JP2017537090A - Ox40結合アゴニスト及びpd−1軸結合アンタゴニストを含む併用療法 - Google Patents

Ox40結合アゴニスト及びpd−1軸結合アンタゴニストを含む併用療法 Download PDF

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JP2017537090A
JP2017537090A JP2017526558A JP2017526558A JP2017537090A JP 2017537090 A JP2017537090 A JP 2017537090A JP 2017526558 A JP2017526558 A JP 2017526558A JP 2017526558 A JP2017526558 A JP 2017526558A JP 2017537090 A JP2017537090 A JP 2017537090A
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antibody
cancer
binding
binding antagonist
agonist
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JP2017537090A5 (enExample
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ジャンヌ チャン,
ジャンヌ チャン,
マールーク フセニ,
マールーク フセニ,
ジョン キム,
ジョン キム,
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Genentech Inc
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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JP2017526558A 2014-11-17 2015-11-16 Ox40結合アゴニスト及びpd−1軸結合アンタゴニストを含む併用療法 Pending JP2017537090A (ja)

Applications Claiming Priority (5)

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US201462080991P 2014-11-17 2014-11-17
US62/080,991 2014-11-17
US201462093400P 2014-12-17 2014-12-17
US62/093,400 2014-12-17
PCT/US2015/060941 WO2016081384A1 (en) 2014-11-17 2015-11-16 Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists

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JP2017537090A true JP2017537090A (ja) 2017-12-14
JP2017537090A5 JP2017537090A5 (enExample) 2018-12-27

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US (2) US20160166685A1 (enExample)
EP (1) EP3221360A1 (enExample)
JP (1) JP2017537090A (enExample)
KR (1) KR20170096112A (enExample)
CN (1) CN106999583A (enExample)
AU (1) AU2015350242A1 (enExample)
BR (1) BR112017010198A2 (enExample)
CA (1) CA2967368A1 (enExample)
IL (1) IL252251A0 (enExample)
MX (1) MX2017006320A (enExample)
RU (1) RU2017121096A (enExample)
SG (2) SG10201807625PA (enExample)
WO (1) WO2016081384A1 (enExample)

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JP2021514198A (ja) * 2017-12-29 2021-06-10 ナンジン ユーマブ−バイオファーマ カンパニー リミテッドNanjing Umab−Biopharma Co., Ltd. 単離された抗体またはその抗原結合断片、および腫瘍治療におけるその使用

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