JP2017530118A5 - - Google Patents

Download PDF

Info

Publication number
JP2017530118A5
JP2017530118A5 JP2017514471A JP2017514471A JP2017530118A5 JP 2017530118 A5 JP2017530118 A5 JP 2017530118A5 JP 2017514471 A JP2017514471 A JP 2017514471A JP 2017514471 A JP2017514471 A JP 2017514471A JP 2017530118 A5 JP2017530118 A5 JP 2017530118A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
alkyl
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017514471A
Other languages
English (en)
Japanese (ja)
Other versions
JP6708329B2 (ja
JP2017530118A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/050202 external-priority patent/WO2016044281A1/en
Publication of JP2017530118A publication Critical patent/JP2017530118A/ja
Publication of JP2017530118A5 publication Critical patent/JP2017530118A5/ja
Application granted granted Critical
Publication of JP6708329B2 publication Critical patent/JP6708329B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017514471A 2014-09-15 2015-09-15 ヌクレオチド類似体 Active JP6708329B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462050624P 2014-09-15 2014-09-15
US62/050,624 2014-09-15
PCT/US2015/050202 WO2016044281A1 (en) 2014-09-15 2015-09-15 Nucleotide analogs

Publications (3)

Publication Number Publication Date
JP2017530118A JP2017530118A (ja) 2017-10-12
JP2017530118A5 true JP2017530118A5 (enExample) 2018-11-01
JP6708329B2 JP6708329B2 (ja) 2020-06-10

Family

ID=55525135

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017514471A Active JP6708329B2 (ja) 2014-09-15 2015-09-15 ヌクレオチド類似体

Country Status (24)

Country Link
US (8) US9493493B2 (enExample)
EP (1) EP3194411B1 (enExample)
JP (1) JP6708329B2 (enExample)
KR (2) KR102871875B1 (enExample)
CN (3) CN111808136B (enExample)
AU (1) AU2015317972B2 (enExample)
BR (1) BR112017005111B1 (enExample)
CA (1) CA2961200C (enExample)
CY (1) CY1125210T1 (enExample)
DK (1) DK3194411T3 (enExample)
EA (1) EA036391B1 (enExample)
ES (1) ES2915381T3 (enExample)
HR (1) HRP20220651T1 (enExample)
HU (1) HUE059067T2 (enExample)
IL (1) IL250836B (enExample)
LT (1) LT3194411T (enExample)
MX (2) MX377983B (enExample)
PL (1) PL3194411T3 (enExample)
PT (1) PT3194411T (enExample)
RS (1) RS63250B1 (enExample)
SG (1) SG11201701957XA (enExample)
SI (1) SI3194411T1 (enExample)
SM (1) SMT202200236T1 (enExample)
WO (1) WO2016044281A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150130355A (ko) 2013-03-15 2015-11-23 더 리전트 오브 더 유니버시티 오브 캘리포니아 비환식 뉴클레오사이드 포스포네이트 디에스테르
SG11201701957XA (en) * 2014-09-15 2017-04-27 Univ California Nucleotide analogs
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
US10745428B2 (en) 2015-12-10 2020-08-18 Idenix Pharmaceuticals Llc Antiviral phosphodiamide prodrugs of tenofovir
US10450335B2 (en) 2015-12-15 2019-10-22 Merck Sharp & Dohme Corp. Antiviral oxime phosphoramide compounds
EP3503895B1 (en) * 2016-08-25 2021-09-15 Merck Sharp & Dohme Corp. Antiviral prodrugs of tenofovir
WO2018080903A1 (en) 2016-10-26 2018-05-03 Merck Sharp & Dohme Corp. Antiviral aryl-amide phosphodiamide compounds
JP6938637B2 (ja) 2016-12-22 2021-09-22 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． テノホビルの抗ウイルス性脂肪族エステルプロドラッグ
AU2017378893A1 (en) 2016-12-22 2019-05-16 Idenix Pharmaceuticals Llc Antiviral benzyl-amine phosphodiamide compounds
CN109863160B (zh) * 2016-12-23 2022-06-07 四川科伦博泰生物医药股份有限公司 核苷磷酸类化合物及其制备方法和用途
CN108276444A (zh) * 2017-01-06 2018-07-13 米文君 一类新的化合物及其用途
CN107011383A (zh) * 2017-04-28 2017-08-04 朱孝云 氘代无环核苷膦酸二酯
US10688112B2 (en) 2017-07-13 2020-06-23 Emory University Lipid disulfide prodrugs and uses related thereto
JP2021528363A (ja) 2018-06-12 2021-10-21 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ホスホンアミドエステル化合物、その塩、その関連する結晶体、その製造方法及びその使用
EP3823629B1 (en) 2018-07-19 2024-12-25 Merck Sharp & Dohme LLC Phosphinic amide prodrugs of tenofovir
JP7678795B2 (ja) 2019-08-22 2025-05-16 エモリー ユニバーシティー ヌクレオシドプロドラッグ及びそれに関する使用
US12173029B2 (en) 2020-07-24 2024-12-24 The Regents Of The University Of California Antiviral prodrugs, pharmaceutical formulations, and methods
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태
WO2025147598A1 (en) * 2024-01-05 2025-07-10 Antiva Biosciences, Inc. Device system and use for hpv infection and cervical intraepithelial neoplasia
WO2025147262A1 (en) * 2024-01-05 2025-07-10 Antiva Biosciences, Inc. Device system and use for hpv infection and cervical intraepithelial neoplasia
WO2025160208A1 (en) * 2024-01-24 2025-07-31 Antiva Biosciences, Inc. Synthesis of ethyl-2-((((2-(2-amino-6-methoxy-9h-purin-9-yl)-ethoxy)-methyl)-(benzyloxy)-phosphoryl)-amino)-propionate
WO2025160227A1 (en) * 2024-01-24 2025-07-31 Antiva Biosciences, Inc. Advantageous compounds for treatment of hpv infection and hpv-induced neoplasia
WO2025162234A1 (en) * 2024-01-29 2025-08-07 Nanjing Zenshine Pharmaceuticals Co., Ltd. Phosphoric acid derivatives and pharmaceutical use thereof

Family Cites Families (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
CS263955B1 (cs) 1986-07-18 1989-05-12 Holy Antonin Způsob výroby N-(3-hydroxy-2-fosfonylmethoxypropyl)derivátů heterocyklických bází
CS263956B1 (cs) 1986-07-18 1989-05-12 Holy Antonin Způsob výroby 9- (S) -, (3-hydroxy-2-fosfonylmetboxypropyl) adeninu
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
CS263953B1 (cs) 1986-07-18 1989-05-12 Holy Antonin Způsob výroby 9-(S)- nebo 9-(RS)-(3 hydroxy-2-íosfonylmethoxypropyl)- ads-ninu
EP0262876B1 (en) 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Nucleoside-phospholipid conjugate
US5650510A (en) 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
GB8724252D0 (en) 1987-10-15 1987-11-18 Ici Plc Fungicides
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5033352A (en) 1989-01-19 1991-07-23 Yamaha Corporation Electronic musical instrument with frequency modulation
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5688778A (en) 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
SK280313B6 (sk) 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
DE69119074T2 (de) 1990-06-15 1996-12-12 University Of North Carolina At Chapel Hill, Chapel Hill, N.C. Kovalente-ther lipidnukleosid-konjugate
DE4026265A1 (de) 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
EP0481214B1 (en) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
DE69123979T2 (de) 1990-10-12 1997-04-30 Max Planck Gesellschaft Abgeänderte ribozyme
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
GB9126209D0 (en) 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5652094A (en) 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
GB9205917D0 (en) 1992-03-18 1992-04-29 Smithkline Beecham Plc Pharmaceuticals
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5532225A (en) 1992-07-31 1996-07-02 Sri International Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6444656B1 (en) 1992-12-23 2002-09-03 Biochem Pharma, Inc. Antiviral phosphonate nucleotides
GB9226879D0 (en) 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
US6005107A (en) 1992-12-23 1999-12-21 Biochem Pharma, Inc. Antiviral compounds
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5817647A (en) 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
DE69426904T2 (de) * 1993-06-29 2001-10-11 Mitsubishi Chemical Corp., Tokio/Tokyo Phosphonat-Nukleotid Ester-Derivate
US5656745A (en) 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
CA2171868A1 (en) 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
DE4418690A1 (de) 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
DE59506763D1 (de) 1994-06-29 1999-10-14 Ciba Sc Holding Ag Neue Kristallmodifikation eines Diketopyrrolopyrrolpigments
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5696277A (en) 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
EP0832896A4 (en) 1995-06-15 1998-11-25 Mitsubishi Chem Corp NUCLEOTIDES DERIVED FROM PHOSPHONATES
US5717095A (en) 1995-12-29 1998-02-10 Gilead Sciences, Inc. Nucleotide analogs
CA2195262C (en) 1996-01-18 2005-08-09 Masaru Ubasawa Phosphonate nucleotide compounds
US5877166A (en) 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
US6686462B2 (en) 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
EP0994715A4 (en) 1997-03-24 2001-08-08 Lilly Co Eli DIFLUORONUCLEOSIDE-PHOSPHONIC ACIDS AND DERIVATIVES THEREOF
BR9813480A (pt) 1997-12-17 2000-10-10 Biocryst Pharm Inc Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza-
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
WO1999062921A1 (en) 1998-06-01 1999-12-09 S & T Science And Technology Inc. Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine
WO2000029414A1 (fr) 1998-11-18 2000-05-25 Viktor Veniaminovich Tets Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methylphosphonates
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
EP1233770B1 (en) 1999-12-03 2008-02-13 The Regents of The University of California at San Diego Phosphonate compounds
AU2001234174A1 (en) 2000-02-29 2001-09-12 Mitsubishi Pharma Corporation Phosphonate nucleotide compound
AU2001282941C1 (en) 2000-07-21 2016-12-22 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
MY141789A (en) 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
CZ292199B6 (cs) 2001-03-08 2003-08-13 Ústav organické chemie a biochemie AV ČR O-Fosfonomethylcholin a jeho alkylestery, způsob jejich přípravy a použití
RU2187509C1 (ru) 2001-03-26 2002-08-20 Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" Производные 5'-h-фосфоната 3'-азидо-3'-дезокситимидина и фармацевтические композиции на их основе
KR20020097384A (ko) 2001-06-20 2002-12-31 미쯔비시 도꾜 세이야꾸 가부시끼가이샤 기존의 약제에 내성변이를 가지는 바이러스에 유효한 약제
EP1406911B1 (en) 2001-06-29 2016-01-06 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic 6-[2-(phosphonomethoxy)alkoxy] pyrimidine derivatives having antiviral activity
US20040023928A1 (en) 2001-10-31 2004-02-05 Colacino Joseph Matthew Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
WO2003050129A1 (en) 2001-12-07 2003-06-19 Eli Lilly And Company Use of phosphonate nucleotide analogue for treating hepatitis b virus infections
EA008775B1 (ru) 2002-04-26 2007-08-31 Джилид Сайэнс, Инк. Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция
US7247621B2 (en) 2002-04-30 2007-07-24 Valeant Research & Development Antiviral phosphonate compounds and methods therefor
WO2003099294A1 (fr) 2002-05-24 2003-12-04 Mitsubishi Pharma Corporation Medicaments a selectivite tissulaire amelioree
WO2004096235A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
CA2523083C (en) 2003-04-25 2014-07-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
SI1644389T1 (sl) 2003-06-16 2011-06-30 Acad Of Science Czech Republic Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogi
CN1950383B (zh) 2003-12-30 2010-06-09 吉里德科学公司 用于治疗病毒性疾病的膦酸酯、单膦酸酰胺化物、双膦酸酰胺化物
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
CN1946734B (zh) 2004-02-26 2012-07-18 贝勒研究院 系统性治疗关节炎的组合物和方法
WO2005087788A2 (en) 2004-03-04 2005-09-22 The Regents Of The University Of California Methods for preparation of nucleoside phosphonate esters
WO2006076015A2 (en) 2004-04-30 2006-07-20 The Regents Of The University Of California 1-[2-(phosphonomethoxy)ethyl]-cytosine and analogs thereof
US8101745B2 (en) * 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
CA2533721C (en) 2005-01-25 2014-09-23 Dirtt Environmental Solutions Ltd. Method for wrapping a non-porous substrate object with a wood veneer
US20070003608A1 (en) 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
CA2606399A1 (en) 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic Use of compounds to enhance processivity of telomerase
WO2007002912A2 (en) 2005-06-29 2007-01-04 Gilead Sciences, Inc. Anti-proliferative compounds, compositions, and methods of use thereof
WO2007002808A1 (en) 2005-06-29 2007-01-04 Gilead Sciences, Inc. Anti-nonmelanoma carcinoma compounds, compositions, and methods of use thereof
US7449612B2 (en) 2006-04-11 2008-11-11 Catalytic Distillation Technologies Paraffin alkylation process
ES2600792T3 (es) 2006-05-03 2017-02-10 Chimerix, Inc. Alcoxialquilésteres metabólicamente estables de fosfonatos, fosfonatos nucleosídicos y fosfatos nucleosídicos antivirales o antiproliferativos
CN101089004A (zh) 2006-06-13 2007-12-19 上海舒盟化学科技有限公司 一种新型的膦酸酯－核苷酸化合物
WO2008104408A2 (en) 2007-02-27 2008-09-04 K. U. Leuven Research & Development Phosphate modified nucleosides useful as substrates for polymerases and as antiviral agents
CN102702260A (zh) 2007-04-27 2012-10-03 奇默里克斯公司 在核苷给药的受体中降低肾中毒性的方法
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
TWI444384B (zh) * 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
WO2009133968A1 (ja) 2008-04-30 2009-11-05 国立大学法人東京大学 電荷変換型三元系ポリプレックス
BRPI1005401A2 (pt) 2009-02-06 2019-04-02 Rfs Pharma, Llc pro-farmácos de purina nucleosídeo monofosfato para o tratamento de câncer e infecções virais
DE102009020261A1 (de) 2009-05-07 2010-11-11 Universität Hamburg Verfahren zur festphasengestützten Herstellung phosphatverbrückter Nucleosid-Konjugate
WO2010135520A1 (en) 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011011710A1 (en) 2009-07-24 2011-01-27 Chimerix, Inc. Methods of treating viral infections
BR112012002551A2 (pt) 2009-08-03 2017-06-13 Chimerix Inc composição e métodos de tratamento de infecções virais e tumores induzidos por vírus
JP2013509433A (ja) * 2009-10-30 2013-03-14 キメリクス，インコーポレイテッド ウイルス関連疾患を処置する方法
ES2629165T3 (es) 2010-02-12 2017-08-07 Chimerix, Inc. Métodos de tratamiento de una infección vírica
US20110218241A1 (en) 2010-03-06 2011-09-08 Cacao Bio-Technologies, Llc Antiviral epicatechins, epicatechin oligomers, or thiolated epicatechins from theobroma cacao for treatment of genital warts
WO2011130557A2 (en) 2010-04-14 2011-10-20 The Regents Of The University Of California Phosphonates with reduced toxicity for treatment of viral infections
EP2611818B1 (en) 2010-08-31 2016-08-24 Chimerix, Inc. Phosphonate ester derivatives and methods of synthesis thereof
CN103403014B (zh) 2011-01-03 2016-07-06 河南美泰宝生物制药有限公司 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途
US9156874B2 (en) 2011-01-03 2015-10-13 Nanjing Molecular Research, Inc. Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
DK2744810T4 (da) 2011-08-16 2023-11-20 Gilead Sciences Inc Tenofovir-alafenamid-hemifumarat
AU2012348332B2 (en) * 2011-12-08 2017-06-29 Haifeng Chen Vectors harboring toxic genes, methods and uses therefor
CN102532199B (zh) 2012-02-29 2015-08-05 刘沛 核苷类化合物之新型苄基胺基磷酸酯前药的结构与合成
KR20150130355A (ko) 2013-03-15 2015-11-23 더 리전트 오브 더 유니버시티 오브 캘리포니아 비환식 뉴클레오사이드 포스포네이트 디에스테르
CN103435672A (zh) 2013-04-25 2013-12-11 刘沛 含有取代苄基的新型核苷磷酸酯前药的结构与合成
CN105899215A (zh) 2013-11-15 2016-08-24 奇默里克斯公司 十六烷氧基丙基膦酸酯的形态
SG11201701957XA (en) 2014-09-15 2017-04-27 Univ California Nucleotide analogs
CN106188192B (zh) 2015-04-29 2019-09-10 刘沛 含d-氨基酸酯的核苷氨基磷酸/膦酸酯衍生物及其医药用途
GB201509431D0 (en) 2015-06-01 2015-07-15 Equigerminal Sa Antiviral composition
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
CN107286190A (zh) 2016-04-13 2017-10-24 刘沛 核苷之烃氧基苄基氨基磷酸/膦酸酯衍生物的制备及其医药用途
WO2018082503A1 (zh) 2016-11-02 2018-05-11 四川科伦博泰生物医药股份有限公司 杂环化合物及其制备方法和用途
CN108276444A (zh) 2017-01-06 2018-07-13 米文君 一类新的化合物及其用途
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Similar Documents

Publication Publication Date Title
JP2017530118A5 (enExample)
JP2019094345A5 (enExample)
JP2010524932A5 (enExample)
HRP20220651T1 (hr) Nukleotidni analozi
JP2020507589A5 (enExample)
JP2013510123A5 (enExample)
JP2015537020A5 (enExample)
PH12020551616A1 (en) N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition thereof, and use thereof
JP2016518437A5 (enExample)
JP2019509276A5 (enExample)
JPWO2023099592A5 (enExample)
JP2016530283A5 (enExample)
JP2017537940A5 (enExample)
HRP20220899T1 (hr) Spojevi policikličkog karbamoilpiridona i njihova farmaceutska uporaba
JP2019510034A5 (enExample)
JP2016540742A5 (enExample)
JP2011500658A5 (enExample)
JP2017523225A5 (enExample)
RU2018128318A (ru) Селективные ингибиторы эстрогеновых рецепторов и их применение
JP2017531619A5 (enExample)
JP2005511547A5 (enExample)
JP2009507896A5 (enExample)
JP2010510237A5 (enExample)
JP2013523784A5 (enExample)
RU2015116953A (ru) Новые соединения