ME02369B - Antitela za terapiju kancera koji eksprimira klaudin 6 - Google Patents
Antitela za terapiju kancera koji eksprimira klaudin 6Info
- Publication number
- ME02369B ME02369B MEP-2016-39A MEP201639A ME02369B ME 02369 B ME02369 B ME 02369B ME P201639 A MEP201639 A ME P201639A ME 02369 B ME02369 B ME 02369B
- Authority
- ME
- Montenegro
- Prior art keywords
- cancer
- cell
- cldn6
- antibody according
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (16)
1. Antitelo koje se sastoji od: (i) teškog lanca antitela, čija sekvenca odgovara sekvenci teškog lanca antitela SEQ ID NO: 36. i (ii) lakog lanca čija sekvenca odgovara sekvenci lakog lanca antitela izabranoj iz grupe koju čine SEQ ID NO: 35, 54 i 55.
2. Antitelo saglasno zahtevu 1, koje je sposobno da se veže za CLDN6 asociran na membrani ćelije koja eksprimira CLDN6 i koje suštinski nije sposobno da se veže za CLDN9.
3. Antitelo saglasno zahtevima 1 ili 2, naznačeno time da nije suštinski sposobno da se veže za CLDN4, koji je asociran na membrani ćelije koja eksprimira CLDN4 i/ili nije suštinski sposobno da se veže za CLDN3 asociranim za membranu ćelije koja eksprimira CLDN3.
4. Antitelo saglasno bilo kojem od zahteva 1-3, koje je specifično za CLDN6.
5. Antitelo saglasno bilo kojem od zahteva 1-4, koje je sposobno da se veže za epitop lokalizovan unutar vanćelijskog domena CLDN6.
6. Antitelo saglasno bilo kojem od zahteva 1-5, naznačeno time daje amino-kiselinska sekvenca CLDN6 sekvenca SEQ ID NO: 2 ili amino-kiselinska sekvenca SEQ ID NO: 8.
7. Antitelo saglasno bilo kojem od zahteva 1-6, koje ispoljava jednu ili više narednih aktivnosti: (i) ubija ćeliju koja eksprimira CLDN6, (ii) inhibira proliferaciju ćelije koja eksprimira CLDN6, (iii) inhibira formiranje kolonija ćelija koje eksprimiraju CLDN6, (iv) posreduje u remisiji uspostavljenih tumora, (v) sprečava formiranje i ponovno formiranje tumora, i (vi) inhibira metastazu ćelija koje eksprimiraju CLDN6.
8. Antitelo saglasno bilo kojem od zahteva 1-7, koje ispoljava jednu ili više imunskih efektorskih funkcija usmerenih prema ćelijama koje ispoljavaju CLDN6 u njegovoj nativnoj formi, naznačeno time da je jedna ili više efektorskih funkcija poželjno izabrana iz grupe koji čine citotoksičnost zavisna od komplementa (CDC), citotoksičnost posredovana antitelima (ADCC), indukcija apoptoze i inhibicija proliferacije, a poželjno je da su efektorske funkcije ADCC i/ili CDC.
9. Antitelo saglasno bilo kojem od zahteva 1-8, naznačeno time da je ćelija koja eksprimira CLDN6 ili ćelija koja nosi CLDN6 u svojoj nativnoj formi, tumorska ćelija.
10. Antitelo, saglasno bilo kojem od zahteva 1-9, naznačeno time da je antitelo monoklonsko ili himerno, ili da je antigen-vezujući fragment antitela.
11. Antitelo saglasno bilo kojem od zahteva 1-10, koje je sposobno da se veže za jedan ili više epitopa na CLDN6 u njegovoj nativnoj konformaciji.
12. Konjugat koji se sastoji od antitela saglasno bilo kojem zahtevu 1-11, povezanog sa nekim terapeutskim agensom, poželjno toksinom ili radioizotopom, lekom ili nekim citotoksičnim agensom.
13. Farmaceutska kompozicija koja sadrži antitelo saglasno bilo kojem od zahteva 1-11 i/ili neki konjugat saglasno zahtevu 12, kao i neki farmaceutski poželjni nosač.
14. Antitelo saglasno bilo kojem od zahteva 1-11 i/ili neki konjugat saglasno zahtevu 12, za primenu u postupku (i) inhibicije rasta kancerske ćelije koja eksprimira CLDN6 i koja je naznačena asocijacijom CLDN6 na membrani ćelije i (ii) ubijanja kancerske ćelije koja eksprimira CLDN6 i koja je naznačena asocijacijom CLDN6 na svojoj ćelijskoj membrani, ili (iii) inhibicije metastatičkog širenja kancerske ćelije koja eksprimira CLDN6 i koja je naznačena asocijacijom CLDN6 na svojoj ćelijskoj membrani.
15. Antitelo saglasno bilo kojem od zahteva 1-11, konjugat saglasno zahtevu 12 ili farmaceutska kompozicija saglasno zahtevu 13, za primenu u postupku tretiranja ili prevencije kancerske bolesti ili poremećaja povezanih sa ćelijama koje eksprimiraju CLDN6 i koje su naznačene asocijacijom CLDN6 na ćelijskoj membrani ćelija subjekta.
16. Antitelo saglasno bilo kojem od zahteva 9, 14 ili 15, naznačeno time da je tumorska ili kancerska ćelija izabrana iz grupe koju sačinjavaju ovarijalni kancer, konkretno ovarijalni adenokarcinom i ovarijalni teratokarcinom, kancer pluća, uključujući sitnoćelijski kancer pluća (SCLC) i ne-sitnoćelijski kancer plućar (NSCLC), konkretno karcinom skvamoznih ćelija pluća i adenokarcinom, kancer želuca, kancer dojke, kancer jetre, kancer pankreasa, kancer kože. konkretno, karcinom bazalnih ćelija i karcinom skvamoznih ćelija, maligni melanom, kancer glave i vrata, konkretno, maligni plejomorfni adenom, sarkom, konkretno sinovijalni sarkom i karcinosarkom, kancer kanala žučne kese, kancer mokraćne bešike, konkretno karcinom prelaznih ćelija i papilarni karcinom, kancer bubrega, konkretno, kancer bubrežnih ćelija, uključujući svetloćelijski kancer i papilarni kancer bubrežnih ćelija, kancer debelog creva, kancer tankog creva, uključujući kancer ileuma, konkretno, adenokarcinom tankog creva i adenokarcinom ileuma, testikularni embrionalni karcinom, placentalni horiokarcinom, kancer grlica materice, testikularni lcancer, konkretno, testikularni teratom i embrionalni testikularni kancer, kancer materice, tumor germinativnih ćelija, kao što je teratokarcinom ili embrionalni karcinom, konkretno tumor germinativnih ćelija testisa i njihove metastatske forme.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486071P | 2011-05-13 | 2011-05-13 | |
| EP11004004 | 2011-05-13 | ||
| EP12715856.6A EP2707390B1 (en) | 2011-05-13 | 2012-04-20 | Antibodies for treatment of cancer expressing claudin 6 |
| PCT/EP2012/001721 WO2012156018A1 (en) | 2011-05-13 | 2012-04-20 | Antibodies for treatment of cancer expressing claudin 6 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02369B true ME02369B (me) | 2016-06-20 |
Family
ID=47176322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-39A ME02369B (me) | 2011-05-13 | 2012-04-20 | Antitela za terapiju kancera koji eksprimira klaudin 6 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9321842B2 (me) |
| EP (4) | EP4464382A3 (me) |
| JP (3) | JP6276176B2 (me) |
| KR (3) | KR102072183B1 (me) |
| CN (3) | CN107090043B (me) |
| AR (2) | AR086306A1 (me) |
| AU (4) | AU2012258087B2 (me) |
| BR (1) | BR112013029212B1 (me) |
| CA (1) | CA2832174C (me) |
| CY (2) | CY1118608T1 (me) |
| DK (2) | DK2707390T3 (me) |
| ES (2) | ES2565063T3 (me) |
| HR (2) | HRP20160212T1 (me) |
| HU (1) | HUE028603T2 (me) |
| IL (1) | IL228738B (me) |
| LT (1) | LT3026064T (me) |
| ME (1) | ME02369B (me) |
| MX (5) | MX372766B (me) |
| NZ (2) | NZ706004A (me) |
| PL (3) | PL3421496T3 (me) |
| RS (2) | RS54627B1 (me) |
| RU (1) | RU2676731C2 (me) |
| SG (1) | SG193551A1 (me) |
| SI (2) | SI2707390T1 (me) |
| SM (1) | SMT201600064B (me) |
| UA (2) | UA127584C2 (me) |
| WO (1) | WO2012156018A1 (me) |
| ZA (1) | ZA201307102B (me) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102712858B (zh) | 2008-11-28 | 2015-08-12 | 索拉兹米公司 | 在重组异养型微生物中制备特制油 |
| WO2010094499A1 (en) | 2009-02-20 | 2010-08-26 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
| EP3305813B1 (en) * | 2009-11-11 | 2020-01-15 | Ganymed Pharmaceuticals GmbH | Antibodies specific for claudin 6 (cldn6) |
| EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| PT3434767T (pt) | 2010-11-30 | 2026-01-23 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de citotoxicidade |
| GB201103955D0 (en) * | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
| HUE028603T2 (en) | 2011-05-13 | 2016-12-28 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer expressing claudin 6 |
| US9758591B2 (en) | 2012-08-24 | 2017-09-12 | The Regents Of The University Of California | Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| PE20160870A1 (es) * | 2013-11-06 | 2016-09-09 | Abbvie Stemcentrx Llc | Anticuerpos anti-claudina novedosos y metodos de uso |
| CN105940107B (zh) | 2013-11-11 | 2021-06-15 | 中外制药株式会社 | 含有改变了抗体可变区的抗原结合分子 |
| WO2015108203A1 (ja) * | 2014-01-15 | 2015-07-23 | 株式会社オーダーメードメディカルリサーチ | 抗ｓｌｃ６ａ６抗体を用いたがん治療用医薬組成物 |
| PT3126381T (pt) * | 2014-04-01 | 2019-04-18 | Ganymed Pharmaceuticals Ag | Imunorrecetores e epítopos de células t específicos da claudina-6 |
| TWI740809B (zh) | 2014-11-11 | 2021-10-01 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
| CN113559075A (zh) | 2014-11-17 | 2021-10-29 | 康泰科思特生物制药公司 | 奥那司酮延长释放组合物和方法 |
| CN106146666B (zh) * | 2015-03-26 | 2019-09-06 | 科济生物医药（上海）有限公司 | 靶向cldn6的免疫效应细胞及其制备方法和应用 |
| CN105504051B (zh) * | 2015-12-17 | 2019-08-30 | 北京天成新脉生物技术有限公司 | 狂犬病毒核蛋白单克隆抗体及其应用 |
| MX2018016330A (es) | 2016-06-27 | 2020-02-17 | Univ California | Combinaciones para tratamiento del cáncer. |
| US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
| JP6914336B2 (ja) * | 2016-12-28 | 2021-08-04 | ジェネンテック， インコーポレイテッド | 進行したｈｅｒ２発現がんの治療 |
| WO2019048040A1 (en) * | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
| DK3826667T3 (da) * | 2017-09-18 | 2024-07-22 | Univ California | Claudin6-antistoffer og fremgangsmåder til behandling af kræft |
| CN117003875A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用 |
| EP3720963A4 (en) | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE WITH CHANGED BINDING OF THE VARIABLE ANTIBODY REGIONS CD3 AND CD137 |
| EP3735463A4 (en) * | 2018-01-05 | 2022-03-02 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| KR102340989B1 (ko) * | 2018-03-28 | 2021-12-20 | 에이비온 주식회사 | 클라우딘 3의 ecl-2에 특이적으로 결합하는 항체, 이의 단편 및 이들의 용도 |
| JP2022520632A (ja) | 2019-02-15 | 2022-03-31 | インテグラル・モレキュラー・インコーポレイテッド | 共通軽鎖を含む抗体及びその使用 |
| KR20210128443A (ko) | 2019-02-15 | 2021-10-26 | 인테그럴 몰큘러 인코포레이티드 | 클라우딘 6 항체 및 이의 용도 |
| DK3941946T3 (da) * | 2019-03-20 | 2025-03-24 | Univ California | Claudin-6-antistoffer og lægemiddelkonjugater |
| EP3941944A4 (en) * | 2019-03-20 | 2022-11-30 | The Regents of the University of California | Claudin-6 bispecific antibodies |
| WO2021006328A1 (en) | 2019-07-10 | 2021-01-14 | Chugai Seiyaku Kabushiki Kaisha | Claudin-6 binding molecules and uses thereof |
| WO2021129927A1 (en) | 2019-12-23 | 2021-07-01 | Biontech Cell & Gene Therapies Gmbh | Treatment with immune effector cells engineered to express an antigen receptor |
| CN111087465B (zh) * | 2019-12-24 | 2020-12-08 | 广州医科大学 | 一种针对密蛋白6的抗体偶联药物及应用 |
| CR20220540A (es) | 2020-03-31 | 2022-12-07 | Chugai Pharmaceutical Co Ltd | Moléculas de union al antígeno multiespecíficas dirigidas a claudina-6 y sus usos |
| AU2021374036A1 (en) * | 2020-11-06 | 2023-06-08 | Amgen Inc. | Polypeptide constructs selectively binding to cldn6 and cd3 |
| EP4301784A4 (en) * | 2021-03-02 | 2025-01-01 | NovaRock Biotherapeutics, Ltd. | Antibodies against claudin-6 and uses thereof |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| US12321428B2 (en) * | 2021-07-08 | 2025-06-03 | Nippon Telegraph And Telephone Corporation | User authentication device, user authentication method, and user authentication computer program |
| JPWO2023053282A1 (me) | 2021-09-29 | 2023-04-06 | ||
| CA3234897A1 (en) * | 2021-10-14 | 2023-04-20 | Kunle Odunsi | Compositions and methods for use of recombinant t cell receptors against claudin 6 |
| WO2024046572A1 (en) | 2022-09-01 | 2024-03-07 | BioNTech SE | Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer |
| JP2024545154A (ja) | 2021-12-09 | 2024-12-05 | ビオンテック・ソシエタス・エウロパエア | Ｃｌｄｎ６発現がんの処置のためのキメラ抗原受容体改変細胞 |
| WO2024088325A1 (zh) * | 2022-10-25 | 2024-05-02 | 科济生物医药（上海）有限公司 | 抗体及其应用 |
| AR130904A1 (es) * | 2022-10-31 | 2025-01-29 | Astellas Pharma Inc | Conjugado de anticuerpo-fármaco que contiene un compuesto agonista dual del receptor tipo toll 7/8 |
| KR20250114330A (ko) | 2022-11-30 | 2025-07-29 | 인테그럴 몰큘러 인코포레이티드 | 클라우딘 6을 표적하는 항체 및 이의 이중특이적 형식 |
| EP4642900A1 (en) | 2022-12-29 | 2025-11-05 | Astellas Pharma, Inc. | Engineered natural killer cells and related methods |
| CN116064622B (zh) * | 2023-02-13 | 2023-10-13 | 优睿赛思(武汉)生物科技有限公司 | Claudin6-mCherry报告基因CHO-K1稳转细胞株制备及应用 |
| WO2024184812A1 (en) * | 2023-03-06 | 2024-09-12 | Beigene Switzerland Gmbh | Anti-cldn6 antibodies and methods of use |
| EP4707305A1 (en) | 2023-05-12 | 2026-03-11 | Pediatric Immunity and Healthcare (Guangzhou) Biotechnology Co., Ltd. | Anti-cldn6 antibody and use thereof |
| AU2024274880A1 (en) | 2023-05-25 | 2026-01-15 | The Regents Of The University Of California | Methods of treating cancer |
| CN120053694B (zh) * | 2025-02-21 | 2025-10-03 | 中国农业大学 | 猪流行性腹泻抗病相关基因cldn4及其编码蛋白的应用 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946788A (en) | 1985-06-11 | 1990-08-07 | Ciba-Geigy Corporation | Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| GB9019812D0 (en) | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
| US5830755A (en) | 1995-03-27 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | T-cell receptors and their use in therapeutic and diagnostic methods |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| WO2002008284A2 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| WO2000073348A2 (en) | 1999-06-02 | 2000-12-07 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| WO2000078961A1 (en) | 1999-06-23 | 2000-12-28 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2000012708A2 (en) | 1998-09-01 | 2000-03-09 | Genentech, Inc. | Further pro polypeptides and sequences thereof |
| US5928631A (en) | 1997-06-09 | 1999-07-27 | The Procter & Gamble Company | Methods for controlling environmental odors on the body using compositions comprising uncomplexed cyclodextrins |
| US20020127584A1 (en) | 1997-09-18 | 2002-09-12 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US5932445A (en) | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6830894B1 (en) * | 1998-11-03 | 2004-12-14 | Adherex Technologies, Inc. | Compounds and methods for modulating claudin-mediated functions |
| JP2002532083A (ja) | 1998-12-17 | 2002-10-02 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ４７個のヒト分泌タンパク質 |
| JP2002536995A (ja) | 1999-02-22 | 2002-11-05 | インサイト・ファーマスーティカルズ・インコーポレイテッド | 結腸の疾患に関連する遺伝子 |
| EP1514933A1 (en) | 1999-07-08 | 2005-03-16 | Research Association for Biotechnology | Secretory protein or membrane protein |
| WO2001053312A1 (en) | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| WO2001051513A2 (en) | 2000-01-14 | 2001-07-19 | Corixa Corporation | Ovarian tumor-associated sequences |
| PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1309620A2 (en) | 2000-06-23 | 2003-05-14 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| JP2004514420A (ja) | 2000-07-20 | 2004-05-20 | ジェネンテック・インコーポレーテッド | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
| WO2002012437A2 (en) | 2000-08-03 | 2002-02-14 | Schooten Wim Van | Production of humanized antibodies in transgenic animals |
| JP3523245B1 (ja) | 2000-11-30 | 2004-04-26 | メダレックス，インコーポレーテッド | ヒト抗体作製用トランスジェニック染色体導入齧歯動物 |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| EP1992643A3 (en) | 2001-06-20 | 2008-12-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| CA2379661A1 (en) | 2002-03-28 | 2003-09-28 | Kursad Turksen | Paracellular drug delivery system |
| KR20040101502A (ko) | 2002-04-16 | 2004-12-02 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
| CA2482596A1 (en) * | 2002-04-22 | 2003-10-30 | Dyax Corp. | Antibodies specific for mucin polypeptide |
| US20070207142A1 (en) | 2002-05-08 | 2007-09-06 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| EP1594447A2 (en) | 2002-10-02 | 2005-11-16 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| PL216630B1 (pl) | 2002-10-17 | 2014-04-30 | Genmab As | Izolowane ludzkie przeciwciało monoklonalne wiążące ludzki CD20, związane z tym przeciwciałem transfektoma, komórka gospodarza, transgeniczne zwierzę lub roślina, kompozycja, immunokoniugat, cząsteczka bispecyficzna, wektor ekspresyjny, kompozycja farmaceutyczna, zastosowanie medyczne, zestaw oraz przeciwciało antyidiotypowe i jego zastosowanie |
| WO2004060270A2 (en) | 2002-10-18 | 2004-07-22 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| AT500651B9 (de) | 2003-05-27 | 2010-04-15 | Altropus Gmbh | Aktiv immunisierender antikörper |
| BRPI0410875A (pt) | 2003-05-30 | 2006-07-04 | Centocor Inc | método de inibição do crescimento de tumor com anticorpos de fator antitecido |
| EP2003196A3 (en) | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2006033664A1 (en) | 2004-03-08 | 2006-03-30 | Avalon Pharmaceuticals | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
| US7431927B2 (en) | 2005-03-24 | 2008-10-07 | Epitomics, Inc. | TNFα-neutralizing antibodies |
| DE102005025041A1 (de) | 2005-05-30 | 2006-12-07 | Bell Flavors & Fragrances Duft Und Aroma Gmbh | Mittel zur Anwendung in Spülmaschinen sowie Vorrichtung für dessen dosierte Einbringung während der Spül- und Trocknungsphasen |
| EP1790664A1 (en) * | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| EP1970384A1 (en) * | 2007-03-14 | 2008-09-17 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| EP2138576A4 (en) | 2007-03-16 | 2011-02-23 | Kyowa Hakko Kirin Co Ltd | ANTI-CLAUDIN-4 ANTIBODY |
| EP1997832A1 (en) | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
| WO2009025759A1 (en) | 2007-08-17 | 2009-02-26 | Progenics Pharmaceuticals (Nevada), Inc. | Tight junction proteins associated with infection and entry of hepatitis c virus (hcv), methods and uses thereof |
| WO2009028663A1 (ja) * | 2007-08-30 | 2009-03-05 | Kyowa Hakko Kirin Co., Ltd. | 抗Claudin-3抗体 |
| EP2060583A1 (en) | 2007-10-23 | 2009-05-20 | Ganymed Pharmaceuticals AG | Identification of tumor-associated markers for diagnosis and therapy |
| CN101939336B (zh) | 2007-11-12 | 2014-05-14 | U3制药有限公司 | Axl抗体 |
| RU2010133547A (ru) | 2008-01-11 | 2012-02-20 | Дзе Юниверсити Оф Токио (Jp) | Анти-cldn антитела |
| CA2721072A1 (en) | 2008-04-11 | 2009-10-15 | Bionovo, Inc. | Anticancer methods employing extracts of gleditsia sinensis lam |
| MX2011000616A (es) | 2008-07-17 | 2011-02-24 | Novartis Ag | Composiciones y metodos de uso para anticuerpos terapeuticos. |
| EP2352764B1 (en) | 2008-10-14 | 2018-03-28 | Ablynx N.V. | AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY |
| DE102009026966A1 (de) | 2008-12-18 | 2010-07-01 | Robert Bosch Gmbh | Betrieb eines Bremskraftverstärkers als Pedalsimulator |
| JP2010178650A (ja) | 2009-02-04 | 2010-08-19 | Univ Of Tokyo | 固形癌の再発予測のための試験方法および再発予防剤 |
| WO2010094499A1 (en) | 2009-02-20 | 2010-08-26 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
| EP2221063A1 (en) | 2009-02-20 | 2010-08-25 | Ganymed Pharmaceuticals AG | Methods and compositions for diagnosis and treatment of cancer |
| EP2322555A1 (en) * | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Antibodies specific for claudin 6 (CLDN6) |
| EP3305813B1 (en) | 2009-11-11 | 2020-01-15 | Ganymed Pharmaceuticals GmbH | Antibodies specific for claudin 6 (cldn6) |
| WO2011105551A1 (ja) | 2010-02-26 | 2011-09-01 | 国立大学法人大阪大学 | 癌幹細胞の検出方法、及び癌の治療剤または再発予防剤 |
| EP2404936A1 (en) * | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| HUE028603T2 (en) | 2011-05-13 | 2016-12-28 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer expressing claudin 6 |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| EP2605017A1 (de) | 2011-12-16 | 2013-06-19 | Protagen AG | Markersequenzen für gynäkologisches Malignom und deren Verwendung |
| MX366178B (es) | 2012-07-19 | 2019-07-01 | Amgen Inc | Proteinas de btnl3, acidos nucleicos, y anticuerpos y los usos de los mismos. |
| WO2015014376A1 (en) | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| EP3388411A1 (en) | 2017-04-13 | 2018-10-17 | Sulzer Chemtech AG | A process for purifying a crude composition including a monoterpene compound, such as a monocyclic monoterpene alcohol, by layer melt crystallization |
-
2012
- 2012-04-20 HU HUE12715856A patent/HUE028603T2/en unknown
- 2012-04-20 MX MX2016006373A patent/MX372766B/es unknown
- 2012-04-20 NZ NZ706004A patent/NZ706004A/en unknown
- 2012-04-20 KR KR1020137030171A patent/KR102072183B1/ko active Active
- 2012-04-20 RS RS20160121A patent/RS54627B1/sr unknown
- 2012-04-20 EP EP24192876.1A patent/EP4464382A3/en active Pending
- 2012-04-20 DK DK12715856.6T patent/DK2707390T3/en active
- 2012-04-20 EP EP15201110.2A patent/EP3026064B1/en active Active
- 2012-04-20 CA CA2832174A patent/CA2832174C/en active Active
- 2012-04-20 DK DK15201110.2T patent/DK3026064T3/en active
- 2012-04-20 UA UAA201708784A patent/UA127584C2/uk unknown
- 2012-04-20 KR KR1020227026991A patent/KR102708094B1/ko active Active
- 2012-04-20 AU AU2012258087A patent/AU2012258087B2/en active Active
- 2012-04-20 ES ES12715856.6T patent/ES2565063T3/es active Active
- 2012-04-20 UA UAA201314474A patent/UA115969C2/uk unknown
- 2012-04-20 CN CN201710009512.8A patent/CN107090043B/zh active Active
- 2012-04-20 EP EP18179328.2A patent/EP3421496B1/en active Active
- 2012-04-20 EP EP12715856.6A patent/EP2707390B1/en active Active
- 2012-04-20 PL PL18179328.2T patent/PL3421496T3/pl unknown
- 2012-04-20 SI SI201230482T patent/SI2707390T1/sl unknown
- 2012-04-20 ES ES18179328T patent/ES2989943T3/es active Active
- 2012-04-20 SG SG2013070701A patent/SG193551A1/en unknown
- 2012-04-20 US US14/117,118 patent/US9321842B2/en active Active
- 2012-04-20 JP JP2014510679A patent/JP6276176B2/ja active Active
- 2012-04-20 NZ NZ724296A patent/NZ724296A/en not_active IP Right Cessation
- 2012-04-20 BR BR112013029212A patent/BR112013029212B1/pt active IP Right Grant
- 2012-04-20 WO PCT/EP2012/001721 patent/WO2012156018A1/en not_active Ceased
- 2012-04-20 KR KR1020207018103A patent/KR102430870B1/ko active Active
- 2012-04-20 ME MEP-2016-39A patent/ME02369B/me unknown
- 2012-04-20 PL PL15201110T patent/PL3026064T3/pl unknown
- 2012-04-20 HR HRP20160212TT patent/HRP20160212T1/hr unknown
- 2012-04-20 PL PL12715856T patent/PL2707390T3/pl unknown
- 2012-04-20 CN CN201710009470.8A patent/CN107011440B/zh active Active
- 2012-04-20 LT LTEP15201110.2T patent/LT3026064T/lt unknown
- 2012-04-20 MX MX2013013053A patent/MX341147B/es active IP Right Grant
- 2012-04-20 RS RS20181513A patent/RS58087B1/sr unknown
- 2012-04-20 SI SI201231496T patent/SI3026064T1/sl unknown
- 2012-04-20 RU RU2013155455A patent/RU2676731C2/ru active
- 2012-04-20 CN CN201280022739.1A patent/CN103748112B/zh active Active
- 2012-05-08 AR ARP120101613A patent/AR086306A1/es active IP Right Grant
-
2013
- 2013-09-20 ZA ZA2013/07102A patent/ZA201307102B/en unknown
- 2013-10-06 IL IL228738A patent/IL228738B/en active IP Right Grant
- 2013-11-08 MX MX2020011778A patent/MX2020011778A/es unknown
- 2013-11-08 MX MX2020001224A patent/MX2020001224A/es unknown
- 2013-11-08 MX MX2020011779A patent/MX2020011779A/es unknown
-
2016
- 2016-03-01 CY CY20161100181T patent/CY1118608T1/el unknown
- 2016-03-04 SM SM201600064T patent/SMT201600064B/xx unknown
- 2016-03-21 US US15/076,536 patent/US10233253B2/en active Active
-
2017
- 2017-07-07 AU AU2017204663A patent/AU2017204663B2/en active Active
-
2018
- 2018-01-11 JP JP2018002528A patent/JP6637083B2/ja active Active
- 2018-07-05 US US16/028,210 patent/US10919974B2/en active Active
- 2018-12-21 CY CY181101393T patent/CY1121085T1/el unknown
-
2019
- 2019-01-03 HR HRP20190014TT patent/HRP20190014T1/hr unknown
- 2019-08-22 AU AU2019219797A patent/AU2019219797B2/en active Active
-
2020
- 2020-12-30 US US17/138,403 patent/US11859008B2/en active Active
-
2021
- 2021-06-28 AR ARP210101787A patent/AR122771A2/es unknown
- 2021-12-03 AU AU2021277764A patent/AU2021277764B2/en active Active
-
2023
- 2023-04-12 JP JP2023064843A patent/JP7636647B2/ja active Active
- 2023-11-27 US US18/520,264 patent/US20240101703A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME02369B (me) | Antitela za terapiju kancera koji eksprimira klaudin 6 | |
| HRP20200591T1 (hr) | Protutijela specifična za klaudin 6 (cldn6) | |
| RU2020111366A (ru) | Триспецифичные связывающие молекулы, которые специфически связывают антигены множества злокачественных опухолей, и способы их применения | |
| JP2022093564A5 (me) | ||
| JP2021508255A5 (me) | ||
| IL256871B2 (en) | Constructs for bispecific antibodies binding dll3 and cd3 and uses thereof | |
| IL317587A (en) | Antibody against SIRPalpha | |
| JP2017537620A5 (me) | ||
| NZ607710A (en) | 4-1bb binding molecules | |
| JP2018536624A5 (me) | ||
| JP2014502955A5 (me) | ||
| JP2012502938A5 (me) | ||
| HRP20150256T1 (hr) | Djelatna sredstva za vezanje notch1-receptora i postupci njihove uporabe | |
| RU2014101669A (ru) | Агенты, связывающие белки r-спондины (rspo), и способы их применения | |
| JP2018027952A5 (me) | ||
| HRP20180262T1 (hr) | Monoklonska anti-gt468 protutijela za liječenje karcinoma | |
| JP2010532169A5 (me) | ||
| FI3747472T3 (fi) | Cd19-inhibiittorin ja btk-inhibiittorin terapeuttiset yhdistelmät | |
| JP2016187356A5 (me) | ||
| MEP10609A (hr) | Nova anti-cd38 antitijela za tretman kancera | |
| JP2018509175A5 (me) | ||
| JP2016047845A5 (me) | ||
| MX2020004410A (es) | Anticuerpos biespecificos con funciones efectoras reducidas. | |
| HRP20200272T1 (hr) | Kombinirana terapija za imunocitokine varijante il-2 usmjerene na tumor i protutijela protiv humanog pd-l1 | |
| RU2016122041A (ru) | Новые анти-клаудин антитела и способы их применения |