JP2009517412A5 - - Google Patents
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- JP2009517412A5 JP2009517412A5 JP2008542573A JP2008542573A JP2009517412A5 JP 2009517412 A5 JP2009517412 A5 JP 2009517412A5 JP 2008542573 A JP2008542573 A JP 2008542573A JP 2008542573 A JP2008542573 A JP 2008542573A JP 2009517412 A5 JP2009517412 A5 JP 2009517412A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- alkyl group
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC([C@@](*)N*)=O Chemical compound CC([C@@](*)N*)=O 0.000 description 2
- XEYUEIQAEAQUAK-UHFFFAOYSA-N CC(C)CN(C(CCCCN)COP(O)(O)=O)S(c(cc1)cc(F)c1N)(=O)=O Chemical compound CC(C)CN(C(CCCCN)COP(O)(O)=O)S(c(cc1)cc(F)c1N)(=O)=O XEYUEIQAEAQUAK-UHFFFAOYSA-N 0.000 description 1
- ZMXIYERNXPIYFR-UHFFFAOYSA-N CCc1c(cccc2)c2ccc1 Chemical compound CCc1c(cccc2)c2ccc1 ZMXIYERNXPIYFR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74064205P | 2005-11-30 | 2005-11-30 | |
| PCT/CA2006/001963 WO2007062526A1 (en) | 2005-11-30 | 2006-11-30 | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517412A JP2009517412A (ja) | 2009-04-30 |
| JP2009517412A5 true JP2009517412A5 (enExample) | 2009-12-17 |
Family
ID=38091843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542573A Pending JP2009517412A (ja) | 2005-11-30 | 2006-11-30 | アスパルチルプロテアーゼ阻害物質のリジンベースのプロドラッグ及びその調製方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8227450B2 (enExample) |
| EP (1) | EP1971615B1 (enExample) |
| JP (1) | JP2009517412A (enExample) |
| CN (1) | CN101405293B (enExample) |
| AU (1) | AU2006319716B2 (enExample) |
| CA (1) | CA2632095A1 (enExample) |
| ES (1) | ES2452718T3 (enExample) |
| WO (1) | WO2007062526A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10149030A1 (de) | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US7388008B2 (en) * | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| ES2452718T3 (es) | 2005-11-30 | 2014-04-02 | Taimed Biologics, Inc. | Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación |
| WO2008023273A2 (en) * | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| AU2007337830A1 (en) | 2006-09-21 | 2008-07-03 | Ambrilia Biopharma Inc. | Benzenesulfonamide derivatives as HIV protease inhibitors |
| WO2009148600A2 (en) * | 2008-06-06 | 2009-12-10 | Concert Pharmaceuticals, Inc. | Deuterated lysine-based compounds |
| CA2762582A1 (en) | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
| EP2632895B1 (en) | 2010-10-28 | 2018-10-03 | Merck Canada Inc. | Hiv protease inhibitors |
| EP2771332B1 (en) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| WO2017209732A1 (en) * | 2016-05-31 | 2017-12-07 | Taimed Biologics, Inc. | A long acting pharmaceutical composition of protease inhibitor |
| US10369129B2 (en) | 2016-05-31 | 2019-08-06 | Taimed Biologics, Inc. | Long acting pharmaceutical composition of protease inhibitor |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013861A (en) | 1985-02-28 | 1991-05-07 | E. R. Squibb & Sons, Inc. | Ester substituted aminoalkanoylureido amino and imino acid and ester compounds |
| SK32693A3 (en) | 1990-10-11 | 1993-09-09 | Boehringer Ingelheim Kg | Cyclopeptides, a method of preparing them and their use as drugs |
| US5614522A (en) | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
| EP0532466A3 (en) | 1991-09-12 | 1993-06-16 | Ciba-Geigy Ag | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use |
| DK0656888T3 (da) | 1992-08-25 | 1998-02-09 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfonamider, anvendelige som retrovirale protease-inhibitorer |
| EP0656886B1 (en) | 1992-08-25 | 1997-06-25 | G.D. Searle & Co. | N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors |
| US6022994A (en) | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| JPH06321950A (ja) | 1993-05-14 | 1994-11-22 | Takeda Chem Ind Ltd | 水溶性ランカシジン誘導体 |
| WO1995006998A1 (en) | 1993-08-31 | 1995-03-09 | Stanley Kugell | Telephone billing method |
| DE69512220T2 (de) | 1994-03-07 | 2000-03-16 | Vertex Pharmaceuticals Inc. | Sulfonamidderivate als aspartylprotease-inhibitoren |
| US5527829A (en) | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| EP0804428B1 (en) | 1995-01-20 | 2007-12-26 | G.D. Searle LLC. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
| US5985870A (en) | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5776718A (en) | 1995-03-24 | 1998-07-07 | Arris Pharmaceutical Corporation | Reversible protease inhibitors |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| CA2243121A1 (en) | 1996-01-26 | 1997-07-31 | Francesco Gerald Salituro | Aspartyl protease inhibitors |
| US5859061A (en) | 1997-01-17 | 1999-01-12 | Pharmacia & Upjohn Company | Bis-sulfonamides hydroxamic acids as MMP inhibitors |
| DE59802394D1 (de) | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| AP2000001856A0 (en) * | 1997-12-24 | 2000-09-30 | Vertex Pharma | Prodrugs of aspartyl protease inhibitors. |
| US5986102A (en) | 1998-04-29 | 1999-11-16 | Pharmacopeia, Inc. | Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases |
| ES2254156T3 (es) | 1999-02-12 | 2006-06-16 | Vertex Pharmaceuticals Incorporated | Inhibidores de aspartil-proteasa. |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| CA2375511A1 (en) * | 1999-06-16 | 2000-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors |
| US6455587B1 (en) | 2000-03-15 | 2002-09-24 | Pharmacor Inc. | Amino acid derivatives as HIV aspartyl protease inhibitors |
| US6506786B2 (en) | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
| JP4283681B2 (ja) | 2002-03-04 | 2009-06-24 | アンブリリア バイオファーマ インコーポレーテッド | Ｈｉｖアスパルチルプロテアーゼ阻害剤としての尿素誘導体 |
| CA2374362C (en) | 2002-03-04 | 2008-01-22 | Brent Richard Stranix | Urea derivatives as hiv aspartyl protease inhibitors |
| KR20050085681A (ko) | 2002-12-16 | 2005-08-29 | 베링거 인겔하임 인터내셔날 게엠베하 | 프로테아제 억제제와 같은 사이토크롬 ｐ450의 억제제와함께 비-뉴클레오시드 역전사효소 억제제(ｎｎｒｔｉ)를함유하는 배합물의 용도 |
| US6632816B1 (en) | 2002-12-23 | 2003-10-14 | Pharmacor Inc. | Aromatic derivatives as HIV aspartyl protease inhibitors |
| CA2550187C (en) | 2004-01-08 | 2012-08-07 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| ES2575871T3 (es) | 2004-08-02 | 2016-07-01 | Ambrilia Biopharma Inc. | Composiciones farmacéuticas que comprende un compuesto a base de lisina y un agente antiviral o antirretroviral VIH |
| US20060287316A1 (en) | 2005-04-27 | 2006-12-21 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors |
| ES2452718T3 (es) | 2005-11-30 | 2014-04-02 | Taimed Biologics, Inc. | Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación |
| WO2008023273A2 (en) | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| AU2007337830A1 (en) | 2006-09-21 | 2008-07-03 | Ambrilia Biopharma Inc. | Benzenesulfonamide derivatives as HIV protease inhibitors |
-
2006
- 2006-11-30 ES ES06817683.3T patent/ES2452718T3/es active Active
- 2006-11-30 WO PCT/CA2006/001963 patent/WO2007062526A1/en not_active Ceased
- 2006-11-30 CN CN200680051907.4A patent/CN101405293B/zh not_active Expired - Fee Related
- 2006-11-30 JP JP2008542573A patent/JP2009517412A/ja active Pending
- 2006-11-30 US US12/086,184 patent/US8227450B2/en not_active Expired - Fee Related
- 2006-11-30 AU AU2006319716A patent/AU2006319716B2/en not_active Ceased
- 2006-11-30 CA CA002632095A patent/CA2632095A1/en not_active Abandoned
- 2006-11-30 EP EP06817683.3A patent/EP1971615B1/en active Active
-
2008
- 2008-06-19 US US12/214,995 patent/US8580995B2/en not_active Expired - Fee Related
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