JP2021535087A5 - - Google Patents
Info
- Publication number
- JP2021535087A5 JP2021535087A5 JP2021505981A JP2021505981A JP2021535087A5 JP 2021535087 A5 JP2021535087 A5 JP 2021535087A5 JP 2021505981 A JP2021505981 A JP 2021505981A JP 2021505981 A JP2021505981 A JP 2021505981A JP 2021535087 A5 JP2021535087 A5 JP 2021535087A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- cycloalkyl
- fibrosis
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018902829 | 2018-08-03 | ||
| AU2018902829A AU2018902829A0 (en) | 2018-08-03 | Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof | |
| PCT/AU2019/050811 WO2020024017A1 (en) | 2018-08-03 | 2019-08-02 | Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535087A JP2021535087A (ja) | 2021-12-16 |
| JP2021535087A5 true JP2021535087A5 (https=) | 2022-08-04 |
| JP7414803B2 JP7414803B2 (ja) | 2024-01-16 |
Family
ID=69230421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021505981A Active JP7414803B2 (ja) | 2018-08-03 | 2019-08-02 | リシルオキシダーゼのハロアリルアミンスルホン誘導体阻害剤およびそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12178791B2 (https=) |
| EP (1) | EP3829520B1 (https=) |
| JP (1) | JP7414803B2 (https=) |
| KR (1) | KR102780601B1 (https=) |
| CN (1) | CN112533897B (https=) |
| AR (1) | AR115906A1 (https=) |
| AU (1) | AU2019315330B2 (https=) |
| CA (1) | CA3105599A1 (https=) |
| ES (1) | ES3010655T3 (https=) |
| MX (1) | MX2021001347A (https=) |
| TW (1) | TW202019877A (https=) |
| WO (1) | WO2020024017A1 (https=) |
| ZA (1) | ZA202100148B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022544031A (ja) * | 2019-07-25 | 2022-10-17 | ファーマクシス リミテッド | リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用 |
| US12578335B2 (en) * | 2020-02-05 | 2026-03-17 | Syntara Limited | Bioprobes for lysyl oxidases and uses thereof |
| WO2021261601A1 (ja) | 2020-06-26 | 2021-12-30 | ラクオリア創薬株式会社 | レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬 |
| US12233056B2 (en) | 2022-04-06 | 2025-02-25 | Syntara Limited | Lysyl oxidase inhibitors for treating myeloid malignancies |
| AU2023331414A1 (en) * | 2022-08-29 | 2025-03-27 | Syntara Limited | Novel selective inhibitors of lysyl oxidases |
| EP4570796A1 (en) * | 2022-11-07 | 2025-06-18 | Eisai R&D Management Co., Ltd. | Method for producing macrolide compound |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4454158A (en) | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4699928A (en) | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| DE10216144A1 (de) | 2002-04-12 | 2003-11-06 | Bayer Ag | Substituierte 2-Phenyl-3(2H)-Pyridazinone |
| DE102004056226A1 (de) | 2004-11-22 | 2006-05-24 | Burchardt, Elmar Reinhold, Dr.Dr. | Neuartige Inhibitoren der Lysyloxidase |
| US20080293969A1 (en) | 2005-11-22 | 2008-11-27 | Ge Healthcare Limited | 18F-Labeled Daa Analogues and Method of Labeling These Analogues as Positron Emission Tomography (Pet) Tracers For Imaging Peripheral Benzodiazepine Receptors |
| US20070293548A1 (en) | 2006-03-31 | 2007-12-20 | Wang Eric Y | Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases |
| US20080293936A1 (en) | 2007-05-23 | 2008-11-27 | Elmar Reinhold Burchardt | Novel inhibitors of lysyl oxidase |
| ES2700141T3 (es) | 2007-08-02 | 2019-02-14 | Gilead Biologics Inc | Anticuerpos inhibidores LOXL2 y usos de los mismos |
| CN101917845A (zh) * | 2007-11-21 | 2010-12-15 | 法马克西斯制药公司 | Ssao/vap-1的卤代烯丙胺抑制剂及其用途 |
| WO2011022670A1 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| AU2013255103B2 (en) * | 2012-05-02 | 2016-09-29 | Syntara Limited | Substituted 3-haloallylamine inhibitors of SSAO and uses thereof |
| AU2016229268B2 (en) | 2015-03-06 | 2020-09-10 | Pharmakea, Inc. | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
| EP3265445B1 (en) | 2015-03-06 | 2021-05-05 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| WO2017003862A1 (en) | 2015-07-01 | 2017-01-05 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| EP3325462A4 (en) | 2015-07-23 | 2019-06-19 | Pharmakea, Inc. | INHIBITORS OF LYSYL OXIDASE-LIKE 2 AND USES OF SAID INHIBITORS |
| EA201891674A1 (ru) | 2016-02-12 | 2019-01-31 | Фармаксис Лтд. | Ингибиторы лизилоксидаз, представляющие собой индольные и азаиндольные производные галогеналлиламина, и их применения |
| GB201602934D0 (en) | 2016-02-19 | 2016-04-06 | Cancer Res Inst Royal | Compounds |
| WO2018048930A1 (en) | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| EP3589619A4 (en) * | 2017-03-02 | 2020-12-16 | Pharmaxis Ltd. | LYSYL OXIDASE INHIBITORS, HALOGENOALLYLAMINE PYRAZOLE DERIVATIVES AND THEIR USES |
| GB201716871D0 (en) | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
-
2019
- 2019-08-02 CN CN201980051571.9A patent/CN112533897B/zh active Active
- 2019-08-02 EP EP19844663.5A patent/EP3829520B1/en active Active
- 2019-08-02 KR KR1020217003279A patent/KR102780601B1/ko active Active
- 2019-08-02 MX MX2021001347A patent/MX2021001347A/es unknown
- 2019-08-02 WO PCT/AU2019/050811 patent/WO2020024017A1/en not_active Ceased
- 2019-08-02 US US17/265,402 patent/US12178791B2/en active Active
- 2019-08-02 CA CA3105599A patent/CA3105599A1/en active Pending
- 2019-08-02 AR ARP190102210A patent/AR115906A1/es unknown
- 2019-08-02 TW TW108127609A patent/TW202019877A/zh unknown
- 2019-08-02 AU AU2019315330A patent/AU2019315330B2/en active Active
- 2019-08-02 JP JP2021505981A patent/JP7414803B2/ja active Active
- 2019-08-02 ES ES19844663T patent/ES3010655T3/es active Active
-
2021
- 2021-01-08 ZA ZA2021/00148A patent/ZA202100148B/en unknown
-
2024
- 2024-11-21 US US18/955,223 patent/US20250082593A1/en active Pending
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