JP2019504899A5 - - Google Patents
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- Publication number
- JP2019504899A5 JP2019504899A5 JP2018561294A JP2018561294A JP2019504899A5 JP 2019504899 A5 JP2019504899 A5 JP 2019504899A5 JP 2018561294 A JP2018561294 A JP 2018561294A JP 2018561294 A JP2018561294 A JP 2018561294A JP 2019504899 A5 JP2019504899 A5 JP 2019504899A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- halogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **c1c(*)[n](CC(F)=CCN)c2c(*)c(*)nnc12 Chemical compound **c1c(*)[n](CC(F)=CCN)c2c(*)c(*)nnc12 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016900478 | 2016-02-12 | ||
| AU2016900478A AU2016900478A0 (en) | 2016-02-12 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| AU2016902593A AU2016902593A0 (en) | 2016-07-01 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| AU2016902593 | 2016-07-01 | ||
| PCT/AU2017/000040 WO2017136871A1 (en) | 2016-02-12 | 2017-02-10 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504899A JP2019504899A (ja) | 2019-02-21 |
| JP2019504899A5 true JP2019504899A5 (https=) | 2020-03-26 |
| JP6849197B2 JP6849197B2 (ja) | 2021-03-24 |
Family
ID=59562850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561294A Expired - Fee Related JP6849197B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
| JP2018561293A Active JP6843888B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561293A Active JP6843888B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10717733B2 (https=) |
| EP (2) | EP3414226A4 (https=) |
| JP (2) | JP6849197B2 (https=) |
| KR (2) | KR20180119582A (https=) |
| CN (2) | CN109071533B (https=) |
| AU (2) | AU2017217239A1 (https=) |
| BR (2) | BR112018067442A8 (https=) |
| CA (2) | CA3013819A1 (https=) |
| CO (2) | CO2018009071A2 (https=) |
| EA (2) | EA037302B9 (https=) |
| IL (2) | IL261119B (https=) |
| MX (1) | MX388745B (https=) |
| PH (2) | PH12018501685A1 (https=) |
| SG (2) | SG11201806700RA (https=) |
| TW (2) | TW201738206A (https=) |
| WO (2) | WO2017136871A1 (https=) |
| ZA (2) | ZA201805675B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6849197B2 (ja) | 2016-02-12 | 2021-03-24 | ファーマクシス リミテッド | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
| US20200069648A1 (en) * | 2017-03-02 | 2020-03-05 | Pharmaxis Ltd. | Haloallylamine pyrazole derivative inhibitors of lysyl oxidases and uses thereof |
| GB201716871D0 (en) | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
| CN107903281B (zh) * | 2017-10-27 | 2019-10-29 | 苏州大学 | 一种合成烷基硼酯化合物的方法 |
| AU2019234574A1 (en) | 2018-03-12 | 2020-09-03 | Abbvie Inc. | Inhibitors of tyrosine kinase 2 mediated signaling |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| CN112533897B (zh) | 2018-08-03 | 2023-07-14 | 法玛西斯有限公司 | 赖氨酰氧化酶的卤代烯丙胺砜衍生抑制剂及其用途 |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| TWI835945B (zh) | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| WO2020146639A2 (en) * | 2019-01-11 | 2020-07-16 | Viscient Biosciences, Inc. | Compositions and methods for the diagnosis and treatment of diseases of the liver |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| AU2020317374A1 (en) * | 2019-07-25 | 2022-02-03 | Pharmaxis Ltd. | Difluorohaloallylamine sulfone derivative inhibitors of lysyl oxidases, methods of preparation, and uses thereof |
| CA3148780A1 (en) | 2019-07-29 | 2021-02-04 | Bent PFAFFENROT | Heteroaryl-substituted pyrazolo-pyridine protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| AU2021207236A1 (en) | 2020-01-15 | 2022-08-11 | Heparegenix Gmbh | 3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as MKK4 inhibitors for treating liver diseases |
| US12578335B2 (en) | 2020-02-05 | 2026-03-17 | Syntara Limited | Bioprobes for lysyl oxidases and uses thereof |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| EP4173639A4 (en) | 2020-06-26 | 2024-03-13 | RaQualia Pharma Inc. | METHOD FOR SELECTING A CANCER PATIENT FOR WHICH COMBINATION THERAPY OF A RETINOID AND A CANCER TREATMENT AGENT WILL BE EFFECTIVE, AND COMBINATION DRUG OF A RETINOID AND A CANCER TREATMENT AGENT |
| JP7384138B2 (ja) * | 2020-09-30 | 2023-11-21 | 株式会社島津製作所 | 電気泳動装置 |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| AU2022357057A1 (en) * | 2021-10-01 | 2024-04-11 | Yuhan Corporation | Bicyclic fused ring derivative or salt thereof and pharmaceutical composition comprising same |
| US12233056B2 (en) | 2022-04-06 | 2025-02-25 | Syntara Limited | Lysyl oxidase inhibitors for treating myeloid malignancies |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| WO2024151519A2 (en) * | 2023-01-09 | 2024-07-18 | University Of Florida Research Foundatin, Incorporated | Pparg modulators |
| CN117069611A (zh) * | 2023-07-12 | 2023-11-17 | 浙江工业大学 | 一种1-(2,4,6-三氯苯基)丙-2-酮o-甲基肟的制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4454158A (en) | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4699928A (en) | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) * | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4997854A (en) * | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| AU2003259965A1 (en) | 2002-08-20 | 2004-03-11 | Neurogenetics, Inc. | Methods and compositions for modulating amyloid beta |
| US9161922B2 (en) * | 2005-07-01 | 2015-10-20 | Case Western Reserve University | Amine oxidase inhibitors |
| WO2007120528A2 (en) | 2006-03-31 | 2007-10-25 | La Jolla Pharmaceutical Company | Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases |
| US20080293936A1 (en) * | 2007-05-23 | 2008-11-27 | Elmar Reinhold Burchardt | Novel inhibitors of lysyl oxidase |
| AU2014200520A1 (en) * | 2007-08-02 | 2014-02-20 | Gilead Biologics, Inc. | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
| CA2693310C (en) | 2007-08-02 | 2018-11-27 | Arresto Biosciences, Inc. | Lox and loxl2 inhibitors, antibodies and uses thereof |
| US20100331297A1 (en) * | 2007-11-07 | 2010-12-30 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| JP2011504485A (ja) * | 2007-11-21 | 2011-02-10 | ファーマクシス リミテッド | Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途 |
| AU2010229144B2 (en) * | 2009-03-23 | 2012-07-12 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| WO2011022670A1 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| EP2672821B9 (en) | 2011-02-11 | 2016-11-23 | GlaxoSmithKline Intellectual Property Development Limited | Cathepsin c inhibitors |
| EP3438087A1 (en) * | 2012-05-02 | 2019-02-06 | Boehringer Ingelheim International GmbH | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
| JP6785217B2 (ja) * | 2014-07-31 | 2020-11-18 | インスティチュート パスツール コリア | ２−アミノ−ベンゾイミダゾール誘導体ならびにこれらの５−リポキシゲナーゼおよび／またはプロスタグランジンｅシンターゼ阻害剤としての使用 |
| JP6849197B2 (ja) | 2016-02-12 | 2021-03-24 | ファーマクシス リミテッド | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
-
2017
- 2017-02-10 JP JP2018561294A patent/JP6849197B2/ja not_active Expired - Fee Related
- 2017-02-10 EA EA201891676A patent/EA037302B9/ru unknown
- 2017-02-10 WO PCT/AU2017/000040 patent/WO2017136871A1/en not_active Ceased
- 2017-02-10 CA CA3013819A patent/CA3013819A1/en not_active Abandoned
- 2017-02-10 AU AU2017217239A patent/AU2017217239A1/en not_active Abandoned
- 2017-02-10 CA CA3013850A patent/CA3013850C/en active Active
- 2017-02-10 SG SG11201806700RA patent/SG11201806700RA/en unknown
- 2017-02-10 BR BR112018067442A patent/BR112018067442A8/pt not_active Application Discontinuation
- 2017-02-10 EP EP17749813.6A patent/EP3414226A4/en not_active Withdrawn
- 2017-02-10 US US16/076,979 patent/US10717733B2/en active Active
- 2017-02-10 CN CN201780019641.3A patent/CN109071533B/zh active Active
- 2017-02-10 CN CN201780019653.6A patent/CN109153642B/zh not_active Expired - Fee Related
- 2017-02-10 AU AU2017217238A patent/AU2017217238B2/en active Active
- 2017-02-10 EP EP17749812.8A patent/EP3414244A4/en active Pending
- 2017-02-10 WO PCT/AU2017/000039 patent/WO2017136870A1/en not_active Ceased
- 2017-02-10 KR KR1020187024804A patent/KR20180119582A/ko not_active Withdrawn
- 2017-02-10 SG SG11201806727TA patent/SG11201806727TA/en unknown
- 2017-02-10 EA EA201891674A patent/EA201891674A1/ru unknown
- 2017-02-10 MX MX2018009645A patent/MX388745B/es unknown
- 2017-02-10 JP JP2018561293A patent/JP6843888B2/ja active Active
- 2017-02-10 US US16/076,985 patent/US10717734B2/en active Active
- 2017-02-10 KR KR1020187024805A patent/KR102742235B1/ko active Active
- 2017-02-10 BR BR112018016484-4A patent/BR112018016484B1/pt active IP Right Grant
- 2017-02-13 TW TW106104664A patent/TW201738206A/zh unknown
- 2017-02-13 TW TW106104662A patent/TW201739454A/zh unknown
-
2018
- 2018-08-07 PH PH12018501685A patent/PH12018501685A1/en unknown
- 2018-08-07 PH PH12018501686A patent/PH12018501686A1/en unknown
- 2018-08-12 IL IL261119A patent/IL261119B/en unknown
- 2018-08-12 IL IL261118A patent/IL261118A/en unknown
- 2018-08-24 ZA ZA2018/05675A patent/ZA201805675B/en unknown
- 2018-08-24 ZA ZA2018/05664A patent/ZA201805664B/en unknown
- 2018-08-28 CO CONC2018/0009071A patent/CO2018009071A2/es unknown
- 2018-08-28 CO CONC2018/0009068A patent/CO2018009068A2/es unknown
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2020
- 2020-06-11 US US16/899,116 patent/US11098045B2/en active Active