JP2017533702A5 - - Google Patents
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- JP2017533702A5 JP2017533702A5 JP2017521144A JP2017521144A JP2017533702A5 JP 2017533702 A5 JP2017533702 A5 JP 2017533702A5 JP 2017521144 A JP2017521144 A JP 2017521144A JP 2017521144 A JP2017521144 A JP 2017521144A JP 2017533702 A5 JP2017533702 A5 JP 2017533702A5
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- Prior art keywords
- cells
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- antigen
- immune cells
- immune
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- 238000000034 method Methods 0.000 claims 39
- 210000002865 immune cell Anatomy 0.000 claims 37
- 239000000427 antigen Substances 0.000 claims 35
- 102000036639 antigens Human genes 0.000 claims 35
- 108091007433 antigens Proteins 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 7
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 6
- 210000000172 cytosol Anatomy 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000003915 cell function Effects 0.000 claims 3
- 239000006285 cell suspension Substances 0.000 claims 3
- 210000004443 dendritic cell Anatomy 0.000 claims 3
- 210000002540 macrophage Anatomy 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 230000003614 tolerogenic effect Effects 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 210000003651 basophil Anatomy 0.000 claims 2
- 239000013592 cell lysate Substances 0.000 claims 2
- 210000003979 eosinophil Anatomy 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 210000003630 histaminocyte Anatomy 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 1
- 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 108090000835 CX3C Chemokine Receptor 1 Proteins 0.000 claims 1
- 102100039196 CX3C chemokine receptor 1 Human genes 0.000 claims 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
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- 229940126062 Compound A Drugs 0.000 claims 1
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- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 1
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 1
- 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims 1
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 108020005198 Long Noncoding RNA Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000031481 Pathologic Constriction Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 108091029810 SaRNA Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 108020004566 Transfer RNA Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000004656 cell transport Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000010924 continuous production Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000018109 developmental process Effects 0.000 claims 1
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- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000006266 hibernation Effects 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- -1 meganuclease Proteins 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 229940078677 sarna Drugs 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 208000037804 stenosis Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021147556A JP2021192630A (ja) | 2014-10-31 | 2021-09-10 | 生体分子の免疫細胞への送達 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073548P | 2014-10-31 | 2014-10-31 | |
| US62/073,548 | 2014-10-31 | ||
| PCT/US2015/058489 WO2016070136A1 (en) | 2014-10-31 | 2015-10-30 | Delivery of biomolecules to immune cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147556A Division JP2021192630A (ja) | 2014-10-31 | 2021-09-10 | 生体分子の免疫細胞への送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533702A JP2017533702A (ja) | 2017-11-16 |
| JP2017533702A5 true JP2017533702A5 (enExample) | 2018-12-13 |
| JP7523203B2 JP7523203B2 (ja) | 2024-07-26 |
Family
ID=55858434
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521144A Active JP7523203B2 (ja) | 2014-10-31 | 2015-10-30 | 生体分子の免疫細胞への送達 |
| JP2021147556A Pending JP2021192630A (ja) | 2014-10-31 | 2021-09-10 | 生体分子の免疫細胞への送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147556A Pending JP2021192630A (ja) | 2014-10-31 | 2021-09-10 | 生体分子の免疫細胞への送達 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11111472B2 (enExample) |
| EP (1) | EP3212772A4 (enExample) |
| JP (2) | JP7523203B2 (enExample) |
| KR (2) | KR102819064B1 (enExample) |
| CN (1) | CN107109362A (enExample) |
| AU (2) | AU2015338893A1 (enExample) |
| BR (1) | BR112017009050A2 (enExample) |
| CA (1) | CA2964392A1 (enExample) |
| IL (1) | IL252005B (enExample) |
| RU (2) | RU2020139190A (enExample) |
| SG (2) | SG11201703044PA (enExample) |
| WO (1) | WO2016070136A1 (enExample) |
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| CA2852672C (en) | 2011-10-17 | 2021-07-20 | Massachusetts Institute Of Technology | A microfluidic system and method for delivering a payload into a cell by causing perturbations in a cell membrane of the cell |
| ES2776698T3 (es) | 2012-12-20 | 2020-07-31 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| JP6502940B2 (ja) | 2013-08-16 | 2019-04-17 | マサチューセッツ インスティテュート オブ テクノロジー | 細胞への物質の選択的送達 |
| AU2015338893A1 (en) | 2014-10-31 | 2017-05-04 | Massachusetts Institute Of Technology | Delivery of biomolecules to immune cells |
| CN113897285A (zh) | 2014-11-14 | 2022-01-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
| AU2016206870B2 (en) | 2015-01-12 | 2022-02-17 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
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| CA3127665A1 (en) | 2019-01-25 | 2020-07-30 | Sqz Biotechnologies Company | Anucleate cell-derived vaccines |
| US20230130686A1 (en) | 2021-10-25 | 2023-04-27 | Massachusetts Institute Of Technology | Devices and systems for delivery of materials to cells |
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2015
- 2015-10-30 AU AU2015338893A patent/AU2015338893A1/en not_active Abandoned
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- 2015-10-30 RU RU2017118935A patent/RU2739794C2/ru active
- 2015-10-30 SG SG11201703044PA patent/SG11201703044PA/en unknown
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- 2015-10-30 EP EP15855640.7A patent/EP3212772A4/en active Pending
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- 2015-10-30 CA CA2964392A patent/CA2964392A1/en active Pending
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