JP7237078B2 - 窒素含有三環式化合物及び医薬品におけるその使用 - Google Patents

窒素含有三環式化合物及び医薬品におけるその使用 Download PDF

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JP7237078B2
JP7237078B2 JP2020541888A JP2020541888A JP7237078B2 JP 7237078 B2 JP7237078 B2 JP 7237078B2 JP 2020541888 A JP2020541888 A JP 2020541888A JP 2020541888 A JP2020541888 A JP 2020541888A JP 7237078 B2 JP7237078 B2 JP 7237078B2
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alkyl
disease
alkoxy
mmol
compound
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JP2021512114A5 (https=
JP2021512114A (ja
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シンエ・ヤン
シャオジュン・ワン
ジュンウェン・ウ
ホン・チェン
シェンティアン・カオ
インジュン・ジャン
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Sunshine Lake Pharma Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020541888A 2018-02-02 2019-01-28 窒素含有三環式化合物及び医薬品におけるその使用 Active JP7237078B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810107007 2018-02-02
CN201810107007.1 2018-02-02
PCT/CN2019/073303 WO2019149158A1 (en) 2018-02-02 2019-01-28 Nitrogenous tricyclic compounds and uses thereof in medicine

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JP2021512114A JP2021512114A (ja) 2021-05-13
JP2021512114A5 JP2021512114A5 (https=) 2022-01-04
JP7237078B2 true JP7237078B2 (ja) 2023-03-10

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US (1) US11208418B2 (https=)
EP (1) EP3746448B1 (https=)
JP (1) JP7237078B2 (https=)
CN (1) CN110128432B (https=)
TW (1) TWI801492B (https=)
WO (1) WO2019149158A1 (https=)

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JP7750836B2 (ja) * 2019-11-29 2025-10-07 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 三環式含窒素化合物の非晶質及びその用途
CN112876493B (zh) * 2019-11-29 2023-05-09 广东东阳光药业有限公司 含氮三环化合物的盐及其用途
CN114315815B (zh) * 2020-10-12 2024-07-19 甘莱制药有限公司 用于调节fxr活性的化合物及其应用
CN115974885A (zh) * 2021-10-15 2023-04-18 广东东阳光药业有限公司 含氮三环化合物的新晶型及其用途
CN118271327A (zh) * 2022-12-30 2024-07-02 广东东阳光药业股份有限公司 三环化合物的晶型及其用途

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