JP2017513904A5 - - Google Patents
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- JP2017513904A5 JP2017513904A5 JP2016564173A JP2016564173A JP2017513904A5 JP 2017513904 A5 JP2017513904 A5 JP 2017513904A5 JP 2016564173 A JP2016564173 A JP 2016564173A JP 2016564173 A JP2016564173 A JP 2016564173A JP 2017513904 A5 JP2017513904 A5 JP 2017513904A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- target
- igf
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 17
- 239000000611 antibody drug conjugate Substances 0.000 claims 14
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 14
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 10
- -1 CD79 Proteins 0.000 claims 9
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 229940125644 antibody drug Drugs 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 108700012439 CA9 Proteins 0.000 claims 3
- 101150013553 CD40 gene Proteins 0.000 claims 3
- 102100025221 CD70 antigen Human genes 0.000 claims 3
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 3
- 108010055196 EphA2 Receptor Proteins 0.000 claims 3
- 108010055334 EphB2 Receptor Proteins 0.000 claims 3
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims 3
- 102100031968 Ephrin type-B receptor 2 Human genes 0.000 claims 3
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 3
- 101710088083 Glomulin Proteins 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 3
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 3
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 3
- 101000893701 Homo sapiens 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 Proteins 0.000 claims 3
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 3
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 3
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 3
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 3
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 3
- 101001018034 Homo sapiens Lymphocyte antigen 75 Proteins 0.000 claims 3
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 3
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 3
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 3
- 101000834948 Homo sapiens Tomoregulin-2 Proteins 0.000 claims 3
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 3
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 3
- 102000003735 Mesothelin Human genes 0.000 claims 3
- 108090000015 Mesothelin Proteins 0.000 claims 3
- 102100023123 Mucin-16 Human genes 0.000 claims 3
- 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 claims 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 3
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 3
- 102100026160 Tomoregulin-2 Human genes 0.000 claims 3
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims 3
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 102000006495 integrins Human genes 0.000 claims 3
- 108010044426 integrins Proteins 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 3
- 101150047061 tag-72 gene Proteins 0.000 claims 3
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 102000001301 EGF receptor Human genes 0.000 claims 2
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 2
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 claims 2
- 108090000144 Human Proteins Proteins 0.000 claims 2
- 102000003839 Human Proteins Human genes 0.000 claims 2
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 2
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 2
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 2
- 102100033579 Trophoblast glycoprotein Human genes 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 102000051957 human ERBB2 Human genes 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960000575 trastuzumab Drugs 0.000 claims 2
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 1
- 125000006781 (C4-C10) cycloalkylcarbonyl group Chemical group 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 201000002740 oral squamous cell carcinoma Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims 1
- 229960002087 pertuzumab Drugs 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14305621 | 2014-04-25 | ||
| EP14305621.6 | 2014-04-25 | ||
| PCT/EP2015/059052 WO2015162293A1 (en) | 2014-04-25 | 2015-04-27 | Antibody-drug-conjugate and its use for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513904A JP2017513904A (ja) | 2017-06-01 |
| JP2017513904A5 true JP2017513904A5 (enExample) | 2018-05-17 |
| JP6567551B2 JP6567551B2 (ja) | 2019-08-28 |
Family
ID=50630737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564173A Active JP6567551B2 (ja) | 2014-04-25 | 2015-04-27 | 抗体−薬物複合体および癌の処置のためのその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US10314921B2 (enExample) |
| EP (2) | EP3607996B1 (enExample) |
| JP (1) | JP6567551B2 (enExample) |
| KR (1) | KR102459647B1 (enExample) |
| CN (1) | CN106470708B (enExample) |
| AU (1) | AU2015250761B2 (enExample) |
| BR (1) | BR112016024363A2 (enExample) |
| CA (1) | CA2946796C (enExample) |
| CY (1) | CY1122472T1 (enExample) |
| DK (1) | DK3134125T3 (enExample) |
| ES (1) | ES2764110T3 (enExample) |
| HR (1) | HRP20192254T1 (enExample) |
| HU (1) | HUE047952T2 (enExample) |
| LT (1) | LT3134125T (enExample) |
| MX (1) | MX378281B (enExample) |
| PL (1) | PL3134125T3 (enExample) |
| PT (1) | PT3134125T (enExample) |
| RS (1) | RS59799B1 (enExample) |
| RU (1) | RU2685259C2 (enExample) |
| SI (1) | SI3134125T1 (enExample) |
| WO (1) | WO2015162293A1 (enExample) |
| ZA (1) | ZA201607415B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| MX378281B (es) | 2014-04-25 | 2025-03-10 | Pf Medicament | Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer. |
| MA39909B1 (fr) * | 2014-04-25 | 2019-05-31 | Pf Medicament | Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer |
| US9808528B2 (en) | 2014-06-18 | 2017-11-07 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates and methods of using same |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗ｈｅｒ２表位之單株抗體及其使用之方法 |
| US10973920B2 (en) | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| EP3288593A1 (en) * | 2015-04-27 | 2018-03-07 | Pierre Fabre Médicament | Conjugate of monomethyl auristatin f and trastuzumab and its use for the treatment of cancer |
| MX390128B (es) | 2015-10-26 | 2025-03-20 | Pf Medicament | Composición para el tratamiento de cáncer con expresión del igf-1r. |
| US9669106B2 (en) * | 2015-10-26 | 2017-06-06 | Pierre Fabre Medicament | Conjugate of monomethyl auristatin F and trastuzumab and its use for the treatment of cancer |
| JP2019510000A (ja) * | 2016-02-26 | 2019-04-11 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | 新規トキシン及びその中間体の製造方法 |
| MY199595A (en) * | 2016-03-02 | 2023-11-08 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
| CN105968038A (zh) * | 2016-05-09 | 2016-09-28 | 湖北华世通生物医药科技有限公司 | 二肽类化合物的盐酸盐及其制备方法 |
| KR20230047507A (ko) | 2016-06-27 | 2023-04-07 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
| JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
| AU2018236272B2 (en) * | 2017-03-15 | 2022-03-31 | Silverback Therapeutics, Inc. | Benzazepine compounds, conjugates, and uses thereof |
| WO2018217459A2 (en) * | 2017-05-23 | 2018-11-29 | Academia Sinica | Conditional internalization of pegylated agents by pretargeting bi-specific peg-binding antibodies for diagnosis and therapy |
| US20210079039A1 (en) * | 2018-04-16 | 2021-03-18 | Avelas Biosciences, Inc. | Compositions and methods for the selective delivery of therapeutic and imaging agents |
| US12150944B2 (en) | 2018-05-11 | 2024-11-26 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Use of anti-HER2 antibody-drug conjugate in cancer treatment |
| CN113453724B (zh) * | 2018-09-27 | 2025-02-25 | 皮埃尔法布雷医药公司 | 基于磺酰基马来酰亚胺的连接子和相应的偶联物 |
| CA3114179A1 (en) * | 2018-09-28 | 2020-04-02 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
| EP3735991A1 (fr) * | 2019-05-06 | 2020-11-11 | Pierre Fabre Medicament | Adc pour un traitement concomitant ou postérieur au docétaxel |
| US11179473B2 (en) | 2020-02-21 | 2021-11-23 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| KR20230047361A (ko) | 2020-07-01 | 2023-04-07 | 아르스 파마슈티컬스 인크. | 항-asgr1 항체 접합체 및 이의 용도 |
| AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
| JP2024510435A (ja) | 2021-03-18 | 2024-03-07 | シージェン インコーポレイテッド | 生体活性化合物の内部移行複合体からの選択的薬物放出 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
| CN118307677B (zh) * | 2023-01-09 | 2025-08-12 | 中国医学科学院医药生物技术研究所 | 一种针对间皮素的单克隆抗体及应用 |
| WO2025087401A1 (zh) * | 2023-10-27 | 2025-05-01 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和用途 |
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| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| MX378281B (es) | 2014-04-25 | 2025-03-10 | Pf Medicament | Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer. |
-
2015
- 2015-04-27 MX MX2016013999A patent/MX378281B/es unknown
- 2015-04-27 CN CN201580034144.1A patent/CN106470708B/zh active Active
- 2015-04-27 DK DK15720314.2T patent/DK3134125T3/da active
- 2015-04-27 PT PT157203142T patent/PT3134125T/pt unknown
- 2015-04-27 SI SI201531056T patent/SI3134125T1/sl unknown
- 2015-04-27 US US15/306,404 patent/US10314921B2/en active Active
- 2015-04-27 EP EP19195042.7A patent/EP3607996B1/en active Active
- 2015-04-27 AU AU2015250761A patent/AU2015250761B2/en not_active Ceased
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