114A5/ja
Application granted granted Critical
Publication of JP7237078B2 publication Critical patent/JP7237078B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020541888A 2018-02-02 2019-01-28 窒素含有三環式化合物及び医薬品におけるその使用 Active JP7237078B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810107007 2018-02-02
CN201810107007.1 2018-02-02
PCT/CN2019/073303 WO2019149158A1 (en) 2018-02-02 2019-01-28 Nitrogenous tricyclic compounds and uses thereof in medicine

Publications (3)

Publication Number Publication Date
JP2021512114A JP2021512114A (ja) 2021-05-13
JP2021512114A5 true JP2021512114A5 (https=) 2022-01-04
JP7237078B2 JP7237078B2 (ja) 2023-03-10

Family

ID=67478601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020541888A Active JP7237078B2 (ja) 2018-02-02 2019-01-28 窒素含有三環式化合物及び医薬品におけるその使用

Country Status (6)

Country Link
US (1) US11208418B2 (https=)
EP (1) EP3746448B1 (https=)
JP (1) JP7237078B2 (https=)
CN (1) CN110128432B (https=)
TW (1) TWI801492B (https=)
WO (1) WO2019149158A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201808283A (zh) * 2016-08-05 2018-03-16 廣東東陽光藥業有限公司 含氮三環化合物及其在藥物中的應用
CN112876490A (zh) * 2019-11-29 2021-06-01 广东东阳光药业有限公司 含氮三环化合物的晶型及其用途
US12492211B2 (en) 2019-11-29 2025-12-09 Sunshine Lake Pharma Co., Ltd. Crystalline form of nitrogen-containing tricyclic compound and use thereof
JP7750836B2 (ja) * 2019-11-29 2025-10-07 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 三環式含窒素化合物の非晶質及びその用途
CN112876493B (zh) * 2019-11-29 2023-05-09 广东东阳光药业有限公司 含氮三环化合物的盐及其用途
CN114315815B (zh) * 2020-10-12 2024-07-19 甘莱制药有限公司 用于调节fxr活性的化合物及其应用
CN115974885A (zh) * 2021-10-15 2023-04-18 广东东阳光药业有限公司 含氮三环化合物的新晶型及其用途
CN118271327A (zh) * 2022-12-30 2024-07-02 广东东阳光药业股份有限公司 三环化合物的晶型及其用途

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69940958D1 (de) 1998-12-23 2009-07-16 Glaxo Group Ltd Bestimmungsmethode fur liganden der nuklearen rezeptoren
IL146732A0 (en) * 1999-06-03 2002-07-25 Nippon Suisan Kaisha Ltd Tricyclic fused heterocycle compounds, process for preparing the same and use thereof
ATE381542T1 (de) 2001-08-13 2008-01-15 Phenex Pharmaceuticals Ag Nr1h4-kern-rezeptor-bindende verbindungen
CN1681388A (zh) * 2002-09-18 2005-10-12 Fmc有限公司 三环衍生物杀虫剂
WO2004048349A1 (en) 2002-11-22 2004-06-10 Smithkline Beecham Corporation Farnesoid x receptor agonists
WO2007076260A2 (en) 2005-12-19 2007-07-05 Smithkline Beecham Corporation Farnesoid x receptor agonists
CA2640476A1 (en) 2006-02-03 2007-08-16 Eli Lilly And Company Compounds and methods for modulating fx-receptors
JP2007230909A (ja) 2006-03-01 2007-09-13 Univ Of Tokyo 置換イソキサゾール誘導体
TW200812982A (en) 2006-05-24 2008-03-16 Lilly Co Eli Compounds and methods for modulating FXR
CN101448791B (zh) * 2006-05-24 2011-11-16 伊莱利利公司 Fxr激动剂
EP1894924A1 (en) 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Heterocyclic FXR binding compounds
EP1894928A1 (en) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Heterocyclic fxr binding compounds
CL2007003035A1 (es) 2006-10-24 2008-05-16 Smithkline Beechman Corp Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos,
KR20100038102A (ko) 2007-06-13 2010-04-12 글락소스미스클라인 엘엘씨 파네소이드 x 수용체 작용제
MX2009013946A (es) 2007-07-02 2010-03-10 Glaxosmithkline Llc Agonistas del receptor de farnesoide x.
TW200906823A (en) 2007-07-16 2009-02-16 Lilly Co Eli Compounds and methods for modulating FXR
EP2128158A1 (en) 2008-05-26 2009-12-02 Phenex Pharmaceuticals AG Heterocyclic cyclopropyl-substituted FXR binding compounds
EP2289883A1 (en) * 2009-08-19 2011-03-02 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
EP2655368A1 (en) 2010-12-20 2013-10-30 Irm Llc Compositions and methods for modulating farnesoid x receptors
WO2012087521A1 (en) 2010-12-20 2012-06-28 Irm Llc Compositions and methods for modulating farnesoid x receptors
CU24152B1 (es) 2010-12-20 2016-02-29 Irm Llc 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
DK3043865T3 (da) 2013-09-11 2021-02-01 Univ Claude Bernard Lyon Fremgangsmåder og farmaceutiske sammensætningr til behandlingen af hepatitis b-virusinfektion
CN104513213A (zh) 2013-09-28 2015-04-15 山东亨利医药科技有限责任公司 Fxr激动剂
BR112016009630B1 (pt) * 2013-11-05 2021-02-09 Novartis Ag receptores de farnesoide x, seus usos, combinação e composição farmacêutica
CN104045635A (zh) 2014-06-23 2014-09-17 华东理工大学 3,4,5-三取代异恶唑类化合物及其用途
EP3034499A1 (en) 2014-12-17 2016-06-22 Gilead Sciences, Inc. Novel FXR (NR1H4) modulating compounds
EP3034501A1 (en) 2014-12-17 2016-06-22 Gilead Sciences, Inc. Hydroxy containing FXR (NR1H4) modulating compounds
MX2017008057A (es) 2014-12-18 2017-09-28 Novartis Ag Derivados de azabiciclooctano como agonistas de fxr para el uso en el tratamiento de enfermedades hepaticas y gastrointestinales.
CN107438612A (zh) * 2014-12-22 2017-12-05 阿卡纳治疗学有限公司 用于治疗疾病的稠合双环化合物
TWI698430B (zh) * 2015-02-13 2020-07-11 南北兄弟藥業投資有限公司 三環化合物及其在藥物中的應用
CN106146483A (zh) 2015-04-23 2016-11-23 上海迪诺医药科技有限公司 杂环类法尼酯衍生物x受体调节剂
CN106946867B (zh) 2016-01-06 2019-11-12 广州市恒诺康医药科技有限公司 Fxr受体调节剂及其制备方法和用途
WO2017128896A1 (zh) 2016-01-26 2017-08-03 江苏豪森药业集团有限公司 Fxr激动剂及其制备方法和应用
CN107021957A (zh) 2016-02-01 2017-08-08 山东轩竹医药科技有限公司 Fxr受体激动剂
CN107021958A (zh) * 2016-02-01 2017-08-08 山东轩竹医药科技有限公司 Fxr受体激动剂
WO2017133521A1 (zh) 2016-02-01 2017-08-10 山东轩竹医药科技有限公司 Fxr受体激动剂
TW201741307A (zh) 2016-02-22 2017-12-01 艾洛斯生物製藥公司 Fxr調節劑及其使用方法
US10080741B2 (en) 2016-04-26 2018-09-25 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use thereof
WO2017189651A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017189663A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017201152A1 (en) 2016-05-18 2017-11-23 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017201150A1 (en) 2016-05-18 2017-11-23 Enanta Pharmaceuticals, Inc. Isoxazole analogs as fxr agonists and methods of use thereof
WO2017201155A1 (en) 2016-05-18 2017-11-23 Enanta Pharmaceuticals, Inc. lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
AR108711A1 (es) 2016-06-13 2018-09-19 Gilead Sciences Inc Compuestos moduladores de fxr (nr1h4)
MX385718B (es) 2016-06-13 2025-03-18 Gilead Sciences Inc Compuestos moduladores de fxr (nr1h4).
TW201808283A (zh) * 2016-08-05 2018-03-16 廣東東陽光藥業有限公司 含氮三環化合物及其在藥物中的應用
CN116854681A (zh) 2016-08-23 2023-10-10 阿德利克斯股份有限公司 用于治疗代谢病状和病症的激素受体调节剂
WO2018039384A1 (en) 2016-08-23 2018-03-01 Ardelyx, Inc. Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as fxr activators
CN108430998B (zh) 2016-09-28 2021-07-09 四川科伦博泰生物医药股份有限公司 氮杂双环衍生物及其制备方法和用途
US10450306B2 (en) 2016-10-04 2019-10-22 Enanta Pharmaceuticals, Inc. Isoxazole analogs as FXR agonists and methods of use thereof
CN107973790A (zh) 2016-10-22 2018-05-01 合帕吉恩治疗公司 杂环fxr调节剂
WO2018081285A1 (en) 2016-10-26 2018-05-03 Enanta Pharmaceuticals, Inc. Urea-containing isoxazole derivatives as fxr agonists and methods of use thereof
CN108017636A (zh) 2016-11-04 2018-05-11 合帕吉恩治疗公司 作为fxr调节剂的含氮杂环化合物
CN108218852A (zh) 2016-12-15 2018-06-29 宁波百纳西药业有限公司 一种螺环化合物、其制备方法、组合物及用途
CN106632294A (zh) 2016-12-15 2017-05-10 宁波百纳西药业有限公司 一种螺环化合物及其药物用途
WO2018133730A1 (zh) 2017-01-20 2018-07-26 四川科伦博泰生物医药股份有限公司 一种杂环化合物及其制备方法和用途
CN108341822B (zh) 2017-01-23 2021-04-16 广州市恒诺康医药科技有限公司 Fxr受体调节剂及其制备方法和应用
PL3612520T3 (pl) 2017-04-12 2022-03-21 Il Dong Pharmaceutical Co., Ltd. Pochodne izoksazolu jako agoniści receptora jądrowego i ich zastosowania
EP3632910B1 (en) 2017-05-26 2024-07-17 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. 3,4-dihydroquinolinones as fxr receptor agonists
KR102400183B1 (ko) 2017-07-06 2022-05-18 수안주 바이오파마슈티컬 컴퍼니 리미티드 Fxr 작용제
CN109320509B (zh) 2017-07-31 2022-02-08 轩竹生物科技股份有限公司 Fxr受体激动剂
CN109320517B (zh) 2017-07-31 2021-08-17 轩竹生物科技有限公司 Fxr受体激动剂
EP3681881B1 (en) 2017-09-14 2022-11-02 Ardelyx, Inc. Hormone receptor modulators for treating metabolic mutagenic and fibrotic conditions and disorders
CN111278817B (zh) 2017-11-01 2023-05-16 百时美施贵宝公司 作为法尼醇x受体调节剂的多环化合物
CN111511731B (zh) 2017-11-01 2023-05-23 百时美施贵宝公司 作为法尼醇x受体调节剂的烯烃化合物
AU2018360575A1 (en) 2017-11-01 2020-06-18 Bristol-Myers Squibb Company Alkene spirocyclic compounds as farnesoid X receptor modulators
PE20201170A1 (es) 2017-11-01 2020-10-28 Bristol Myers Squibb Co Compuestos biciclicos en puente como moduladores del receptor farnesoide x
WO2019118571A1 (en) 2017-12-12 2019-06-20 Enanta Pharmaceuticals, Inc. Isoxazole analogs as fxr agonists and methods of use thereof
KR20200102415A (ko) 2017-12-22 2020-08-31 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 이소옥사졸 유도체, 그 제조 방법 및 그 용도
CN108264506B (zh) 2018-01-17 2021-01-26 中国药科大学 异黄酮衍生物、其制备方法和医药用途

Similar Documents

Publication Publication Date Title
JP2021512114A5 (https=)
JP2019524784A5 (https=)
JP2018505203A5 (https=)
RU2017131875A (ru) Трехъядерные соединения и их применение в медицине
CN115244056A (zh) 稠合咪唑类衍生物、其制备方法及其在医药上的应用
JP2021508686A5 (https=)
CN112955448A (zh) 芳环或芳杂环类化合物及其制备方法和医药用途
JP2019537557A5 (https=)
RU2020121150A (ru) Твердые формы ингибитора калликреина плазмы и его солей
JP2020535134A5 (https=)
JP2017514856A5 (https=)
JP2019504899A5 (https=)
JP2017531002A5 (https=)
JP2014520823A5 (https=)
JP2014500319A (ja) ファルネソイドx受容体を調節するための組成物および方法
JP2016500063A5 (https=)
JP2016517432A5 (https=)
JP2013525458A5 (https=)
CN106660974A (zh) 含氨磺酰基的1,2,5‑噁二唑类衍生物、其制备方法及其在医药上的应用
JP2019504898A5 (https=)
JP2013542937A5 (https=)
JP2009507909A5 (https=)
JP2014525427A5 (https=)
JP2017526677A5 (https=)
JP2019517463A5 (https=)