TWI801492B - 含氮三環化合物及其在藥物中的應用 - Google Patents

Info

Publication number

TWI801492B

TWI801492B TW108103632A TW108103632A TWI801492B TW I801492 B TWI801492 B TW I801492B TW 108103632 A TW108103632 A TW 108103632A TW 108103632 A TW108103632 A TW 108103632A TW I801492 B TWI801492 B TW I801492B

Authority

TW

Taiwan

Prior art keywords

compound

alkyl

item

present

alkoxy

Prior art date

2018-02-02

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 189
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• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims abstract description 33
• 150000003839 salts Chemical class 0.000 claims abstract description 26
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• 125000003545 alkoxy group Chemical group 0.000 claims description 27
• 229910052794 bromium Inorganic materials 0.000 claims description 20
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• 229910052731 fluorine Inorganic materials 0.000 claims description 20
• 229910052739 hydrogen Inorganic materials 0.000 claims description 20
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• 150000002431 hydrogen Chemical class 0.000 claims description 19
• 238000002360 preparation method Methods 0.000 claims description 19
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 18
• 229910052805 deuterium Inorganic materials 0.000 claims description 18
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 14
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• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 12
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• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims description 8
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• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 8
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• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 8
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• 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 7
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• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 7
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• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 6
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• PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 claims description 3
• XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 3
• LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims description 3
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