|
DE2947526A1
(de)
|
1978-11-29 |
1980-06-12 |
Ono Pharmaceutical Co |
Prostacyclin-analoge
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
JPS61289034A
(ja)
|
1985-06-17 |
1986-12-19 |
Teijin Ltd |
イソカルバサイクリン類脂肪乳剤
|
|
US4837342A
(en)
|
1986-02-28 |
1989-06-06 |
Sagami Chemical Research Center |
Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
GB9011588D0
(en)
|
1990-05-24 |
1990-07-11 |
Wellcome Found |
Prostaglandin analogues for use in medicine
|
|
US6165500A
(en)
|
1990-08-24 |
2000-12-26 |
Idea Ag |
Preparation for the application of agents in mini-droplets
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5190972A
(en)
|
1992-01-27 |
1993-03-02 |
The University Of Melbourne |
Method of combatting cyclosporine organ toxicity with prostaglandin analogs
|
|
CA2091152C
(en)
|
1993-03-05 |
2005-05-03 |
Kirsten Westesen |
Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
|
|
US5576016A
(en)
|
1993-05-18 |
1996-11-19 |
Pharmos Corporation |
Solid fat nanoemulsions as drug delivery vehicles
|
|
US6638621B2
(en)
|
2000-08-16 |
2003-10-28 |
Lyotropic Therapeutics, Inc. |
Coated particles, methods of making and using
|
|
US6441245B1
(en)
|
1997-10-24 |
2002-08-27 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
ES2214753T3
(es)
|
1997-11-14 |
2004-09-16 |
United Therapeutics Corporation |
Uso de 9-desoxi-2',9-alfa-metano-3-oxa-4,5,6-trinor-3,7-(1',3'-interfenilen)-13,14-dihidro-prostaglandina f1 para tratar la enfermedad vascular periferica.
|
|
EP1043031A4
(en)
|
1997-12-26 |
2007-05-02 |
Astellas Pharma Inc |
MEDICAL COMPOSITIONS WITH DELAYED ACTIVE INGREDIENTS
|
|
JP2002521423A
(ja)
|
1998-07-31 |
2002-07-16 |
コリア インスティチュート オブ サイエンス アンド テクノロージ |
遺伝子又は薬物運搬体としての脂質エマルジョン及び固形脂質微粒子
|
|
US6265495B1
(en)
*
|
1998-09-22 |
2001-07-24 |
Nippon Shokubai Co., Ltd. |
Method for production of esterified product
|
|
US6521212B1
(en)
|
1999-03-18 |
2003-02-18 |
United Therapeutics Corporation |
Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
|
|
KR20020012169A
(ko)
|
1999-03-31 |
2002-02-15 |
유나이티드 쎄러퓨틱스 코포레이션 |
프로스타글란딘 화합물, 조성물 및 말초혈관질병 및폐고혈압증의 치료방법
|
|
US6242482B1
(en)
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6306435B1
(en)
|
2000-06-26 |
2001-10-23 |
Yung Shin Pharmaceutical Industrial Co. Ltd. |
Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
|
|
WO2003000236A1
(en)
|
2001-06-23 |
2003-01-03 |
Lyotropic Therapeutics, Inc |
Particles with improved solubilization capacity
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US6803386B2
(en)
|
2002-01-16 |
2004-10-12 |
United Therapeutics Corporation |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
|
|
AU2003258075A1
(en)
|
2002-08-06 |
2004-02-23 |
Lyotropic Therapeutics, Inc. |
Lipid-drug complexes in reversed liquid and liquid crystalline phases
|
|
AU2004240640A1
(en)
|
2003-05-19 |
2004-12-02 |
Baxter International Inc. |
Solid particles comprising an anticonvulsant or an immunosuppressive coated with one or more surface modifiers
|
|
ES2272914T3
(es)
|
2003-05-20 |
2007-05-01 |
Ethypharm |
Composicion farmaceutica oral de liberacion sostenida.
|
|
CN102697790A
(zh)
|
2003-05-22 |
2012-10-03 |
联合治疗公司 |
化合物和释放前列环素类似物的方法
|
|
CN1917866B
(zh)
|
2003-12-16 |
2010-12-15 |
联合治疗公司 |
曲前列环素或它的衍生物,或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途
|
|
US7199157B2
(en)
|
2003-12-16 |
2007-04-03 |
United Therapeutics Corporation |
Use of treprostinil to improve kidney functions
|
|
DE602005020269D1
(de)
|
2004-04-12 |
2010-05-12 |
United Therapeutics Corp |
Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
|
|
GB0416328D0
(en)
|
2004-07-21 |
2004-08-25 |
Univ Cardiff |
Use of dry powder compositions for pulmonary delivery
|
|
CA2574958A1
(en)
|
2004-07-26 |
2006-02-09 |
Cotherix, Inc. |
Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
|
|
EP1806148A4
(en)
|
2004-10-22 |
2009-12-02 |
Ono Pharmaceutical Co |
THERAPEUTIC PREPARATION FOR INHALATION
|
|
US20070178166A1
(en)
|
2005-12-15 |
2007-08-02 |
Acusphere, Inc. |
Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
|
|
CA2654492C
(en)
|
2006-05-15 |
2017-06-27 |
United Therapeutics Corporation |
Treprostinil administration using a metered dose inhaler
|
|
US20090036465A1
(en)
|
2006-10-18 |
2009-02-05 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
CA2678258A1
(en)
|
2007-02-09 |
2008-08-14 |
United Therapeutics Corporation |
Treprostinil treatment for interstitial lung disease and asthma
|
|
US20090074828A1
(en)
|
2007-04-04 |
2009-03-19 |
Massachusetts Institute Of Technology |
Poly(amino acid) targeting moieties
|
|
CN103181893A
(zh)
|
2007-09-07 |
2013-07-03 |
联合治疗公司 |
针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法
|
|
WO2009078965A1
(en)
|
2007-12-17 |
2009-06-25 |
United Therapeutics Corporation |
An improved process to prepare treprostinil, the active ingredient in remodulin
|
|
JP6219016B2
(ja)
|
2008-05-08 |
2017-10-25 |
ユナイテッド セラピューティクス コーポレーション |
トレプロスチニル一水和物
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
WO2009158010A1
(en)
|
2008-06-27 |
2009-12-30 |
Concert Pharmaceuticals, Inc. |
Prostacyclin analogs
|
|
WO2010039531A1
(en)
|
2008-09-23 |
2010-04-08 |
Resolvyx Pharmaceuticals, Inc. |
Therapeutic compounds
|
|
EP2330893A4
(en)
|
2008-09-25 |
2013-01-09 |
Aradigm Corp |
DEEP PULMONARY ADMINISTRATION OF TREPROSTINIL
|
|
RU2482851C2
(ru)
|
2009-02-20 |
2013-05-27 |
Микро Лабс Лимитед |
Хранение стабильного продукта простагландина
|
|
CN102421288B
(zh)
|
2009-05-07 |
2015-04-22 |
联合治疗公司 |
前列环素类似物的固体剂型
|
|
US8519178B2
(en)
|
2009-06-22 |
2013-08-27 |
Johnson Matthey Public Limited Company |
Method for the purification of prostaglandins
|
|
WO2011003058A1
(en)
|
2009-07-03 |
2011-01-06 |
Concert Pharmaceuticals, Inc. |
Prostacyclin derivatives
|
|
AU2010280684B2
(en)
|
2009-08-07 |
2016-07-28 |
Scipharm Sarl |
Composition for the treatment of cystic fibrosis
|
|
GB2486371A
(en)
|
2009-08-21 |
2012-06-13 |
Targeted Delivery Technologies Ltd |
Vesicular formulations
|
|
CN101669904B
(zh)
|
2009-09-29 |
2011-06-22 |
北京中海康医药科技发展有限公司 |
一种依前列醇脂质纳米粒及制备方法
|
|
US9062094B2
(en)
|
2010-01-22 |
2015-06-23 |
Ascendis Pharma As |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
|
|
EP2525829A1
(en)
|
2010-01-22 |
2012-11-28 |
Ascendis Pharma A/S |
Dipeptide-based prodrug linkers for aromatic amine-containing drugs
|
|
KR20160132501A
(ko)
|
2010-03-15 |
2016-11-18 |
유나이티드 세러퓨틱스 코오포레이션 |
폐고혈압의 치료
|
|
CN103261142B
(zh)
|
2010-06-03 |
2014-12-10 |
联合治疗公司 |
曲前列环素的制备
|
|
WO2011159693A2
(en)
|
2010-06-15 |
2011-12-22 |
United Therapeutics Corporation |
Oral treatment of digital ischemic lesions
|
|
US20120010159A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
JP5780775B2
(ja)
|
2011-02-18 |
2015-09-16 |
株式会社Lttバイオファーマ |
プロスタグランジンi2誘導体を含有するナノ粒子
|
|
ES2581762T3
(es)
|
2011-03-02 |
2016-09-07 |
United Therapeutics Corporation |
Síntesis de producto intermedio para la producción de treprostinil
|
|
CN103561725B
(zh)
|
2011-03-14 |
2018-08-31 |
国立大学法人北海道大学 |
用于肺递送的载体、导入剂及用途
|
|
HK1198628A1
(en)
|
2011-08-12 |
2015-05-22 |
Ascendis Pharma A/S |
Polymeric hyperbranched carrier-linked prodrugs
|
|
BR112014003225A2
(pt)
|
2011-08-12 |
2017-03-01 |
Ascendis Pharma As |
profármacos de treprostinil ligados a veículo
|
|
AU2012296953B2
(en)
|
2011-08-12 |
2016-10-20 |
Ascendis Pharma A/S |
Sustained release composition of prostacyclin
|
|
EP2741779A1
(en)
|
2011-08-12 |
2014-06-18 |
Ascendis Pharma A/S |
High-loading water-soluble carrier-linked prodrugs
|
|
US20140323402A1
(en)
|
2011-08-12 |
2014-10-30 |
Ascendis Phama A/S |
Protein Carrier-Linked Prodrugs
|
|
EP3643306A3
(en)
|
2011-08-12 |
2020-08-26 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
SI2674413T1
(sl)
|
2012-06-15 |
2017-10-30 |
Scipharm Sarl |
Postopek za pripravo treprostinila in derivatov le-tega
|
|
JP6746313B2
(ja)
|
2012-08-01 |
2020-08-26 |
ユナイテッド セラピューティクス コーポレイション |
プロスタサイクリン処理された内皮前駆細胞による肺動脈性高血圧症の処置
|
|
CN104684561A
(zh)
|
2012-08-01 |
2015-06-03 |
联合治疗公司 |
利用间充质干细胞的肺动脉高血压的治疗
|
|
WO2014085813A1
(en)
|
2012-11-30 |
2014-06-05 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
KR102466885B1
(ko)
|
2013-01-09 |
2022-11-11 |
유나이티드 세러퓨틱스 코오포레이션 |
프로스타시클린 및 중간엽 줄기 세포를 사용한 혈관병증의 치료
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
EP3712142B1
(en)
|
2013-01-11 |
2022-07-06 |
Corsair Pharma, Inc. |
Prodrugs of treprostinil
|
|
WO2014159050A1
(en)
|
2013-03-14 |
2014-10-02 |
United Therapeutics Corporation |
Solid forms of treprostinil
|
|
EP2970081A4
(en)
|
2013-03-15 |
2016-10-12 |
United Therapeutics Corp |
SALTS OF TREPROSTINIL
|
|
WO2014160638A1
(en)
|
2013-03-25 |
2014-10-02 |
United Therapeutics Corporation |
Process of making prostacyclin compounds with linker thiol and pegylated forms
|
|
CA2911172C
(en)
|
2013-04-30 |
2021-10-19 |
United Therapeutics Corporation |
Controlled release pharmaceutical formulations
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
ES2959419T3
(es)
|
2013-10-11 |
2024-02-26 |
Pulmokine Inc |
Formulaciones secas por aspersión
|
|
US9469600B2
(en)
|
2013-10-25 |
2016-10-18 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
ES2908142T3
(es)
|
2014-06-13 |
2022-04-27 |
United Therapeutics Corp |
Formulaciones de treprostinil
|
|
CN107108427A
(zh)
|
2014-10-20 |
2017-08-29 |
联合治疗学有限公司 |
用于制备前列环素衍生物的中间体的合成
|
|
US10343979B2
(en)
|
2014-11-18 |
2019-07-09 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
EP3452170A4
(en)
|
2016-05-05 |
2020-04-01 |
Liquidia Technologies, Inc. |
TREPROSTINIL IN POWDER FORM FOR TREATING PULMONAL HYPERTENSION
|
|
WO2017223400A1
(en)
|
2016-06-24 |
2017-12-28 |
Insmed Incorporated |
Prostacyclin compounds and compositions for treating sarcoidosis
|
|
WO2018058124A1
(en)
|
2016-09-26 |
2018-03-29 |
United Therapeutics Corporation |
Treprostinil prodrugs
|
|
EP3673895A1
(en)
|
2018-12-28 |
2020-07-01 |
Université Libre de Bruxelles |
Dry powder inhalation formulation and its use for the therapeutic treatment of lungs
|
|
CN119632930A
(zh)
|
2019-04-29 |
2025-03-18 |
英斯梅德股份有限公司 |
曲前列素前药的干粉组合物及其使用方法
|