JP2009517412A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009517412A5 JP2009517412A5 JP2008542573A JP2008542573A JP2009517412A5 JP 2009517412 A5 JP2009517412 A5 JP 2009517412A5 JP 2008542573 A JP2008542573 A JP 2008542573A JP 2008542573 A JP2008542573 A JP 2008542573A JP 2009517412 A5 JP2009517412 A5 JP 2009517412A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- alkyl group
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC([C@@](*)N*)=O Chemical compound CC([C@@](*)N*)=O 0.000 description 2
- XEYUEIQAEAQUAK-UHFFFAOYSA-N CC(C)CN(C(CCCCN)COP(O)(O)=O)S(c(cc1)cc(F)c1N)(=O)=O Chemical compound CC(C)CN(C(CCCCN)COP(O)(O)=O)S(c(cc1)cc(F)c1N)(=O)=O XEYUEIQAEAQUAK-UHFFFAOYSA-N 0.000 description 1
- ZMXIYERNXPIYFR-UHFFFAOYSA-N CCc1c(cccc2)c2ccc1 Chemical compound CCc1c(cccc2)c2ccc1 ZMXIYERNXPIYFR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74064205P | 2005-11-30 | 2005-11-30 | |
| PCT/CA2006/001963 WO2007062526A1 (en) | 2005-11-30 | 2006-11-30 | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517412A JP2009517412A (ja) | 2009-04-30 |
| JP2009517412A5 true JP2009517412A5 (enExample) | 2009-12-17 |
Family
ID=38091843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542573A Pending JP2009517412A (ja) | 2005-11-30 | 2006-11-30 | アスパルチルプロテアーゼ阻害物質のリジンベースのプロドラッグ及びその調製方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8227450B2 (enExample) |
| EP (1) | EP1971615B1 (enExample) |
| JP (1) | JP2009517412A (enExample) |
| CN (1) | CN101405293B (enExample) |
| AU (1) | AU2006319716B2 (enExample) |
| CA (1) | CA2632095A1 (enExample) |
| ES (1) | ES2452718T3 (enExample) |
| WO (1) | WO2007062526A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10149030A1 (de) | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| WO2007062526A1 (en) | 2005-11-30 | 2007-06-07 | Ambrilia Biopharma Inc. | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
| AU2007287353A1 (en) * | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| ES2628730T3 (es) | 2006-09-21 | 2017-08-03 | Taimed Biologics, Inc. | Inhibidores de proteasa |
| WO2009148600A2 (en) * | 2008-06-06 | 2009-12-10 | Concert Pharmaceuticals, Inc. | Deuterated lysine-based compounds |
| CA2762582A1 (en) | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
| US9079834B2 (en) | 2010-10-28 | 2015-07-14 | Merck Canada Inc. | HIV protease inhibitors |
| US9133157B2 (en) | 2011-10-26 | 2015-09-15 | Merck Canada Inc. | HIV protease inhibitors |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| US10369129B2 (en) | 2016-05-31 | 2019-08-06 | Taimed Biologics, Inc. | Long acting pharmaceutical composition of protease inhibitor |
| JP6704058B2 (ja) * | 2016-05-31 | 2020-06-03 | タイメド・バイオロジクス・インコーポレイテッドＴａｉＭｅｄ Ｂｉｏｌｏｇｉｃｓ Ｉｎｃ． | プロテアーゼ阻害剤の長時間作用性医薬組成物 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013861A (en) * | 1985-02-28 | 1991-05-07 | E. R. Squibb & Sons, Inc. | Ester substituted aminoalkanoylureido amino and imino acid and ester compounds |
| CA2089747A1 (en) | 1990-10-11 | 1992-04-12 | Gerd Schnorrenberg | Cyclopeptides, a method of preparing them, and their use as drugs |
| US5614522A (en) * | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
| EP0532466A3 (en) | 1991-09-12 | 1993-06-16 | Ciba-Geigy Ag | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use |
| ATE161828T1 (de) * | 1992-08-25 | 1998-01-15 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfonami e verwendbar als retrovirale protease-inhibitoren |
| US6022994A (en) * | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| CA2142998C (en) * | 1992-08-25 | 2008-01-29 | Michael L. Vazquez | N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors |
| JPH06321950A (ja) | 1993-05-14 | 1994-11-22 | Takeda Chem Ind Ltd | 水溶性ランカシジン誘導体 |
| AU6548294A (en) | 1993-08-31 | 1995-03-22 | Stanley Kugell | Telephone billing method |
| MX9603909A (es) | 1994-03-07 | 1997-03-29 | Vertex Pharma | Derivados de sulfonamida como inhibidores de proteasa aspartilo. |
| US5527829A (en) | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| DE69637380T2 (de) * | 1995-01-20 | 2009-09-17 | G.D. Searle Llc, Chicago | Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen |
| US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5776718A (en) * | 1995-03-24 | 1998-07-07 | Arris Pharmaceutical Corporation | Reversible protease inhibitors |
| US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| WO1997027180A1 (en) | 1996-01-26 | 1997-07-31 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| AU720615B2 (en) | 1997-01-17 | 2000-06-08 | Pharmacia & Upjohn Company | Bis-sulfonomides hydroxamic acids as MMP inhibitors |
| ATE210639T1 (de) * | 1997-05-09 | 2001-12-15 | Hoechst Ag | Substituierte diaminocarbonsäuren |
| US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| EP1042280A2 (en) * | 1997-12-24 | 2000-10-11 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| US5986102A (en) | 1998-04-29 | 1999-11-16 | Pharmacopeia, Inc. | Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases |
| EP1159278B1 (en) | 1999-02-12 | 2005-11-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| CA2375511A1 (en) * | 1999-06-16 | 2000-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors |
| US6455587B1 (en) * | 2000-03-15 | 2002-09-24 | Pharmacor Inc. | Amino acid derivatives as HIV aspartyl protease inhibitors |
| US6506786B2 (en) * | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
| JP4283681B2 (ja) | 2002-03-04 | 2009-06-24 | アンブリリア バイオファーマ インコーポレーテッド | Ｈｉｖアスパルチルプロテアーゼ阻害剤としての尿素誘導体 |
| CA2374362C (en) * | 2002-03-04 | 2008-01-22 | Brent Richard Stranix | Urea derivatives as hiv aspartyl protease inhibitors |
| KR20050085681A (ko) | 2002-12-16 | 2005-08-29 | 베링거 인겔하임 인터내셔날 게엠베하 | 프로테아제 억제제와 같은 사이토크롬 ｐ450의 억제제와함께 비-뉴클레오시드 역전사효소 억제제(ｎｎｒｔｉ)를함유하는 배합물의 용도 |
| US6632816B1 (en) * | 2002-12-23 | 2003-10-14 | Pharmacor Inc. | Aromatic derivatives as HIV aspartyl protease inhibitors |
| DE602004024584D1 (de) | 2004-01-08 | 2010-01-21 | Medivir Ab | Inhibitoren der nicht-nukleotidischen reversen transkriptase |
| EP2165709B1 (en) * | 2004-08-02 | 2016-03-16 | Ambrilia Biopharma Inc. | Pharmaceutical compositions comprising a lysine based compound and an HIV antiviral or antiretroviral agent |
| US7388008B2 (en) * | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| US20060287316A1 (en) * | 2005-04-27 | 2006-12-21 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors |
| WO2007062526A1 (en) | 2005-11-30 | 2007-06-07 | Ambrilia Biopharma Inc. | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
| AU2007287353A1 (en) | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| ES2628730T3 (es) | 2006-09-21 | 2017-08-03 | Taimed Biologics, Inc. | Inhibidores de proteasa |
-
2006
- 2006-11-30 WO PCT/CA2006/001963 patent/WO2007062526A1/en not_active Ceased
- 2006-11-30 AU AU2006319716A patent/AU2006319716B2/en not_active Ceased
- 2006-11-30 JP JP2008542573A patent/JP2009517412A/ja active Pending
- 2006-11-30 EP EP06817683.3A patent/EP1971615B1/en active Active
- 2006-11-30 CN CN200680051907.4A patent/CN101405293B/zh not_active Expired - Fee Related
- 2006-11-30 CA CA002632095A patent/CA2632095A1/en not_active Abandoned
- 2006-11-30 US US12/086,184 patent/US8227450B2/en not_active Expired - Fee Related
- 2006-11-30 ES ES06817683.3T patent/ES2452718T3/es active Active
-
2008
- 2008-06-19 US US12/214,995 patent/US8580995B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6401771B2 (ja) | ヘモグロビンの修飾のための化合物及びその使用 | |
| JP2008523069A5 (enExample) | ||
| JP2008533191A5 (enExample) | ||
| JP6799178B2 (ja) | ４−メトキシピロール誘導体の中間体の製造方法 | |
| JP2010280684A5 (enExample) | ||
| RU2014110400A (ru) | Способ и промежуточные соединения для получения макролактамов | |
| WO2008051873A3 (en) | Phenylurea compounds as soluble epoxide hydrolase inhibitors | |
| JPWO2014017515A1 (ja) | ４−［５−（ピリジン−４−イル）−１ｈ−１，２，４−トリアゾール−３−イル］ピリジン−２−カルボニトリルの結晶多形およびその製造方法 | |
| KR20080008399A (ko) | 비스(티오-히드라지드 아미드) 염의 합성 방법 | |
| JP2008517965A5 (enExample) | ||
| JP2018501268A (ja) | チゾキサニドホスフェート及びアルカンスルホネート並びにその医薬用途 | |
| RU2019113149A (ru) | Низкомолекулярные активаторы амфк | |
| RU2007106443A (ru) | Соли аммония и клатраты аммонийной соли и минеральной соли в качестве носителя и действующего начала для фармацевтическо-медицинского применения и в качестве агента фазового переноса для применения в химии | |
| JP2012036221A5 (enExample) | ||
| CN110483417A (zh) | 一种DACOs类NNRTIs氨基酸酯衍生物、其制备方法、药物组合物及应用 | |
| CN109734679B (zh) | 一种异硫氰酸酯和磷氮硫系阻燃剂的联合制备方法 | |
| JP2008534534A5 (enExample) | ||
| JP2007525527A5 (enExample) | ||
| JP2007519685A5 (enExample) | ||
| JP2007522151A5 (enExample) | ||
| CN100491333C (zh) | 高纯度烯胺类的制备方法 | |
| JP3303050B2 (ja) | アゾニアアダマンタン化合物およびこのものからのアザアダマンタン化合物の製造方法並びに該アゾニアアダマンタン化合物の製造方法 | |
| JP2007534737A5 (enExample) | ||
| JP2006513137A5 (enExample) | ||
| RU2010105978A (ru) | Производные фуранозы |