AU2015349969B2 - Methods of manufacturing treprostinil and treprostinil derivative prodrugs - Google Patents

Methods of manufacturing treprostinil and treprostinil derivative prodrugs Download PDF

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Publication number
AU2015349969B2
AU2015349969B2 AU2015349969A AU2015349969A AU2015349969B2 AU 2015349969 B2 AU2015349969 B2 AU 2015349969B2 AU 2015349969 A AU2015349969 A AU 2015349969A AU 2015349969 A AU2015349969 A AU 2015349969A AU 2015349969 B2 AU2015349969 B2 AU 2015349969B2
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alkyl
linear
treprostinil
formula
branched
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AU2015349969A1 (en
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Donna M. Konicek
Franziska LEIFER
Zhili Li
Vladimir Malinin
Walter Perkins
Adam PLAUNT
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Insmed Inc
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Insmed Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015349969A 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs Active AU2015349969B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462081515P 2014-11-18 2014-11-18
US62/081,515 2014-11-18
PCT/US2015/061427 WO2016081658A1 (en) 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs

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AU2015349969A1 AU2015349969A1 (en) 2017-05-25
AU2015349969B2 true AU2015349969B2 (en) 2020-02-06

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US (5) US10343979B2 (enExample)
EP (2) EP3904326A1 (enExample)
JP (1) JP6866043B2 (enExample)
AU (1) AU2015349969B2 (enExample)
CA (1) CA2967385C (enExample)
ES (1) ES2873873T3 (enExample)
WO (1) WO2016081658A1 (enExample)

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WO2021252446A1 (en) 2020-06-09 2021-12-16 United Therapeutics Corporation Fumaryl diketopiperidine prodrugs of treprostinil
US11826328B2 (en) 2020-12-14 2023-11-28 United Therapeutics Corporation Stable treprostinil prodrugs
KR20240012354A (ko) 2021-03-03 2024-01-29 유나이티드 쎄러퓨틱스 코포레이션 (e)-3,6-비스[4-(n-카보닐-2-프로페닐)아미도부틸]-2,5-디케토피페라진(fdkp)을 추가로 포함하는, 트레프로스티닐 및 이의 프로드러그의 건조 분말 조성물
KR20240141319A (ko) 2022-02-08 2024-09-26 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 일로프로스트 조합 치료 요법
IL322116A (en) 2023-01-19 2025-09-01 United Therapeutics Corp Analogues of treprostinil
US20250197338A1 (en) 2023-11-09 2025-06-19 United Therapeutics Corporation Syntheses of compounds useful for producing treprostinil

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Also Published As

Publication number Publication date
JP2017535555A (ja) 2017-11-30
AU2015349969A1 (en) 2017-05-25
CA2967385C (en) 2023-05-16
US20190337888A1 (en) 2019-11-07
EP3904326A1 (en) 2021-11-03
CA2967385A1 (en) 2016-05-26
EP3221291B1 (en) 2021-03-31
HK1244783A1 (en) 2018-08-17
US20170320813A1 (en) 2017-11-09
US20230250051A1 (en) 2023-08-10
US11148997B2 (en) 2021-10-19
US10343979B2 (en) 2019-07-09
US20220135513A1 (en) 2022-05-05
US20250162982A1 (en) 2025-05-22
WO2016081658A1 (en) 2016-05-26
JP6866043B2 (ja) 2021-04-28
EP3221291A1 (en) 2017-09-27
EP3221291A4 (en) 2018-06-27
ES2873873T3 (es) 2021-11-04

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