ATE417823T1 - Verbindungen auf lysinbasis - Google Patents
Verbindungen auf lysinbasisInfo
- Publication number
- ATE417823T1 ATE417823T1 AT04761606T AT04761606T ATE417823T1 AT E417823 T1 ATE417823 T1 AT E417823T1 AT 04761606 T AT04761606 T AT 04761606T AT 04761606 T AT04761606 T AT 04761606T AT E417823 T1 ATE417823 T1 AT E417823T1
- Authority
- AT
- Austria
- Prior art keywords
- lysine
- based compounds
- cycloalkyl
- alkyl
- nao
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2004/001440 WO2006012725A1 (en) | 2004-08-02 | 2004-08-02 | Lysine based compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417823T1 true ATE417823T1 (de) | 2009-01-15 |
Family
ID=35786842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04761606T ATE417823T1 (de) | 2004-08-02 | 2004-08-02 | Verbindungen auf lysinbasis |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1773763B1 (de) |
| JP (1) | JP4579970B2 (de) |
| CN (1) | CN1942436B (de) |
| AT (1) | ATE417823T1 (de) |
| AU (2) | AU2004322123B2 (de) |
| BR (1) | BRPI0418651A (de) |
| CA (1) | CA2560071C (de) |
| DE (1) | DE602004018548D1 (de) |
| ES (2) | ES2319996T3 (de) |
| HK (1) | HK1105406A1 (de) |
| IL (1) | IL180958A0 (de) |
| MX (1) | MX2007001278A (de) |
| NO (1) | NO20071152L (de) |
| RU (1) | RU2009139259A (de) |
| WO (1) | WO2006012725A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| EP1773763B1 (de) | 2004-08-02 | 2008-12-17 | Ambrilia Biopharma Inc. | Verbindungen auf lysinbasis |
| EP1971615B1 (de) * | 2005-11-30 | 2014-01-01 | TaiMed Biologics, Inc. | Auf lysme basierende prodrugs von aspartylproteaseinhibitoren und verfahren zu ihrer herstellung |
| CA2657316A1 (en) * | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| JP5401652B2 (ja) | 2006-09-21 | 2014-01-29 | タイメッド バイオロジクス インコーポレイテッド | プロテアーゼ阻害剤 |
| WO2009148600A2 (en) * | 2008-06-06 | 2009-12-10 | Concert Pharmaceuticals, Inc. | Deuterated lysine-based compounds |
| EP2435037B1 (de) | 2009-05-27 | 2014-11-12 | Merck Sharp & Dohme Corp. | Hiv-proteasehemmer |
| US9079834B2 (en) | 2010-10-28 | 2015-07-14 | Merck Canada Inc. | HIV protease inhibitors |
| US9187415B2 (en) | 2010-10-29 | 2015-11-17 | Merck Canada Inc. | Sulfonamides as HIV protease inhibitors |
| EP2771332B1 (de) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen- und Thiazol-Sulfonamid-Derivate als HIV Protease Inhibitoren zur Behandlung von AIDS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| CA2405151A1 (en) * | 2000-04-07 | 2001-10-18 | University Of Maryland, Baltimore | Bile acid containing prodrugs with enhanced bioavailability |
| US6617310B2 (en) * | 2000-07-19 | 2003-09-09 | Bristol-Myers Squibb Pharma Company | Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines |
| WO2002016395A1 (en) * | 2000-08-18 | 2002-02-28 | The Board Of Trustees Of The University Of Illinois | Prodrugs of betulinic acid derivatives for the treatment of cancer and hiv |
| US6506786B2 (en) * | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
| US6632816B1 (en) * | 2002-12-23 | 2003-10-14 | Pharmacor Inc. | Aromatic derivatives as HIV aspartyl protease inhibitors |
| EP1773763B1 (de) | 2004-08-02 | 2008-12-17 | Ambrilia Biopharma Inc. | Verbindungen auf lysinbasis |
-
2004
- 2004-08-02 EP EP04761606A patent/EP1773763B1/de active Active
- 2004-08-02 MX MX2007001278A patent/MX2007001278A/es active IP Right Grant
- 2004-08-02 EP EP08021798.7A patent/EP2165709B1/de not_active Not-in-force
- 2004-08-02 JP JP2007501073A patent/JP4579970B2/ja not_active Expired - Fee Related
- 2004-08-02 AU AU2004322123A patent/AU2004322123B2/en not_active Ceased
- 2004-08-02 BR BRPI0418651-6A patent/BRPI0418651A/pt not_active IP Right Cessation
- 2004-08-02 CN CN2004800427980A patent/CN1942436B/zh not_active Expired - Fee Related
- 2004-08-02 ES ES04761606T patent/ES2319996T3/es active Active
- 2004-08-02 WO PCT/CA2004/001440 patent/WO2006012725A1/en active Application Filing
- 2004-08-02 CA CA2560071A patent/CA2560071C/en not_active Expired - Fee Related
- 2004-08-02 ES ES08021798.7T patent/ES2575871T3/es active Active
- 2004-08-02 AT AT04761606T patent/ATE417823T1/de not_active IP Right Cessation
- 2004-08-02 DE DE602004018548T patent/DE602004018548D1/de active Active
-
2007
- 2007-01-25 IL IL180958A patent/IL180958A0/en unknown
- 2007-03-01 NO NO20071152A patent/NO20071152L/no not_active Application Discontinuation
- 2007-10-02 HK HK07110638.0A patent/HK1105406A1/xx not_active IP Right Cessation
-
2009
- 2009-10-23 RU RU2009139259/04A patent/RU2009139259A/ru not_active Application Discontinuation
- 2009-10-28 AU AU2009230800A patent/AU2009230800A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1942436B (zh) | 2011-03-23 |
| EP1773763A4 (de) | 2007-08-08 |
| AU2004322123A1 (en) | 2006-02-09 |
| MX2007001278A (es) | 2007-09-14 |
| CA2560071A1 (en) | 2006-02-09 |
| WO2006012725A1 (en) | 2006-02-09 |
| CA2560071C (en) | 2012-09-25 |
| JP4579970B2 (ja) | 2010-11-10 |
| ES2575871T3 (es) | 2016-07-01 |
| NO20071152L (no) | 2007-03-01 |
| BRPI0418651A (pt) | 2007-05-29 |
| DE602004018548D1 (de) | 2009-01-29 |
| EP2165709A3 (de) | 2010-06-23 |
| HK1105406A1 (en) | 2008-02-15 |
| AU2009230800A1 (en) | 2009-11-19 |
| AU2004322123B2 (en) | 2009-08-13 |
| JP2007525527A (ja) | 2007-09-06 |
| EP1773763B1 (de) | 2008-12-17 |
| IL180958A0 (en) | 2007-07-04 |
| ES2319996T3 (es) | 2009-05-18 |
| EP2165709A2 (de) | 2010-03-24 |
| RU2009139259A (ru) | 2011-04-27 |
| EP1773763A1 (de) | 2007-04-18 |
| EP2165709B1 (de) | 2016-03-16 |
| CN1942436A (zh) | 2007-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |