EP0994715A4 - Difluoronucleoside phosphonic acids and derivatives thereof - Google Patents

Difluoronucleoside phosphonic acids and derivatives thereof

Info

Publication number
EP0994715A4
EP0994715A4 EP98910503A EP98910503A EP0994715A4 EP 0994715 A4 EP0994715 A4 EP 0994715A4 EP 98910503 A EP98910503 A EP 98910503A EP 98910503 A EP98910503 A EP 98910503A EP 0994715 A4 EP0994715 A4 EP 0994715A4
Authority
EP
European Patent Office
Prior art keywords
difluoronucleoside
derivatives
phosphonic acids
phosphonic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98910503A
Other languages
German (de)
French (fr)
Other versions
EP0994715A1 (en
Inventor
Larry W Hertel
Julian S Kroin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0994715A1 publication Critical patent/EP0994715A1/en
Publication of EP0994715A4 publication Critical patent/EP0994715A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
EP98910503A 1997-03-24 1998-03-19 Difluoronucleoside phosphonic acids and derivatives thereof Withdrawn EP0994715A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4150797P 1997-03-24 1997-03-24
US41507P 1997-03-24
PCT/US1998/005477 WO1998042351A1 (en) 1997-03-24 1998-03-19 Difluoronucleoside phosphonic acids and derivatives thereof

Publications (2)

Publication Number Publication Date
EP0994715A1 EP0994715A1 (en) 2000-04-26
EP0994715A4 true EP0994715A4 (en) 2001-08-08

Family

ID=21916882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98910503A Withdrawn EP0994715A4 (en) 1997-03-24 1998-03-19 Difluoronucleoside phosphonic acids and derivatives thereof

Country Status (5)

Country Link
EP (1) EP0994715A4 (en)
JP (1) JP2001518931A (en)
AU (1) AU6473098A (en)
CA (1) CA2284263A1 (en)
WO (1) WO1998042351A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101745B2 (en) 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
DE102006037786A1 (en) 2006-08-11 2008-03-20 Resprotect Gmbh Nucleosides, pharmaceuticals containing them and their use
EA032227B1 (en) 2013-03-15 2019-04-30 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Acyclic nucleoside phosphonate diesters
CN111808136A (en) 2014-09-15 2020-10-23 加利福尼亚大学董事会 Nucleotide analogs
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376518A1 (en) * 1988-12-12 1990-07-04 Eli Lilly And Company Phospholipid nucleosides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
EP0184365B1 (en) * 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376518A1 (en) * 1988-12-12 1990-07-04 Eli Lilly And Company Phospholipid nucleosides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9842351A1 *

Also Published As

Publication number Publication date
EP0994715A1 (en) 2000-04-26
WO1998042351A1 (en) 1998-10-01
JP2001518931A (en) 2001-10-16
AU6473098A (en) 1998-10-20
CA2284263A1 (en) 1998-10-01

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