AU6473098A - Difluoronucleoside phosphonic acids and derivatives thereof - Google Patents

Difluoronucleoside phosphonic acids and derivatives thereof

Info

Publication number
AU6473098A
AU6473098A AU64730/98A AU6473098A AU6473098A AU 6473098 A AU6473098 A AU 6473098A AU 64730/98 A AU64730/98 A AU 64730/98A AU 6473098 A AU6473098 A AU 6473098A AU 6473098 A AU6473098 A AU 6473098A
Authority
AU
Australia
Prior art keywords
difluoronucleoside
derivatives
phosphonic acids
phosphonic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU64730/98A
Inventor
Larry W. Hertel
Julian S. Kroin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU6473098A publication Critical patent/AU6473098A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU64730/98A 1997-03-24 1998-03-19 Difluoronucleoside phosphonic acids and derivatives thereof Abandoned AU6473098A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4150797P 1997-03-24 1997-03-24
US60041507 1997-03-24
PCT/US1998/005477 WO1998042351A1 (en) 1997-03-24 1998-03-19 Difluoronucleoside phosphonic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
AU6473098A true AU6473098A (en) 1998-10-20

Family

ID=21916882

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64730/98A Abandoned AU6473098A (en) 1997-03-24 1998-03-19 Difluoronucleoside phosphonic acids and derivatives thereof

Country Status (5)

Country Link
EP (1) EP0994715A4 (en)
JP (1) JP2001518931A (en)
AU (1) AU6473098A (en)
CA (1) CA2284263A1 (en)
WO (1) WO1998042351A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1831235B1 (en) 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
DE102006037786A1 (en) 2006-08-11 2008-03-20 Resprotect Gmbh Nucleosides, pharmaceuticals containing them and their use
RS57796B1 (en) 2013-03-15 2018-12-31 Univ California Acyclic nucleoside phosphonate diesters
SG11201701957XA (en) 2014-09-15 2017-04-27 Univ California Nucleotide analogs
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
CA2004695C (en) * 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipid nucleosides

Also Published As

Publication number Publication date
WO1998042351A1 (en) 1998-10-01
JP2001518931A (en) 2001-10-16
EP0994715A1 (en) 2000-04-26
CA2284263A1 (en) 1998-10-01
EP0994715A4 (en) 2001-08-08

Similar Documents

Publication Publication Date Title
AU6482398A (en) Sulfonylaminocarboxylic acids
PL338357A1 (en) Some 5-alkyl-2-arylaminophenyloacetic acids and their derivatives
AU6972398A (en) Phosphonic acid derivatives
AU6490396A (en) Substituted-pent-4-ynoic acids
AU1151099A (en) Azaoxindole derivatives
AU6482498A (en) Substituted diaminocarboxylic acids
AU1825899A (en) Dota-biotin derivatives
AU5683196A (en) N-benzyl-3-indoleacetic acids as cyclooxygenase-2-inhibitors and antiinflammatory drugs
AU7935398A (en) Diaminorhodamine derivatives
AU6117998A (en) 3-oxadiazolylquinoxaline derivatives
PL339660A1 (en) Derivatives of amidocarboxylic acids
AU2006699A (en) Phosphinic alkanoic acid derivatives
AU9781998A (en) Huchordin and uses thereof
AU4161797A (en) Benzoperimidine-carboxylic acids and derivatives thereof
AU1559199A (en) Isothiazolcarboxylic acid derivatives
AU1364995A (en) 5-vinyl- and 5-ethinyl-quinolone- carboxylic acids
AU6593898A (en) Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids
AU7813598A (en) Betulinol derivatives
AU8748798A (en) 4-aminoquinazoline derivatives
AU1174199A (en) Biphenylamidine derivatives
AU6729498A (en) Thiazolimine derivatives
AU8038798A (en) Cis-substituted fluoromethylpyrrolidine derivatives
AU6473098A (en) Difluoronucleoside phosphonic acids and derivatives thereof
AU6120298A (en) 2-peperazinone-1-acetic acid derivatives and their use
AU1684099A (en) Amino acid derivatives