CA2967385C - Methods of manufacturing treprostinil and treprostinil derivative prodrugs - Google Patents

Methods of manufacturing treprostinil and treprostinil derivative prodrugs Download PDF

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Publication number
CA2967385C
CA2967385C CA2967385A CA2967385A CA2967385C CA 2967385 C CA2967385 C CA 2967385C CA 2967385 A CA2967385 A CA 2967385A CA 2967385 A CA2967385 A CA 2967385A CA 2967385 C CA2967385 C CA 2967385C
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CA
Canada
Prior art keywords
alkyl
linear
branched
treprostinil
formula
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CA2967385A
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English (en)
French (fr)
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CA2967385A1 (en
Inventor
Vladimir Malinin
Walter Perkins
Franziska LEIFER
Donna M. Konicek
Zhili Li
Adam PLAUNT
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Insmed Inc
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Insmed Inc
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Publication of CA2967385A1 publication Critical patent/CA2967385A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2967385A 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs Active CA2967385C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462081515P 2014-11-18 2014-11-18
US62/081,515 2014-11-18
PCT/US2015/061427 WO2016081658A1 (en) 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs

Publications (2)

Publication Number Publication Date
CA2967385A1 CA2967385A1 (en) 2016-05-26
CA2967385C true CA2967385C (en) 2023-05-16

Family

ID=56014536

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2967385A Active CA2967385C (en) 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs

Country Status (7)

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US (5) US10343979B2 (enExample)
EP (2) EP3904326A1 (enExample)
JP (1) JP6866043B2 (enExample)
AU (1) AU2015349969B2 (enExample)
CA (1) CA2967385C (enExample)
ES (1) ES2873873T3 (enExample)
WO (1) WO2016081658A1 (enExample)

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US10781160B1 (en) * 2019-10-04 2020-09-22 Chirogate International Inc. Hexadecyl Treprostinil crystals and methods for preparation thereof
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Also Published As

Publication number Publication date
CA2967385A1 (en) 2016-05-26
ES2873873T3 (es) 2021-11-04
US20250162982A1 (en) 2025-05-22
US20230250051A1 (en) 2023-08-10
JP2017535555A (ja) 2017-11-30
EP3221291A4 (en) 2018-06-27
EP3221291A1 (en) 2017-09-27
US20220135513A1 (en) 2022-05-05
US11148997B2 (en) 2021-10-19
AU2015349969A1 (en) 2017-05-25
US10343979B2 (en) 2019-07-09
EP3221291B1 (en) 2021-03-31
HK1244783A1 (en) 2018-08-17
WO2016081658A1 (en) 2016-05-26
AU2015349969B2 (en) 2020-02-06
US20190337888A1 (en) 2019-11-07
EP3904326A1 (en) 2021-11-03
JP6866043B2 (ja) 2021-04-28
US20170320813A1 (en) 2017-11-09

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