JP6866043B2 - トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 - Google Patents

トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 Download PDF

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JP6866043B2
JP6866043B2 JP2017526523A JP2017526523A JP6866043B2 JP 6866043 B2 JP6866043 B2 JP 6866043B2 JP 2017526523 A JP2017526523 A JP 2017526523A JP 2017526523 A JP2017526523 A JP 2017526523A JP 6866043 B2 JP6866043 B2 JP 6866043B2
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alkyl
acid
linear
branched
formula
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JP2017535555A (ja
JP2017535555A5 (enExample
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マリニン，ウラジミール
パーキンス，ウォルター
ライファー，フランツィスカ
エム． コニーチェク，ドナ
エム． コニーチェク，ドナ
リ，ジーリー
プラウント，アダム
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Insmed Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017526523A 2014-11-18 2015-11-18 トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 Active JP6866043B2 (ja)

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US201462081515P 2014-11-18 2014-11-18
US62/081,515 2014-11-18
PCT/US2015/061427 WO2016081658A1 (en) 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs

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JP2017535555A JP2017535555A (ja) 2017-11-30
JP2017535555A5 JP2017535555A5 (enExample) 2018-12-27
JP6866043B2 true JP6866043B2 (ja) 2021-04-28

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US (5) US10343979B2 (enExample)
EP (2) EP3221291B1 (enExample)
JP (1) JP6866043B2 (enExample)
AU (1) AU2015349969B2 (enExample)
CA (1) CA2967385C (enExample)
ES (1) ES2873873T3 (enExample)
WO (1) WO2016081658A1 (enExample)

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Publication number Publication date
AU2015349969B2 (en) 2020-02-06
US20250162982A1 (en) 2025-05-22
AU2015349969A1 (en) 2017-05-25
US20170320813A1 (en) 2017-11-09
ES2873873T3 (es) 2021-11-04
EP3904326A1 (en) 2021-11-03
EP3221291A4 (en) 2018-06-27
CA2967385C (en) 2023-05-16
EP3221291A1 (en) 2017-09-27
US20190337888A1 (en) 2019-11-07
US11148997B2 (en) 2021-10-19
US20220135513A1 (en) 2022-05-05
HK1244783A1 (en) 2018-08-17
US10343979B2 (en) 2019-07-09
WO2016081658A1 (en) 2016-05-26
JP2017535555A (ja) 2017-11-30
CA2967385A1 (en) 2016-05-26
EP3221291B1 (en) 2021-03-31
US20230250051A1 (en) 2023-08-10

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