|
DE2947526A1
(de)
|
1978-11-29 |
1980-06-12 |
Ono Pharmaceutical Co |
Prostacyclin-analoge
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
JPS61289034A
(ja)
|
1985-06-17 |
1986-12-19 |
Teijin Ltd |
イソカルバサイクリン類脂肪乳剤
|
|
US4837342A
(en)
|
1986-02-28 |
1989-06-06 |
Sagami Chemical Research Center |
Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
GB9011588D0
(en)
|
1990-05-24 |
1990-07-11 |
Wellcome Found |
Prostaglandin analogues for use in medicine
|
|
US6165500A
(en)
|
1990-08-24 |
2000-12-26 |
Idea Ag |
Preparation for the application of agents in mini-droplets
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5190972A
(en)
|
1992-01-27 |
1993-03-02 |
The University Of Melbourne |
Method of combatting cyclosporine organ toxicity with prostaglandin analogs
|
|
CA2091152C
(en)
|
1993-03-05 |
2005-05-03 |
Kirsten Westesen |
Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
|
|
US5576016A
(en)
|
1993-05-18 |
1996-11-19 |
Pharmos Corporation |
Solid fat nanoemulsions as drug delivery vehicles
|
|
US6638621B2
(en)
|
2000-08-16 |
2003-10-28 |
Lyotropic Therapeutics, Inc. |
Coated particles, methods of making and using
|
|
US6441245B1
(en)
|
1997-10-24 |
2002-08-27 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
KR100638684B1
(ko)
|
1997-11-14 |
2006-10-27 |
유나이티드 세러퓨틱스 코오포레이션 |
말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도
|
|
AU742250B2
(en)
|
1997-12-26 |
2001-12-20 |
Astellas Pharma Inc. |
Sustained release medicinal compositions
|
|
WO2000006120A1
(en)
|
1998-07-31 |
2000-02-10 |
Korea Institute Of Science And Technology |
Lipid emulsion and solid lipid nanoparticle as a gene or drug carrier
|
|
US6265495B1
(en)
*
|
1998-09-22 |
2001-07-24 |
Nippon Shokubai Co., Ltd. |
Method for production of esterified product
|
|
US6521212B1
(en)
|
1999-03-18 |
2003-02-18 |
United Therapeutics Corporation |
Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
|
|
EP1164846A1
(en)
|
1999-03-31 |
2002-01-02 |
United Therapeutics Corporation |
Prostaglandin compounds, compositions and methods of treating peripheral vascular disease and pulmonary hypertension
|
|
US6242482B1
(en)
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6306435B1
(en)
|
2000-06-26 |
2001-10-23 |
Yung Shin Pharmaceutical Industrial Co. Ltd. |
Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
|
|
CA2451432A1
(en)
|
2001-06-23 |
2003-01-03 |
Lyotropic Therapeutics, Inc. |
Particles with improved solubilization capacity
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US6803386B2
(en)
|
2002-01-16 |
2004-10-12 |
United Therapeutics Corporation |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
|
|
WO2004012680A2
(en)
|
2002-08-06 |
2004-02-12 |
Lyotropic Therapeutics, Inc. |
Lipid-drug complexes in reversed liquid and liquid crystalline phases
|
|
CN1791386A
(zh)
|
2003-05-19 |
2006-06-21 |
巴克斯特国际公司 |
抗癫痫和抗痴呆药物以及免疫抑制剂的小－颗粒药物制剂
|
|
ATE341312T1
(de)
|
2003-05-20 |
2006-10-15 |
Ethypharm Sa |
Orale pharmazeutische zusammensetzung mit verzögerter freisetzung
|
|
ES2670872T3
(es)
|
2003-05-22 |
2018-06-01 |
United Therapeutics Corporation |
Polimorfo de una sal de dietanolamina de treprostinil
|
|
JP4906514B2
(ja)
|
2003-12-16 |
2012-03-28 |
ユナイテッド セラピューティクス コーポレイション |
腎臓機能改善のためのトレプロスチニルの用途
|
|
US8765813B2
(en)
|
2003-12-16 |
2014-07-01 |
United Therapeutics Corporation |
Use of treprostinil to treat and prevent ischemic lesions
|
|
CA2562614C
(en)
|
2004-04-12 |
2013-09-17 |
United Therapeutics, Inc. |
Use of treprostinil to treat neuropathic diabetic foot ulcers
|
|
GB0416328D0
(en)
|
2004-07-21 |
2004-08-25 |
Univ Cardiff |
Use of dry powder compositions for pulmonary delivery
|
|
EP1796653A2
(en)
|
2004-07-26 |
2007-06-20 |
Actelion Pharmaceuticals Ltd. |
Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
|
|
WO2006043655A1
(ja)
|
2004-10-22 |
2006-04-27 |
Ono Pharmaceutical Co., Ltd. |
吸入用医薬組成物
|
|
JP2009519972A
(ja)
|
2005-12-15 |
2009-05-21 |
アキュスフィア， インコーポレイテッド |
粒子ベースの経肺投与または経鼻投与用製薬の製造方法
|
|
JP5797376B2
(ja)
|
2006-05-15 |
2015-10-21 |
ユナイテッド セラピューティクス コーポレーション |
定量吸入器を用いたトレプロスチニル投与
|
|
US20090036465A1
(en)
|
2006-10-18 |
2009-02-05 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
US20080280986A1
(en)
|
2007-02-09 |
2008-11-13 |
United Therapeutics Corporation |
Treprostinil treatment for interstitial lung disease and asthma
|
|
WO2008124632A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Amphiphilic compound assisted nanoparticles for targeted delivery
|
|
EP2711024B1
(en)
|
2007-09-07 |
2019-03-06 |
United Therapeutics Corporation |
Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
|
|
WO2009078965A1
(en)
|
2007-12-17 |
2009-06-25 |
United Therapeutics Corporation |
An improved process to prepare treprostinil, the active ingredient in remodulin
|
|
KR20110010753A
(ko)
|
2008-05-08 |
2011-02-07 |
유나이티드 세러퓨틱스 코오포레이션 |
트레프로스티닐 일수화물
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
US20110294815A1
(en)
|
2008-06-27 |
2011-12-01 |
Harbeson Scott L |
Prostacyclin analogs
|
|
WO2010039531A1
(en)
|
2008-09-23 |
2010-04-08 |
Resolvyx Pharmaceuticals, Inc. |
Therapeutic compounds
|
|
US20120177693A1
(en)
|
2008-09-25 |
2012-07-12 |
Aradigm Corporation |
Deep lung pulmonary delivery of treprostinil
|
|
AU2010220061A1
(en)
|
2009-02-20 |
2010-09-10 |
Micro Labs Limited |
Storage stable prostaglandin product
|
|
EP2427054A4
(en)
|
2009-05-07 |
2014-01-15 |
United Therapeutics Corp |
SOLID COMPOSITIONS BASED ON PROSTACYCLINE ANALOGS
|
|
US8519178B2
(en)
|
2009-06-22 |
2013-08-27 |
Johnson Matthey Public Limited Company |
Method for the purification of prostaglandins
|
|
US20120270934A1
(en)
|
2009-07-03 |
2012-10-25 |
Concert Pharmaceuticals, Inc. |
Prostacyclin derivatives
|
|
US20120184622A1
(en)
|
2009-08-07 |
2012-07-19 |
Scipharm Sarl |
Composition for the treatment of cystic fibrosis
|
|
US20120232034A1
(en)
|
2009-08-21 |
2012-09-13 |
Henk-Andre Kroon |
Vesicular formulations
|
|
CN101669904B
(zh)
|
2009-09-29 |
2011-06-22 |
北京中海康医药科技发展有限公司 |
一种依前列醇脂质纳米粒及制备方法
|
|
WO2011089216A1
(en)
|
2010-01-22 |
2011-07-28 |
Ascendis Pharma As |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
|
|
WO2011089215A1
(en)
|
2010-01-22 |
2011-07-28 |
Ascendis Pharma As |
Dipeptide-based prodrug linkers for aromatic amine-containing drugs
|
|
JP5681276B2
(ja)
|
2010-03-15 |
2015-03-04 |
ユナイテッド セラピューティクス コーポレイション |
肺高血圧症のための治療
|
|
US8481782B2
(en)
|
2010-06-03 |
2013-07-09 |
United Therapeutics Corporation |
Treprostinil production
|
|
WO2011159693A2
(en)
|
2010-06-15 |
2011-12-22 |
United Therapeutics Corporation |
Oral treatment of digital ischemic lesions
|
|
US20120010159A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
JP5780775B2
(ja)
|
2011-02-18 |
2015-09-16 |
株式会社Ｌｔｔバイオファーマ |
プロスタグランジンｉ２誘導体を含有するナノ粒子
|
|
KR101454571B1
(ko)
|
2011-03-02 |
2014-10-23 |
유나이티드 세러퓨틱스 코오포레이션 |
트레프로스티닐 생산을 위한 중간체 합성
|
|
JP5850915B2
(ja)
|
2011-03-14 |
2016-02-03 |
国立大学法人北海道大学 |
肺送達のためのベクター、導入剤及び使用
|
|
CA2843506C
(en)
|
2011-08-12 |
2020-05-12 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
AU2012296949B2
(en)
|
2011-08-12 |
2016-09-15 |
Ascendis Pharma A/S |
High-loading water-soluble carrier-linked prodrugs
|
|
EP2741781A1
(en)
|
2011-08-12 |
2014-06-18 |
Ascendis Pharma A/S |
Carrier-linked treprostinil prodrugs
|
|
EP2741778A1
(en)
|
2011-08-12 |
2014-06-18 |
Ascendis Pharma A/S |
Polymeric hyperbranched carrier-linked prodrugs
|
|
US9872864B2
(en)
|
2011-08-12 |
2018-01-23 |
Ascendis Pharma A/S |
Sustained release composition of prostacyclin
|
|
WO2013024049A1
(en)
|
2011-08-12 |
2013-02-21 |
Ascendis Pharma A/S |
Protein carrier-linked prodrugs
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
LT2674413T
(lt)
|
2012-06-15 |
2017-09-25 |
Scipharm Sąrl |
Treprostinilo ir jo darinių gavimo būdas
|
|
ES2869701T3
(es)
|
2012-08-01 |
2021-10-25 |
United Therapeutics Corp |
Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
|
|
IN2015DN00934A
(enExample)
|
2012-08-01 |
2015-06-12 |
United Therapeutics Corp |
|
|
JP6357481B2
(ja)
|
2012-11-30 |
2018-07-11 |
インスメッド， インコーポレイテッド |
プロスタサイクリン化合物およびプロスタサイクリン化合物を使用する方法
|
|
AU2014205557B2
(en)
|
2013-01-09 |
2017-08-10 |
United Therapeutics Corporation |
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
ES2927844T3
(es)
|
2013-01-11 |
2022-11-11 |
Corsair Pharma Inc |
Profármacos de treprostinil
|
|
CA3125504C
(en)
|
2013-03-14 |
2023-10-24 |
United Therapeutics Corporation |
Solid forms of treprostinil
|
|
KR20150128903A
(ko)
|
2013-03-15 |
2015-11-18 |
유나이티드 세러퓨틱스 코오포레이션 |
트레프로스티닐의 염
|
|
WO2014160638A1
(en)
|
2013-03-25 |
2014-10-02 |
United Therapeutics Corporation |
Process of making prostacyclin compounds with linker thiol and pegylated forms
|
|
EP2991639A4
(en)
|
2013-04-30 |
2016-11-30 |
United Therapeutics Corp |
PHARMACEUTICAL FORMULATIONS WITH CONTROLLED RELEASE
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
WO2015054574A1
(en)
|
2013-10-11 |
2015-04-16 |
Zisman Lawrence S |
Spray dry formulations
|
|
SI3060041T1
(sl)
|
2013-10-25 |
2021-04-30 |
Insmed Incorporated |
Spojine prostaciklina
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
ES2908142T3
(es)
|
2014-06-13 |
2022-04-27 |
United Therapeutics Corp |
Formulaciones de treprostinil
|
|
US9593061B2
(en)
|
2014-10-20 |
2017-03-14 |
United Therapeutics Corporation |
Synthesis of intermediates for producing prostacyclin derivatives
|
|
EP3904326A1
(en)
|
2014-11-18 |
2021-11-03 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
US10898494B2
(en)
|
2016-05-05 |
2021-01-26 |
Liquidia Technologies, Inc. |
Dry powder treprostinil for the treatment of pulmonary hypertension
|
|
WO2017223400A1
(en)
|
2016-06-24 |
2017-12-28 |
Insmed Incorporated |
Prostacyclin compounds and compositions for treating sarcoidosis
|
|
CA3038276A1
(en)
|
2016-09-26 |
2018-03-29 |
United Therapeutics Corporation |
Treprostinil prodrugs
|
|
EP3673895A1
(en)
|
2018-12-28 |
2020-07-01 |
Université Libre de Bruxelles |
Dry powder inhalation formulation and its use for the therapeutic treatment of lungs
|
|
CN114072136B
(zh)
|
2019-04-29 |
2024-11-29 |
英斯梅德股份有限公司 |
曲前列素前药的干粉组合物及其使用方法
|