JP2019504899A5 - - Google Patents
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- Publication number
- JP2019504899A5 JP2019504899A5 JP2018561294A JP2018561294A JP2019504899A5 JP 2019504899 A5 JP2019504899 A5 JP 2019504899A5 JP 2018561294 A JP2018561294 A JP 2018561294A JP 2018561294 A JP2018561294 A JP 2018561294A JP 2019504899 A5 JP2019504899 A5 JP 2019504899A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- halogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **c1c(*)[n](CC(F)=CCN)c2c(*)c(*)nnc12 Chemical compound **c1c(*)[n](CC(F)=CCN)c2c(*)c(*)nnc12 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016900478 | 2016-02-12 | ||
| AU2016900478A AU2016900478A0 (en) | 2016-02-12 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| AU2016902593A AU2016902593A0 (en) | 2016-07-01 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| AU2016902593 | 2016-07-01 | ||
| PCT/AU2017/000040 WO2017136871A1 (en) | 2016-02-12 | 2017-02-10 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504899A JP2019504899A (ja) | 2019-02-21 |
| JP2019504899A5 true JP2019504899A5 (https=) | 2020-03-26 |
| JP6849197B2 JP6849197B2 (ja) | 2021-03-24 |
Family
ID=59562850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561293A Active JP6843888B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用 |
| JP2018561294A Expired - Fee Related JP6849197B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561293A Active JP6843888B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10717734B2 (https=) |
| EP (2) | EP3414226A4 (https=) |
| JP (2) | JP6843888B2 (https=) |
| KR (2) | KR102742235B1 (https=) |
| CN (2) | CN109153642B (https=) |
| AU (2) | AU2017217238B2 (https=) |
| BR (2) | BR112018067442A8 (https=) |
| CA (2) | CA3013850C (https=) |
| CO (2) | CO2018009068A2 (https=) |
| EA (2) | EA201891674A1 (https=) |
| IL (2) | IL261118A (https=) |
| MX (1) | MX388745B (https=) |
| PH (2) | PH12018501686A1 (https=) |
| SG (2) | SG11201806727TA (https=) |
| TW (2) | TW201739454A (https=) |
| WO (2) | WO2017136870A1 (https=) |
| ZA (2) | ZA201805675B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201891674A1 (ru) | 2016-02-12 | 2019-01-31 | Фармаксис Лтд. | Ингибиторы лизилоксидаз, представляющие собой индольные и азаиндольные производные галогеналлиламина, и их применения |
| EP3589619A4 (en) * | 2017-03-02 | 2020-12-16 | Pharmaxis Ltd. | LYSYL OXIDASE INHIBITORS, HALOGENOALLYLAMINE PYRAZOLE DERIVATIVES AND THEIR USES |
| GB201716871D0 (en) | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
| CN107903281B (zh) * | 2017-10-27 | 2019-10-29 | 苏州大学 | 一种合成烷基硼酯化合物的方法 |
| AR117398A1 (es) | 2018-03-12 | 2021-08-04 | Abbvie Inc | Inhibidores de la señalización mediada por tirosina cinasa 2 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| CN112533897B (zh) | 2018-08-03 | 2023-07-14 | 法玛西斯有限公司 | 赖氨酰氧化酶的卤代烯丙胺砜衍生抑制剂及其用途 |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| TWI835945B (zh) | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| WO2020146639A2 (en) * | 2019-01-11 | 2020-07-16 | Viscient Biosciences, Inc. | Compositions and methods for the diagnosis and treatment of diseases of the liver |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| JP2022544031A (ja) * | 2019-07-25 | 2022-10-17 | ファーマクシス リミテッド | リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用 |
| BR112022001488A2 (pt) | 2019-07-29 | 2022-04-19 | Heparegenix Gmbh | Inibidores de proteínas quinases de pirazolo-piridina substituída com heteroarila para promover regeneração do fígado ou redução ou prevenção de morte de hepatócitos |
| CA3164361A1 (en) | 2020-01-15 | 2021-07-22 | Heparegenix Gmbh | 3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases |
| US12578335B2 (en) | 2020-02-05 | 2026-03-17 | Syntara Limited | Bioprobes for lysyl oxidases and uses thereof |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| WO2021261601A1 (ja) | 2020-06-26 | 2021-12-30 | ラクオリア創薬株式会社 | レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬 |
| JP7384138B2 (ja) * | 2020-09-30 | 2023-11-21 | 株式会社島津製作所 | 電気泳動装置 |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US20250066308A1 (en) * | 2021-10-01 | 2025-02-27 | Yuhan Corporation | Bicyclic fused ring derivative or salt thereof and pharmaceutical composition comprising same |
| US12233056B2 (en) | 2022-04-06 | 2025-02-25 | Syntara Limited | Lysyl oxidase inhibitors for treating myeloid malignancies |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| WO2024151519A2 (en) * | 2023-01-09 | 2024-07-18 | University Of Florida Research Foundatin, Incorporated | Pparg modulators |
| CN117069611A (zh) * | 2023-07-12 | 2023-11-17 | 浙江工业大学 | 一种1-(2,4,6-三氯苯基)丙-2-酮o-甲基肟的制备方法 |
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| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4454158A (en) | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4699928A (en) | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) * | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4997854A (en) * | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| WO2004018997A2 (en) | 2002-08-20 | 2004-03-04 | Neurogenetics, Inc. | Methods and compositions for modulating amyloid beta |
| US9161922B2 (en) * | 2005-07-01 | 2015-10-20 | Case Western Reserve University | Amine oxidase inhibitors |
| US20070293548A1 (en) | 2006-03-31 | 2007-12-20 | Wang Eric Y | Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases |
| US20080293936A1 (en) | 2007-05-23 | 2008-11-27 | Elmar Reinhold Burchardt | Novel inhibitors of lysyl oxidase |
| AU2014200520A1 (en) * | 2007-08-02 | 2014-02-20 | Gilead Biologics, Inc. | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
| ES2700141T3 (es) * | 2007-08-02 | 2019-02-14 | Gilead Biologics Inc | Anticuerpos inhibidores LOXL2 y usos de los mismos |
| CA2705303A1 (en) * | 2007-11-07 | 2009-05-14 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| CN101917845A (zh) * | 2007-11-21 | 2010-12-15 | 法马克西斯制药公司 | Ssao/vap-1的卤代烯丙胺抑制剂及其用途 |
| US8569512B2 (en) * | 2009-03-23 | 2013-10-29 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| WO2011022670A1 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| US8841463B2 (en) * | 2011-02-11 | 2014-09-23 | Glaxosmithkline Intellectual Property Development Limited | Cathepsin C inhibitors |
| AU2013255103B2 (en) * | 2012-05-02 | 2016-09-29 | Syntara Limited | Substituted 3-haloallylamine inhibitors of SSAO and uses thereof |
| KR102494596B1 (ko) * | 2014-07-31 | 2023-01-31 | 재단법인 한국파스퇴르연구소 | 2-아미노-벤즈이미다졸 유도체 및 5-리폭시게나아제 및/또는 프로스타글란딘 e 합성효소 억제제로서의 이들의 용도 |
| EA201891674A1 (ru) | 2016-02-12 | 2019-01-31 | Фармаксис Лтд. | Ингибиторы лизилоксидаз, представляющие собой индольные и азаиндольные производные галогеналлиламина, и их применения |
-
2017
- 2017-02-10 EA EA201891674A patent/EA201891674A1/ru unknown
- 2017-02-10 SG SG11201806727TA patent/SG11201806727TA/en unknown
- 2017-02-10 CA CA3013850A patent/CA3013850C/en active Active
- 2017-02-10 BR BR112018067442A patent/BR112018067442A8/pt not_active Application Discontinuation
- 2017-02-10 WO PCT/AU2017/000039 patent/WO2017136870A1/en not_active Ceased
- 2017-02-10 EA EA201891676A patent/EA037302B9/ru unknown
- 2017-02-10 KR KR1020187024805A patent/KR102742235B1/ko active Active
- 2017-02-10 BR BR112018016484-4A patent/BR112018016484B1/pt active IP Right Grant
- 2017-02-10 CA CA3013819A patent/CA3013819A1/en not_active Abandoned
- 2017-02-10 JP JP2018561293A patent/JP6843888B2/ja active Active
- 2017-02-10 MX MX2018009645A patent/MX388745B/es unknown
- 2017-02-10 AU AU2017217238A patent/AU2017217238B2/en active Active
- 2017-02-10 AU AU2017217239A patent/AU2017217239A1/en not_active Abandoned
- 2017-02-10 SG SG11201806700RA patent/SG11201806700RA/en unknown
- 2017-02-10 US US16/076,985 patent/US10717734B2/en active Active
- 2017-02-10 EP EP17749813.6A patent/EP3414226A4/en not_active Withdrawn
- 2017-02-10 CN CN201780019653.6A patent/CN109153642B/zh not_active Expired - Fee Related
- 2017-02-10 WO PCT/AU2017/000040 patent/WO2017136871A1/en not_active Ceased
- 2017-02-10 KR KR1020187024804A patent/KR20180119582A/ko not_active Withdrawn
- 2017-02-10 EP EP17749812.8A patent/EP3414244A4/en active Pending
- 2017-02-10 CN CN201780019641.3A patent/CN109071533B/zh active Active
- 2017-02-10 US US16/076,979 patent/US10717733B2/en active Active
- 2017-02-10 JP JP2018561294A patent/JP6849197B2/ja not_active Expired - Fee Related
- 2017-02-13 TW TW106104662A patent/TW201739454A/zh unknown
- 2017-02-13 TW TW106104664A patent/TW201738206A/zh unknown
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2018
- 2018-08-07 PH PH12018501686A patent/PH12018501686A1/en unknown
- 2018-08-07 PH PH12018501685A patent/PH12018501685A1/en unknown
- 2018-08-12 IL IL261118A patent/IL261118A/en unknown
- 2018-08-12 IL IL261119A patent/IL261119B/en unknown
- 2018-08-24 ZA ZA2018/05675A patent/ZA201805675B/en unknown
- 2018-08-24 ZA ZA2018/05664A patent/ZA201805664B/en unknown
- 2018-08-28 CO CONC2018/0009068A patent/CO2018009068A2/es unknown
- 2018-08-28 CO CONC2018/0009071A patent/CO2018009071A2/es unknown
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2020
- 2020-06-11 US US16/899,116 patent/US11098045B2/en active Active