CY1121085T1 - Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6 - Google Patents

Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6

Info

Publication number
CY1121085T1
CY1121085T1 CY181101393T CY181101393T CY1121085T1 CY 1121085 T1 CY1121085 T1 CY 1121085T1 CY 181101393 T CY181101393 T CY 181101393T CY 181101393 T CY181101393 T CY 181101393T CY 1121085 T1 CY1121085 T1 CY 1121085T1
Authority
CY
Cyprus
Prior art keywords
cancer
treatment
breast
claudine
antibodies
Prior art date
Application number
CY181101393T
Other languages
English (en)
Inventor
Ugur Sahin
Özlem Türeci
Michael Koslowski
Korden Walter
Stefan Wöll
Maria Kreuzberg
Bernd Hubner
Michael Erdeljan
Michael Weichel
Original Assignee
Ganymed Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganymed Pharmaceuticals Gmbh filed Critical Ganymed Pharmaceuticals Gmbh
Publication of CY1121085T1 publication Critical patent/CY1121085T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει αντισώματα χρήσιμα ως θεραπευτικά για θεραπευτική και/ή προληπτική αγωγή ασθενειών σχετιζόμενων με κύτταρα που εκφράζουν CLDN6, που περιλαμβάνουν ογκοσχετιζόμενες ασθένειες όπως ωοθηκικό καρκίνο, καρκίνο πνεύμονα, γαστρικό καρκίνο, καρκίνο μαστού, ηπατικό καρκίνο παγκρεατικό καρκίνο, καρκίνο δέρματος, κακόηθες μελάνωμα, καρκίνο κεφαλής και αυχένα, σάρκωμα, καρκίνο χοληφόρων πόρων, καρκίνο ουροδόχου κύστης, νεφρικό καρκίνο, καρκίνο κόλου, πλακούντιο χόριο καρκίνωμα, καρκίνο τραχήλου μήτρας, καρκίνο όρχεων, και καρκίνο μήτρας.
CY181101393T 2011-05-13 2018-12-21 Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6 CY1121085T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161486071P 2011-05-13 2011-05-13
EP11004004 2011-05-13
PCT/EP2012/001721 WO2012156018A1 (en) 2011-05-13 2012-04-20 Antibodies for treatment of cancer expressing claudin 6
EP12715856.6A EP2707390B1 (en) 2011-05-13 2012-04-20 Antibodies for treatment of cancer expressing claudin 6

Publications (1)

Publication Number Publication Date
CY1121085T1 true CY1121085T1 (el) 2019-12-11

Family

ID=47176322

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100181T CY1118608T1 (el) 2011-05-13 2016-03-01 Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6
CY181101393T CY1121085T1 (el) 2011-05-13 2018-12-21 Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20161100181T CY1118608T1 (el) 2011-05-13 2016-03-01 Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6

Country Status (29)

Country Link
US (5) US9321842B2 (el)
EP (3) EP2707390B1 (el)
JP (3) JP6276176B2 (el)
KR (3) KR102430870B1 (el)
CN (3) CN103748112B (el)
AR (2) AR086306A1 (el)
AU (4) AU2012258087B2 (el)
BR (1) BR112013029212B1 (el)
CA (1) CA2832174C (el)
CY (2) CY1118608T1 (el)
DK (2) DK3026064T3 (el)
ES (1) ES2565063T3 (el)
HK (1) HK1195320A1 (el)
HR (2) HRP20160212T1 (el)
HU (1) HUE028603T2 (el)
IL (1) IL228738B (el)
LT (1) LT3026064T (el)
ME (1) ME02369B (el)
MX (4) MX341147B (el)
NZ (3) NZ724296A (el)
PL (2) PL3026064T3 (el)
RS (2) RS58087B1 (el)
RU (1) RU2676731C2 (el)
SG (1) SG193551A1 (el)
SI (2) SI3026064T1 (el)
SM (1) SMT201600064B (el)
UA (2) UA127584C2 (el)
WO (1) WO2012156018A1 (el)
ZA (1) ZA201307102B (el)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2714096T3 (es) 2008-11-28 2019-05-27 Corbion Biotech Inc Producción de aceites adaptados en microorganismos heterotróficos
FI2398902T3 (fi) 2009-02-20 2023-11-28 Astellas Pharma Inc Menetelmiä ja koostumuksia syövän diagnoosia ja hoitoa varten
KR102126964B1 (ko) * 2009-11-11 2020-06-25 가니메드 파마슈티칼스 게엠베하 클라우딘 6 특이적 항체
EP2404936A1 (en) * 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
GB201103955D0 (en) * 2011-03-09 2011-04-20 Antitope Ltd Antibodies
DK3026064T3 (en) 2011-05-13 2019-01-14 Ganymed Pharmaceuticals Gmbh ANTIBODIES FOR TREATMENT OF CANCER EXPRESSING CLAUDIN 6
CN104662044B (zh) 2012-08-24 2018-10-30 加利福尼亚大学董事会 用于治疗ror1癌症并抑制转移的抗体和疫苗
WO2015014376A1 (en) * 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
RU2016122041A (ru) * 2013-11-06 2017-12-11 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые анти-клаудин антитела и способы их применения
JPWO2015068847A1 (ja) 2013-11-11 2017-03-09 中外製薬株式会社 改変された抗体可変領域を含む抗原結合分子
EP3095462B1 (en) 2014-01-15 2019-08-14 Order-Made Medical Research Inc. Therapeutic pharmaceutical composition employing anti-slc6a6 antibody
RS58627B2 (sr) * 2014-04-01 2022-06-30 Biontech Cell&Gene Therapies Gmbh Klaudin-6-specifični imuno receptori i t-ćelijski epitopi
TWI831044B (zh) 2014-11-11 2024-02-01 日商中外製藥股份有限公司 抗原結合分子、包含抗原結合分子的醫藥組合物以及製造及選擇抗原結合分子之方法
US10786461B2 (en) 2014-11-17 2020-09-29 Context Biopharma Inc. Onapristone extended-release compositions and methods
CN106146666B (zh) * 2015-03-26 2019-09-06 科济生物医药（上海）有限公司 靶向cldn6的免疫效应细胞及其制备方法和应用
CN105504051B (zh) * 2015-12-17 2019-08-30 北京天成新脉生物技术有限公司 狂犬病毒核蛋白单克隆抗体及其应用
IL299099A (en) 2016-06-27 2023-02-01 Univ California Combinations of cancer treatments
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
CN110099926A (zh) * 2016-12-28 2019-08-06 豪夫迈·罗氏有限公司 晚期her2表达性癌症的治疗
WO2019048040A1 (en) * 2017-09-06 2019-03-14 Ganymed Pharmaceuticals Gmbh ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER
EP4435009A2 (en) * 2017-09-18 2024-09-25 The Regents of the University of California Claudin6 antibodies and methods of treating cancer
KR20200061376A (ko) 2017-09-29 2020-06-02 다이이찌 산쿄 가부시키가이샤 항체-피롤로벤조디아제핀 유도체 콘쥬게이트
TW201938194A (zh) 2017-12-05 2019-10-01 日商中外製藥股份有限公司 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子
US20210054076A1 (en) * 2018-01-05 2021-02-25 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
KR102340989B1 (ko) * 2018-03-28 2021-12-20 에이비온 주식회사 클라우딘 3의 ecl-2에 특이적으로 결합하는 항체, 이의 단편 및 이들의 용도
JP2022520632A (ja) 2019-02-15 2022-03-31 インテグラル・モレキュラー・インコーポレイテッド 共通軽鎖を含む抗体及びその使用
WO2020168059A1 (en) * 2019-02-15 2020-08-20 Integral Molecular, Inc. Claudin 6 antibodies and uses thereof
WO2020191342A1 (en) * 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 antibodies and drug conjugates
CA3134056A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
MX2022000111A (es) 2019-07-10 2022-02-10 Chugai Pharmaceutical Co Ltd Moleculas de union a claudina-6 y usos de las mismas.
WO2021129927A1 (en) 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor
CN111087465B (zh) * 2019-12-24 2020-12-08 广州医科大学 一种针对密蛋白6的抗体偶联药物及应用
PE20221760A1 (es) 2020-03-31 2022-11-11 Chugai Pharmaceutical Co Ltd Moleculas de union al antigeno multiespecificas dirigidas a claudina-6 y sus usos
AU2021374036A1 (en) * 2020-11-06 2023-06-08 Amgen Inc. Polypeptide constructs selectively binding to cldn6 and cd3
AU2022232375A1 (en) 2021-03-09 2023-09-21 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
US20230008868A1 (en) * 2021-07-08 2023-01-12 Nippon Telegraph And Telephone Corporation User authentication device, user authentication method, and user authentication computer program
JPWO2023053282A1 (el) 2021-09-29 2023-04-06
CA3234897A1 (en) * 2021-10-14 2023-04-20 Kunle Odunsi Compositions and methods for use of recombinant t cell receptors against claudin 6
WO2024046572A1 (en) 2022-09-01 2024-03-07 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
EP4444342A1 (en) 2021-12-09 2024-10-16 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
WO2024088325A1 (zh) * 2022-10-25 2024-05-02 科济生物医药（上海）有限公司 抗体及其应用
WO2024095964A1 (ja) * 2022-10-31 2024-05-10 アステラス製薬株式会社 Ｔｏｌｌ様受容体７／８デュアルアゴニスト化合物を含む抗体薬物複合体
US12049502B2 (en) 2022-11-30 2024-07-30 Integral Molecular, Inc. Antibodies directed to claudin 6, including bispecific formats thereof
WO2024141977A1 (en) 2022-12-29 2024-07-04 Astellas Pharma Inc. Engineered natural killer cells and related methods
CN116064622B (zh) * 2023-02-13 2023-10-13 优睿赛思(武汉)生物科技有限公司 Claudin6-mCherry报告基因CHO-K1稳转细胞株制备及应用
WO2024184812A1 (en) * 2023-03-06 2024-09-12 Beigene Switzerland Gmbh Anti-cldn6 antibodies and methods of use

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946788A (en) 1985-06-11 1990-08-07 Ciba-Geigy Corporation Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
GB9019812D0 (en) 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
US5830755A (en) 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5677139A (en) 1995-04-21 1997-10-14 President And Fellows Of Harvard College In vitro differentiation of CD34+ progenitor cells into T lymphocytes
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO2000012708A2 (en) 1998-09-01 2000-03-09 Genentech, Inc. Further pro polypeptides and sequences thereof
WO2000078961A1 (en) 1999-06-23 2000-12-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US5928631A (en) 1997-06-09 1999-07-27 The Procter & Gamble Company Methods for controlling environmental odors on the body using compositions comprising uncomplexed cyclodextrins
US20020127584A1 (en) 1997-09-18 2002-09-12 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US5932445A (en) 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
EP1127119A1 (en) 1998-11-03 2001-08-29 Adherex Technologies, Inc. Compounds and methods for modulating claudin-mediated functions
CA2362423A1 (en) 1998-12-17 2000-06-22 Human Genome Sciences, Inc. 47 human secreted proteins
JP2002536995A (ja) 1999-02-22 2002-11-05 インサイト・ファーマスーティカルズ・インコーポレイテッド 結腸の疾患に関連する遺伝子
ATE357518T1 (de) 1999-06-02 2007-04-15 Genentech Inc Verfahren und zusammensetzungen zur inhibierung des neoplastischen zellwachstums
EP1067182A3 (en) 1999-07-08 2001-11-21 Helix Research Institute Secretory protein or membrane protein
EP1242443A4 (en) 1999-12-23 2005-06-22 Nuvelo Inc NEW NUCLEIC ACIDS AND POLYPEPTIDES
WO2001051513A2 (en) 2000-01-14 2001-07-19 Corixa Corporation Ovarian tumor-associated sequences
DK1309726T4 (en) 2000-03-30 2019-01-28 Whitehead Inst Biomedical Res RNA Sequence-Specific Mediators of RNA Interference
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1309620A2 (en) 2000-06-23 2003-05-14 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA2416456A1 (en) 2000-07-20 2002-01-31 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2416538A1 (en) 2000-07-20 2002-01-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU2001284703B2 (en) 2000-08-03 2007-03-22 Therapeutic Human Polyclonals Inc. Production of humanized antibodies in transgenic animals
PT1354034E (pt) 2000-11-30 2008-02-28 Medarex Inc Roedores transgénicos transcromossómicos para produção de anticorpos humanos
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
EP2000482A1 (en) 2001-06-20 2008-12-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CA2379661A1 (en) 2002-03-28 2003-09-28 Kursad Turksen Paracellular drug delivery system
AU2003230874A1 (en) 2002-04-16 2003-11-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20030235868A1 (en) * 2002-04-22 2003-12-25 Dyax Corporation Antibodies specific for mucin polypeptide
US20070207142A1 (en) 2002-05-08 2007-09-06 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
AU2003295328A1 (en) 2002-10-02 2004-04-23 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
MXPA05004022A (es) 2002-10-17 2005-10-05 Genmab As Anticuerpos monoclonales humanos contra cd20.
JP2006516192A (ja) 2002-10-18 2006-06-29 ジェネンテック・インコーポレーテッド 腫瘍の診断と治療のための組成物と方法
AT500651B9 (de) 2003-05-27 2010-04-15 Altropus Gmbh Aktiv immunisierender antikörper
KR20060035608A (ko) 2003-05-30 2006-04-26 센토코 인코포레이티드 항 조직 인자 항체로 종양 성장을 저해하는 방법
US20060019256A1 (en) 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
WO2006033664A1 (en) 2004-03-08 2006-03-30 Avalon Pharmaceuticals Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods
US7431927B2 (en) 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
DE102005025041A1 (de) 2005-05-30 2006-12-07 Bell Flavors & Fragrances Duft Und Aroma Gmbh Mittel zur Anwendung in Spülmaschinen sowie Vorrichtung für dessen dosierte Einbringung während der Spül- und Trocknungsphasen
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
EP1970384A1 (en) * 2007-03-14 2008-09-17 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
EP2138576A4 (en) 2007-03-16 2011-02-23 Kyowa Hakko Kirin Co Ltd ANTI-CLAUDIN-4 ANTIBODY
EP1997832A1 (en) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
WO2009025759A1 (en) * 2007-08-17 2009-02-26 Progenics Pharmaceuticals (Nevada), Inc. Tight junction proteins associated with infection and entry of hepatitis c virus (hcv), methods and uses thereof
WO2009028663A1 (ja) * 2007-08-30 2009-03-05 Kyowa Hakko Kirin Co., Ltd. 抗Claudin-3抗体
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
CA2711557A1 (en) * 2008-01-11 2009-07-16 The University Of Tokyo Anti-cldn6 antibody
WO2009126926A2 (en) 2008-04-11 2009-10-15 Bionovo, Inc. Anticancer methods employing extracts of gleditsia sinensis lam
EP2352764B1 (en) 2008-10-14 2018-03-28 Ablynx N.V. AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY
DE102009026966A1 (de) 2008-12-18 2010-07-01 Robert Bosch Gmbh Betrieb eines Bremskraftverstärkers als Pedalsimulator
JP2010178650A (ja) 2009-02-04 2010-08-19 Univ Of Tokyo 固形癌の再発予測のための試験方法および再発予防剤
EP2221063A1 (en) 2009-02-20 2010-08-25 Ganymed Pharmaceuticals AG Methods and compositions for diagnosis and treatment of cancer
FI2398902T3 (fi) * 2009-02-20 2023-11-28 Astellas Pharma Inc Menetelmiä ja koostumuksia syövän diagnoosia ja hoitoa varten
EP2322555A1 (en) * 2009-11-11 2011-05-18 Ganymed Pharmaceuticals AG Antibodies specific for claudin 6 (CLDN6)
KR102126964B1 (ko) 2009-11-11 2020-06-25 가니메드 파마슈티칼스 게엠베하 클라우딘 6 특이적 항체
WO2011105551A1 (ja) 2010-02-26 2011-09-01 国立大学法人大阪大学 癌幹細胞の検出方法、及び癌の治療剤または再発予防剤
EP2404936A1 (en) 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
DK3026064T3 (en) 2011-05-13 2019-01-14 Ganymed Pharmaceuticals Gmbh ANTIBODIES FOR TREATMENT OF CANCER EXPRESSING CLAUDIN 6
JP6077997B2 (ja) 2011-09-07 2017-02-08 中外製薬株式会社 癌幹細胞の分離
EP2605017A1 (de) 2011-12-16 2013-06-19 Protagen AG Markersequenzen für gynäkologisches Malignom und deren Verwendung
EP2875046B1 (en) 2012-07-19 2020-02-26 Amgen Inc. Human btnl3 proteins, nucleic acids, and antibodies and uses thereof
WO2015014376A1 (en) 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells

Also Published As

Publication number Publication date
ZA201307102B (en) 2016-08-31
HK1195320A1 (en) 2014-11-07
HRP20160212T1 (hr) 2016-05-06
CN107090043A (zh) 2017-08-25
HRP20190014T1 (hr) 2019-02-22
HUE028603T2 (en) 2016-12-28
IL228738B (en) 2018-10-31
EP2707390B1 (en) 2015-12-30
RS58087B1 (sr) 2019-02-28
CN107090043B (zh) 2021-12-07
NZ741567A (en) 2023-10-27
CN103748112A (zh) 2014-04-23
AU2017204663B2 (en) 2019-05-23
NZ724296A (en) 2020-05-29
US20160264677A1 (en) 2016-09-15
JP2023089133A (ja) 2023-06-27
ME02369B (me) 2016-06-20
SI3026064T1 (sl) 2019-03-29
KR102708094B1 (ko) 2024-09-24
DK2707390T3 (en) 2016-02-29
ES2565063T3 (es) 2016-03-31
JP6276176B2 (ja) 2018-02-07
RS54627B1 (en) 2016-08-31
RU2676731C2 (ru) 2019-01-10
SMT201600064B (it) 2016-04-29
CN107011440A (zh) 2017-08-04
RU2018145274A (ru) 2019-01-24
AU2017204663A1 (en) 2017-07-27
AR086306A1 (es) 2013-12-04
JP2018095650A (ja) 2018-06-21
AU2012258087B2 (en) 2017-07-20
NZ617214A (en) 2016-04-29
MX2020001224A (es) 2020-07-20
AU2021277764A1 (en) 2021-12-23
SG193551A1 (en) 2013-10-30
NZ706004A (en) 2016-12-23
JP6637083B2 (ja) 2020-01-29
CA2832174C (en) 2024-02-27
CN107011440B (zh) 2021-03-05
US20140127219A1 (en) 2014-05-08
MX2013013053A (es) 2014-05-27
MX2020011779A (es) 2020-11-24
EP3421496C0 (en) 2024-08-07
EP3421496B1 (en) 2024-08-07
CY1118608T1 (el) 2017-07-12
KR20220116069A (ko) 2022-08-19
IL228738A0 (en) 2013-12-31
UA115969C2 (uk) 2018-01-25
EP2707390A1 (en) 2014-03-19
BR112013029212A2 (pt) 2016-11-29
BR112013029212B1 (pt) 2020-05-19
SI2707390T1 (sl) 2016-04-29
WO2012156018A1 (en) 2012-11-22
MX341147B (es) 2016-08-09
US10919974B2 (en) 2021-02-16
KR102072183B1 (ko) 2020-02-03
AU2012258087A1 (en) 2013-11-21
EP3421496A1 (en) 2019-01-02
DK3026064T3 (en) 2019-01-14
WO2012156018A8 (en) 2013-10-17
EP3026064A1 (en) 2016-06-01
EP3026064B1 (en) 2018-10-17
US11859008B2 (en) 2024-01-02
CA2832174A1 (en) 2012-11-22
US10233253B2 (en) 2019-03-19
AR122771A2 (es) 2022-10-05
KR20140033045A (ko) 2014-03-17
UA127584C2 (uk) 2023-10-25
PL2707390T3 (pl) 2016-06-30
US20190010244A1 (en) 2019-01-10
PL3026064T3 (pl) 2019-05-31
MX2020011778A (es) 2020-11-24
US20210179730A1 (en) 2021-06-17
AU2019219797A1 (en) 2019-09-12
LT3026064T (lt) 2019-01-25
US9321842B2 (en) 2016-04-26
US20240101703A1 (en) 2024-03-28
KR20200078692A (ko) 2020-07-01
JP2014516956A (ja) 2014-07-17
KR102430870B1 (ko) 2022-08-09
AU2019219797B2 (en) 2021-09-09
CN103748112B (zh) 2017-02-15
RU2013155455A (ru) 2015-06-20

Similar Documents

Publication Publication Date Title
CY1121085T1 (el) Αντισωματα για θεραπευτικη αγωγη καρκινου που εκφραζει κλαυδινη 6
CY1123192T1 (el) Αντισωματα ειδικα στην κλαουδινη 6 (cldν6)
JOP20200192A1 (ar) أجسام مضادة لـ tigit
CY1122456T1 (el) Μονοκλωνικα αντισωματα εναντιον παραγοντα 15 αυξησης και διαφοροποιησης (gdf-15), και χρησεις αυτων για θεραπευτικη αγωγη καρκινικης καχεξιας και καρκινου
MX2021014286A (es) Proteinas multiespecificas.
MX2017004715A (es) Anticuerpos anti-ox40 humanizados y usos de los mismos.
PH12017500002A1 (en) Anti-cdh6 antibody drug conjugates
EA202092609A1 (ru) Антитела к cd38 для лечения острого миелолейкоза
MX361259B (es) Uso de un fragmento de peptido hmgb1 para el tratamiento del infarto al miocardio.
TR201900071T4 (tr) Kontrollü Over Stimülasyonuna Yönelik Bileşim
MX2018009794A (es) Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados.
MX2021007141A (es) Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido.
NZ720106A (en) A process for the preparation of regadenoson
MX2021007143A (es) Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido.
TR201905218T4 (tr) Nörodejenerati̇f hastaliklarin tedavi̇si̇ i̇çi̇n yararli vi̇tanoli̇dler.
MX2020000636A (es) Proteinas sinteticas y usos terapeuticos de las mismas.
EA201690263A1 (ru) Улучшенные способы получения перампанеля
MX2015014470A (es) Analogos de combretastatina.
TW201612192A (en) Therapy for GIST
TR201821021T4 (tr) Kanser tedavi̇si̇ne yöneli̇k claudin 6 ekspresyonlu anti̇korlar.
EA201992022A1 (ru) Терапевтическая рнк
EA201691620A1 (ru) Циклопропиламины в качестве ингибиторов lsd1